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Problem-based learning in pharmacology:a survey of department heads in Taiwan, China

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Acta Pharmacologica Sinica 2004年第9期 137-139页

作者： Ying-tung LAUdepartment of physiology and Pharmacology School of Medicine, chang Cung university, Taoyuan, Taiwan, China

Problem-based learning (PEL) requires active student participation and the use of clinical cases as a trigger to learn within a given area. It has gained much attention as a pedagogic alternative in the course of reform in medical education due to information overload. From discipline-based consideration, it is interesting to understand the views of department heads of pharmacology about implementing PBL for their medical students. According to a

关键词： problem-based learning pharmacology medical education

Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats

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Acta Pharmacologica Sinica 2006年第8期27卷 971-980页

作者： Xiao-hui LI~2 Jun-bao DU~(2,6) Ding-fang BU~3 Xiu-ying TANG~4 Chao-shu TANG~5 ~1department of Pediatrics,Peking university First Hospital,Key Laboratory of Molecular Cardiovascular Diseases,Ministry of Education ~3 Laboratory Center ~4Laboratory of Electron Microscopy,Peking university First Hospital,Beijing 100034,China ~5department of physiology,Peking university Health Science Center,Beijing 100083,China department of Pediatrics Peking University First Hospital Key Laboratory of Molecular Cardiovascular Diseases Ministry of Education Beijing China Laboratory Center Peking University First Hospital Beijing China Laboratory of Electron Microscopy Peking University First Hospital Beijing China department of physiology Peking University Health Science Center Beijing China

Aim:To explore the possible role of endogenous hydrogen sulfide （H2S）,a novelgasotransmitter,in the pathogenesis of pulmonary vascular structural remodeling（PVSR） induced by high pulmonary blood ***:Thirty-two Sprague-Dawley male rats were randomly divided into sham,shunt,sham+NaHS （a H2Sdonor） and shunt+NaHS *** in shunt and shunt+NaHS groups under-went an abdominal aorta-inferior vena cava shunt,and rats in shunt+NaHS andsham+NaHS groups were intraperitoneally injected with *** was inves-tigated using optical microscope and transmission electron *** H2S was evaluated by sulfide-sensitive *** oxide synthase（NOS）,heme oxygenase （HO-1）,proliferative cell nuclear antigen （PCNA） andextracellular signal-regulated kinase （ERK） activation were analyzed by ***:After 11 weeks of shunting,PVSR developed with a decrease inlung tissue H2S production and an increase in nitric oxide （NO）.However,lungtissue carbon monoxide （CO） did not *** the treatment with NaHS for11 weeks,H2S donor ameliorated PVSR and downregulated PCNA expression andERK activation with an increase in lung tissue CO production and HO-1 proteinexpression but a decrease in NO production,NOS activity and eNOS proteinexpression in shunted ***:H2S exerted a regulatory effect on PVSRinduced by high pulmonary blood ***,H2S down-regulated theERK/MAPK signal pathway,inhibited the NO/NOS pathway and enhanced theCO/HO pathway in rats with high pulmonary blood flow.

关键词： hydrogen sulfide pulmonary hypertension structure remodeling nitric oxide/nitric oxide synthase carbon monoxide/heme oxygenase

Contraceptive effect of Curcuma longa (L.) in male albino rat

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Asian Journal of Andrology 2004年第1期6卷 71-74页

作者： Purohit Ashok Bhagat Meenakshi Reproductive physiology Section Department of Zoology JNV University Jodhpur (Raj.) 342005 IndiaReproductive Physiology Section Department of Zoology JNV University Jodhpur (Raj.) 342005 India

Aim: To study the contraceptive effect of the crude extracts of Curcuma longa in male albino rats. Methods: Rats were fed orally with Curcuma longa aqueous and 70 % alcoholic extract for 60 days (500 mg·kg-1· day-1). Results: A reduction in sperm motility and density was observed in both the treated groups. Conclusion: Curcuma longa may have affected the androgen synthesis either by inhibiting the Leydig cell function or the hypo-thalamus pituitary axis and as a result, spermatogenesis is arrested.

