检索结果-南通市图书馆

TMR Non-Drug Therapy 2020年第3期3卷 131-136页

作者： Wa Cai wei-ting huang wei-Dong Shen Department of Acupuncture Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Acupuncture&Anesthesia Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:Transcutaneous acupoint electrical stimulation(TAES)treatment is effective for post-operative *** investigation was designed to study the feasibility and effectiveness of TAES treatment for pre-operative ***:62 volunteered surgical patients were included in the pilot *** all received TAES treatment for 30 minutes in the evening of the day before ***(LI4)and Neiguan(PC6)of both sides were selected as the treatment *** anxiety degrees were measured by State-Trait Anxiety *** rate and blood pressure were also ***:After TAES,pre-operative anxiety measured by State-Trait Anxiety Inventory dropped by almost 12%,and both heart rate and systolic blood pressure decreased ***:The pilot investigation of TAES for pre-operative anxiety can successfully test the feasibility of outcome measurements and provide necessary data for calculating the sample size of a subsequent randomized controlled trial.

关键词： Transcutaneous acupoint electrical stimulation State-Trait Anxiety Inventory Pre-operative anxiety Pilot investigation

Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第13期21卷 3960-3969页

作者： Chih-Chi Kuo Yu-Lueng Shih Her-Young Su Ming-De Yan Chung-Bao Hsieh Chin-Yu Liu wei-ting huang Mu-Hsien Yu Ya-Wen Lin Graduate Institute of Medical Sciences National Defense Medical Center Division of Gastroenterology Department of Internal MedicineTri-Service General HospitalNational Defense Medical Center Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical Center Cancer Center Wan Fang HospitalTaipei Medical University Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical Center Department of Nutritional Science Fu Jen Catholic University Department and Graduate Institute of Microbiology and Immunology Graduate Institute of Medical SciencesNational Defense Medical Center Graduate Institute of Life Sciences National Defense Medical Center

AIM: To examine the methylation levels of interleukin-1 receptor-associated kinase 3(IRAK3) and GLOXD1 and their potential clinical applications in hepatocellular carcinoma(HCC).METHODS: m RNA expression and promoter methylation of IRAK3 and GLOXD1 in HCC cells were analyzed by reverse transcription-polymerase chain reaction(RTPCR) and methylation-specific PCR(MSP), respectively. Using pyrosequencing results, we further established a quantitative MSP(Q-MSP) system for the evaluation of IRAK3 and GLOXD1 methylation in 29 normal controls and 160 paired HCC tissues and their adjacent nontumor tissues. We also calculated Kaplan-Meier survival curves to determine the applications of gene methylation in the prognosis of ***: IRAK3 and GLOXD1 expression was partially restored in several HCC cell lines after treatment with 5-aza-2′-deoxycytidine(DNA methyltransferase inhibitor; 5DAC). A partial decrease in the methylated band was also observed in the HCC cell lines after 5DAC treatment. Using GLOXD1 as an example, we found a significant correlation between the data obtained from the methylation array and from pyrosequencing. The methylation frequency of IRAK3 and GLOXD1 in HCC tissues was 46.9% and 63.8%, respectively. Methylation of IRAK3 was statistically associated with tumor stage. Moreover, HCC patients with IRAK3 methylation had a trend toward poor 3-year disease-free survival(P < 0.05). CONCLUSION: IRAK3 and GLOXD1 were frequently methylated in HCC tissues compared to normal controls and nontumor tissues. IRAK3 methylation was associated with tumor stage and poor prognosis of patients. These data suggest that IRAK3 methylation is a novel prognostic marker in HCC.

关键词： IRAK3 GLOXD1 Hepatocellular carcinoma DNA methylat

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei huang Jiayi Wen Xin Xiong ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

维普期刊数据库

基于ORB-SLAM的室内机器人定位和三维稠密地图构建

在线全文

学校读者我要写书评

暂无评论

计算机应用 2017年第5期37卷 1439-1444页

作者：侯荣波魏武黄婷邓超锋华南理工大学自动化科学与工程学院广州510640

针对在室内机器人定位和三维稠密地图构建系统中,现有方法无法同时满足高精度定位、大范围和快速性要求的问题,应用具有跟踪、地图构建和重定位三平行线程的ORB-SLAM算法估计机器人三维位姿;然后拼接深度摄像头KINECT获得的三维稠密点云... 详细信息

针对在室内机器人定位和三维稠密地图构建系统中,现有方法无法同时满足高精度定位、大范围和快速性要求的问题,应用具有跟踪、地图构建和重定位三平行线程的ORB-SLAM算法估计机器人三维位姿;然后拼接深度摄像头KINECT获得的三维稠密点云,提出空间域上的关键帧提取方法剔除冗余的视频帧;接着提出子地图法进一步减少地图构建的时间,最终提高算法的整体速度。实验结果表明,所提系统能够在大范围环境中准确定位机器人位置,在运动轨迹为50 m的大范围中,机器人的均方根误差为1.04 m,即误差为2%,同时整体速度为11帧/秒,其中定位速度达到17帧/秒,可以满足室内机器人定位和三维稠密地图构建的精度、大范围和快速性的要求。

