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Neural Regeneration Research 2018年第11期13卷 1937-1944页

作者： Xiao-Ying Zhang Li-ming Zhang wei-dong mi Yun-Feng Li Anesthesia and Operation Center Chinese PLA General Hospital Beijing China State Key Laboratory of Toxicology and Medical Countermeasures Beijing China

Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.

关键词： nerve regeneration YL-IPA08 hippocampus dentate gyrus lipopolysaccharide neuroinflammation depression translocator protein neural regeneration

Using preoperative N-terminal pro-B-type natriuretic peptide levels for predicting major adverse cardiovascular events and myocardial injury after noncardiac surgery in Chinese advanced-age patients

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Journal of Geriatric Cardiology 2022年第10期19卷 768-779页

作者： Kai ZHANG Chang LIU Jian TAN Yu-Hai XU Jiang-Bei CAO Yan-Hong LIU Qiang FU Jing-Sheng LOU wei-dong mi Hao LI Department of Anesthesiology the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese PLA BeijingChina Department of Thoracic Surgery the Seventh Medical CentreChinese PLA General HospitalBeijingChina Department of Anesthesiology Air Force Medical CenterBeijingChina

BACKGROUND N-terminal pro-B-type natriuretic peptide(NT-proBNP)is often viewed as an indicator for heart ***,the prognostic association and the predictive utility of NT-proBNP for postoperative major adverse cardiovascular events(MACEs)and myocardial injury after noncardiac surgery(miNS)among older patients are *** In this study,we included 5033 patients aged 65 years or older who underwent noncardiac surgery with preoperative NT-proBNP *** regression was adopted to model the associations between preoperative NT-proBNP and the risk of MACEs and *** receiver operating characteristic curve was used to determine the predictive value of *** A total of 5033 patients were enrolled,63 patients(1.25%)and 525 patients(10.43%)had incident postoperative MACEs and miNS,*** of the receiver operating characteristic curve indicated that the cutoff values of ln(NT-proBNP)for MACEs and miNS were 5.16(174 pg/mL)and 5.30(200 pg/mL),*** preoperative ln(NT-proBNP)to the Revised Cardiac Risk Index score and the Cardiac and Stroke Risk Model boosted the area under the receiver operating characteristic curves from 0.682 to 0.726 and 0.787 to 0.804,*** inclusion of preoperative NT-proBNP in the prediction models significantly increased the reclassification and *** Increased preoperative NT-proBNP was associated with a higher risk of postoperative MACEs and *** inclusion of NT-proBNP enhances the predictive ability of the preexisting models.

关键词： patients preoperative surgery

阿司匹林诱生型脂氧素A4对小鼠脊髓撞击损伤后神经病理性疼痛的影响及机制探讨

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中国现代医学杂志 2017年第8期27卷 27-31页

作者：郭云翮李祥米卫东山西大同大学医学院外科教研室山西大同037009

目的评估阿司匹林诱生型脂氧素A4(ATL)对小鼠脊髓损伤(SCI)模型中神经炎症和神经病理痛的影响。方法成年FVB小鼠T10节段脊髓进行改良Allen'脊髓撞击损伤。小鼠随机分成ATL组和Vehicle组,分别在SCI手术后4和24 h鞘内注射ATL(300 pmol)或v... 详细信息

目的评估阿司匹林诱生型脂氧素A4(ATL)对小鼠脊髓损伤(SCI)模型中神经炎症和神经病理痛的影响。方法成年FVB小鼠T10节段脊髓进行改良Allen'脊髓撞击损伤。小鼠随机分成ATL组和Vehicle组,分别在SCI手术后4和24 h鞘内注射ATL(300 pmol)或vehicle。采用von Frey方法评估两组小鼠后脚机械刺激的敏感性;采用PCR方法检测两组小鼠脊髓小胶质细胞标记物和细胞因子信使核糖核酸(m RNA)表达;此外,通过小鼠大脑皮层组织小胶质细胞培养来评估ATL对小胶质细胞的激活和肿瘤坏死因子-α(TNF-α)释放的直接影响。结果与Vehicle组小鼠比较,ATL处理导致SCI诱导的小鼠机械痛敏降低;脊髓小胶质细胞标记物和促炎性细胞因子m RNA水平也下降。而且,ATL处理对小胶质细胞标记物IBA-1和促炎性因子TNF-α表达影响。此外,原代皮层小胶质细胞表达ATL相应受体ALX,ATL通过ALX发挥抗炎作用。结论ATL通过ALX受体调节小胶质细胞激活和TNF-α释放,最终降低小鼠SCI后神经病理性疼痛。

