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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan Fan Tao Zhang Xin ding Yushuo Gu Qing Li wei Jiang Kelong Fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Deterministic processes drive turnover-dominated beta diversity of breeding birds along the central Himalayan elevation gradient

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Avian Research 2024年第2期15卷 163-171页

作者： Zhifeng ding Jianchao Liang Le Yang Cong wei Huijian Hu Xingfeng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Institute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong510260China Tibet Plateau Institute of Biology Lhasa850001China Zhejiang Zhoushan Island Ecosystem Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai200241China

Beta diversity,the variation of community composition among sites,bridges alpha and gamma diversity and can reveal the mechanisms of community assembly through applying distance-decay models and/or partitioning beta diversity into turnover and nestedness components from functional and phylogenetic *** as the most natural experiment system provide good opportunities for exploring beta diversity patterns and the underlying ecological ***,we simultaneously consider distance-decay models and multiple di-mensions of beta diversity to examine spatial variations of bird communities,and to evaluate the relative importance of niche-based and neutral community assembly mechanisms along a 3600-m elevational gradient in the central Himalayas,*** results showed that species turnover dominates taxonomic,functional,and phylogenetic beta *** observed strongest evidence of spatial distance decays in taxonomic similarities of birds,followed by its phylogenetic and functional *** component was highest in taxonomic beta diversity,while nestedness component was highest in functional beta ***,all correlations of assemblage similarity with climatic distance were higher than that with spatial *** values of overall taxonomic,functional,and phylogenetic beta diversity and their turnover components increase with increasing elevational distance,while the standardized values of taxonomic and phylogenetic nestedness decreased with increasing elevational *** results highlighted the niche-based deterministic processes in shaping elevational bird diversity patterns that were determined by the relative roles of decreasing trend of environmental filtering and increasing trend of limiting similarity along elevation distances.

关键词： Beta diversity Bird Community assembly Functional trait Himalaya Nestedenss Phylogenetic distance Turnover

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Transient Analysis of a Reactor Coolant Pump Rotor Seizure Nuclear Accident

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1331-1349页

作者： Mengdong An weiyuan zhong wei Xu Xiuli Wang Research Center of Fluid Machinery Engineering and Technology Zhenjiang212013China School of Energy and Power Engineering Jiangsu UniversityZhenjiang212013China

The reactor coolant pump(RCP)rotor seizure accident is defined as a short-time seizure of the RCP *** event typically leads to an abrupt flow decrease in the corresponding loop and an ensuing reactor and turbine *** significant reduction of core coolant flow while the reactor is being operated at full load can have very negative *** potentially dangerous event is typically characterized by a complex transient behavior in terms of flow conditions and energy transformation,which need to be analyzed and *** study constructed transient flow and rotational speed mathematical models under various degrees of rotor seizure using the test data collected from a dedicated transient rotor seizure test ***,bidirectional fluid-solid coupling simulations were conducted to investigate the flow evolution *** is found that the influence of the impeller structure size and transient braking acceleration on the unsteady head(Hu)is dominant in rotor seizure accident ***,the present results also show that the rotational acceleration additional head(Hu1)is much higher than the instantaneous head(Hu2).

关键词： Reactor coolant pump bidirectional fluid-solid coupling rotor seizure nuclear accident

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An electromagnetic semi-active dynamic vibration absorber for thin-walled workpiece vibration suppression in mirror milling

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1315-1334页

作者： Jianghua KONG Bei ding wei WANG Zhixia WANG Juliang XIAO Hongyun QIU School of Mechanical Engineering Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Nonlinear Dynamics and Control Tianjin 300350China Key Laboratory of Modern Mechanisms and Equipment Design of the State Ministry of Education Tianjin UniversityTianjin 300350China

As critical components of aircraft skins and rocket fuel storage tank shells,large thin-walled workpieces are susceptible to vibration and deformation during machining due to their weak local *** address these challenges,we propose a novel tunable electromagnetic semi-active dynamic vibration absorber(ESADVA),which integrates with a magnetic suction follower to form a followed ESADVA(follow-ESADVA)for mirror *** system combines a tunable magnet oscillator with a follower,enabling real-time vibration absorption and condition feedback throughout the milling ***,the device supports self-sensing and frequency adjustment by providing feedback to a linear actuator,which alters the distance between *** resolves the traditional issue of being unable to directly monitor vibration at the machining point due to space constraints and tool *** frequency shift characteristics and vibration absorption performance are comprehensively *** and experimental results demonstrate that the prototyped follow-ESADVA achieves frequency synchronization with the milling tool,resulting in a vibration suppression rate of approximately 47.57%.Moreover,the roughness of the machined surface decreases by18.95%,significantly enhancing the surface *** results of this work pave the way for higher-quality machined surfaces and a more stable mirror milling process.