关键词： Leydig cells Curcuma longa seminiferous tubules antiandrogens spermatozoa male contraception

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Preliminary study of analgesic effect of scorpion venom on central Mervous　system

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吉林大学学报(医学版) 1994年第4期20卷 323-325页

作者： He Yan,Liu Minzhi,wei Junjie (department of physiology and Inorganic Chemistry) 白求恩医科大学生理系吉林长春白求恩医科大学无机化学系吉林长春

ＰｒｅｌｉｍｉｎａｒｙｓｔｕｄｙｏｆａｎａｌｇｅｓｉｃｅｆｆｅｃｔｏｆｓｃｏｒｐｉｏｎｖｅｎｏｍｏｎｃｅｎｔｒａｌｎｅｒｖｏｕｓｓｙｓｔｅｍＨｅＹａｎ，ＬｉｕＭｉｎｚｈｉ，ＷｅｉＪｕｎｊｉｅ（Ｄｅｐａｒｔｍｅｎｔｏｆ... 详细信息

ＰｒｅｌｉｍｉｎａｒｙｓｔｕｄｙｏｆａｎａｌｇｅｓｉｃｅｆｆｅｃｔｏｆｓｃｏｒｐｉｏｎｖｅｎｏｍｏｎｃｅｎｔｒａｌｎｅｒｖｏｕｓｓｙｓｔｅｍＨｅＹａｎ，ＬｉｕＭｉｎｚｈｉ，ＷｅｉＪｕｎｊｉｅ（ＤｅｐａｒｔｍｅｎｔｏｆＰｈｙｓｉｏｌｏｇｙａｎｄＩｎｏｒ...

关键词： orpion venom analgesics/pharmacology rain/drug efects

Genistein inhibits carotid sinus baroreceptor activity in anesthetized male rats

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Acta Pharmacologica Sinica 2005年第7期26卷 840-844页

作者： Hui-juan MA Yi-xian LIU Fu-wei WANG Li-xuan WANG Rui-rong HE Yu-ming WU~2 department of physiology,Institute of Basic Medicine,Hebei Medical university,Shijiazhuang 050017,China department of physiology Institute of Basic Medicine Hebei Medical University Shijiazhuang China

Aim:To study the effect of genistein(GST)on carotid baroreceptor activity(CBA).Methods:The functional curve of carotid baroreceptor(FCCB)was con-structed and the functional parameters of carotid baroreceptor were measured byrecording sinus nerve afferent discharge in anesthetized male rats with perfusedisolated carotid ***:GST at 50,100,and 200 μmol/L inhibited theCBA,which shifted FCCB to the fight and downward,with a marked decrease inpeak slope and peak integral value of carotid sinus nerve discharge in a concen-tration-dependent *** with 100 μmol/L N~G-nitro-L-arginine me-thyl ester,an inhibitor of nitric oxide synthase,did not affect the effect of GST *** with 500 nmol/L Bay K8644,an agonist of calcium channels,could completely abolish the effect of GST on CBA.A potent inhibitor of tyrosinephosphatase,sodium orthovanadate(1 mmol/L),could attenuate the inhibitoryeffect of ***:GST inhibits CBA,and the effect may be mediated byprotein tyrosine kinase inhibition and a decrease in Ca2+influx through the stretch-activated channels.

关键词： genistein carotid sinus baroreflex proteintyrosine kinase Bay K8644 L-NAME

EFFECTS OF ELECTROACUPUNCTURE ON EPILEPTIFORM HIPPOCAMPAL UNIT ACTIVITY INDUCED BY INTRACERE-BROVENTRICUILAR INJECTION OF CORIARIA LACTONE

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针刺研究 1989年第Z1期 49-50页

作者： Gao Chong Liao weihong Yang Jizeng department of physiology, Chengdu Traditional Chinese Medicine College, Chengdu department of physiology, The Third Military Medical university, Chongqing

In our present study we build up a new experimental model in the rat forepilepsy and examine the effects of electroacupuncture on epileptiform hippo-campal unit activity. Experiments were carried out on conscious immobilized male rats, CoriariaLactone at a concentration of 30μg/10μl in saline was injected intracerebrove-ntricularly. Electrocorticography (ECoG) and hippocampal unit activity wererecorded simultaneously on the side of brain which received the drug *** some cases, the hippocampal EEG was also recorded. Acupuncture of Da-zhui, Shenzhu, Taichong and Kunlun were stumulated respectively.

