检索结果-南通市图书馆

Histological origin of pseudomyxoma peritonei in Chinese women:Clinicopathology and

World Journal of Gastroenterology 2011年第30期17卷 3531-3537页

作者： Ai-Tao Guo xin Song Li-xin wei Po zhao Department of Pathology The General Hospital of PLA 100853 Beijing China

AIM： To investigate the myxoma peritonei （PMP） histological origin of pseudo- n Chinese women. METHODS： The clinical and pathological data were reviewed for 35 women with PMP, and specimens of the peritoneal, appendiceal and ovarian lesions of each patient were examined using the PV-6000 immunohistochemistry method. Antibodies included cytokeratin （CK）7, CK20, mucin （MUC）-1, MUC-2, carbohydrate antigen （CA）-125, estrogen receptor （ER）, and progesterone receptor （PR）. RESULTS： Abundant colloidal mucinous tumors were observed in the peritoneum in all 35 cases. Thirty-one patients had a history of appendectomy, 28 of whom had mucinous lesions. There was one patient with appendicitis, one whose appendix showed no apparent pathological changes, and one with unknown surgical pathology. Ovarian mucinous tumors were found in 24 patients. The tumors were bilateral in 13 patients, on the right-side in nine, and on the left side in two. Twenty patients had combined appendiceal and ovarian lesions; 16 of whom had undergone initial surgery for appendiceal lesions. Four patients had undergone initial surgery for ovarian lesions, and relapse occurred in these patients at 1, 11, 32 and 85 mo after initial surgery. Appendi-ceal mucinous tumors were found in each of these four patients. Thirty-three of the 35 patients showed peritoneal lesions that were positive for CK20 and MUC-2, but negative for CK7, MUC-1, CA125, ER and PR. The expression patterns in the appendix and the ovary were similar to those of the peritoneal lesions. In one of the remaining two cases, CK20, CK7 and MUC-2 were positive, and MUC-1, CA125, ER and PR were negative. The ovaries were not resected. The appendix of one patient was removed at another hospital, and no specimen was evaluated. In the other case, the appendix appeared to be normal during surgery, and was not resected. Peritoneal and ovarian lesions were negative for CK20, MUC-2, CK7, MUC-1, CA125, ER and PR. CONCLUSION： Most PMP originated from the ap

关键词： Pseudomyxoma peritonei Peritoneum Tumor origin Ovary Appendix Immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feasibility of cetuximab and chemoradiotherapy combination in Chinese patients with unresectable stage Ⅲ non-small cell lung cancer:a preliminary report

引用

Chinese Journal of Cancer Research 2015年第2期27卷 172-180页

作者： Di Liu Yu-xin Shen wei-xin zhao Guo-Liang Jiang Jia-Yan Chen Min Fan Department of Radiation Oncology Fudan University Shanghai Cancer Center Department of Radiation Oncology The First Affiliated Hospital of Nanjing Medical University

Objective： In recent years, the combination of cetuximab and chemoradiotherapy （CRT） has been used to treat stage III non-small cell lung cancer （NSCLC）; however, limited data are available for Chinese patients. Herein, we report preliminary data from a phase I/II study testing the combination of cetuximab with inductive chemotherapy, followed by concurrent CRT （CCRT） in Chinese patients with stage III NSCLC. Methods： Eligibility criteria were Zubrod performance status （PS） 0-1, forced expiratory volume in 1 second （FEV1）〉_1.2 L and adequate organ function. Enrolled patients received weekly cetuximab （initial dose of 400 mg/m2 on day 1 of week 1 and a maintenance dose of 250 mg/m2 on week 2 to the end of CCRT） with cisplatin/vinorelbine （NP） chemotherapy （every 3 weeks for 2 cycles from week 2, followed by two cycles of concomitant NP chemotherapy and intensity-modulated thoracic radiotherapy （TRT）（60-66 Gy/2 Gy）. The primary endpoints were toxicity and feasibility. All patients received positron emission tomography- computerized tomography （PET-CT） scans within the 2 weeks prior to enrollment. Univariate analyses were used to assess the correlation between SUV-T, SUV-N, SUV-TOTAL, gender, age, histology, tumor-node- metastasis （TNM） stage, PS and smoking status and survival. Survival curves were generated for different populations using the Kaplan-Meier method and compared using a log-rank test. Results： Seventeen patients were enrolled and 16 completed the full regime. The overall response rate （ORR） was 58.8% and 82.3% after the induction and CCRT phases, respectively. With a median follow-up duration of 27.6 months, the median survival was 27.6 months [95% confidence interval （CI）： 11.3-43.9 months] with 1- and 2-year survival rates of 88.2% （95% CI, 60.6-96.9%） and 58.8% （95% CI, 60.6-77.8%）, respectively. Three patients remain progression-free to date, and the median progression-free survival （PFS） was 13.5 months （95% CI, 6.8-20.2 months）. No treatment-rela

