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Journal of Electronic Science and Technology 2024年第2期22卷 16-23页

作者： Cheng-wei Zhang Zhi-qin Zhao wei Yang Li-Lai Zhou Hai-yu Zhu Southwest China Institute of Electronic Technology Chengdu610036China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Tencent Company Shenzhen518054China

Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is proposed.For the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing tasks.Finally,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing process.By using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as well.It is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.

关键词： Multi graphics processing unit Radar imaging Sea-ship Shooting and bouncing rays

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 458-474页

作者： wei Ding wei-wei Chen Yi-qin Wang Xue-Zhong Xu Yi-Bo Wang Yong-Min Yan yu-Lin Tan Department of General Surgery Wujin Hospital Affiliated with Jiangsu UniversityChangzhou 213003Jiangsu ProvinceChina Changzhou Medical Center Nanjing Medical UniversityChangzhou 213017Jiangsu ProvinceChina Department of General Surgery The Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213003Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal system.ZNF710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRNA)that is upregulated in GC cells.AIM To assess the correlation between ZNF710-AS1-201 and immune microenvir-onment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC cells.METHODS We obtained data from The Cancer Genome Atlas and Wujin Hospital.We assessed cell growth,migration,invasion,and programmed cell death using cell counting kit-8,EdU,scratch,Transwell,and flow cytometry assays.Quantitative real-time polymerase chain reaction(qRT-PCR)was used to identify the potential downstream targets of ZNF710-AS1-201.RESULTS In GC tissues with low ZNF710-AS1-201 expression,immunoassays detected significant infiltration of various antitumor immune cells,such as memory CD8 T cells and activated CD4 T cells.In the low-expression group,the half-maximal inhibitory concentrations(IC_(50)s)of 5-fluorouracil,cisplatin,gemcitabine,and trametinib were lower,whereas the IC_(50)s of dasatinib and vorinostat were higher.The malignant degree of GC was higher and the stage was later in the high-expression group.Additionally,patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival rates.In vitro,the overexpression of ZNF710-AS1-201 greatly enhanced growth,metastasis,and infiltration while suppressing cell death in HGC-27 cells.In contrast,the reduced expression of ZNF710-AS1-201 greatly hindered cell growth,enhanced apoptosis,and suppressed the metastasis and invasion of MKN-45 cells.The expression changes in ZNF710 were significant,but the corresponding changes in isocitrate dehydrogenase-2,Semaphorin 4B,ARHGAP10,RGMB,hsa-miR-93-5p,and ZNF710-AS1-202 were not consistent or statistically significant after overexpression or knockdown of ZNF710-AS1-201,as determined by qRT-PCR.CONCLUSION Immune-related lncRNA ZNF710-AS1-201 faci

关键词： Gastric cancer ZNF710-AS1-201 Proliferation Metastasis Invasion Apoptosis

Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases:A prospective,blind clinical study

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World Journal of Gastroenterology 2024年第9期30卷 1121-1131页

作者： Yan-Ling Yang Huang-Wen qin Zhao-yu Chen Hui-Ning Fan Yi yu wei Da Jin-Shui Zhu Jing Zhang Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Traditional esophagogastroduodenoscopy(EGD),an invasive examination method,can cause discomfort and pain in patients.In contrast,magnetically controlled capsule endoscopy(MCE),a noninvasive method,is being applied for the detection of stomach and small intestinal diseases,but its application in treating esophageal diseases is not widespread.AIM To evaluate the safety and efficacy of detachable string MCE(ds-MCE)for the diagnosis of esophageal diseases.METHODS Fifty patients who had been diagnosed with esophageal diseases were pros-pectively recruited for this clinical study and underwent ds-MCE and conven-tional EGD.The primary endpoints included the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for patients with esophageal diseases.The secondary endpoints consisted of visualizing the esophageal and dentate lines,as well as the subjects'tolerance of the procedure.RESULTS Using EGD as the gold standard,the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for esophageal disease detection were 85.71%,86.21%,81.82%,89.29%,and 86%,respectively.ds-MCE was more comfortable and convenient than EGD was,with 80%of patients feeling that ds-MCE examination was very comfortable or comfortable and 50%of patients believing that detachable string v examination was very convenient.CONCLUSION This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD,providing a novel noninvasive method for treating esophageal diseases.