关键词：阿司匹林诱生型脂氧素A4 脊髓损伤神经病理性疼痛小鼠

手性Schiff Base-Ti(OR)4配合物催化醛的不对称硅腈化反应

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高等学校化学学报 1998年第9期 3-5页

作者： FENG Xiao ming, GONG Liu Zhu, HU Wen Hao, LI Zhi, PAN wei dong, mi Ai Qiao, JIANG Yao Zhong * (Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041)

设计合成了新型手性Ｓａｌｅｎ－Ｔｉ（ＯＲ）４配合物催化剂，用其催化一系列醛的不对称硅腈化反应，得到了ｅ．ｅ．值为２２．４％～８７．１％的氰醇．催化剂中抗衡离子的Ｌｅｗｉｓ碱强烈地影响催化活性，但对反应的对映选择性影响... 详细信息

设计合成了新型手性Ｓａｌｅｎ－Ｔｉ（ＯＲ）４配合物催化剂，用其催化一系列醛的不对称硅腈化反应，得到了ｅ．ｅ．值为２２．４％～８７．１％的氰醇．催化剂中抗衡离子的Ｌｅｗｉｓ碱强烈地影响催化活性，但对反应的对映选择性影响很小，并探讨了其不对称催化反应机理．

关键词： Schifbase-Ti(OR)4配合物抗衡离子催化不对称硅腈化反应

侧脑室注射GT-0198对坐骨神经慢性压迫性损伤大鼠的研究

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中国现代医学杂志 2018年第25期28卷 6-10页

作者：郭云翮李祥米卫东山西大同大学医学院外科教研室山西大同037009

目的观察侧脑室注射选择性甘氨酸转运体-2(Gly T2)抑制剂GT-0198对大鼠慢性压迫损伤(CCI)神经病理性疼痛模型的镇痛作用。方法实验大鼠随机分为正常对照组和CCI组。CCI组大鼠进行坐骨神经压迫性损伤模型复制。采用旋转实验评估正常大鼠... 详细信息

目的观察侧脑室注射选择性甘氨酸转运体-2(Gly T2)抑制剂GT-0198对大鼠慢性压迫损伤(CCI)神经病理性疼痛模型的镇痛作用。方法实验大鼠随机分为正常对照组和CCI组。CCI组大鼠进行坐骨神经压迫性损伤模型复制。采用旋转实验评估正常大鼠的运动功能。采用电子Von Frey实验、冷板实验和热痛刺激反应分别评估CCI大鼠机械、冷和热痛觉过敏。侧脑室注射GT-0198(10、50和100μg)后观察其镇痛作用。结果正常对照组大鼠侧脑室注射GT-0198不影响其运动功能。GT-0198抑制CCI组大鼠机械和冷痛觉过敏,并呈剂量依赖性。GT-0198(100μg)的镇痛作用可被侧脑室注射甘氨酸受体拮抗剂—士的宁(STR)完全逆转。结论选择性Gly T2抑制剂GT-0198可用于治疗大鼠CCI神经病理性疼痛,同时不影响运动功能。

关键词：甘氨酸转运体-2抑制剂慢性压迫性损伤神经病理性疼痛大鼠

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对中医心理病因之奖惩教育场合异常的探讨

医学争鸣 2016年第6期37卷 37-38,42页

作者：李世通杜金全汪卫东王米渠中国中医科学院广安门医院南区北京102600 四川省南充市嘉陵区第三人民医院四川南充637000 中国中医科学院广安门医院北京100053 成都中医药大学四川成都610075