关键词： semi-active dynamic vibration absorber(SADVA) mirror milling selfsensing vibration absorption tuning thin-walled workpiece

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Magnetic-field-assisted triboelectric nanogenerator for harvesting multi-directional wave energy

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Nano Research 2024年第8期17卷 7144-7152页

作者： Mengru ding Jianlong Wang Da Zhao Hengyu Li Xiaojun Cheng Jianming Wen zhong Lin Wang Tinghai Cheng Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China Guangzhou Institute of Blue Energy Guangzhou 510555China College of Engineering Zhejiang Normal UniversityJinhua 321004China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA

Ocean wave energy is a significant and promising source of renewable ***,the energy harvesting is challenging due to the multi-directional nature of *** paper proposes a magnetic-field-assisted triboelectric nanogenerator(MFATENG)for harvesting multi-directional wave *** incorporating a magnetic field,the planar motion of the pendulum is converted into spatial motion,increasing the triggering of multilayered TENG(M-TENG)and enhancing the output energy of the *** results demonstrate that the output energy of the MFA-TENG is increased by 73%by utilizing the magnetic ***,a spring model based on the origami-structured M-TENG is established to analyze the effect of different equivalent stiffnesses on the performance of the M-TENG,aiming to obtain optimal output *** results showcase the impressive output performance of the M-TENG,generating outputs of 250 V,18μA,and 255 ***,the proposed MFA-TENG effectively harvests multi-directional wave energy under water-wave driven *** study significantly enhances the ability of the MFA-TENG to harvest multi-directional wave energy and presents a promising approach for self-powered marine monitoring in the future.

关键词： triboelectric nanogenerator magnetic-field-assisted spring model multi-directional wave energy

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Properties and Characteristics of Regolith-Based Materials for Extraterrestrial Construction

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Engineering 2024年第6期37卷 159-181页

作者： Cheng Zhou Yuyue Gao Yan Zhou wei She Yusheng Shi Lieyun ding Changwen Miao National Center of Technology Innovation for Digital Construction Huazhong University of Science and TechnologyWuhan 430074China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Southeast UniversityNanjing 214135China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The construction of extraterrestrial bases has become a new goal in the active exploration of deep *** the construction techniques,in situ resource-based construction is one of the most promising because of its good sustainability and acceptable economic cost,triggering the development of various types of extraterrestrial construction materials.A comprehensive survey and comparison of materials from the perspective of performance was conducted to provide suggestions for material selection and *** types of typical construction materials are discussed in terms of their reliability and applicability in extreme extraterrestrial ***,thermal and optical,and radiation-shielding properties are *** influencing factors and optimization methods for these properties are *** the perspective of material properties,the existing challenges lie in the comprehensive,long-term,and real characterization of regolith-based construction ***,the suggested future directions include the application of high-throughput characterization methods,accelerated durability tests,and conducting extraterrestrial experiments.

关键词： Extraterrestrial construction Characterization Mechanical property Thermal property Optical property Radiation-shielding

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Transcriptome-based analysis of key signaling pathways affecting the formation of primordial germ cell in chickens

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Journal of Integrative Agriculture 2024年第5期23卷 1644-1657页

作者： Ying ding Qiong Zhi Qisheng Zuo Kai Jin wei Han Bichun Li Key Laboratory of Animal Genetics Breeding and Molecular Design of Jiangsu ProvinceCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China Yangzhou UniversityYangzhou225009China Poultry Research Institute Chinese Academy of Agricultural Sciences/Jiangsu Institute of Poultry ScienceYangzhou 225009China

Bone morphogenetic protein 4(BMP4)can induce the formation of chicken primordial germ cells(PGCs)in vitro;however,its regulatory mechanism in poultry remains *** study aimed to use RNA-seq to analyze PGCs in chicken embryos and iPGCs induced by BMP4 in vitro,clarify the internal regulatory factors of PGCs,analyze the mechanism of the formation of PGCs,and lay a theoretical foundation for the further optimization of PGCs induction *** stem cells(ESCs),PGCs and iPGCs induced by BMP4 in vitro were *** transcriptional maps of the three cell types were studied using *** results showed 6,142 genes differentially expressed between PGCs and iPGCs,of which 2,728 were upregulated in iPGCs and 3,414 were downregulated in *** to that in ESCs,BMP4 was significantly upregulated in PGCs and *** results showed that both the TGF-βand Wnt signaling pathways were activated during the formation of PGCs in vitro and in vivo,and the activation was more significant during iPGCs induced by *** expression of Nodal,an inhibitory factor of TGF-βsignaling,was significantly decreased in PGCs and iPGCs,but was not expressed in iPGCs,which further supports our ***,the Lysosome and PI3K-AKT signaling pathways were significantly enriched in PGCs and iPGCs,***,transmission electron microscopy(TEM)results showed that the number of autolysosomes was significantly higher after the addition of BMP4,which is consistent with the KEGG ***,the number of PGCs was significantly reduced after ATG14 was interfered in vivo and in *** conclusion,this study screened out the key signaling pathways during the formation of PGCs,aiming to provide help for enriching the mechanism network regulating PGCs formation in chicken and laying a theoretical foundation for further improving the efficiency of inducing PGCs in vitro.