关键词： In EFFECTS OF ELECTROACUPUNCTURE ON EPILEPTIFORM HIPPOCAMPAL UNIT ACTIVITY INDUCED BY INTRACERE-BROVENTRICUILAR INJECTION OF CORIARIA LACTONE

Flow Cytometric Analysis of the Toxicity of Nitrofen in Cultured Keratinocytes

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Biomedical and Environmental Sciences 1999年第2期12卷 144-149页

作者： YIN LEI JIN XI-PENG YU XIAO-ZHONG AND LIN HUI-FEN(Laboratory of Skin physiology and Toxicology, School of Public Health,Shanghai Medical university, Shanghai 200032, China department of Dermatology, for City university, for 466, Japan) 上海医科大学公共卫生学院上海 200032 上海医科大学公共卫生学院上海

Lactate dehydrogenase (LDH) release test, 3 H-thymidine (3 H-TdR) and 3 H-leucine (3 H-Leu) incoopration tests and flow cytometric analysis (FCM) of cell cycle were empoyed to elucidate cellular and molecular mechanism of nitrofen-induced toxicity in cultured *** results showed that cell morphologic damages were observed after exposure to 1.0 mmol/L and 10.0 mmol/L nitrofen. LDH release increased in a dose- and time-dependent manner. Depressions in 3H -TdR and 3 H-Leu incorpration were found even at 0.01 mmol/L, and increased with the exposure dose. Cell cycle was analyzed from the DNA- histogram with propidium iodde stain. The results showed that there was no pronounced alteration in cell cycle after cells exposed to 0.01 and 0.1 mmol/L nitrofen. At dose of 1.0 mmol/L, S phase cells increased 2 times of that of control. With the increase of dose, G2/M phase cells became to increase about 5 times of that of the control. At 1 .0 mmol/L, time course of cell cycle after exposure was observed. At the beginning of exposure, cells in S phase and G2/M phase were about 8 .7 % and 11 %. Following 24 h incubation with nitrofen, cells in S phase increased to 18.0% with almost no change in G2/M. 72 h after exposure, G2/M phase cells increased to 63 .3%. The forve results demonstrated that S phase and G2/M phase blockage in cultured keratinocytes after exposed to nitrofen seems of importance in the mechanism of nitrofen-induced toxicity.

关键词： Flow Cytometric Analysis of the Toxicity of Nitrofen in Cultured Keratinocytes

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STUDIES ON THE REACTIONS OF HIPPOCAMPAL FORMATION IN PAIN MODULATION AND ACUPUNCTURE ANALGESIA

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针刺研究 1989年第Z1期 45-46页

作者： Liu Zuozhou Liao weihong department of physiology, The Third Military Medical university, Chongqing, China

It has been proved that the hippocampal formation is closely related tosome behaviour reactions (such as learning and memory), visceraI activities,and neuro-endocrine regulations. However, what roles the hippocampus mayplay in pain modulation and analgesic mechanism still need further *** we have done some works in this field. The blood pressure increased accompanying hippocampal EEG's slowrhythmic activity (SRA or theta rhythm) which had a higher amplitude and alonger time course. This EEG wave was specific and could be used as one ofindexes of nociceptive response. Our experiments also demonstrated that theblood pressure increase could be induced by peripheral somatic noxious stimu-

关键词： EEG STUDIES ON THE REACTIONS OF HIPPOCAMPAL FORMATION IN PAIN MODULATION AND ACUPUNCTURE ANALGESIA

Regeneration of plants from callus tissues of hairy roots induced by Agrobacterium rhizogenes on Alhagi pseudoalhagi

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Cell Research 2001年第4期11卷 279-284页

作者： WANG YU MEI, JIANG BO WANG, DA LUO , JING FEN JIA National Laboratory of Plant Molecular genetics, Institute of Plant physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China department of Bi National Laboratory of Plant Molecular genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of sciences Shanghai China department of Biology Northwest University Xi'an China

The legume forage Alhagi pseudoalhagi was transformed by the Agrobacterium rhizogenes strain A4 using cotyledon and hypocotyl segments as infection materials. Regenerated plants were achieved from sterile calli derived from hairy roots, which occurred at or near the infection sites. The regenerated plants from hairy root were characterized by normal leaf morphology and stem growth but a shallow and more extensive root system than normal plants. Opine synthesis, PCR and Southern blot confirmed that T- DNA had been integrated into the A. pseudoalhagi genome. Acetosyringone (AS) was found to be vital for successful transformation of A. pseudoalhagi.

关键词： Alhagi pseudoalhagi Agrobacterium rhizogenes hairy root regeneration.