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A tracking and predicting scheme for ping pong robot

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第2期12卷 110-115页

作者： yuan-hui ZHANG wei wei Dan yu Cong-wei ZHONG School of Electrical Engineering Zhejiang University Hangzhou 310027 China

We describe a new tracking and predicting scheme applied to a lab-made ping pong robot. The robot has a monocular vision system comprised of a camera and a light. We propose an optimized strategy to calibrate the light center using the least square method. An ellipse fitting method is used to precisely locate the center of ball and shadow on the captured image. After the triangulation of the ball position in the world coordinates, a tracking algorithm based on a Kalman filter outputs an accurate estimation of the flight states including the ball position and velocity. Furthermore, a neural network model is constructed and trained to predict the following flight path. Experimental results show that this scheme can achieve a good predicting precision and success rate of striking an incoming ball. The robot can achieve a success rate of about 80% to return a flight ball of 5 m/s to the opposite court.

关键词： Ping pong robot Calibration Trajectory tracking Kalman filter Neural network

Two new flavonoid diglycosides from Cephalotaxus sinensis

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Chinese Chemical Letters 2007年第7期18卷 837-839页

作者： wei Li Rong Ji Dai yu Hong yu Liang Li wei wei Meng yu Lin Deng School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China

Two new acetylated flavonoid diglycosides, scutellarein-5-O-[α-L-rhamnopyranosyl-（1 → 4）-β-D-6-O-acetylglucopyranoside]（1）, apigenin-5-O-[α-L-rhamnopyranosyl-（1→ 2）-β-D-3,6-di-O-acetylglucopyranoside] （2）, were isolated from the leaves of Cephalotaxus sinensis. Their structures were determined by chemical and spectroscopic methods including HR-FAB-MS,^1H-^1H COSY, HSQC and HMBC experiments.

关键词： Cephalotaxus sinensis (Rehd et Wile) Li Flavonoid diglycosides Scutellarein-5-O-[α-L-rhamnopyranosyl-(1→ 4)-β-D-6-O-acetylglucopyranoside] Apigenin-5-O-[α-L-rhamnopyranosyl-(1 → 2)-β-D-3,6-di-O-acetylglucopyranoside]

Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the miR23a-3p/EPHB2 Pathway

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Current Medical Science 2024年第5期44卷 954-963页

作者： Yan YANG Jing-wen HUANG wei-wei yu Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aimed to investigate the reasons behind the lower survival rates in male lung cancer patients than in female lung cancer *** Through various techniques,such as Argonaute immunoprecipitation,luciferase assays,and ChIP,this study confirmed the positive effects of androgen receptor(AR)on lung cancer cell invasion across different in vitro cell lines and in vivo mouse *** The findings suggest that AR enhanced the invasion of lung cancer cells by modifying EPHB2 signals at the protein expression level,which in turn required changes in *** miRNA-23a-3p could counteract the intensified invasion of lung cancer cells mediated by *** This study revealed that AR may facilitate the lung cancer matastasis by modulating miRNA-23a-3p/EPHB2 signaling and that targeting this signaling pathway could provide new approaches to inhibit lung cancer metastasis.

关键词： androgen receptor lung cancer metastasis miRNA-23a-3p EPHB2

Comparative Analysis of Regulatory Motif Discovery Tools for Transcription Factor Binding Sites

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Genomics, Proteomics & Bioinformatics 2007年第2期5卷 131-142页

作者： wei wei Xiao-Dan yu Department of Pathobiology Center of Computational Biology Institute of Basic Medical Sciences Beijing100850 China

In the post-genomic era, identification of specific regulatory motifs or transcription factor binding sites （TFBSs） in non-coding DNA sequences, which is essential to elucidate transcriptional regulatory networks, has emerged as an obstacle that frustrates many researchers. Consequently, numerous motif discovery tools and correlated databases have been applied to solving this problem. However, these existing methods, based on different computational algorithms, show diverse motif prediction efficiency in non-coding DNA sequences. Therefore, understanding the similarities and differences of computational algorithms and enriching the motif discovery literatures are important for users to choose the most appropriate one among the online available tools. Moreover, there still lacks credible criterion to assess motif discovery tools and instructions for researchers to choose the best according to their own projects. Thus integration of the related resources might be a good approach to improve accuracy of the application. Recent studies integrate regulatory motif discovery tools with experimental methods to offer a complementary approach for researchers, and also provide a much-needed model for current researches on transcriptional regulatory networks. Here we present a comparative analysis of regulatory motif discovery tools for TFBSs.