关键词： RNA-seq BMP4 PGCs ATG14 chicken

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The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 712-728页

作者： Xiaoxuan zhong Xiang wei Yan Xu Xuehai Zhu Bo Huo Xian Guo Gaoke Feng Zihao Zhang Xin Feng Zemin Fang Yuxuan Luo Xin Yi ding-Sheng Jiang Division of Cardiovascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart ***,we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum-and PDGF-BB-induced vascular smooth muscle cells(VSMCs),and in tissues of carotid artery injury-induced neointimal ***2 overexpression in VSMCs(Smyd2-vTg)facilitates,but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in *** sequencing revealed that SMYD2 knockdown represses the expression of serum response factor(SRF)target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC ***3 directly interacts with and deacetylates SRF,which enhances SRF transcriptional activity in ***,SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its ***966,a specific inhibitor of HDAC3,not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs,but also inhibits carotid artery injury-induced neointima formation in ***3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent *** results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia.

关键词： Neointimaformation Histonemethylation Histoneacetylation SRFacetylation SMYD2 HDAC3 LLY-507 RGFP966

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Breaking the Fe_(3)O_(4)-wrapped copper microstructure to enhance copper-slag separation

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2312-2325页

作者： Xiaopeng Chi Haoyu Liu Jun Xia Hang Chen Xiangtao Yu wei Weng Shuiping zhong Zijin School of Geology and Mining Fuzhou UniversityFuzhou 350108China Fujian Key Laboratory of Green Extraction and High-Value Utilization of New Energy Metals Fuzhou UniversityFuzhou 350108China Zijin Mining Group Co. Ltd.Longyan 364200China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

The precipitation of Fe_(3)O_(4)particles and the accompanied formation of Fe_(3)O_(4)-wrapped copper structure are the main obstacles to copper recovery from the molten slag during the pyrometallurgical smelting of copper ***,the commercial powdery pyrite or anthracite is replaced with pyrite-anthracite pellets as the reductants to remove a large amount of Fe_(3)O_(4)particles in the molten slag,resulting in a deep fracture in the Fe_(3)O_(4)-wrapped copper microstructure and the full exposure of the copper matte *** 1wt%composite pellet is used as the reductant,the copper matte droplets are enlarged greatly from 25μm to a size observable by the naked eye,with the copper content being enriched remarkably from 1.2wt%to 4.5wt%.Density functional theory calculation results imply that the formation of the Fe_(3)O_(4)-wrapped copper structure is due to the preferential adhesion of Cu_(2)S on the Fe_(3)O_(4)particles.X-ray photoelectron spectroscopy,Fourier transform infrared spectrometer(FTIR),and Raman spectroscopy results all reveal that the high-efficiency conver-sion of Fe_(3)O_(4)to FeO can decrease the volume fraction of the solid phase and promote the depolymerization of silicate network *** a consequence,the settling of copper matte droplets is enhanced due to the lowered slag viscosity,contributing to the high efficiency of copper-slag separation for copper *** results provide new insights into the enhanced in-situ enrichment of copper from mol-ten slag.

关键词： pyrometallurgical smelting process slag cleaning reductants copper matte

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The medium-temperature dependence of jet transport coefficient in high-energy nucleus-nucleus collisions

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Nuclear Science and Techniques 2024年第7期35卷 173-191页

作者： Man Xie Qing-Fei Han En-Ke Wang Ben-wei Zhang Han-zhong Zhang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum Matter South China Normal UniversityGuangzhou510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan430079China

The medium-temperature T dependence of the jet transport coefficient̂q was studied via the nuclear modification factor RAA(p_(T))and elliptical flow parameter v_(2)(p_(T))for large transverse momentum p_(T) hadrons in high-energy nucleus-nucleus *** a next-to-leading-order perturbative QCD parton model for hard scatterings with modified fragmentation functions due to jet quenching controlled by q,we check the suppression and azimuthal anisotropy for large p_(T) hadrons,and extract q by global fits to RAA(pT)and v_(2)(pT)data in A+A collisions at RHIC and LHC,*** numerical results from the best fits show that q∕T^(3) goes down with local medium-temperature T in the parton jet *** with the case of a constant q∕T^(3),the going-down T dependence of q∕T^(3) makes a hard parton jet to lose more energy near T_(c) and therefore strengthens the azimuthal anisotropy for large pT *** a result,v_(2)(p_(T))for large pT hadrons was enhanced by approximately 10%to better fit the data at RHIC/*** the first-order phase transition from QGP to the hadron phase and the additional energy loss in the hadron phase,v_(2)(p_(T))is again enhanced by 5-10%at RHIC/LHC.

关键词： Jet quenching Jet transport parameter Hadron suppression Elliptic flow coefficient Energy loss asymmetry

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