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Clinicopathologic characteristics of gastric carcinoma in elderly patients: A comparison with young patients

World Journal of Gastroenterology 2005年第1期11卷 22-26页

作者： Dong-Yi Kim Jae-Kyoon Joo Seong-Yeob Ryu Young-Kyu Park Young-Jin Kim Shin-kon.Kim Division of Gastroenterologic Surgery

AIM:To examine the clinicopathologic features of elderly patients with gastric carcinoma and to investigate the relationship between prognosis and ***: We reviewed the hospital records of 2 014patients with gastric carcinoma retrospectively to compare the clinicopathologic findings in elderly (age ＞70 years) and young (age ＜36 years) patients during the period from 1986 to 2000 in a tertiary referral center in Gwangju, Korea. Overall survival was the main outcome ***: Of the 2 014 patients, 194 (9.6%) were in the elderly group and 137 (6.8%) were in the young *** elderly and young patients had similar distributions with respect to depth of invasion, nodal involvement, hepatic metastasis, peritoneal dissemination, tumor stage at the initial diagnosis, and type of surgery. Synchronous multiple carcinomas were found in 14/194 (7.2%) of the elderly group and 4/137 (2.9%) of the young group (P＜0.05). Using the Borrmann classification, type Ⅳ was more frequent in the young patients than in the elderly patients (P＜0.05).Significantly more elderly patients had a well or moderately differentiated histology, and more young patients had a poorly differentiated histology and signet ring cell carcinoma (P＜0.001). The 5-year survival rates of elderly and young patients did not differ statistically (52.8% vs 46.5%,P = 0.5290). Multivariate analysis showed that the histologic type, nodal involvement and operative curability were significant prognostic factors, and age itself was not an independent prognostic factor of survival for elderly gastric carcinoma ***: Elderly patients with gastric carcinoma do not have a worse prognosis than young patients. The important prognostic factor is whether the patients undergo a curative resection.

关键词： Gastric carcinomas Prognosis Age Surgery

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GATA4 mutations are uncommon in patients with 46,XY disorders of sex development without heart anomaly

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Asian Journal of Andrology 2018年第6期20卷 629-631页

作者： Maki Igarashi Kentaro Mizuno Masafumi kon.Satoshi Narumi Yoshiyuki Kojima Yutaro Hayashi Tsutomu Ogata Maki Fukami Department of Molecular Endocrinology National Research Institute for Child Health and Development Tokyo 157-8535 Japan Department of Nephro-Urology Nagoya City University Graduate School of Medical Sciences Nagoya 467-8601 Japan Department of Urology Fukushima Medical University Fukushima 960-1295 Japan Department of Pediatrics Hamamatsu University School of Medicine Hamamatsu 431-3192 Japan

Dear Editor, Disorders of sex development （DSDs） are a group of conditions in which chromosomal, gonadal, or anatomical sex is atypical.1 DSD in genetic males （46,XY DSD） primarily results from impaired androgen production or action or perturbed genital morphogenesis？ The current understanding of the genetic basis of 46,XY DSD remains fragmentary. For example, although more than 15 genes have been implicated in the development ofnonsyndromic hypospadias,2 one of the most common forms of 46,XY DSD,~ mutations in these genes account for 〈20% of the cases.3

关键词： TRANSCRIPTION HYPOSPADIAS ETIOLOGY GENE

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Optimal biliary drainage for inoperable Klatskin's tumor based on Bismuth type

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World Journal of Gastroenterology 2007年第29期13卷 3948-3955页

作者： Sang Hyub Lee Joo Kyung Park Won Jae Yoon Jun Kyu Lee Ji kon.Ryu Yong Bum Yoon Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul South Korea

