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Attenuation of rock blasting induced ground vibration in rock-soil interface

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 770-778页

作者： Bhagya Jayasinghe Zhiye Zhao Anthony goh Teck Chee Hongyuan Zhou Yilin Gui School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijingChina School of Civil Engineering and Geosciences Newcastle UniversityNewcastle upon TyneUK

Blasting has been widely used in mining and construction industries for rock *** paper presents the results of a series of field tests conducted to investigate the ground wave propagation through mixed geological *** tests were conducted at a site in the northwestern part of Singapore composed of residual soil and granitic *** field test aims to provide measurement data to better understand the stress wave propagation in soil/rock and along their *** accelerometers were used for the free field vibration *** measured results are presented and discussed,and empirical formulae for predicting peak particle velocity (PPV) attenuation along the ground surface and in soil/rock were derived from the measured ***,the ground vibration attenuation across the soil-rock interface was carefully examined,and it was found that the PPV of ground vibration was decreased by 37.2% when it travels from rock to soil in the vertical direction.

关键词： Rock blasting Field tests Blast wave propagation Peak particle velocity (PPV) Rock-soil interface

Estimation of diaphragm wall deflections for deep braced excavation in anisotropic clays using ensemble learning

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Geoscience Frontiers 2021年第1期12卷 365-373页

作者： Runhong Zhang Chongzhi Wu Anthony T.C.goh Thomas Bohlke Wengang Zhang School of Civil Engineering Chongqing UniversityChongqing400045China School of Civil and Environmental Engineering Nanyang Technological University639798Singapore Institute of Engineering Mechanics Karlsruhe Institute of Technology(KIT)Kaiserstraße 1076131KarlsruheGermany Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing400045China

This paper adopts the NGI-ADP soil model to carry out finite element analysis,based on which the effects of soft clay anisotropy on the diaphragm wall deflections in the braced excavation were *** than one thousand finite element cases were numerically analyzed,followed by extensive parametric *** models were developed via ensemble learning methods(ELMs),including the e Xtreme Gradient Boosting(XGBoost),and Random Forest Regression(RFR)to predict the maximum lateral wall deformation(δhmax).Then the results of ELMs were compared with conventional soft computing methods such as Decision Tree Regression(DTR),Multilayer Perceptron Regression(MLPR),and Multivariate Adaptive Regression Splines(MARS).This study presents a cutting-edge application of ensemble learning in geotechnical engineering and a reasonable methodology that allows engineers to determine the wall deflection in a fast,alternative way.

关键词： Anisotropic clay NGI-ADP Wall deflection Ensemble learning eXtreme gradient boosting Random forest regression

Management of recurrent hepatocellular carcinoma after resection

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 780-783页

作者： Hwee Leong Tan Brian K.P.goh Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingaporeSingapore Duke-NUS Medical School Singapore SingaporeSingapore

Introduction Hepatocellular carcinoma(HCC)is currently the fifth most common cancer globally,accounting for the third highest cancer-related deaths(1).Liver resection is the treatment modality of choice for resectable HCCs with adequate liver function in the absence of portal hypertension(1),but actuarial recurrence rates remain as high as 70%at 5 years post-resection(2).The recurrence of HCC post-resection portends poorer prognosis,with a 24%reduction in 5-year survival(2).While there have been a multitude of guidelines for the management of primary HCC across the world(3),the international expert consensus recently published by Wen et *** the first systematic,evidence-based consensus guidelines for the management of recurrent HCC(RHCC)following liver resection(4).

关键词： resection Liver globally

Understanding of chemoprophylaxis and concordance in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第5期16卷 578-582页

作者： Adam Low Melanie Love Robert Walt Katherine Kane Bertus Eksteen Jason goh Department of Gastroenterology Queen Elizabeth Hospital University Hospital Birmingham NHS Foundation Trust Edgbaston Birmingham B15 6HT United Kingdom Department of Liver Medicine Queen Elizabeth Hospital University Hospital Birmingham NHS Foundation Trust Edgbaston Birmingham B15 6HT United Kingdom

AIM:To assess patients' understanding for the reasons for taking 5-aminosalicylic acid or ursodeoxycholic acid as chemoprophylaxis against colorectal carcinoma associated with in? ammatory bowel disease (IBD). METHODS: A questionnaire-based study using a 5 point opinion scale was performed. One hundred and ninety-two patients with colitis only and 74 patients with primary sclerosing cholangitis and IBD were invited to take part. RESULTS: Overall response rate was 58%. Sixtyfour percent of patients claimed full concordance with chemoprophylaxis for maintenance of remission. Eightyfour percent of patients considered daily concordance during remission to be very important. Seventy-five percent stated they understood the reasons for taking the drugs. However, only 50% of the patients were aware of any link of their condition to bowel cancer. Seventy-nine percent of patients felt their concordance and understanding would be improved if they were informed of the chemoprophylactic potential of the medication.

