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Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease:The Gut and Obesity Asia initiative

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World Journal of Gastroenterology 2020年第19期26卷 2416-2426页

作者： Panyavee Pitisuttithum Wah-Kheong Chan George Boon-Bee goh Jian-Gao Fan Myeong Jun Song Phunchai Charatcharoenwitthaya Ajay Duseja Yock-Young Dan Kento Imajo Atsushi Nakajima Khek-Yu Ho Khean-Lee goh Vincent Wai-Sun Wong Sombat Treeprasertsuk Department of Medicine Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Department of Medicine University of MalayaKuala Lumpur 50603Malaysia Department of Gastroenterology&Hepatology Singapore General HospitalSingapore 169608Singapore Department of Gastroenterology Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Internal Medicine The Catholic University of KoreaDaejeon 301-723South Korea Division of Gastroenterology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Department of Hepatology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Medicine National University of Singapore 119228Singapore Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China

BACKGROUND Gamma-glutamyl transferase(GGT)is associated with the risk of cardiovascular disease(CVD)in the general *** To identify the association of baseline GGT level and QRISK2 score among patients with biopsy-proven nonalcoholic fatty liver disease(NAFLD).METHODS This was a retrospective study involving 1535 biopsy-proven NAFLD patients from 10 Asian centers in 8 countries using data collected by the Gut and Obesity in Asia(referred to as“GO ASIA”)*** patients with available baseline GGT levels and all 16 variables for the QRISK2 calculation(QRISK2-2017;developed by researchers at the United Kingdom National Health Service;https://***/2017/;10-year cardiovascular risk estimation)were included and compared to healthy controls with the same age,sex,and *** risk was ***2 score>10%was defined as the high-CVD-risk *** stages 3 and 4(F3 and F4)were considered advanced *** A total of 1122 patients(73%)had complete data and were included in the final analysis;314(28%)had advanced *** median age(interquartile range[IQR])of the study population was 53(44-60)years,532(47.4%)were females,and 492(43.9%)were of Chinese *** median 10-year CVD risk(IQR)was 5.9%(2.6-10.9),and the median relative risk of CVD over 10 years(IQR)was 1.65(1.13-2.2)compared to healthy individuals with the same age,sex,and *** high-CVD-risk group was significantly older than the low-risk group(median[IQR]:63[59-67]vs 49[41-55]years;P<0.001).Higher fibrosis stages in biopsy-proven NAFLD patients brought a significantly higher CVD risk(P<0.001).Median GGT level was not different between the two groups(GGT[U/L]:Median[IQR],high risk 60[37-113]vs low risk 66[38-103],P=0.56).There was no correlation between baseline GGT level and 10-year CVD risk based on the QRISK2 score(r=0.02).CONCLUSION The CVD risk of NAFLD patients is higher than that of healthy *** GGT level cannot predict CVD ri

关键词： Nonalcoholic fatty liver disease Gamma glutamyl transferase QRISK Cardiovascular risk Gut and Obesity in Asia

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Elucidation of thermally induced internal porosity in zinc oxide nanorods

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Nano Research 2018年第5期11卷 2412-2423页

作者： Albertus D. Handoko Laura-Lynn Liew Ming Lin Gopinathan Sankar Yonghua Du Haibin Su Zhili Dong Gregory K. L. goh Institute of Materials Research and Engineering Agency for Science Technology and Research (A＊STAR) Singapore 138634 Singapore School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Chemistry University College London London WC1H0AJ UK Institute of Chemical and Engineering Sciences Agency for Science Technology and Research (A＊STAR) Singapore 627833 Singapore

In situ electron microscopy, tomography, photoluminescence, and X-ray absorption spectroscopy were utilized to monitor and explain the formation and growth of internal pores within ZnO nanorods. Careful examination using electron microscopy and tomography indicate that nanosized intemal pores start appearing within the individual solution-grown ZnO nanorods upon exposure to 200 ℃. The pore volume growth rate is proportional to the heat treatment time, indicating that the process is diffusion controlled, akin to a reverse Ostwald ripening-like process. A manageable pore growth rate of 1.4-4.4 nm^3·min^-1 was observed at 540 ℃, suggesting that the effective control over internal porosity can be achieved by carefully controlling the heat-treatment profile. Mechanistic studies using X-ray absorption spectroscopy indicated that the pore formation is linked to the significant reduction of the number of zinc vacancies after heat treatment. An optimum condition exists where most of the native surface defects are removed, while the bulk defects are contained within the internal pores. It is also demonstrated that the internal porosity can be exploited to improve the visible light absorption of ZnO. A combination of the lower defect density and improved light absorption of the heat-treated ZnO films thus lead to an increase in the photo- electrochemical response of more than 20× compared to that of the as-grown ZnO.