AIM： To investigate differences in the effects of biliary drainage procedures in patients with inoperable Klatskin＇s tumor based on Bismuth type, considering endoscopic retrograde biliary drainage （ERBD）, external percutaneous transhepatic biliary drainage （EPTBD） and internal biliary stenting via the PTBD tract （IPTBD）. METHODS： The initial success rate, cumulative patency rate, and complication rate were compared retrospectively, according to the Bismuth type and ERBD, EPTBD, and IPTBD. Patency was defined as the duration for adequate initial bile drainage or to the point of the patient＇s death associated with inadequate drainage. RESULTS： One hundred thirty-four patients （93 men, 41 women; 21 Bismuth type Ⅱ, 47Ⅲ, 66 Ⅳ; 34 ERBD, 66 EPTBD, 34 IPTBD） were recruited. There were no differences in demographics among the groups. Adequate initial relief of jaundice was achieved in 91% of patients without a significant difference in the results among different procedures or Bismuth types. The cumulative patency rates for ERBD and IPTBD were better than those for EPTBD with Bismuth type Ⅲ. IPTBD provided an excellent response for Bismuth type IV. However, there was no difference in the patency rate among drainage procedures for Bismuth type Ⅱ. Procedure-related cholangitis occurred less frequently with EPTBD than with ERBD and IPTBD. CONCLUSION： ERBD is recommended as the firstline drainage procedure for the palliation of jaundice in patients with inoperable Klatskin＇s tumor of Bismuth type Ⅱ or Ⅲ, but IPTBD is the best option for Bismuth type Ⅳ.

关键词： Klatskin's tumor Palliation Drainage Bile ducts Intervention

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Advanced simulation of die wear caused by wire vibrations during wire-drawing process

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Transactions of Nonferrous Metals Society of China 2012年第7期22卷 1723-1731页

作者： LEE Kyung-Hun LEE San g-kon.KIM Byung-Min Precision Manufacturing Systems Division Pusan National University30 Jangjeon-DongKumjeong-GuBusan 609-735Korea Daegyeong Regional Division Korea Institute of Industrial Technology711Hosan-dongDalseo-guDaegu 704-230Korea School of Mechanical Engineering Pusan National University30 Jangjeon-DongKumjeong-GuBusan 609-735Korea

An advanced simulation that considers the effect of wire vibrations was proposed for predicting accurately wear profiles of a die used in a wire-drawing *** effect of wire vibrations,the changes in the wear profiles,and the generation of ringing during die approach were investigated by this *** vibrations occurring between the die and the drum are governed by a partial differential equation called the wave equation,which is a function of the wire length,tension,density,and initial wire *** wire-drawing process was simulated by the commercial code Abaqus FEA,and the die wear profiles were predicted by Archard’s wear *** predicted profiles were compared with measured profiles of a worn drawing die after producing 5 t of AISI 1010 wire;the die was made of tungsten carbide with a Brinell hardness of HB *** profiles predicted by considering the effect of wire vibrations are in good agreement with the experimental data,indicating that the advanced simulation can be used to accurately predict the die wear profiles when ringing is observed during die approach.

关键词： wire drawing wire vibrations die wear profile ringing

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Effect of Different Parts of <i>Kigelia africana</i>Fruit Aqueous Extracts on Sperm Parameters and Testis

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Advances in Reproductive Sciences 2021年第3期9卷 171-188页

作者： Maïmouna Coura kon. Blaise Wokapeu Kpan Ibrahima Kandé Roger Koffi Kouakou Romuald Sylvère Koman yao kon.n Koffi Kouakou Laboratory Biology and Health Biology of Development and Reproduction Unit Biosciences UFR Félix HOUPHOU&Euml T-BOIGNY University Abidjan C&ocirc te d’Ivoire Laboratory of Natural Environments and Biodiversity Conservation Botanical Research and Training Unit Félix HOUPHOU&Euml T-BOIGNY University Abidjan C&ocirc te d’Ivoire UFR Science of Nature Nangui Abrogoua University Abidjan C&ocirc te d’Ivoire National Floristic Center (CNF) Abidjan C&ocirc te d’Ivoire

Kigelia africana is a plant of ivoirian pharmocopae commonly used in infertility treatment. The Kigelia africanawhole fruit extracts are known to improve sperm parameters like density, morphologie and mobility. However, data related to efficiency of different parts of the fruit are lack. The aim of this study was to know the effects of aqueous extracts of the whole Kigelia africana fruit (AP) and of the fruit without the peel (SP) on the sperm parameters and testicular tissue of mice. The phytochemical composition analysis of the SP and AP aqueous extracts of Kigelia africana fruit reveals several secondary metabolites in variable abundance. The sperm densities (Figure 1) of the SP (~78.106 spz/ml ± 2.60) and AP (~96.15 × 106 spz/ml ± 2.44) groups were higher than that of the control (~63.95.106<

关键词： Kigelia Spermatogenesis Density Mobility Testis

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Anticancer Activities and QSAR Study of Novel Agents with a Chemical Profile of Benzimidazolyl-Retrochalcone