关键词：同时定位和地图构建室内机器人 ORB-SLAM 关键帧提取 KINECT 图优化

维普期刊数据库

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing Shi Yu Song Xue-Xue Liang ting Chen huang-Yu Hao Xue Han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(Pting was lower in observed group(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

苏丹红Ⅰ、Ⅱ标准物质纯度的核磁共振法测定

分析测试学报 2010年第2期29卷 194-198页

作者：张伟黄挺徐蓓全灿中国计量科学研究院化学计量与分析科学研究所北京100013

采用核磁共振氢谱法(1H NMR)测定了苏丹红Ⅰ及苏丹红Ⅱ标准物质的纯度。分别以国家一级标准物质苯甲酸(GBW 13233)和国家二级标准物质尼泊金乙酯(GBW(E)100064)为内标,以氘代氯仿为溶剂,使用B ruker AVANCE DRX-500 NMR仪进行检测。实... 详细信息

采用核磁共振氢谱法(1H NMR)测定了苏丹红Ⅰ及苏丹红Ⅱ标准物质的纯度。分别以国家一级标准物质苯甲酸(GBW 13233)和国家二级标准物质尼泊金乙酯(GBW(E)100064)为内标,以氘代氯仿为溶剂,使用B ruker AVANCE DRX-500 NMR仪进行检测。实验优化了弛豫时间、扫描次数等定量参数,对定量峰的选择与积分进行了讨论。优化后的弛豫时间为30 s,扫描次数为32次;苏丹红Ⅰ、Ⅱ的纯度分别为96.1%、87.5%,其测量相对标准偏差分别为0.4%、0.6%。

关键词：核磁共振法苏丹红标准物质

维普期刊数据库

Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen Shan-Jin Lu Rui-Sui huang Qiong Chen Li-Feng huang Jian-Ning huang Xue wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai huang Yi Hu Xiao-Dong Zhou Cong He Jia-wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

Cauda equina syndrome with urinary retention as a postoperative complication of lumbar spine surgery:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第10期13卷 40-45页

作者： Kai-Wu Yang wei-Hong Lai Da-wei huang Department of Urology Chiayi Christian HospitalChiayi 600566Taiwan Department of Neurosurgery Chiayi Christian HospitalChiayi 600566Taiwan

BACKGROUND Cauda equina syndrome(CES)is characterized by a group of symptoms that may be caused by inflammation,spinal cord compression,venous congestion,or *** syndrome is commonly an indication for surgical intervention but has not been determined as a postoperative complication following surgery for lumbar spine *** SUMMARY To report the case of a 54-year-old male patient who had CES following spinal surgery,with no obvious compression lesions found during re-exploration,suggesting that vascular insufficiency may have contributed to the ***,a series of urodynamic studies on bladder recovery patterns in such complications have also been *** Postoperative CES requires urgent imaging and exploration to rule out compression;noncompressive cases,including vascular insufficiency may performed conservative management.

关键词： Cauda equina syndrome Lumbar spine surgery Urinary retention Urodynamic study Postoperative complication Case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金微素的化学Ⅱ.異金微素及其同型物

化学学报 1955年第2期 142-150页

作者：丁宏勋黄耀曾丁维钰黄敬坚中国科学院有机化学研究所

脫二甲胺金黴素(II),經稀鹼溶液處理,得到脫二甲胺異金黴素(V),它也可從異金黴素(IV)經鋅粉醋酸氫化製得,熱解後產生3-甲-4-氯-7-羥隣苯甲醇甲酸內酯(VII)。金黴素經稀鹼液處理變為異金黴素,呈多晶形,其鹽酸鹽亦有多晶現象。異金黴素經... 详细信息

脫二甲胺金黴素(II),經稀鹼溶液處理,得到脫二甲胺異金黴素(V),它也可從異金黴素(IV)經鋅粉醋酸氫化製得,熱解後產生3-甲-4-氯-7-羥隣苯甲醇甲酸內酯(VII)。金黴素經稀鹼液處理變為異金黴素,呈多晶形,其鹽酸鹽亦有多晶現象。異金黴素經鋅粉真空蒸餾或熱解皆得到隣苯甲醇甲酸內酯(VII)。脫二甲胺脫羥金黴素(III)經稀鹼液處理變為脫二甲胺脫羥異金黴素(VI),它經鋅粉真空蒸餾或熱解亦得到隣苯甲醇甲酸內酯(VII)。

关键词：二甲胺苯甲醇甲酸 II 苄醇局部麻醉药蚁酸饱和脂肪酸金徽紫外吸收光谱同型