关键词： zinc oxide solution growth hydrothermal porosity photocatalysis photocurrent

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A Toddler with Rhabdomyosarcoma Presenting as Acute Otitis Media with Mastoid Abscess

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Chinese Medical Journal 2016年第10期129卷 1249-1250页

作者： Sze Yin Ng Bee See goh Department of Otorhinolaryngology Penang General Hospital 10450 Georgetown Pulau Pinang Malaysia Department of Otorhinolaryngology Head and Neck Surgery Universiti Kebangsaan Malaysia Medical Centre 56000 Cheras Kuala Lumpur Malaysia Institute of Ear Hearing and Speech (Institute-HEARS) Universiti Kebangsaan Malaysia Jalan Temerloh 56000 Cheras Kuala Lumpur Malaysia

Rhabdomyosarcoma （RMS） is a malignant tumor which involves the striated muscle, and it is most common in the pediatric age group. Usually, children with RMS present with persistent ear discharge, aural polyp and hearing loss which are similar to the symptoms seen in chronic otitis media （COM）. This similarity with COM often delays the diagnosis. The histological diagnosis of RMS is always a challenge because there are many other conditions which exhibit similar characteristic features such as an aural polyp. We discussed an unusual case of RMS in a 1 5-month-old girl who presented with acute otitis media （AOM） and mastoid abscess. The biopsy of the aural polyp confirmed the diagnosis.

关键词： Mastoid Abscess Otitis Media Polyps Rhabdomyosarcoma

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Additive manufacturing of composite materials and functionally graded structures using selective heat melting technique

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Journal of Materials Science & Technology 2020年第12期47卷 243-252页

作者： Kalaimani Markandan Ruijing Lim Pawan Kumar Kanaujia Ian Seetoh Muhammad Raziq bin Mohd Rosdi Zhi Huey Tey Jun Seng goh Yee Cheong Lam Changquan Lai Temasek Laboratories Nanyang Technological University50 Nanyang Drive637553Singapore School of Physical&Mathematical Sciences Nanyang Technological University21 Nanyang Link637371Singapore School of Mechanical&Aerospace Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore School of Materials Science&Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore

The feasibility of using selective heat melting(SHM) to fabricate composite materials and functionally graded structures was *** report,for the first time,the successful 3 D printing of copper(Cu)-polyethylene(PE) composite,iron(Fe)-polyethylene(PE) composite and functionally graded CuO foams using the SHM *** was found that a low feed rate,high airflow rate and high airflow temperature were required for efficient delivery of heat from the emitted hot air to the powder bed,so that the PE binder particles can melt and form dense composites with smooth *** best mechanical properties were exhibited by composites with 80 vol.% PE,as lower PE concentrations led to deficient binding of the metal particles,while higher PE concentrations meant that very few metal particles were available to strengthen the *** strength exhibited by Cu-PE composites was comparable to engineering plastics such as polycarbonate,with the added advantage of being electrically *** average conductivity of the samples,0.152±0.28 S/m,was on par with physically crosslinked graphene *** subjecting a Cu-PE composite,with Cu concentration graded from 10 vol.% to 30 vol.%,to a high temperature debinding and sintering treatment in air,CuO foam with graded porosity can be *** CuO foam was observed to fail in a layer-by-layer manner under mechanical compression,which is a characteristic of functionally graded *** study shows that,compared to existing 3 D printing techniques,SHM can be cheaper,have wider material compatibility,occupy a smaller footprint and potentially induce less residual stresses in the fabricated ***,it could be a valuable complement to current additive manufacturing techniques for fabricating mechanically strong composite materials and functionally graded structures.