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Open Journal of Medicinal Chemistry 2020年第3期10卷 113-127页

作者： Ouattara Mahama kon. Aboudramane kon. Soleymane Collet Sylvain Diomandé Sekou Sissouma Drissa Department of Therapeutic Chemistry and Organic Chemistry UFR SPB FHB University Abidjan C&#244 te d’Ivoire Department of Chemistry UFR Environment Jean LorougnonGuédé University Daloa C&#244 te d’Ivoire Laboratory of Organic Chemistry and Natural Substances UFR SSMT FHB University Abidjan C&#244 te d’Ivoire Chemistry and Interdisciplinarity: Synthesis Analysis Modelling (CEISAM) University of Nantes Nantes France

The present pharmacochemical and modelling work focused on a benzimidazolyl-chalcone series. These previously synthesized compounds were evaluated in vitro for their anticancer activities against a panel of seven human cancer cell lines and normal fibroblasts. Among the new benzimidazole-supported chalcones, nine (9) compounds (compounds 1 - 4, 6 - 8 and compounds 10 and 11) showed promising anticancer activities with IC50s ranging from 0.83 to 2.58 μM. Compounds 2 and 6 with IC50s of 0.83 and 0.86 μM, respectively, were shown to be potent inhibitors of HCT-116 colon cancer cell proliferation. It was therefore necessary, for a development of this new series of chalcones, to establish through a QSAR study, their quantum descriptors according to the DFT calculation method and following the B3LYP/6-31+G (d,p) theory. These descriptive and predictive studies focused on the colon HCT 116 cell line which was found to be more sensitive to the anticancer action of our benzimidazolyl-retrochalcones. QSAR study showed that the electronic energy (Eelec), lipophilicity (logP), chemical softness (S) and chemical hardness (η) of benzimidazolyl-retrochalcones play an important role in inhibiting cancer cell proliferation.

关键词： Retrochalcone Benzimidazole Anticancer Agents QSAR Quantum Descriptors DFT Method

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Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction:A randomized controlled trial

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 493-499页

作者： Jin Ho Choi Kyong Joo Lee Woo Hyun Paik Namyoung Park Jung Won Chun Sang Hyub Lee Ji kon.Ryu Yong-Tae Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University Wonju College of MedicineWonjuKorea

Background:Endoscopic biliary drainage is the treatment of choice for patients with malignant distal common bile duct ***-expandable metal stents have clinical advantages including an increased duration of patency that may be prolonged by acetylsalicylic acid(ASA)*** aim of this study was to investigate whether ASA had a positive effect on the patency of self-expandable metal stents compared with ***:This prospective,multicenter,double-blinded,and randomized placebo-controlled trial was conducted from October 2017 to May 2020 in *** who underwent palliative endoscopic biliary drainage with self-expandable metal stents for malignant distal bile duct obstruction were enrolled,and allocated to ASA treatment or *** study outcomes were the rate of stent dysfunction at 6 months,duration of stent patency,risk factors for stent dysfunction,and any adverse ***:Interim analysis included 24 and 28 patients in the ASA and placebo groups,*** was no significant difference between the ASA and placebo groups in stent dysfunction(25.0%vs.20.7%,P=0.761)or the duration of stent patency(150.97±10.55 vs.158.07±8.70 days,P=0.497).Six patients experienced suspected ASA-related adverse events,and there was one lethal ***:ASA did not prolong stent *** study was terminated early because of the possibility of serious adverse events related to ASA treatment of these patients receiving palliative care.

关键词： Endoscopic retrograde cholangiopancreatography Self expandable metallic stents Randomized controlled trial Acetylsalicylic acid

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Ileal angiomyolipoma manifested by small intestinal intussusception

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World Journal of Gastroenterology 2009年第11期15卷 1398-1400页

作者： Chang Ho Lee Jong Hun Kim Doo Hyun Yang Yong Hwang Myoung Jae Kang Young kon.Kim Min Ro Lee Department of Surgery Chonbuk National University Medical SchoolJeonju 561-180 South Korea Department of Pathology Chonbuk National University Medical SchoolJeonju 561-180 South Korea Department of Radiology Chonbuk National University Medical SchoolJeonju 561-180South Korea

Angiomyolipomas(AMLs),a form of benign mesenchymal hamartoma,arise primarily in the kidneys of patients with or without tuberous ***-renal AMLs are very rare and are most commonly found in the liver. AMLs of the small intestine are exceedingly ***, a case of a 28-year-old man,who presented with ileal intussusception caused by ileal AML is *** clinicopathological and immunohistochemical findings of ileal AMLs are discussed and the literature on small intestinal AMLs is reviewed.

