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Chromosome-level assembly of triploid genome of Sichuan pepper(Zanthoxylum armatum)

Horticultural Plant Journal 2024年第2期10卷 437-449页

作者： Lizhi Song Yue Huang Hao zuo Ning Tang Zhengguo Li Wenbiao Jiao Feng Xu Qiang Xu Zexiong chen National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Chongqing Key Laboratory of Economic Plant Biotechnology Chongqing University of Arts and SciencesChongqing 402160China School of Life Sciences Chongqing UniversityChongqing 400030China College of Horticulture and Gardening Yangtze UniversityJingzhouHubei 434025China College of Informatics Huazhong Agricultural UniversityWuhanHubei 430070China

As an important spice species in Rutaceae, the Sichuan pepper (Zanthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green prickly ash which was widely cultivated in a major production area including Chongqing and Sichuan province, China. We generated 712 Gb (~112×) PacBio long reads and 511 Gb (~82×) Hi-C data, and yielded an assembly of 99 pseudochromosomes with total size of 5.32 Gb and contig N50 of 796 kb. The genomic analyses and cytogenetic experiments both indicated that the cultivarZhuye Huajiao’ was a triploid. We identified a Zanthoxylum-specific whole genome duplication event emerging about 24.8 million years ago (Mya). We also detected a transposition burst event (0.3-0.4 Mya) responsible for the large genome size of Z. armatum. Metabolomic analysis of the Zanthoxylum fruits during development stages revealed profiles of39 volatile aroma compounds and 528 secondary metabolites, from which six types of sanshools were identified. Based on metabolomic and transcriptomic network analysis, we screened candidate genes encoding long chain acyl-CoA synthetase, fatty acid desaturase,branched-chain amino acid aminotransferase involved in sanshool biosynthesis and three genes encoding terpene synthase during fruit development. The multi-omics data provide insights into the evolution of Zanthoxylum and molecular basis of numbing and aroma flavor of Sichuan pepper.

关键词： Zanthoxylum armatum Genome Sanshool Terpenoid

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Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

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BIOCELL 2024年第7期48卷 1105-1113页

作者： CHUNLING LIANG JING chen XIAOJIE chen wei YAN JIE YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

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Real-time,single-particle chemical composition,volatility and mixing state measurements of urban aerosol particles in southwest China

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Journal of Environmental Sciences 2024年第2期136卷 361-371页

作者： Luyao chen Junke Zhang Jiaqi Li Xiaojuan Huang Yuzheng Xiang Jing chen Tingru Pan wei Zhang Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China School of Atmospheric Sciences Chengdu University of Information TechnologyChengdu 610225China Sichuan Environmental Monitoring Center Chengdu 610074China

To investigate the volatility of atmospheric particulates and the evolution of other particulate properties(chemical composition,particle size distribution and mixing state)with temperature,a thermodenuder coupled with a single particle aerosol mass spectrometer was used to conduct continuous observations of atmospheric fine particles in chengdu,southwest *** of their complex sources and secondary reaction processes,the average mass spectra of single particles contained a variety of chemical components(including organic,inorganic and metal species).When the temperature rose from room temperature to280℃,the relative areas of volatile and semi-volatile components decreased,while the relative areas of less or non-volatile components ***(>80%)nitrate and sulfate existed in the form of NH_(4)NO_(3)and(NH_(4))_(2)SO_(4),and their volatilization temperatures were50–100℃and 150–280℃,*** contribution of biomass burning(BB)and vehicle emission(VE)particles increased significantly at 280℃,which emphasized the important role of regional biomass burning and local motor vehicle emissions to the core of *** the increase in temperature,the particle size of the particles coated with volatile or semi-volatile components was reduced,and their mixing with secondary inorganic components was significantly *** formation of K-nitrate(KNO_(3))and K-sulfate(KSO_(4))particles was dominated by liquid-phase processes and photochemical reactions,*** KNO_(3)and BB particles is the key to improving *** new results are helpful towards better understanding the initial sources,pollution formation mechanisms and climatic effects of fine particulate matter in this megacity in southwest China.