关键词： Cetuximab induction chemotherapy concurrent chemoradiotherapy (CRT) positron emission tomography-computerized tomography (PET-CT) locally advanced non-small cell lung cancer (NSCLC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite oxide with surface doping of Y and its application in Pd-only three-way catalyst

引用

Rare Metals 2024年第2期43卷 749-757页

作者： Zheng zhao wei-xin zhao Yong-Qi Zhang Mei-Sheng Cui Yong-Ke Hou Dong-Ming Chen Juan-Yu Yang Zong-Yu Feng Xiao-wei Huang National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.GRINM Group Corporation LimitedBeijing100088China Griem Hi-Tech Co.Ltd. Langfang065000China Rare Earth Functional Materials(Xiong’an)Innovation Venter Co.Ltd. Baoding071700China

The ceria-zirconia compound oxide-supported noble metal Pd(Pd@CZ)is widely used in three-way ***,the surface structure of CZ plays an important role in catalytic activity of ***,how to regulate the surface structure of CZ and clarify the structure–activity relationship is still a *** this paper,a strategy is proposed to develop high activity Pd@CZ nanocatalysts by tuning Y doping sites in *** precipitate-deposition method is developed to prepare the novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite with surface doping of Y(CZ-Y-S).In addition,the Pd@CZ-Y-S(Pd supported on CZ-Y-S)exhibits superior catalytic activity for HC,CO,and NO oxide,wherein,for CO and C_(3)H_(6) oxidation,the low-temperature activity of Pd@CZ-Y-S is still 20%higher than that of Pd@CZ-Y-B(Y bulk doping)and commercial Pd@CZ after 1000℃/4 h *** effect mechanism is further studied by density functional theory(DFT)*** with Pd@CZ-Y-B,Pd@CZ-Y-S shows the lower CO oxide reaction energy barriers due to the weaker adsorption strength of *** Y surface doping strategy could provide valuable insights for the development of highly efficient Pd@CZ catalyst with extensive applications.

关键词： Rare earth Ceria-zirconia-supported Pd Surface doping Experiment and theory Catalytic application

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Principle and progress of radical treatment for locally advanced esophageal squamous cell carcinoma

引用

World Journal of Clinical Cases 2022年第35期10卷 12804-12811页

作者： Xiao-Fei Zhang Pei-Yi Liu Shu-Juan Zhang Kuai-Le zhao wei-xin zhao Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Clinical Research Center for Radiation Oncology Shanghai Key Laboratory of Radiation Oncology Shanghai 200032China Department of Orthopedics Tongren HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai 200336China Department of Oncology The Second People's Hospital of KashgarKashgar 844000Xinjiang Uygur Autonomous RegionChina

Esophageal squamous cell carcinoma is one of the most common malignant tumors in the digestive system in China and the *** patients are diagnosed as locally advanced or advanced *** chemoradiotherapy is the standard treatment for locally advanced esophageal squamous cell *** study intends to summarize the evidence-based medical evidence of the treatment principle of locally advanced esophageal squamous cell carcinoma,the selection of radiotherapy dose,the outline of radiotherapy target and the selection of chemotherapy *** a result,the effect of radiotherapy and chemotherapy is equivalent to that of surgery for the radical treatment of esophageal squamous cell *** the era of immunization,it is recommended to use involved field *** plus cisplatin regimen is the standard chemotherapy *** regimen and paclitaxel plus fluorouracil regimen are optional concurrent chemotherapy *** toxic and side effects of different chemotherapy regimens are different,which can be selected according to the actual situation of patients.