关键词： Angiomyolipoma Intussusception Hamartoma Ileum Colectomy

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Revision of bilateral self-expandable metallic stents placed using the stent-in-stent technique for malignant hilar biliary obstruction

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 437-442页

作者： Jun Hyuk Son Hee Seung Lee Sang Hyub Lee Seungmin Bang Jinwoo Kang Woo Hyun Paik Ji kon.Ryu Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Inje University Ilsan Paik HospitalGoyangKorea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulKorea Department of Gastroenterology and Hepatology SMG-SNU Boramae Medical CenterSeoulKorea

Background: Endoscopic biliary decompression using bilateral self-expandable metallic stent(SEMS) placed using the stent-in-stent(SIS) technique is considered favorable for unresectable malignant hilar biliary obstruction(MHBO). However, occlusion of the bilateral SIS placement is frequent and revision can be challenging. This study was performed to investigate the efficacy, the long-term patency and the appropriate approach for revision of occluded bilateral SIS placement in unresectable MHBO. Methods: From January 2011 to July 2016, thirty-eight patients with unresectable MHBO underwent revision of occluded bilateral SIS placement. Clinical data including success rates and patency of revision, were retrospectively analyzed. Results: The technical success rate of revision was 76.3%. The clinical success rate of revision was 51.7% and mean patency of revision was 49.1 days. No significant predictive factor for clinical failure of revision was observed. The cell size of SEMS was not found to have significant effects on clinical success rates or revision patency. Conclusions: Revision of occluded bilateral SIS placement for MHBO showed fair patency and clinical success rate. Revision method and cell size of SEMS were not found to influence clinical outcomes.

关键词： Malignant hilar biliary obstruction Self-expandable metallic stent Stent-in-stent Revision

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γ-酮醛清道夫水杨胺对尿毒症ApoE-/-小鼠动脉粥样硬化的作用

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西安交通大学学报（医学版） 2020年第1期41卷 47-52页

作者：申燕陈胜男赵艳 VALENTINA kon 西安交通大学第一附属医院肾内科陕西西安710061 西安交通大学第一附属医院心血管内科陕西西安710061 美国范德堡大学医学中心儿科肾脏与高血压系田纳西纳什维尔37232

目的观察γ-酮醛清道夫水杨胺(salicylamine,SAM)对尿毒症ApoE-/-小鼠动脉粥样硬化(atherosclerosis,AS)及其表型的影响。方法ApoE-/-小鼠通过5/6肾切除术建立尿毒症模型,对照组仅行假手术。实验动物分为对照组、尿毒症组及尿毒症SAM干... 详细信息

目的观察γ-酮醛清道夫水杨胺(salicylamine,SAM)对尿毒症ApoE-/-小鼠动脉粥样硬化(atherosclerosis,AS)及其表型的影响。方法ApoE-/-小鼠通过5/6肾切除术建立尿毒症模型,对照组仅行假手术。实验动物分为对照组、尿毒症组及尿毒症SAM干预组,分别以SAM或安慰剂干预6周。干预结束后检测体质量、血压、血脂、肾功能、血清SAM浓度、主动脉AS斑块面积及斑块组分。结果与对照组相比,尿毒症组主动脉AS病变面积明显增大,AS斑块组分中坏死面积增大,巨噬细胞含量增多,胶原含量减少。SAM干预6周,尿毒症小鼠AS损伤面积、AS斑块中坏死面积及巨噬细胞含量减少,胶原含量增加,但不影响体质量、血压、血脂和肾功能,未发生药物蓄积和毒性作用。结论SAM能减轻尿毒症ApoE-/-小鼠加速发展的AS病变并使斑块的稳定性增加,这些作用不依赖于对血压、血脂或肾功能的影响,同时不引起药物蓄积及毒性作用。

关键词： γ-酮醛清道夫水杨胺尿毒症 ApoE-/-小鼠动脉粥样硬化水杨胺(salicylamine)

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