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Acupuncture Regulates the Balance of CD4^+ T Cell Subtypes in Experimental Asthma mice

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Chinese Journal of Integrative Medicine 2019年第8期25卷 617-624页

作者： dong ming WANG Wen-qian CHEN Juan LI mi-hui XU Fei CUI Jie dong Jing-cheng wei Ying Gumei Community Health Center of min hang District Shanghai (201102)China Department of Integrative Medicine Huashan Hospital Fudan University Shanghai (200040)China Institutes of Integrative Medicine of Fudan University Shanghai (200040)China Department of Pediatric Neurological Rehabilitation Maternal and Child Health Hospital of Dengfeng Dengfeng (452470) Henan ProvinceChina

Objective: To evaluate the involvement of different CD4+ T cell subtypes in the anti-asthmatic effects of acupuncture in asthmatic mice. Methods: BALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Acupoints Dazhui (GV 14), bilateral Fengmen (BL 12) and Feishu (BL 13) were selected for manual acupuncture treatment every other day for 4 weeks and Huantiao (GB 30) was selected for sham acupuncture. Airway hyperresponsiveness was examined by Buxco Pulmonary System. Pulmonary histopathology analysis was performed for inflammatory cell infiltration and mucus hypersecretion by haematoxylin eosin staining and periodic acid-Schiff staining. Inflammatory mediators assays of serum were investigated by enzyme-linked immunosorbent assay and Bio-Plex. CD4+ T cell subpopulations including the expression levels of important factors in T lymphocyte polarization in lung tissue were examined by flow cytometric and Western blot analyses. Related pathways were detected by Western blot assay. Results: Compared with the OVA-induced asthma model group, acupuncture could attenuate airway hyperresponsiveness, inhibit inflammatory cell infiltration and mucus hypersecretion (P<0.05 or P<0.01). Furthermore, acupuncture increased the expressions of T-bet and Foxp3+, the cell numbers of CD4+ interferon gamma (IFN-γ)+ and CD4+ Foxp3+ in lung tissue and the level of Treg type cytokine interleukin (IL)-10 in serum (P<0.05 or P<0.01). Meanwhile, acupuncture reduced the RAR-related orphan receptor gamma t (RORγ t) level, the cell numbers of CD4+ IL-17A+ as well as the levels of IL-5, IL-13 and IL-17A in serum (P<0.05 or P<0.01). In addition, both acupuncture and sham acupuncture could inhibit the phosphorylation of p38 and p44/42 (P<0.01). Conclusion: Acupuncture could alleviate allergic airway infla

关键词： acupuncture asthma Th2 Th17 Treg

瓜蒌- 薤白调节肠道菌群治疗冠心病模型大鼠的作用及机制

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中国组织工程研究 2025年第5期29卷 917-927页

作者：孙广瀚谢珍聪孙咪徐洋郭栋山东中医药大学第一临床医学院山东省济南市250014 山东中医药大学教师发展中心山东省济南市250355 山东中医药大学药物研究院山东省济南市250355

背景:基于网络药理学方法发现瓜蒌-薤白药对中主要生物活性化合物对冠心病有多功能作用;然而其治疗冠心病的机制尚未得到充分阐释。目的:探讨瓜蒌-薤白通过调节肠道微生物的组成改善冠心病的作用及机制。方法:40只SD大鼠按随机数字表法... 详细信息

背景:基于网络药理学方法发现瓜蒌-薤白药对中主要生物活性化合物对冠心病有多功能作用;然而其治疗冠心病的机制尚未得到充分阐释。目的:探讨瓜蒌-薤白通过调节肠道微生物的组成改善冠心病的作用及机制。方法:40只SD大鼠按随机数字表法分为空白组、模型组、阳性药组、药对组,除空白组外,其余大鼠连续灌胃脂肪乳剂和注射垂体后叶素制备冠心病大鼠模型。造模后模型组大鼠灌胃蒸馏水(10 mL/kg)进行对照,阳性药组大鼠每日灌胃辛伐他汀4 mg/kg,药对组每日灌胃瓜蒌-薤白7.56 g/kg,各组大鼠给药均为14 d。观察大鼠心电图、心肌病理及血脂变化,并通过16S rDNA测序技术研究大鼠经干预后肠道微生物结构。结果与结论:①心电图结果显示模型组ST抬高;阳性药组与药对组心电图无明显问题。②与空白组相比,模型组总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平均显著增高(P0.05),Simpson指数降低(Pmicutes、Muribaculaceae_norank等相对丰度降低;与阳性药相比,药对组Desulfobacterota、Bacteroides等相对丰度升高,Firmicutes、[Eubacterium]_coprostanoligenes_group_norank等相对丰度降低;LEfSe结果发现差异显著的种群富集于药对组最多,其次是空白组、阳性药组,模型组最少。⑥结论:瓜蒌-薤白可以通过调节肠道菌群改善冠心病的发生发展,为进一步研发瓜蒌-薤白提供新的启示。

关键词： “瓜蒌-薤白”药对 16S rDNA 冠心病肠道菌群大鼠

Metachronous mixed cellularity classical Hodgkin’s lymphoma and T-cell leukemia/lymphoma: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8177-8185页

作者： Yang dong Lai-Jun Deng mi-mi Li Department of Clinical Pharmacy Weifang Hospital of Traditional Chinese MedicineWeifang 261000Shandong ProvinceChina Department of Hematology Weifang Hospital of Traditional Chinese MedicineWeifang 261000Shandong ProvinceChina Department of Pathology Weifang Hospital of Traditional Chinese MedicineWeifang 261000Shandong ProvinceChina

BACKGROUND The development of peripheral T-cell lymphoma(PTCL)after chemotherapy for Hodgkin’s lymphoma(HL)is rare,and highly aggressive TCL/leukemia has not been reported to *** relationship between HL and PTCL needs further exploration to understand the pathogenesis of metachronous lymphoma(ML)and find effective treatment *** report a patient with ML,whose biopsy of a right cervical lymph node initially confirmed classical HL(CHL).CASE SUMMARY We report a patient with ML,whose biopsy of a right cervical lymph node initially confirmed CHL,with typical reed–sternberg cells expressing CD30 and PAX-5.T-cell leukemia/lymphoma occurred 3 years after treatment,and a lymph node biopsy at the onset confirmed PTCL,nonspecific type,expressing CD3,CD4 and *** patient was treated with standard doses of chemotherapy,programmed cell death-ligand 1 monoclonal antibody,and chidamide,all of which failed to achieve complete *** patient was diagnosed with refractory state,and eventually died of leukocyte *** The accuracy of the diagnosis needs to be confirmed when chemotherapeutic drugs are not effective.

关键词： Classical Hodgkin’s lymphoma T-cell lymphoma/leukemia Bone marrow Chemotherapy Drug resistance Case report

A nonlinear dynamic macro-element for demand assessment of bridge substructures subjected to ship collision

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第11期12卷 826-836页

作者： wei FAN Wan-cheng YUAN mi ZHOU IState Key Laboratory of Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China 2Department of Civil Engineering Purdue University West Lafayette 47907 USA Key Laboratory for Old Bridge Detection and Reinforcement Technology of ministry of Transportation Chang＇an University Xi ＇an 710064 China

For the dynamic demand assessment of bridge structures under ship impact loading,it may be prudent to adopt analytical models which permit rapid analysis with reasonable ***,a nonlinear dynamic macro-element is proposed and implemented to quantify the demand of bridge substructures subjected to ship *** the proposed nonlinear macro-element,a combination of an elastic-plastic spring and a dashpot in parallel is employed to describe the mechanical behavior of ship-bows with strain rate *** on the analytical model using the proposed macro-element,a typical substructure under 5000 deadweight tonnage(DWT) ship collision is *** analyses indicate that the responses of the structure using the nonlinear macro-element agree with the results from the high resolution model,but the efficiency and feasibility of the proposed method increase significantly in practical ***,comparisons between some current design codes(AASHTO,JTGD60-2004,and TB10002.1-2005) and the developed dynamic analysis method suggest that these design codes may be improved,at least to consider the effect of dynamic amplification on structural demand.