关键词： motif TFBS non-coding DNA sequence computational algorithm motif discovery tool

Baihui(DU20)-penetrating-Qubin(GB7) acupuncture inhibits apoptosis in the perihemorrhagic penumbra

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Neural Regeneration Research 2018年第9期13卷 1602-1608页

作者： Beng Zhang Xiao-Hong Dai Xue-Ping yu wei Zou wei Teng Xiao-wei Sun wei-wei yu Hao Liu Hui Wang Meng-Juan Sun Meng Li Heilongjiang University of Chinese Medicine Harbin Heilongjiang Province China First Affiliated Hospital Heilongjiang University of Chinese Medicine Harbin Heilongjiang Province China Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine Heilongjiang University of Chinese Medicine HarbinHeilongjiang Province China Department of Acupuncture and Moxibustion Tongde Hospital of Zhejiang Province Hangzhou Zhejiang Province China

Baihui（DU20）-penetrating-Qubin（GB7） acupuncture can inhibit inflammatory reactions and activate signaling pathways related to proliferation after intracerebral ***,there is no research showing the relationship between this treatment and cell *** models of intracerebral hemorrhage were established by injecting 60 μL of autologous blood into the right side of the *** hours later,the needle traveled subcutaneously from the Baihui acupoint to Qubin *** needle was alternately rotated（180 ± 10 turns/min） manually along clockwise and counter-clockwise *** lasted for 7 days,and was performed three times each for 6 minutes with 6-minute intervals between *** intraperitoneally receiving Sonic hedgehog pathway activator,purmorphamine（1 mg/kg per day）,served as positive *** and sensory function were assessed using the Ludmila Belayev *** of pathological changes were measured in the perihemorrhagic penumbra using hematoxylin-eosin *** was examined by terminal deoxynucleotidyl transferase（Td T）-mediated d UTP nick end labeling *** of smoothened（Smo） and glioma-associated homolog 1（Gli1） was determined by western blot *** results showed that Baihui-penetrating-Qubin acupuncture promoted recovery of motor and sensory function,reduced the apoptotic cell percentage in the perihemorrhagic penumbra,and up-regulated Smo and Gli1 *** conclude that Baihui-penetrating-Qubin acupuncture can mitigate hemorrhage and promote functional recovery of the brain in a rat model of intracerebral hemorrhage,possibly by activating the Sonic hedgehog pathway.

关键词： nerve regeneration acupuncture treatment intracerebral hemorrhage neurological function Ludmila Belayev test TUNEL assay purmorphamine Smo Ptchl Glil neural regeneration

Decorin Induces Cardiac Hypertrophy by Regulating the CaMKⅡ/MEF-2 Signaling Pathway In Vivo

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Current Medical Science 2021年第5期41卷 857-862页

作者： Yan YANG wei-wei yu Wen YAN Qin XIA Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Cardiac hypertrophy is an adaptive reaction of the heart against cardiac overloading,but continuous cardiac hypertrophy can lead to cardiac remodeling and heart *** hypertrophy is mostly considered reversible,and recent studies have indicated that decorin not only prevents cardiac fibrosis associated with hypertension,but also achieves therapeutic effects by blocking fibrosis-related signaling ***,the mechanism of action of decorin remains unknown and ***:We determined the degree of myocardial hypertrophy by measuring the ratios of the heart weight/body weight and left ventricular weight/body weight,histological analysis and *** blotting was performed to detect the expression levels of CaMKⅡ,p-CaMKⅡ and MEF-2 in the ***:Our results confirmed that decorin can regulate the CaMKⅡ/MEF-2 signaling pathway,with inhibition thereof being similar to that of decorin in reducing cardiac ***:Taken together,the results of the present study showed that decorin induced cardiac hypertrophy by regulating the CaMKⅡ/MEF-2 signaling pathway in vivo,revealing a new therapeutic approach for the prevention of cardiac hypertrophy.