关键词： Selective heat melting Functionally graded materials Additive manufacturing Multimaterial

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Intercalation-pseudocapacitance hybrid anode for high rate and energy lithium-ion capacitors

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Journal of Energy Chemistry 2021年第4期30卷 459-467页

作者： Chang Liu Ali Khosrozadeh Qing-Qing Ren Ling-Hui Yan Kokswee goh Shi-Han Li Jian Liu Lei Zhao Da-Ming Gu Zhen-Bo Wang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Lab of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina School of Engineering Faculty of Applied ScienceUniversity of British ColumbiaKelowna V1V 1V7BCCanada

Existing rechargeable batteries not only fail to meet the demand for high power applications but also cause heavy metal ***-ion capacitors(LICs),which can achieve higher charging speeds and energy densities than supercapacitors,have attracted extensive ***,sluggish Li-ion diffusion of the battery-type anode results in limited rate performance of ***,highperformance LICs using both battery and capacitor type Mn_(2)V_(2)O_(7)-graphene(MVO-G)anodes and hempstem-derivated activated carbon(HSAC)cathodes with a large surface area are first *** addition to high pseudocapacitance,the MVO-G possesses the advantage of fast Li^(+)storage performance making it a suitable choice for advanced LIC *** is employed to enhance overall conductivity and cycling stability leading to enhanced energy *** MVO-G//HSAC LICs exhibit a high energy density of 148.1 Wh kg^(-1) at a power density of 150 W kg^(-1) and 25 Wh kg^(-1) even at15 k W kg^(-1).More importantly,the MVO-G//HSAC LICs also show excellent cycling stability of 90%after15,000 cycles,which is expected for high performance energy storage systems.

关键词： Manganese vanadate Graphene Pseudocapacity Hempstem-based activated carbons Lithium ion capacitor

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Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

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分子细胞生物学报:英文版 2015年第2期7卷 119-131页

作者： Jason Howitt Ley-Hian Low Ulrich Putz Anh Doan Jenny Lackovic Choo-Peng goh Jenny Gunnersen John Silke Seong-Seng Tan Brain Development and Regeneration Division Florey Institute of Neuroscience and Mental HealthThe University of MelbourneParkvilleVictoria 3010Australia Department of Anatomy and Neuroscience The University of MelbourneParkvilleVictoria 3010Australia Cell Signalling and Cell Death Laboratory Walter and Eliza Hall InstituteThe University of MelbourneParkvilleVictoria 3010Australia

Pten controls a signaling axis that is implicated to regulate cell proliferation,growth,survival,migration,and *** molecular mechanisms underlying the specificity of Pten responses to such diverse cellular functions are currently poorly *** report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial *** deletion of Ndfip1 resulted in a loss of Pten nuclear compartmentalization and increased cell proliferation,despite cytoplasmic Pten remaining active in regulating PI3K/Akt *** lacking nuclear Pten were found to have dysregulated levels of Plk1 and cyclin D1 that could drive cell *** vivo,transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors,resulting in *** results show that local partitioning of Pten from the cytoplasm to the nucleus represents a key mechanism contributing to the specificity of Pten signaling during cell proliferation.

关键词： Akt autism cancer cell cycle microcephaly nuclear trafficking ubiquitin

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Clinical Assessment of a Pharmaceutical Polyphenol Fruit Extract Gel to Inhibit Dental Plaque

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Pharmacology & Pharmacy 2021年第9期12卷 177-189页

作者： Steven P. goh David M. goh E. Russell Vickers Suite 1 76A Archer St Chatswood NSW 2067 Australia Clinical Stem Cells Sydney Australia

Oral bacteria (e.g. Porphyromonas gingivalis) are associated and potentially co-causative in several medical conditions including Alzheimer’s disease and increased cardiovascular risk. Naturally occurring polyphenols are a developing class of antimicrobial pharmaceutical agents. The use of plant-based polyphenol compounds is an attractive area of medical and dental research due to their high safety factor from their presence in vegetables and fruits. This preliminary study evaluated polyphenols found in berries to reduce bacterial dental plaque accumulation. The study was an in vivo single blind randomized controlled trial of seven subjects with a novel tooth gel using validated measurements. Results showed a significant reduction in plaque accumulation (p = 0.005) and a non-significant trend to reduce gingivitis (p = 0.08). The bioactive gel showed no local or systemic adverse effects and was well tolerated by subjects.

