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Transurethral resection of the prostate is an independent risk factor for biochemical recurrence after radical prostatectomy for prostate cancer

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Asian Journal of Andrology 2020年第2期22卷 217-221页

作者： Kun Jin Shi Qiu Xin-Yang liao Xiao-Nan Zheng Xiang Tu Lian-Sha Tang Lu Yang qiang wei Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Center of Biomedical Big Data West China HospitalSichuan UniversityChengdu 610041China

Biochemical recurrence(BCR)is important for measuring the oncological outcomes of patients who undergo radical prostatectomy(RP).Whether transurethral resection of the prostate(TURP)has negative postoperative effects on oncological outcomes remains *** primary aim of our retrospective study was to determine whether a history of TURP could affect the postoperative BCR *** retrospectively reviewed patients with prostate cancer(PCa)who had undergone RP between January 2009 and October *** data on age,prostate volume,serum prostate-specific antigen levels(PSA),biopsy Gleason score(GS),metastasis stage(TNM),D’Amico classification,and American Society of Anesthesiologists(ASA)classification were *** analyses including Cox proportional hazard models and sensitivity analyses which included propensity score matching,were performed,and the inverse-probability-of-treatment-weighted estimator and standardized mortality ratio-weighted estimator were *** included 1083 patients,of which 118 had a history of *** matching,the non-TURP group differed from the TURP group with respect to GS(P=0.047),prostate volume(mean:45.19 vs 36.00 ml,P<0.001),and PSA level(mean:29.41 vs 15.11 ng ml?1,P=0.001).After adjusting for age,PSA level,T stage,N stage,M stage,and GS,the TURP group showed higher risk of BCR(hazard ratio[HR]:2.27,95%confidence interval[CI]:1.13–3.94,P=0.004).After matching(ratio 1:4),patients who underwent TURP were still more likely to develop BCR according to the adjusted propensity score(HR:2.00,95%CI:1.05–3.79,P=0.034).Among patients with PCa,those with a history of TURP were more likely to develop BCR after RP.

关键词： biochemical recurrence prostate cancer radical prostatectomy transurethral resection

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Molybdenum and tungsten chalcogenides for lithium/sodium-ion batteries: Beyond MoS2

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Journal of Energy Chemistry 2019年第6期28卷 100-124页

作者： Junda Huang Zengxi wei Jiaqin liao wei Ni Caiyun Wang Jianmin Ma School of Physics and Electronics Hunan UniversityChangsha 4 J0082HunanChina Faculty of Technology University of OuluOulu 90014Finland Panzhihua University Panzhihua 617000SichuanChina ARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research InstituteAIIM FacilityUniversity of WollongongNorth WollongongNSW 2500Australia Institute of Advanced Electrochemical Energy Xi'an University of TechnologyXi'an 710048ShaanxiChina

Molybdenum and tungsten chalcogenides have attracted tremendous attention in energy storage and conversion due to their outstanding physicochemical and electrochemical *** are intensive studies on molybdenum and tungsten chalcogenides for energy storage and conversion,however,there is no systematic review on the applications of WS2,Mo Se2and WSe2as anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs),except Mo *** the importance of these contents,it is extremely necessary to overview the recent development of novel layered WS2,Mo Se2and WSe2beyond Mo S2in energy ***,we will systematically overview the recent progress of WS2,Mo Se2and WSe2as anode materials in LIBs and *** review will also discuss the opportunities,and perspectives of these materials in the energy storage fields.

关键词： MoSe2 WS2 WSe2 Lithium-ion batteries Sodium-ion batteries

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A novel robust aerodynamic optimization technique coupled with adjoint solvers and polynomial chaos expansion

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Chinese Journal of Aeronautics 2022年第10期35卷 35-55页

作者： wei ZHANG qiang WANG Fanzhi ZENG Chao YAN National Key Laboratory of Computational Fluid Dynamics Beihang UniversityBeijing 100083China Aerospace Times Feipeng Company Limited China Academy of Aerospace Electronics TechnologyKunshan 215000China China Academy of Aerospace Aerodynamics Beijing 100074China

Uncertainty is common in the life cycle of an aircraft, and Robust Aerodynamic Optimization(RAO) that considers uncertainty is important in aircraft design. To avoid the curse of dimensionality in surrogate-based optimization, this study proposes an adjoint RAO technique called “R-Opt”. Polynomial Chaos Expansion(PCE) is coupled with the R-Opt technique to quantify uncertainty in the responses of the target(including its mean and standard deviation). Only one process of PCE model construction is required in each iteration, and the gradients of uncertainty can be inferred via chain rules. The proposed method is more efficient than prevalent methods,and avoids the problem of a disagreement over the best PCE basis from among a number of PCE models(especially in case of sparse PCE). It also supports the application of sparse *** benchmark tests and two airfoil cases were used to verify R-Opt, and the optimal solutions were deemed to be robust. It improved the mean aerodynamic performance and reduced the standard deviation of the target.