关键词： Atmospheric fine particles TD-SPAMS Chemical composition Volatility Mixing state

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Cation-Anion Redox Active Organic Complex for High Performance Aqueous Zinc Ion Battery

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Energy & Environmental Materials 2024年第1期7卷 60-67页

作者： Lilin Zhang Yining chen Zongyuan Jiang Jingwei chen Cong wei Wenzhuo Wu Shaohui Li Qun Xu School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Ocean University of China Qingdao 266100China

Organic redox compounds are attractive cathode materials in aqueous zinc-ion batteries owing to their low cost,environmental friendliness,multiple-electron-transfer reactions,and resource ***,the realized energy density is constrained by the limited capacity and low ***,copper-tetracyanoquinodimethane(CuTCNQ),an organic charge-transfer complex is evaluated as a zinc-ion battery cathode owing to the good electron acceptation ability in the cyano groups that improves the voltage *** electrochemical activation,electrolyte optimization,and adoption of graphene-based separator,CuTCNQ-based aqueous zinc-ion batteries deliver much improved rate performance and cycling stability with anti-self-discharge *** structural evolution of CuTCNQ during discharge/charge are investigated by ex situ Fourier transform infra-red(FT-IR)spectra,ex situ X-ray photoelectron spectroscopy(XPS),and in situ ultraviolet visible spectroscopy(UV-vis),revealing reversible redox reactions in both cuprous cations(Cu^(+))and organic anions(TCNQ^(x-1)),thus delivering a high voltage output of 1.0 V and excellent discharge capacity of 158 mAh g^(-1).The remarkable electrochemical performance in Zn//CuTCNQ is ascribed to the strong inductive effect of cyano groups in CuTCNQ that elevated the voltage output and the graphene-modified separator that inhibited CuTCNQ dissolution and shuttle effect in aqueous electrolytes.

关键词： cathode materials cyano groups electrochemical activation organic charge-transfer complex zinc-ion battery

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Heterogeneous information phase space reconstruction and stability prediction of filling body–surrounding rock combination

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1500-1511页

作者： Dapeng chen Shenghua Yin weiguo Long Rongfu Yan Yufei Zhang Zepeng Yan Leiming Wang wei chen School of Civil and Resources Engineering University of Science and Technology of BeijingBeijing 100083China Production Technology Department Longshou MineJinchuan Group Co.Ltd.Jinchang 737100China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China

Traditional research believes that the filling body can effectively control stress concentration while ignoring the problems of unknown stability and the complex and changeable stress distribution of the filling body–surrounding rock combination under high-stress *** monitoring data processing methods cannot fully consider the complexity of monitoring objects,the diversity of monitoring methods,and the dynamics of monitoring *** solve this problem,this paper proposes a phase space reconstruction and stability prediction method to process heterogeneous information of backfill–surrounding rock *** three-dimensional monitoring system of a large-area filling body–surrounding rock combination in Longshou Mine was constructed by using drilling stress,multipoint displacement meter,and *** information,such as the stress and displacement of the filling body–surrounding rock combination,was continuously *** with the average mutual information method and the false nearest neighbor point method,the phase space of the heterogeneous information of the filling body–surrounding rock combination was then *** this paper,the distance between the phase point and its nearest point was used as the index evaluation distance to evaluate the stability of the filling body–surrounding rock *** evaluated distances(ED)revealed a high sensitivity to the stability of the filling body–surrounding rock *** new method was then applied to calculate the time series of historically ED for 12 measuring points located at Longshou *** moments of mutation in these time series were at least 3 months ahead of the roadway return *** the ED prediction experiments,the autoregressive integrated moving average model showed a higher prediction accuracy than the deep learning models(long short-term memory and Transformer).Furthermore,the root-mean-square error distribution of the prediction results peaked at 0

关键词： deep mining filling body–surrounding rock combination phase space reconstruction multiple time series stability prediction

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Axial enantiomers with donor-regulated TADF feature for multicolor circularly polarized electroluminescence

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Science China Chemistry 2024年第6期67卷 2039-2045页

作者： chen-Hao Guo Wen-Long Zhao Ke-Ke Tan wei-chen Guo Liheng Feng Chuan-Feng chen Meng Li School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral *** pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide *** the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)***,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,*** results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor ***,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),*** convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.