关键词： Clinical trial Detachable string magnetically controlled capsule endoscopy Esophagogastroduodenoscopy Noninvasive diagnosis Esophageal diseases

Sperm acrosin activity may be a useful factor in choosing between ICSI and IVF for infertile male patients

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Asian Journal of Andrology 2024年第1期26卷 85-90页

作者： Ye-Na Hu Liang Hu Xin-yu Yin Huan Zhang Yang-qin Peng Gang Liu Ge Lin wei-Na Li The Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Department of Andrology Reproductive and Genetic Hospital of CITiC-XiangyaChangsha 410013China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410013China Hunan Guangxiu Hi-tech Life Technology Co. Ltd.Changsha 410013China

The clinical applications of acrosin activity are limited.We analyzed 61578 male partners in infertile couples who visited the outpatient department of the Reproductive and Genetic Hospital of CITIC-Xiangya(Changsha,China)between August 2014 and December 2019 to determine the reference ranges and thresholds for acrosin activity in infertile Chinese men;to determine whether correlations exist between acrosin activity and age,sperm concentration,sperm morphology,or sperm motility;and to evaluate whether acrosin activity could serve as an effective prognostic indicator for choosing between in vitro fertilization(IvF)and intracytoplasmic sperm injection(icsl)in the clinic.The cut-off value for the normal reference range of acrosin activity for male partners in infertile couples was 24.78μlU per 106 sperm.There was no significant association between acrosin activity and age,sperm concentration,semen volume,total sperm count,progressive motility,or total motile spermatozoa.A weak positive correlation was found between acrosin activity and normal sperm morphology.There was a statistically significant difference in abnormal acrosome morphology between the group with high acrosin activity(>24.78μlU per 106 sperm)and the group with low acrosin activity(<24.78μlU per 106 sperm).The group with a low IVF fertilization rate had a high index of abnormal acrosomal morphology at 21.2%,while the group with a high IVF fertilization rate had a low index of 0.2%.At an acrosin activity of<24.78μlU per 10 sperm,in one cycle of the same patient,the fertilization rate,normal fertilization rate,and good-quality embryo rate for Icsl were significantly higher than those for IVF.Therefore,the most promising application of acrosin activity could be in the selection of IcsI over IVF for infertile male patients with complete fertilization failure or a low fertilization rate.

关键词： acrosin activity fertilization rate ICSI IVF semen parameters

Application of CFD and FEA Coupling to Predict Structural Dynamic Responses of A Trimaran in Uni-and Bi-Directional Waves

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China Ocean Engineering 2024年第1期38卷 81-92页

作者： LIAO Xi-yu XIA Jin-song CHEN Zhan-yang TANG qin ZHAO Nan ZHAO wei-dong GUI Hong-bin Marine Design&Research Institute of China Shanghai 200011China Ship Structure Division China Ship Scientific Research CenterWuxi 214082China College of Ocean Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China School of Foreign Studies Jiangnan UniversityWuxi 214122China

To predict the wave loads of a flexible trimaran in different wave fields,a one-way interaction numerical simulation method is proposed by integrating the fluid solver(Star-CCM+)and structural solver(Abaqus).Differing from the existing coupled CFD-FEA method for monohull ships in head waves,the presented method equates the mass and stiffness of the whole ship to the hull shell so that any transverse and longitudinal section stress of the hull in oblique waves can be obtained.Firstly,verification study and sensitivity analysis are carried out by comparing the trimaran motions using different mesh sizes and time step schemes.Discussion on the wave elevation of uni-and bi-directional waves is also carried out.Then a comprehensive analysis on the structural responses of the trimaran in different uni-directional regular wave and bi-directional cross sea conditions is carried out,respectively.Finally,the differences in structural response characteristics of trimaran in different wave fields are studied.The results show that the present method can reduce the computational burden of the two-way fluid-structure interaction simulations.

关键词： CFD-FEA fluid-structure coupling structural responses trimaran bi-directional cross sea

Measurement of the high energyγ-rays from heavy ion reactions usingČerenkov detector

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Nuclear Science and Techniques 2024年第2期35卷 123-130页

作者： Da-wei Si Yan Zhou Sheng Xiao Zhi qin Dong Guo yu-Hao qin Yi-Jie Wang Bo-yuan Zhang Bai-Ting Tian Zhi-Gang Xiao Department of Physics Tsinghua UniversityBeijing 100084China

The energetic bremsstrahlung photons up to 100 MeV produced in heavy ion collisions can be used as a sensitive probe for short-range correlation in atomic nuclei. The energy of the γ-rays can be measured by collecting the Čerenkov light in the medium induced by the fast electrons generated in the Compton scattering or electromagnetic shower of the incident γray. Two types of detectors based on pure water and lead glass as sensitive materials were designed for this purpose. The γresponse and optical photon propagation in the detectors were simulated based on electromagnetic and optical processes in Geant4. The inherent energy resolutions of 0.022(4) + 0.51(2)∕E^(1/2)_(γ) for water and 0.0026(3) + 0.446(3)∕E^(1/2)_(γ) for lead glass were obtained. The geometry sizes of the lead glass and water were optimized to 30 cm × 30 cm × 30 cm and 60 cm × 60 cm ×120 cm, respectively, to detect high-energy γ-rays at 160 MeV. The Hough transform method was applied to reconstruct the direction of the incident γ-rays, providing the ability to experimentally distinguish the high-energy γ-rays produced in the reactions on the target from random background cosmic-ray muons.