关键词： decorin cardiac hypertrophy calcium/calmodulin-dependent protein kinaseⅡ myocyte enhancer factor 2 atrial natriuretic peptide

Hydrogen Peroxide in Plants:a Versatile Molecule of the Reactive Oxygen Species Network

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Journal of Integrative Plant Biology 2008年第1期50卷 2-18页

作者： Li-Juan Quan Bo Zhang wei-wei Shi Hong-yu Li MOE Key Laboratory of Arid and Grassland Ecology School of Life Sciences Lanzhou University Lanzhou 730000 China

Plants often face the challenge of severe environmental conditions, which include various biotic and abiotic stresses that exert adverse effects on plant growth and development. During evolution, plants have evolved complex regulatory mechanisms to adapt to various environmental stressors. One of the consequences of stress is an increase in the cellular concentration of reactive oxygen species （ROS）, which are subsequently converted to hydrogen peroxide （H2O2）. Even under normal conditions, higher plants produce ROS during metabolic processes. Excess concentrations of ROS result in oxidative damage to or the apoptotic death of cells. Development of an antioxidant defense system in plants protects them against oxidative stress damage. These ROS and, more particularly, H2O2, play versatile roles in normal plant physiological processes and in resistance to stresses. Recently, H2O2 has been regarded as a signaling molecule and regulator of the expression of some genes in cells. This review describes various aspects of H2O2 function, generation and scavenging, gene regulation and cross-links with other physiological molecules during plant growth, development and resistance responses.

关键词： antioxidant system gene regulation hydrogen peroxide (H2O2) reactive oxygen species (ROS) signaling molecule.

Contrary Regulation of TIMP-1 and MMP-9 by Hepatocyte Growth Factor Antibody after Lung Injury

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Chinese Medical Sciences Journal 2011年第4期26卷 216-220页

作者： wei-wei yu Qin Xia Institute of General Department Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective To study the influence of hepatocyte growth factor (HGF) antibody on the lung expression level of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Methods Thirty male Wistar rats were randomly divided into 3 groups: control group, model group, and intervention group. Endotoxin was intratracheally infused in the model and intervention groups. HGF antibody was injected in the rats of the intervention group from day 1 to day 14, while the same volume of saline was injected in the control group. The rats were sacrificed on day 28 after endotoxin treatment. The amounts of MMP-9 mRNA and TIMP-1 mRNA were measured by reverse transcription-polymerase chain reaction, and protein expression levels of MMP-9 and TIMP-1 were measured by immunohistochemistry. Results In the model group, both mRNA and protein expression levels of TIMP-1 were significantly increased, the same as MMP-9. In the intervention group, the increase of TIMP-1 was remarkably reduced compared with the model group, while the mRNA and protein expression levels of MMP-9 were still increased. Conclusion HGF activity may accelerate the repair of lung injury through contrary regulating the expression levels of TIMP-1 and MMP-9.

关键词： hepatocyte growth factor matrix metalloproteinases-9 tissue inhibitor of metalloproteinases- 1

HeTDSE:A GPU based program to solve the full-dimensional time-dependent Schr?dinger equation for two-electron helium subjected to strong laser fields

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Chinese Physics B 2021年第7期30卷 216-225页

作者： Xi Zhao Gangtai Zhang Tingting Bai Jun Wang wei-wei yu School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710062China College of Physics and Optoelectronics Technology Baoji University of Arts and SciencesBaoji 721016China College of Mathematics and Information Science Baoji University of Arts and SciencesBaoji 721013China Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Department of Physics Kansas State UniversityManhattanKS 66506USA School of Physics and Electronics Qiannan Normal College for NationalitiesDuyun 558000China School of Physics and Electronic Technology Liaoning Normal UniversityDalian 116029China

Electron–electron correlation plays an important role in the underlying dynamics in physics and *** is the simplest and most fundamental two-electron *** dynamic process of helium in a strong laser field is still a challenging issue because of the large calculation *** this study,a graphic processing unit(GPU)open ACC based ab initio numerical simulations package He TDSE is developed to solve the full-dimensional time-dependent Schrodinger equation of helium subjected to a strong laser *** TDSE uses B-spline basis sets expansion method to construct the radial part of the wavefunction,and the spherical harmonic functions is used to express for the angular *** algorithm is employed for the time *** example shows that He TDSE running on an NVIDIA Kepler K20 GPU can outperform the one on an Intel E5-2640 single CPU core by a factor of *** TDSE code package can be obtained from the author or from the author's personal website(doi:10.13140/RG.2.2.15334.45128)directly under the GPL license,so He TDSE can be downloaded,used and modified freely.

关键词： strong field physics TDSE OPENACC GPU electron correlation helium