关键词： Nonlinear macro-element Ship-bridge collision P-a curve Dynamic demand Design codes

Kinetics of discontinuous precipitation in Cu–20Ni–20Mn alloy

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International Journal of minerals,Metallurgy and Materials 2016年第3期23卷 323-329页

作者： wei-bin Xie Qiang-song Wang Guo-liang Xie Xu-jun mi dong-mei Liu Xue-Cheng Gao State Key Laboratory for Fabrication and Processing of Non-ferrous Metals General Research Institute for Nonferrous Metals

The morphology and growth kinetics of discontinuous precipitation （DP） in a Cu-20Ni-20Mn alloy were investigated in the tem- perature range of523-573 K by optical microscopy, scanning electron microscopy, and transmission electron microscopy. A lamellar mixed structure consisting of alternating larnellae of a matrix and NiMn phase was observed in DP colonies. The volume fraction of regions formed by a DP reaction was determined by quantitative metallographic measurements. The kinetics of DP was evaluated on the basis of the John- son-MehI-Avrami Kohnogorov equation, which resulted in a time exponent of approximately 1.5. We confirmed that the nucleation of the discontinuous precipitate was confined to grain edges or boundaries at an early stage of the reaction. The activation energy of DP process was determined to be approximately （72.7 ± 7.2） kJ/mol based on the Arrhenius equation; this result suggests that DP is controlled by gn-ain boundary diffusion. The hardness values exhibited good correlation with the volume fraction of DP; this correlation was attributed to the plvsence of the ordered N iMn phase.

关键词： copper nickel manganese alloys: microstructural evolution precipitation kinetics

Attenuating effect of daidzein on polychlorinated biphenyls-induced oxidative toxicity in mouse testicular cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第7期9卷 567-571页

作者： Da-lei ZHANG Yu-ling mi Kai-ming WANG wei-dong ZENG Cai-qiao ZHANG College of Animal Sciences Zhejiang University Hangzhou 310029 China Department of Physiology College of Medicine Nanehang University Nanehang 330006 China

The attenuating effect of daidzein (DAI) on oxidative toxicity induced by Aroclor 1254 (A1254) was investigated in mouse testicular cells. Cells were exposed to A1254 alone or with DAI. The oxidative damage was estimated by measuring malondialdehyde (MDA) formation, superoxide dismutase (SOD) activity and glutathione (GSH) content. Results show that A1254 induced a decrease of germ cell number, an elevation in thiobarbituric acid reactive substances (TBARS) but a decrease in SOD activity and GSH content. However, simultaneous supplementation with DAI decreased TBARS level and increased SOD activity and GSH content. Consequently, dietary DAI may restore the intracellular antioxidant system to attenuate the oxidative toxicity of A1254 in testicular cells.

关键词： Daidzein (DAI) Polychlorinated biphenyl (PCB) Oxidative damage. Germ cell

Computational Path Planner for Product Assembly in Complex Environments

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Chinese Journal of Mechanical Engineering 2013年第2期26卷 282-292页

作者： SHANG wei LIU Jianhua NING Ruxin LIU mi School of Mechanical Engineering Beijing Institute of Technology