关键词： Adjoint technique Polynomial chaos expansion Robust design Uncertainty analysis Uncertainty gradient propagation

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Optimizing the Copy-on-Write Mechanism of Docker by Dynamic Prefetching

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Tsinghua Science and Technology 2021年第3期26卷 266-274页

作者： Yan Jiang wei Liu Xuanhua Shi weizhong qiang National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabHuazhong University of Science and TechnologyWuhan 430074China

Docker,as a mainstream container solution,adopts the Copy-on-Write(CoW)mechanism in its storage *** mechanism satisfies the need of different containers to share the same ***,when a single container performs operations such as modification of an image file,a duplicate is created in the upper readwrite layer,which contributes to the runtime *** the accessed image file is fairly large,this additional overhead becomes *** we present the concept of Dynamic Prefetching Strategy Optimization(DPSO),which optimizes the Co W mechanism for a Docker container on the basis of the dynamic prefetching *** the beginning of the container life cycle,DPSO pre-copies up the image files that are most likely to be copied up later to eliminate the overhead caused by performing this operation during application *** experimental results show that DPSO has an average prefetch accuracy of greater than 78%in complex scenarios and could effectively eliminate the overhead caused by the CoW mechanism.

关键词： Docker container Copy-on-Write(CoW) storage driver prefetch strategy

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Conceptual design and preliminary experiment of icing risk management and protection system

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Chinese Journal of Aeronautics 2022年第6期35卷 101-115页

作者： qiang WU Haojun XU Binbin PEI Yang wei School of Aeronautics Engineering Air Force Engineering UniversityXi’an 710038China

Icing is one of the main external environmental factors that causes aircraft to lose *** flight safety assurance system under icing condition is particularly ***,most of the systems do not consider the coupling characteristics of aerodynamics and flight dynamics of icing *** will affect the accuracy of the calculation ***,the icing risk management system helps the pilot to realize the possible dangers in advance and perform correct maneuvers,based on quantitative assessment and visualization methods of flight *** envelope protection system realizes flight safety guarantee based on the real-time boundary protection method of key flight ***,based on distributed simulation technology,a flight simulator was used as a platform to integrate the icing risk management system and envelope protection system to realize man-in-the-loop *** fictional but historically motivated icing scenarios are designed to test the system,and the results demonstrate that the icing risk management and protection system would be useful for aviation safety and can also be used for pilot training and reproducing flight accidents to find the causes.

关键词： Flight risk Flight simulator Icing Quantitative assessment Visualization

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Appraising the potential of calcium sulfoaluminate cement-based grouts in simulated permafrost environments

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Frontiers of Structural and Civil Engineering 2023年第5期17卷 722-731页

作者： Jian ZHAO Guangping HUANG Lin liao wei Victor LIU Department of Civil and Environmental Engineering University of AlbertaEdmonton T6G 1H9Canada College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China

The aim of this study is to appraise the potential of calcium sulfoaluminate(CSA)cement-based grouts in simulated permafrost *** hydration and performance of CSA cement-based grouts cured in cold environments(10,0,and−10℃)are investigated using a combination of tests,including temperature recording,X-ray diffraction(XRD)tests,thermogravimetric analysis(TGA),and unconfined compressive strength(UCS)*** recorded temperature shows a rapid increase in temperature at the early stage in all the ***,results of the TGA and XRD tests show the generation of a significant quantity of hydration products,which indicates the rapid hydration of CSA cement-based grouts at the early stage at low ***,the CSA cement-based grouts exhibit remarkably high early *** UCS values of the samples cured for 2 h at−10,0,and 10℃ are 6.5,12.0,and 12.3 MPa,*** UCS of the grouts cured at−10,0,and 10℃ increases continuously with age and ultimately reached 14.9,19.0,and 30.6 MPa at 28 d,*** findings show that the strength of grouts fabricated using CSA cement can develop rapidly in cold environments,thus rendering them promising for permafrost applications.

关键词： permafrost low temperatures calcium sulfoaluminate cement-based grouts hydration reaction compressive strength

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Glow Discharge Plasma-Assisted Preparation of Nickel-Based Catalyst for Carbon Dioxide Reforming of Methane

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Chinese Journal of Chemical Physics 2008年第5期21卷 481-486页

作者： Fang Guo wei Chu Jun-qiang Xu Lin Zhong Department of Chemical Engineering Sichuan University Chengdu 610065 China Department of Chemical and Biological Engineering Chongqing Institute of Technology Chongqing 400050 China