关键词： Esophageal squamous cell carcinoma Radical radiotherapy and chemotherapy Involving field irradiation Chemoradiotherapy Radical treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Structure and Spectra Characters of 2-Benzoly-3-(4-(1,2,4-triazole)-5-anilino-thiophene and 2-(4-Methyl-benzoly)-3-(4- chlrolphenyl)-3-(1,2,4-triazole)-5-anilino-thiophene

引用

有机化学 2004年第Z1期24卷 25-26页

作者： CAO,Ke-Guang WANG,Zhong-wei zhao,xin-Qi School of Material Science and Engineering Beijing Institute of Technology Beijing 100081 Chengde Petroleum College Chengde 067000 School of Material Science and Engineering Beijing Institute of Technology Beijing 100081 School of Material Science and Engineering Beijing Institute of Technology Beijing 100081

　　Triazole derivatives are widely studied, because they represent the largest group of modern fungicides and are widely used both in human and veterinary therapy and in agriculture. We synthesized the title compound in which the thiophene ring was substituted by a 1,2,4-triazole group, a phenacyl group, a phenylaminol group and a benzene ring.……

关键词：

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PagERF81 regulates lignin biosynthesis and xylem cell differentiation in poplar

引用

Journal of Integrative Plant Biology 2023年第5期65卷 1134-1146页

作者： xin-wei zhao Qiao Wang Dian Wang wei Guo Meng-Xuan Hu Ying-Li Liu Gong-Ke Zhou Guo-Hua Chai Shu-Tang zhao Meng-Zhu Lu State Key Laboratory of Tree Genetics and Breeding Research Institute of ForestryChinese Academy of ForestryBeijing 100091China Collegeof Resources and Environment QingdaoAgricultural UniversityQingdao 266109China CollegeofAgronomy QingdaoAgriculturalUniversityQingdao 266109China TaishanAcademyof Forestry Sciences Taian271000China College of Landscape Architecture and Forestry Qingdao Agricultural UniversityQingdao 266109China State Key Laboratory of Subtropical Silviculture College of Forestry and BiotechnologyZhejiang A&F UniversityHangzhou 311300China

Lignin is a major component of plant cell walls and is essential for plant growth and development. Lignin biosynthesis is controlled by a hierarchical regulatory network involving multiple transcription factors. In this study, we showed that the gene encoding an APETALA 2/ethylene-responsive element binding factor(AP2/ERF) transcription factor, PagERF81,from poplar 84 K(Populus alba × P. glandulosa) is highly expressed in expanding secondary xylem cells. Two independent homozygous Pagerf81 mutant lines created by gene editing, produced significantly more but smaller vessel cells and longer fiber cells with more lignin in cell walls, while PagERF81 overexpression lines had less lignin,compared to non-transgenic controls. Transcriptome and reverse transcription quantitative PCR data revealed that multiple lignin biosynthesis genes including Cinnamoyl CoA reductase 1(PagCCR1),Cinnamyl alcohol dehydrogenase 6(PagCAD6), and 4-Coumarate-CoA ligase-like 9(Pag4CLL9) were upregulated in Pagerf81 mutants, but down-regulated in PagERF81 overexpression lines. In addition, a transient transactivation assay revealed that PagERF81 repressed the transcription of these three ***, yeast one hybrid and electrophoretic mobility shift assays showed that PagERF81 directly bound to a GCC sequence in the PagCCR1 promoter. No known vessel or fiber cell differentiation related genes were differentially expressed, so the smaller vessel cells and longer fiber cells observed in the Pagerf81 lines might be caused by abnormal lignin deposition in the secondary cell walls. This study provides insight into the regulation of lignin biosynthesis, and a molecular tool to engineer wood with high lignin content, which would contribute to the lignin-related chemical industry and carbon sequestration.

关键词： lignin biosynthesis PagERF81 Populus secondary cell wall xylem development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Difference in failure patterns of pT3-4N0-3M0 esophageal cancer treated by surgery vs surgery plus radiotherapy

引用

World Journal of Gastrointestinal Oncology 2019年第12期11卷 1172-1181页

作者： Ya Zeng Wen Yu Qi Liu wei-wei Yu Zheng-Fei Zhu wei-xin zhao Jun Liu Jia-Ming Wang Xiao-Long Fu Yuan Liu Xu-wei Cai Department of Radiation Oncology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200030China Department of Radiation Oncology Shanghai Jiao Tong University Affiliated Shanghai Sixth People’s HospitalShanghai 200030China Department of Statistics Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

BACKGROUND There has been no study comparing the difference in the failure patterns between patients with or without postoperative radiotherapy(PORT)after esophagectomy for pT3-4N0-3M0 esophageal squamous cell carcinoma(ESCC).AIM To investigate the difference in the failure patterns of stage pT3-4N0-3M0 ESCC patients with or without *** Patients with stage pT3-4N0-3M0 ESCC,who underwent surgery with or without PORT,were enrolled in this *** primary endpoint was to investigate the difference in the failure patterns between patients with or without PORT after *** secondary endpoint was to estimate whether patients with stage pT3-4 ESCC could achieve a disease-free survival(DFS)advantage after receiving adjuvant *** analyses were performed by the Kaplan-Meier method,Cox regression model,and Chi-squared test or Fisher’s exact *** In total,230 patients with stage pT3-4N0-3M0 ESCC were included in this ***-six patients who received PORT were screened from a prospective cohort(S+R arm).And 174 patients involving surgery alone were retrospectively selected from July 2006 to October 2014(S arm).There were no significant differences in the clinical or pathological characteristics of patients between the two arms,except for tumor location(P=0.031).The failure patterns between the two arms were significantly different(P<0.001).Patients in the S arm had a significantly higher proportion of locoregional recurrence and a lower proportion of distant metastasis than those in the S+R arm(92.0%vs 35.7%,P<0.001 and 19.0%vs 75.0%,P<0.001,respectively).The difference in the median DFS between the two arms was statistically significant(12.7 vs 8 mo,P=0.048).Univariate analysis and multivariate analysis both demonstrated that the number of lymph node metastases≥3(HR=0.572,95% CI:0.430-0.762,P<0.001)was an independent poor prognostic factor for DFS in patients with stage pT3-4N0-3M0 *** PORT could improve DFS and local c

关键词： Esophageal squamous cell carcinoma Postoperative radiotherapy Failure patterns Disease-free survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transcatheter aortic valve implantation： preliminary experience in West China Hospital

引用

Chinese Medical Journal 2013年第6期126卷 1189-1191页

作者： CHEN Mao FENG Yuan TANG Hong wei xin zhao Zhen-gang XU Yuan-ning HUANG De-jia Department of Cardiology West China Hospital Sichuan University Chengdu Sichuan 610041 China

Transcatheter aortic valve implantation （TAVI） is a promising alternative, to surgical aortic vane replacement for patients with symptomatic severe aortic stenosis （AS） who were deemed at a high surgical risk. This novel technique has kept evolving rapidly throughout the world in the past decade, but was not introduced to China until recently. Here we report our clinical experience in TAVI based on the largest cohort of Chinese patients in a single center.

关键词： transcatheter aortic valve implantation," aortic valve," stenosis bicuspid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

近红外光谱和特征光谱的山茶油掺假鉴别方法研究

引用

光谱学与光谱分析 2017年第1期37卷 75-79页

作者：褚璇王伟赵昕姜洪喆王伟刘声泉中国农业大学工学院现代农业装备优化设计北京市重点实验室北京100083 塔里木大学机械电气化工程学院新疆阿拉尔843300

山茶油素有"东方橄榄油"美誉,实现掺假山茶油的鉴别具有重要实用价值,采用近红外光谱技术对掺有葵花油的山茶油进行检测。分别以1%,5%,10%为梯度制备掺假比例不同的山茶油样品,并根据掺假比例将其分为A组(0%~5%)和B组(6%~10%)共11个样... 详细信息

山茶油素有"东方橄榄油"美誉,实现掺假山茶油的鉴别具有重要实用价值,采用近红外光谱技术对掺有葵花油的山茶油进行检测。分别以1%,5%,10%为梯度制备掺假比例不同的山茶油样品,并根据掺假比例将其分为A组(0%~5%)和B组(6%~10%)共11个样品,C组(15%~40%)6个和D组(50%~100%)6个样品。将每个掺假样品充分混匀后再分为9份,依次采集其1 000~2 500nm范围的吸收光谱,共获得207条光谱曲线。每组样品的光谱数据按2∶1随机分为训练集与验证集。经去除首尾噪声后,通过主成分分析法(principal component analysis,PCA)降维,并利用前四个主成分建立了鉴别山茶油不同掺假等级的主成分-支持向量机判别模型,训练集与验证集的总体判别准确率分别达96.38%和94.20%;进一步,通过对前四个主成分的载荷系数的分析,并结合原始光谱,提取建模过程中权重较大的波长并解析其化学含义,最终确定出五个特征波长:1 212,1 705,1 826,1 905及2 148nm,以此波长重新建立近红外特征光谱山茶油掺假等级判别模型,对训练集与验证集的总体判别准确率也达到了94.20%和92.75%。研究结果表明,利用近红外光谱和特征光谱均能够较好实现山茶油掺假等级的鉴别,同时所建立的近红外特征光谱模型也为设计相应的掺假山茶油实用便携式检测仪器提供了理论基础。

关键词：山茶油掺假检测近红外光谱技术特征光谱支持向量机

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

引用

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei Huang Jiayi Wen xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：