关键词： axial chirality thermally activated delayed fluorescence circularly polarized luminescence electroluminescence organic light-emitting diodes

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Sutured scleral fixation of existing subluxated/dislocated acrylic one-piece intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 665-669页

作者： wei-Yu Huang Yung-Jen chen Department of Ophthalmology Chi Mei Medical CenterTainan City 710TaiwanChina Department of Ophthalmology Chang Gung Memorial HospitalKaohsiung City 833TaiwanChina

AIM:To evaluate the visual and refractive outcomes in cases after sutured scleral fixation of existing subluxated or dislocated acrylic one-piece intraocular lenses(IOLs).METHODS:This study retrospectively enrolled a consecutive series of patients who underwent a surgery of sutured existing subluxated or dislocated IOLs from October 2018 to June *** patients underwent comprehensive preoperative and postoperative ophthalmologic examination,and data were collected including age,sex,surgical indications,best-corrected visual acuity,refractive error,intraocular *** of intraoperative and postoperative surgical complications was ***:A total of 20 consecutive cases were enrolled for analysis with mean final follow-up period 9.8±*** acuity improved from a mean of 0.35(0.46±0.32 logMAR)preoperatively to 0.61(0.21±0.18 logMAR)at the 3-month follow-up(P=0.002).The mean amount of preoperative keratometric astigmatism and total postoperative refractive astigmatism was-1.24±0.80 diopters(D)and-1.42±0.97 D,*** was no statistically significant difference between preoperative and postoperative astigmatism(P=0.156).The mean IOL-induced astigmatism was-0.23±0.53 *** mean spherical equivalent at the 3-month follow-up was-0.1±0.94 *** major complications were noted during the follow-up ***:Surgical techniques using sutured scleral fixation of existing subluxated or dislocated acrylic one-piece IOLs result in favorable visual and refractive outcomes without major complications.

关键词： intraocular lens dislocation intraocular lens subluxation lens dislocation lens subluxation scleral fixation

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Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-Chun Zhu wei-wei Peng Jie Wang Hong-wei Zhao Ai-Guo Li Min chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

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Controlled fluorescent switch based on a cation grease/brake rotor system of pillar[5]arene

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Chinese Chemical Letters 2024年第3期35卷 5-7页

作者： wei-Lei Zhou Siwei Wang Yong chen College of Chemistry and Material Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional MoleculesInnovation Team of Optical Functional Molecular DevicesInner Mongolia Minzu UniversityTongliao 028000China College of Chemistry Nankai UniversityTianjin 300071China

In recent years,molecular shuttles,motors,pumps,and elevators,*** specifically respond external physical or chemical stimuli including light,temperature,pH,redox,solvent and chemical additive to change the structure a... 详细信息

关键词： additive system showing

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A bilateral heterogeneous graph model for interpretable job recommendation considering both reciprocity and competition

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Frontiers of Engineering Management 2024年第1期11卷 128-142页

作者： Xiaowei SHI Qiang wei Guoqing chen School of Economics and Management Tsinghua UniversityBeijing 100084China

Amidst the inefficiencies of traditional job-seeking approaches in the recruitment ecosystem, the importance of automated job recommendation systems has been magnified. However, existing models optimized to maximize user clicks for general product recommendations prove inept in addressing the unique challenges of job recommendation, namely reciprocity and competition. Moreover, sparse data on online recruitment platforms can further negatively impact the performance of existing job recommendation algorithms. To counteract these limitations, we propose a bilateral heterogeneous graph-based competition iteration model. This model comprises three integral components: 1) two bilateral heterogeneous graphs for capturing multi-source information from people and jobs and alleviating data sparsity, 2) fusion strategies for synthesizing attributes and preferences to produce mutually beneficial job matches, and 3) a competition-enhancing strategy for dispersing competition realized through a two-stage optimization algorithm. Augmented by granular attention mechanisms for enhanced interpretability, the model’s efficacy, competition dispersion, and interpretability are validated through rigorous empirical evaluations on a real-world recruitment platform.

关键词： job recommendation competition reciprocity interpretability

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