关键词： Bremsstrahlungγ-rays Čerenkov Geant4 Energy resolution Direction reconstruction Hough transform

C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2069-2093页

作者： wei Zhou Xincong Jiang Chuan qin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai200240China Hikvision Research Institute Hangzhou Hikvision Digital Technology Co.Ltd.Hangzhou310051China

Edge devices,due to their limited computational and storage resources,often require the use of compilers for program optimization.Therefore,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge AI.One widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target program.However,this process consumes significant time and resources.To improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization techniques.Some researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test cases.Nevertheless,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related bugs.In this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source codes.This approach avoids being limited to specific compiler states and extends to a broader range of compiler bugs.Specifically,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a fuzzer.Using this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with bugs.Subsequently,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test case.This reduction in redundant testing cases leads to time savings.Comprehensive evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhances testing efficiency.Across four datasets,C-COR

关键词： Compiler testing test case prioritization code representation

Control of chiral-optical activities by magnetic field based on the transformation of achiral binary crystals into chiral ternary crystals

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Science China Chemistry 2024年第7期67卷 2300-2305页

作者： Zhiyan Chen Yan Lv wei qin College of Physics Qingdao UniversityQingdao 266071China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shandong Linuo Photovoltaic Hi-Tech Co. Ltd.Jinan 250100China

Multicomponent self-assembled chiral systems have attracted great attention due to their promising application in the area of spin-photonics and optoelectronics.In this work,through introducing an achiral third component into an achiral binary crystal,a chiral organic ternary crystal is fabricated,where both pronounced chiral-optical coupling and magnetic field dependence of chiral-optical activities are observed.The transformation of achiral structure into chiral structure generates a significant effect on the polarized state of light and the electron spin resonance signals.Moreover,the coupling between circularly polarized photon and spin is observed in chiral ternary crystal with pronounced chiral orbit,where obvious magnetic field-transmissivity loop is generated.Furthermore,temperature could increase the magnitude of lattice parameters to lead to a larger helix radius to increase the chiral orbit effect.Overall,this work indicates that the further exploration of photon-chiral orbit-spin interactions in organic chiral ternary crystals is promising.

关键词： organic chiral ternary crystals chiral orbit chiral-optical activities magnetic field

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

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Bone Research 2024年第1期12卷 137-152页

作者： weicheng Lu Jianfei Yan Chenyu Wang Wenpin qin Xiaoxiao Han Zixuan qin yu wei Haoqing Xu Jialu Gao Changhe Gao Tao Ye Franklin R.Tay Lina Niu Kai Jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary injury.Inflammasome-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal tissues.These proteins initiate inflammatory dysfunction,such as neurogenic heterotopic ossification.This recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention strategies.Accordingly,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two issues.Histological examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast pyroptosis.The relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in vivo.Intravenous injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in vivo.The present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

Effect of Iron on the Stability of Rhodochrosite at the Topmost Lower Mantle Conditions

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Journal of Earth Science 2024年第2期35卷 504-513页

作者： Tianlei Zhai Fei qin Shengxuan Huang Shan qin yu Gong Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing100871China School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

Carbonates are viewed as the principal oxidized carbon carriers during subduction,and thus the stability of subducted carbonates has significant implications for the deep carbon cycle.Here we investigate the high pressure-temperature behaviors of rhodochrosite in the presence of iron up to∼34 GPa by in-situ X-ray diffraction and ex-situ Raman spectroscopy.At relatively low temperature below∼1500 K,MnCO_(3)breaks down into MnO and CO_(2).Upon heating to∼1800 K,however,the MnCO_(3)-Fe^(0)reactions occur with the formation of Mn_(3)O_(4),Fe^(O)and reduced carbon.A'three-stage'reaction mechanism is proposed to understand the kinetics of the carbon-iron-manganese redox coupling.The results suggest that Fe^(0)can serve as a reductant to greatly affect the stability of rhodochrosite,which implies that the effect of Fe-metal should be seriously considered for the high pressure-temperature behaviors of other predominant carbonates at Earth's mantle conditions,particularly at depths greater than∼250 km.

关键词： deep carbon cycle rhodochrosite reduced mantle diamond formation high pressure tectonics geochemistry