Assembly path planning is a crucial problem in assembly related design and manufacturing processes. Sampling based motion planning algorithms are used for computational assembly path planning. However, the performance of such algorithms may degrade much in environments with complex product structure, narrow passages or other challenging scenarios. A computational path planner for automatic assembly path planning in complex 3D environments is presented. The global planning process is divided into three phases based on the environment and specific algorithms are proposed and utilized in each phase to solve the challenging issues. A novel ray test based stochastic collision detection method is proposed to evaluate the intersection between two polyhedral objects. This method avoids fake collisions in conventional methods and degrades the geometric constraint when a part has to be removed with surface contact with other parts. A refined history based rapidly-exploring random tree （RRT） algorithm which bias the growth of the tree based on its planning history is proposed and employed in the planning phase where the path is simple but the space is highly constrained. A novel adaptive RRT algorithm is developed for the path planning problem with challenging scenarios and uncertain environment. With extending values assigned on each tree node and extending schemes applied, the tree can adapts its growth to explore complex environments more efficiently. Experiments on the key algorithms are carried out and comparisons are made between the conventional path planning algorithms and the presented ones. The comparing results show that based on the proposed algorithms, the path planner can compute assembly path in challenging complex environments more efficiently and with higher success. This research provides the references to the study of computational assembly path planning under complex environments.

关键词： assembly path planning motion planning stochastic collision detection rapidly-exploring random tree adaptive RRT

Sodium Nitrate Passivation as a Novel Insulation Technology for Soft Magnetic Composites

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Engineering 2023年第1期20卷 134-142页

作者： mi Yan Qiming Chen dong Liu Chen Wu Jian Wang State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China School of Chemical Engineering Shandong University of TechnologyZibo 255049China National Institute for Materials Science Tsukuba 305-0047Japan

Sodium nitrate passivation has been developed as a new insulation technology for the production of FeSiAl soft magnetic composites (SMCs). In this work, the evolution of coating layers grown at different pH values is investigated involving analyses on their composition and microstructure. An insulation coating obtained using an acidic NaNO_(3) solution is found to contain Fe2O_(3), SiO_(2), Al2O_(3), and AlO(OH). The Fe2O_(3) transforms into Fe3O4 with weakened oxidizability of the NO_(3)– at an elevated pH, whereas an alkaline NaNO_(3) solution leads to the production of Al2O_(3), AlO(OH), and SiO_(2). Such growth is explained from both thermodynamic and kinetic perspectives and is correlated to the soft magnetic properties of the FeSiAl SMCs. Under tuned passivation conditions, optimal performance with an effective permeability of 97.2 and a core loss of 296.4 mW∙cm−3 is achieved at 50 kHz and 100 mT.

关键词： Soft magnetic composites Surface passivation Insulation technology Growth mechanism Magnetic performance

Genome-wide analysis of the invertase genes in strawberry(Fragaria×ananassa)

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Journal of Integrative Agriculture 2021年第10期20卷 2652-2665页

作者： YUAN Hua-zhao PANG Fu-hua CAI wei-jian CHEN Xiao-dong ZHAO mi-zhen YU Hong-mei Institute of Pomology Jiangsu Academy of Agricultural Sciences/Jiangsu Key Laboratory for Horticultural Crop Genetic ImprovementNanjing 210014P.R.China

Sugar is an important material basis in fruit development,and strawberry fruit flavour and sweetness largely depend on the sugar content and ***(INVs)play an important role in the regulation of sugar accumulation because they irreversibly catalyse the hydrolysis of sucrose into the corresponding nucleoside diphosphate-glucose,glucose or fructose in *** this work,we provided a comprehensive analysis of the INV gene family in octoploid strawberry(Fragaria×ananassa),including the gene structure,chromosomal locations,conserved domains,and gene evolution and expression profiles during strawberry fruit *** study revealed that polyploid events resulted in the abundant amplification(almost three-or four-fold)of the INV gene in the F.×ananassa genome,and these amplified INV genes showed dominant expression in strawberry *** than half of the FaINVs transcripts with low expression had incomplete coding sequences by alternative *** studies have shown that cell wall invertases(CWINV)are involved in the regulation of phloem unloading and sink strength *** expression of FaCWINV1 was markedly upregulated during fruit development and strongly expressed in ripe ***,a significant correlation was observed between the total sugar content and the FaCWINV1 expression *** findings suggest that FaCWINV1 may be involved in sugar accumulation in strawberry *** together,the results of our study will be beneficial for further research into the functions of INVs in the regulation of fruit ripening.

关键词： strawberry sugar invertases fruit ripening