关键词： Dental Plaque Gingivitis Polyphenol Quercetin Randomized Controlled Trial

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Recent advances in high-loading catalysts for low-temperature fuel cells: From nanoparticle to single atom

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SusMat 2021年第4期1卷 569-592页

作者： Lixiao Shen Miao Ma Fengdi Tu Zigang Zhao Yunfei Xia Kokswee goh Lei Zhao Zhenbo Wang Guangjie Shao College of Environment and Chemical Engineering State Key Laboratory of Metastable Materials Science and TechnologyHebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseYanshan UniversityQinhuangdaoP.R.China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Lab of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinP.R.China

Low-temperature fuel cells(LTFCs)are considered to be one of the most promising power sources for widespread application in sustainable and renew-able energy conversion *** remarkable advances have been made in the mass activity of catalysts,mass transport impedance needs to be urgently addressed at a well-designed membrane electrode assembly(MEA)*** the loading of electrocatalysts is conducive to prepare thinner and more efficient MEAs owing to the resulting enhanced reactant permeability,better proton diffusion,and lower electrical ***,recent progress in high-loading(≥40 wt.%)Pt nanoparticle catalysts(NPCs)and high-loading(≥2 wt.%)single-atom catalysts(SACs)for LTFC applications are reviewed.A summary of various synthetic approaches and support materials for high-loading Pt NPCs and SACs is systematically *** influences of high surface area and appropriate surface functionalization for Pt NPCs,as well as coordina-tion environment,spatial confinement effect,and strong metal-support interac-tions(SMSI)for SACs are ***,this review presents some ideas regarding challenges and future opportunities of high-loading catalysts in the application of LTFCs.

关键词： high-loading catalysts low-temperature fuel cells membrane electrode assembly nanoparticle catalysts single-atom catalysts

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Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria

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World Journal of Gastroenterology 2013年第1期19卷 97-102页

作者： goh Eun Chung Nam Ju Heo Min Jung Park Su Jin Chung Hae Yeon Kang Seung Joo Kang Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM:To investigate the relationship between Helicobacter pylori(***) seropositivity and the presence of ***:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System Gangnam Center for a routine check-up and underwent tests for *** immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were *** study subjects completed a structured questionnaire,anthropometric measurements and laboratory *** immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the *** presence of microalbuminuria was defined as a UACR from 30 to 300 μg/*** presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic *** logistic regression analysis was performed to identify the risk *** dependent variable was microalbuminuria,and the independent variables were the other study ***:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were *** them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with *** with microalbuminuria had a significantly higher *** seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that *** seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL < glucose < 126 mg/dL,and ≥ 126 mg/dL or history of DM),*** seropositivity was found to be significantly associated with microalbuminuria in diabetic subjects after adjust

关键词： Helicobacter pylori Seropositivity Microalbuminuria Atherosclerosis Diabetes

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Recent advances in non-toxic quantum dots and their biomedical applications

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Progress in Natural Science:Materials International 2019年第6期29卷 628-640页

作者： Chunyan Zhu Zhao Chen Shuai Gao Ban Leng goh Ismail Bin Samsudin Kai Wen Lwe Yunlong Wu Caisheng Wu Xiaodi Su Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical Sciences Xiamen University Department of Chemistry National University of Singapore Institute of Materials Research and Engineering Agency for Science Technology and Research

Quantum dots(QDs) with unique quantum confinement effect and electro-optical properties are attractive for biomedical applications. Toxic effects of traditional semiconductor QDs made of heavy metal ions have serious safety concerns for their undesired environmental or healthy impact. Recent reports on core-shell structure modification of QDs by using biocompatible ligands or polymers is one way to be effectively minimizing toxicity effects of traditional QDs. Furthermore, designs of heave metal-free and metal-free QDs formulations are more promising alternatives, due to the non-toxic and eco-friendly nature of the starting materials. In article, we will review the recent designs of non-toxic or less toxic QDs, including carbon-based, biomolecules-based, siliconbased, and ternary I-III-VI QDs, and their biological applications(bio-imaging, drug delivery, gene therapy and immunoassay).

关键词： Quantum dots Non-toxic Bio-imaging Core-shell Metal-free

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