A plasma-assisted method was employed to prepare Ni/γ-All2O3 catalyst for carbon dioxide reforming of methane reaction. The novel catalyst possessed higher activity and better coke-suppression performance than those of the conventional calcination catalyst. To achieve the same CH4 conversion, the conventional catalyst needed higher reaction temperature, about 50 ℃ higher than that of the N2 plasma-treated catalyst. After the evaluation test, the deactivation rate of the novel catalyst was 1.7%, compared with 15.2% for the conventional catalyst. Different from the characterization results of the calcined catalyst, a smaller average pore diameter and a higher specific surface area were obtained for the plasma-treated catalyst. The variations of the reduction peak temperatures and areas indicated that the catalyst reducibility was promoted by plasma assistance. The dispersion of nickel was also remarkably improved, which was helpful for controlling the ensemble size of metal atoms on the catalyst surface. The modification effect of plasma- assisted preparation on the surface property of alumina supported catalyst was speculated to account for the concentration increase of absorbed CO2. An enhancement of CO2 adsorption was propitious to the inhibition of carbon formation. The coke amount deposited on plasma treated catalyst was much smaller than that on the conventional catalyst.

关键词： Nickel-based catalyst Plasma CO2 reforming of CH4 Coke Adsorption of CO2

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Human prostate cancer stem cells： new features unveiled

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Asian Journal of Andrology 2011年第3期13卷 355-356页

作者： Yuting Sun wei-qiang Gao Department of Discovery Oncology Genentech Inc. South San Francisco CA 94080 USA Renji-MedX Clinical Stern Cell Research Center Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Med-X Research Institute Shanghai Jiao Tong University Shanghai 200030. China

Cancer stem cells （CSCs） are a rare subpopulation of phenotypically distinct cancer cells exhibiting stem cell characteristics. They are tumourigenic, meanwhile capable of self-renewal and forming differentiated progenies. CSCs are believed to be resistant to the standard therapeutics, and provide the cell reservoir for tumour initiation.1 Understanding CSCs or in another word, tumour-initiating cells, is of critical therapeutic importance.

关键词： Cells Lymphocytes Cancer (genus) Neoplasms Stems

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A novel gain design method to improve the consensus performance of output-feedback multi-agent systems

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Control Theory and Technology 2016年第4期14卷 335-346页

作者： wei ZHENG qiang LING Hai LIN Department of Automation University of Science and Technology of China Hefei Anhui 230027 China Department of Electrical Engineering University of Notre Dame Notre Dame IN 46556 U.S.A.

This paper considers the consensus problem of a group of homogeneous agents. These agents are governed by a general linear system and can only directly measure the output, instead of the state. In order to achieve the consensus goal, each agent estimates its state through a Luenberger observer, exchanges its estimated state with neighbors, and constructs the control input with the estimated states of its own and neighbors. Due to the existence of observation and process noises, only practical consensus, instead of asymptotical consensus, can be achieved in such multi-agent systems. The performance of the achieved practical consensus can be measured by the ultimate mean square deviation of the states of agents. That performance is closely related to the observation gains of the state observers and the control gains of agents. This paper proposes a method to optimize such performance with respect to the concerned observation and control gains. That method starts with a set of feasible observation and control gains and formulates a group of linear matrix inequalities （LMIs）. Solving these LMIs gives some intermediate matrix variables. By perturbing observation and control gains, and the intermediate matrix variables, the original LMIs yield another group of LMIs, which can be solved to provide a descent direction of observation and control gains. Moving along that descent direction, observation and control gains can be improved to yield better performance and work as the starting point of the next iteration. By iteratively repeating this procedure, we can hopefully improve the consensus performance of the concerned multi-agent system. Simulations are done to demonstrate the effectiveness of the proposed method.

关键词： Consensus output-feedback multi-agent systems least mean square deviation perturbation method

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Factors to consider in developing individual pharmaceutical product quality risk profiles useful to government procurement agencies

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Acta Pharmaceutica Sinica B 2016年第1期6卷 79-92页

作者： wei Xu Garth Boehm qiang Zheng School of Pharmaceutical Sciences Peking University Center for Pharmaceutical Information and Engineering Research Peking University Department of Industrial Engineering and Management College of EngineeringPeking University

Governments that procure pharmaceutical products from an Essential Medicine List(EML)bear special responsibility for the quality of these *** this article we examine the possibility of developing a pharmaceutical product quality risk assessment scheme for use by government procurement *** use the Chinese EML as a basis,and US recall data is examined as it is publically *** is justified as the article is only concerned with inherent product quality *** establishing a link between Chinese essential medicines and those available in the US,we examine US recall data to separate product specific *** conclude that,in addition to existing manufacturing based risks,there are two other product specific risks that stand out from all others,degradation and dissolution *** for relative product risk for degradation is needed to be developed and further work is required to better understand dissolution failures which largely occur with modified-release solid oral *** conclude that a product specific quality risk profile would be enhanced by including a risk assessment for degradation for all products,and in the case of solid oral products,dissolution.

关键词： Chinese essential medicine Product-specific quality risk Chemical stability Dissolution Risk assessment US recall data

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