关键词： Inflammatory bowel disease Primary sclerosing cholangitis Colorectal cancer 5-aminosalicylic acid Concordance

A phosphotungstic acid coupled silica-Nafion composite membrane with significantly enhanced ion selectivity for vanadium redox flow battery

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Journal of Energy Chemistry 2020年第2期29卷 177-184页

作者： Xiao-Bing Yang Lei Zhao Kokswee goh Xu-Lei Sui Ling-Hui Meng Zhen-Bo Wang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina

An ultra-high ion-selective Nafion composite membrane modified by phosphotungstic acid(PWA)coupled silica for vanadium redox flow battery(VRB)was constructed and prepared through solution *** composite membrane exhibits excellent proton conductivity and vanadium ions blocking property by incorporating the nanohybrid composed of silica and PWA into the Nafion *** tuning for the filling amount of the nanohybrid endows the obtained membranes preeminent vanadium barrier property including a minimum vanadium permeability of 3.13×10-7cm2min-1and a maximum proton conductivity of 0.081 S cm-1at 25°*** indicate an ion selectivity of 2.59×105S min cm-3,which is 6.8times higher than that of recast Nafion(0.33×105S min cm-3).As a result,the VRB with the composite membrane shows superior battery performance containing a lower self-discharge rate,higher capacity retention and more robust cyclic stability compared with recast Nafion over a range of current densities from 40 to 100 m A cm-2.

关键词： Vanadium redox flow battery Modified silica Phosphotungstic acid Low vanadium permeability

Metabolic disturbances associated with antipsychotic drug treatment in patients with schizophrenia:State-of-the-art and future perspectives

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World Journal of Psychiatry 2021年第10期11卷 696-710页

作者： Shen-Chieh Chang Kah Kheng goh Mong-Liang Lu Department of Psychiatry Wan Fang HospitalTaipei Medical UniversityTaipei 116Taiwan Department of Psychiatry School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 116Taiwan

Metabolic disturbances and obesity are major cardiovascular risk factors in patients with schizophrenia,resulting in a higher mortality rate and shorter life expectancy compared with those in the general *** schizophrenia and metabolic disturbances may share certain genetic or pathobiological risks,antipsychotics,particularly those of second generation,may further increase the risk of weight gain and metabolic disturbances in patients with *** review included articles on weight gain and metabolic disturbances related to antipsychotics and their mechanisms,monitoring guidelines,and *** all antipsychotics are associated with weight gain,but the degree of the weight gain varies *** certain neurotransmitter receptorbinding affinities and hormones are correlated with weight gain and specific metabolic abnormalities,the precise mechanisms underlying antipsychoticinduced weight gain and metabolic disturbances remain *** evidence indicates the role of genetic polymorphisms associated with antipsychotic-induced weight gain and antipsychotic-induced metabolic *** many guidelines for screening and monitoring antipsychotic-induced metabolic disturbances have been developed,they are not routinely implemented in clinical *** studies have also investigated strategies for managing antipsychotic-induced metabolic ***,patients and their caregivers must be educated and motivated to pursue a healthier life through smoking cessation and dietary and physical activity *** lifestyle intervention fails,switching to another antipsychotic drug with a lower metabolic risk or adding adjunctive medication to mitigate weight gain should be *** medications are essential for schizophrenia treatment,hence clinicians should monitor and manage the resulting weight gain and metabolic disturbances.

关键词： Antipsychotics Metabolic disturbances weight gain Schizophrenia Monitor Intervention

Bolstering functionality in multilayer and bilayer WS2 via focused laser micro-engraving

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Science China(Information Sciences) 2023年第6期66卷 94-101页

作者： Si Min CHAN Eng Tuan POH Jin Feng LEONG Kuan Eng Johnson goh Chorng Haur SOW Department of Physics National University of Singapore Institute of Materials Research and Engineering Agency for ScienceTechnology and Research (A~*STAR) Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University

Laser thinning of multilayer transition metal dichalcogenide(TMD)crystals has long been explored for its potential to produce localized domains of optically functional monolayers. Despite the high spatial control and resolution of the laser, the range of appropriate applications for these laser-thinned domains is still limited by the peripheral regions of unaltered thick multilayers. Herein, we report a newfound property of the laser-thinned regions to adhere strongly to the underlying substrate when lasered down to the monolayer limit. Upon a brief sonication in various solvents, the surrounding pristine multilayers can be lifted off, solely leaving behind the post-lasered monolayer patterns. Coupled with the flexible maneuver of the laser, various monolayer designs can be achieved, including micro-antenna, waveguide, and electrode geometries with lateral line widths at 1.5 μm resolution. Furthermore, we also detail the optical properties of the monolayers obtained from laser thinning, with those acquired from multilayers containing more defectbound excitons, whereas those lasered from bilayers presenting a trion-dominated profile similar to as-grown monolayers. Together, these findings allow for faster and more efficient multilayer removal and areal shaping of optically active monolayer domains, in comparison to multistep and complex standard lithographic etching(lithography–etch–develop)procedures.

关键词： WS$_2$ monolayer micro-patterning focused laser sonication lift-off

Assessment of basal heave stability for braced excavations in anisotropic clay using extreme gradient boosting and random forest regression

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Underground Space 2022年第2期7卷 233-241页

作者： Wengang Zhang Runhong Zhang Chongzhi Wu Anthony T.C.goh Lin Wang School of Civil Engineering Chongqing UniversityChongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing 400045China School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore

A finite-element analysis considering the anisotropy for the undrained shear strength was performed to examine the effects of the total stress-based anisotropic model NGI-ADP(developed by Norwegian Geotechnical Institute based on the Active-Direct simple shear-Passive concept)parameters on the base stability of deep braced excavations in *** parameters included the ratio of the plane strain passive shear strength to the plane strain active shear strength s_(u)^(P)=s_(u)^(A),the ratio of the unloading/reloading shear modulus to the plane strain active shear strength G_(ur)=s_(u)^(A),the plane strain active shear strength s_(u)^(A),the unit weight c,the excavation width B,the wall thickness b,and the wall penetration depth *** to the numerical results for 1778 hypothetical cases,extreme gradient boosting(XGBoost)and random forest regression(RFR)were adopted to predict the factor of safety(FS)against basal heave for deep braced *** results indicated that the anisotropic characteristics of soil parameters need to be considered when determining the FS against basal heave for braced *** and RFR can yield a reasonable prediction of the *** paper presents a cuttingedge application of ensemble learning methods in geotechnical engineering.

关键词： Anisotropy NGI-ADP Basal heave Braced excavation Ensemble learning

Studying neurological disorders using induced pluripotent stem cells and optogenetics

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Neural Regeneration Research 2015年第11期10卷 1720-1722页

作者： Eunice W.M.Chin Eyleen L.K.goh Program in Neuroscience and Behavioral Disorders Duke-NUS Graduate Medical School Singapore NUS Graduate School for Integrative Singapore Sciences and Engineering National University of Singapore Department of Physiology Yong Loo Lin School of Medicine National University of Singapore KK Research Center KK Women’s and Children’s HospitalSingapore

Neurological disorders are amongst the most widely studied human ***,they are also one of the most poorly *** most of these disorders are polygenic,genotype still plays an important role in their *** example,in schizophrenia and autism spectrum disorders,there is a 40-60%concordance rate in monozygotic twins,with 60-90%heritability（Burmeister et al.,2008）.However,the mechanisms by which multiple genes and their genomic variations influence the phenotypes of the disorders remain to be understood. The complexities of the disorders are tur- ther compounded by the individual rarity of the genomic variations and their variable penetrance （Cook and Scherer, 2008）. Thus, conventional disease modeling, such as gene knockout in cells or in animals, to attain the desired disease genotype may not be the most suitable platform for tackling most neurological disorders.

关键词： PSCs cell stem Studying neurological disorders using induced pluripotent stem cells and optogenetics