本研究是以中医心理之教育治疗病因理论和临床实践为基础,从公开场合奖惩、家庭场合奖惩、单独场合奖惩3个方面展开探讨家庭教育之奖惩场合异常,为中医心理临床诊疗和家庭教育预防提供新思路。

关键词：中医心理教育治疗奖惩教育场合

Formation of the Moping Dome in the Xuefengshan Orocline, Central China and its Tectonic Significance

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Acta Geologica Sinica(English Edition) 2013年第3期87卷 720-729页

作者： SHI wei dong Shuwen LI Jianhua TIAN mi WU Guoli Institute of Geomechanics Chinese Academy of Geological Sciences Key Laboratory of Neotectonic Movement and Geohazard Ministry of Land and Resources Chinese Academy of Geological Sciences Wuxi Research Institute of Petroleum Geology SINOPEC Institute of Geology and Geophysics Chinese Academy of Sciences

Many equiaxial dome-like structures developed in the north segment of the Xuefengshan orocline, Central China are obviously inconcordant with the NE-trending linear structures in this area, which contain important records for understanding the structural framework and evolution of this belt. In this paper, taking one of the typical dome-like structures in the Xuefengshan orcline （e.g. Moping dome-like structure） as an example, based on its structural framework interpratatoin, superposed deformation analysis and paleo-stress fields reconstruction, we propose the Moping dome- like structure is composed of two populations of different-striking thrust-fold structures, -E-trending and NE-striking structures, indicative of two-stages shortening, -N- and NW-striking, respectively. Together with the geochronological analysis, we suggest the first stage of shortening occurred in Late Triassic to Early Jurassic, due to the Indosinian intercollisional orogeny of the Yangtze Block and the North China Block. The second occurred during Late Jurassic-Early Cretaceous owing to Yanshanian intracontinental orogeny, leading to the intensive superposition of the NE-trending structures onto the -E-trending structures, and the final ocurrence of the Moping dome. Thus, our study indicates the Xuefengshan arc-shape belt also experienced two-phase deformation, and resulted from the superposition of NE-SW structures onto -E-W structures in Late Jurassic-Early Cretaceous, which could provide new structural evidence for probing the Mesozoic tectonic framework and evolution of the Xuefengshan orocline.

关键词： Xuefengshan orocline Moping dome superposed structure paleo-stress field intracontinental orogeny

Expansion and expression diversity of FAR1/FRS-like genes provides insights into flowering time regulation in roses

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Plant Diversity 2021年第2期43卷 173-179页

作者： mi-Cai Zhong Xiao-dong Jiang wei-Hua Cui Jin-Yong Hu CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Roses are important horticultural plants with enormous diversity in flowers and flowering ***,molecular regulation of flowering time variation in roses remains poorly ***,we report an expansion of the FAR1/FRS-like genes that correlates well with the switch to prostrate-toerect growth of shoots upon flowering in Rosa wichuraiana‘Basye's Thornless'(BT).With the availability of the high-quality chromosome-level genome assembly for BT that we developed recently,we identified 91 RwFAR1/FRS-like genes,a significant expansion in contrast to 52 in Rosa chinensis‘Old Blush’(OB),a founder genotype in modern rose *** FAR1/FRS-like proteins feature distinct variation in protein domain *** dispersed expansion of RwFAR1/FRS-like genes occurred specifically in clade I and II and is significantly associated with transposon insertion in *** of the RwFAR1/FRS-like genes showed relatively higher expression level than their corresponding orthologs in ***1/FRS-like genes regulate light-signaling processes,shade avoidance,and flowering time in Arabidopsis ***,the expansion and duplication of RwFAR1/FRS-like genes,followed by diversification in gene expression,might offer a novel leverage point for further understanding the molecular regulation of the variation in shoot-growth behavior and flowering time in roses.

关键词： Rose FAR1/FRS-Like genes Gene family expansion Flowering time Shoot growth behavior

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou Ke Yajing Zhao Xin min Yanghong Li Ruiyu mi Yangai Liu Xiaowen Wu minghao Fang Zhaohui Huang Engineering Research Center of ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes