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Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis

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Bioactive Materials 2020年第3期5卷 667-679页

作者： Dong Lou Yu Luo Qian Pang wei-qiang tan Lie Ma MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016PR China

Diabetic chronic wound,characterized by prolonged inflammation and impaired angiogenesis,has become one of the most serious challenges in clinic and pose a significant healthcare burden *** a great variety of wound dressings have been developed,few of encouraged achievements were obtained so *** this study,the gene-activated strategy was applied to enhance sustained expression of vascular endothelial growth factor(VEGF)and achieve better healing outcomes by regulating inflammation and promoting *** gene-activated bilayer dermal equivalents(Ga-BDEs),which has good biocompatibility,were fabricated by loading the nano-sized complexes of Lipofectamine 2000/plasmid DNA-encoding VEGF into a collagen-chitosan scaffold/silicone membrane bilayer dermal *** DNA complexes were released in a sustained manner and showed the effective transfection capacities to up-regulate the expression of VEGF in *** overcome cutaneous contraction of rodents and mimic the wound healing mechanisms of the human,a reformative rat model of full-thickness diabetic chronic wound was *** the treatment of Ga-BDEs,speeding wound healing was observed,which is accompanied by the accelerated infiltration and phenotype shift of macrophages and enhanced angiogenesis in early and late healing phases,*** proved that Ga-BDEs possess the functions of immunomodulation and pro-angiogenesis ***,the better regeneration outcomes,including deposition of oriented collagen and fast reepithelialization,were *** these results indicated that,being different from traditional pro-angiogenic concept,the up-regulated expression of VEGF by Ga-BDEs in a sustained manner shows versatile potentials for promoting the healing of diabetic chronic wounds.

关键词： Gene-activated dermal equivalent Vascular endothelial growth factor Inflammation Angiogenesis Diabetic chronic wounds

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Photosynthetic biomaterials: applications of photosynthesis in algae as oxygenerator in biomedical therapies

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Bio-Design and Manufacturing 2021年第3期4卷 596-611页

作者： Yong Wang Yanan Xue Tao Zhang Qingqing Fang Mingyuan Jin Xiaofeng Wang Zhengcai Wang Yanyan Hu Wanyi Zhao Dong Lou wei-qiang tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of Medicine3 East Qingchun RoadHangzhou 310016China Department of Plastic Surgery The Fourth Affiliated HospitalZhejiang University School of MedicineN1 Shangcheng RoadYiwu 322000China

For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue ***,the oxygen in our environment is vital for *** a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen,photosynthesis has been widely studied in scientific research and used in production of food,fuel,and *** recent years,photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy,tissue regeneration,transplantation,and in treatment of specific *** review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.

关键词： Biomaterials Photosynthesis Hypoxia Myocardial infarction Photodynamic therapy Tissue engineering

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Flexible electrical stimulation device with Chitosan-Vaseline®dressing accelerates wound healing in diabetes

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Bioactive Materials 2021年第1期6卷 230-243页

作者： Xiao-Feng Wang Meng-Lu Li Qing-Qing Fang Wan-Yi Zhao Dong Lou Yan-Yan Hu Jun Chen Xiao-Zhi Wang wei-qiang tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016Zhejiang ProvincePR China Key Laboratory of Micro-Nano Electronic Devices and Smart Systems of Zhejiang Province College of Information Science&Electronic EngineeringZhejiang UniversityHangzhou310027Zhejiang ProvincePR China Innovation Center for Signaling Network College of Life SciencesZhejiang UniversityHangzhou310058Zhejiang ProvincePR China

The healing process of diabetic wounds is typically disordered and prolonged and requires both angiogenesis and *** of the endogenous electric fields(EFs)may lead to disordered cell *** stimulation(ES)that mimics endogenous EFs is a promising method in treating diabetic wounds;however,a microenvironment that facilitates cell migration and a convenient means that can be used to apply ES are also ***-Vaseline■gauze(CVG)has been identified to facilitate wound healing;it also promotes moisture retention and immune regulation and has antibacterial *** this study,we created a wound dressing using CVG together with a flexible ES device and further evaluated its potential as a treatment for diabetic *** found that high voltage monophasic pulsed current(HVMPC)promoted healing of diabetic wounds in *** studies carried out in vitro,we found that HVMPC promoted the proliferation and migration of human umbilical vein endothelial cells(HUVECs)by activating PI3K/Akt and ERK1/2 ***,we determined that the flexible ES-chitosan dressing may promoted healing of diabetic wounds by accelerating angiogenesis,enhancing epithelialization,and inhibiting scar *** findings provide support for the ongoing development of this multidisciplinary product for the care and treatment of diabetic wounds.

关键词： Diabetic wounds Flexible electronic device Electrical stimulation Chitosan-vaseline■gauze Wound healing

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Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration

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Bioactive Materials 2024年第5期35卷 330-345页

作者： Yong Wang Yuan Zhang Yun-Peng Yang Ming-Yuan Jin Sha Huang Ze-Ming Zhuang Tao Zhang Li-Li Cao Xiao-Ying Lin Jun Chen Yong-Zhong Du Jian Chen wei-qiang tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of Medicine3 East Qingchun RoadHangzhou310016China Department of Ultrasound in Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang University866 Yu-Hang-Tang RoadHangzhou310058China MOE Key Laboratory of Biosystems Homeostasis&Protection College of Life SciencesZhejiang UniversityHangzhou310058China

The management of chronic wounds in diabetes remains challenging due to the complexity of impaired wound healing,delayed healing,susceptibility to infection,and elevated risk of reopening,highlighting the need for effective chronic wound management with innovative approaches such as multifunctional ***,we have produced HA-DA@rhCol hydrogels consisting of dopamine-modified hyaluronic acid and recombinant human collagen type-III(rhCol)by oxidative coupling of the catechol group using the H_(2)O_(2)/HRP catalytic *** post-reactive hydrogel has a good porous structure,swelling rate,reasonable degradation,rheological and mechanical properties,and the catechol group and dopamine impart to the hydrogel tissue adhesiveness,antioxidant capacity,and excellent photothermal effects leading to superior in vitro antimicrobial *** addition,the ability of rhCol to confer hydrogels to promote angiogenesis and wound repair has also been *** and hemolysis tests demonstrated the good biocompatibility of the *** closure,collagen deposition and immunohistochemical examination confirmed the ability of the hydrogel to promote diabetic wound *** summary,the adhesive hemostatic antioxidative hydrogel with rhCol to promote wound healing in diabetic rat is an excellent chronic wound dressing.

关键词： Hyaluronic acid hydrogel Recombinant human collagen Antioxidant and anti-inflammation Antibacterial Diabetic wound

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE wei HUANG Jin ZHU Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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小型化T隔板多层基片集成波导滤波器设计

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微波学报 2018年第2期34卷 35-38页

作者：王晓薇徐自强谭力陈钊电子科技大学能源科学与工程学院

基于LTCC工艺设计并制作了一种多层T隔板基片集成波导（TSSIW）滤波器。该滤波器以TSSIW谐振腔为基础,利用其灵活的同层与异层的耦合方式实现四阶交叉耦合结构,并节省60%以上的电路面积。实验结果显示滤波器中心频率为9.4 GHz,工作带宽... 详细信息

基于LTCC工艺设计并制作了一种多层T隔板基片集成波导（TSSIW）滤波器。该滤波器以TSSIW谐振腔为基础,利用其灵活的同层与异层的耦合方式实现四阶交叉耦合结构,并节省60%以上的电路面积。实验结果显示滤波器中心频率为9.4 GHz,工作带宽为500 MHz,通带最小插入损耗小于2.5 d B,回波损耗优于15 d B,表明该滤波器具有体积小、易于集成的特点,同时保持了TSSIW优秀的频率选择性和寄生响应。

关键词：滤波器 T隔片基片集成波导低温共烧陶瓷基片集成波导

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong tang Zhetuo Qi Haiyang Xie Shusen Zheng qiang wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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木质纤维素酸催化制备糠醛的工艺及机理研究进展

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农业工程学报 2017年第15期33卷 272-282页

作者：王琼王闻亓伟余强谭雪松庄新姝袁振宏王忠铭广东省新能源和可再生能源研究开发与应用重点实验室中国科学院可再生能源重点实验室中国科学院广州能源研究所广州510640 生物质能源河南省协同创新中心郑州450002

糠醛是一种重要的生物质基平台化合物,国内外学者针对生物质产糠醛展开诸多研究,尤其是酸催化水解领域。该文综述了糠醛制备工艺在不同时期的情况,阐述并评价了目前新颖的同步产糠醛与纤维素基化学品工艺。对酸(稀布朗斯特酸和路易斯金... 详细信息

糠醛是一种重要的生物质基平台化合物,国内外学者针对生物质产糠醛展开诸多研究,尤其是酸催化水解领域。该文综述了糠醛制备工艺在不同时期的情况,阐述并评价了目前新颖的同步产糠醛与纤维素基化学品工艺。对酸(稀布朗斯特酸和路易斯金属盐)催化木糖和半纤维素的反应动力学进行系统归纳,并阐述了相关机理的研究进展。最后,对现在研究热点——酸/有机溶剂作用体系中有机溶剂的作用机制进行归纳,并对计算化学在其中的最新研究情况进行总结。该文旨在为学者开展生物质产糠醛的研究提供信息,有利于学者进行选择性研究。

关键词：生物质催化动力学糠醛有机溶剂机理

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On the General and Resonant Solutions of Atoms Reflected by an Evanescent Laser Wave

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Chinese Physics Letters 1996年第8期13卷 587-589页

作者： tan wei-han LI qiang-ning Department of Physics Shanghai UniversityShanghai 200072 and Shanghai Institute of Optics and fine Mechanics Chinese Academy of SciencesShanghai 201800

Usually the reflection of two level atoms by a detuning evanescent laser wave was studied in past few years.1-3 In previous paper we have presented an exact solution for this model based on the matrix Laplace transformation technique,and proceeded the numerical calculations for a given set of parameters.4 However in the special case of resonance interaction considered in this paper,the solution for Schrödinger wave equation and reflectivity calculation can be greatly simplified;besides,the resonant solution provides a check to the numerical data based on the general solution of the previous paper.

关键词： parameters wave simplified

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不同机械直播穴距与播种量对早稻产量形成的影响

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江西农业大学学报 2017年第1期39卷 9-17页

作者：贾维强谭雪明李木英石庆华潘晓华江西农业大学作物生理生态与遗传育种教育部重点实验室/江西省作物生理生态与遗传育种重点实验室/江西农业大学双季稻现代化生产协同创新中心江西南昌330045

选用杂交稻品种株两优819和常规稻品种中早35,探讨4种穴距的2种穴播量对早稻产量形成的影响,以明确双季早稻机械穴直播合理的穴距和穴播量。结果表明,机直播穴距均以11 cm处理产量最高。穴距11 cm条件下,株两优819播种量3和5粒处理的产... 详细信息

选用杂交稻品种株两优819和常规稻品种中早35,探讨4种穴距的2种穴播量对早稻产量形成的影响,以明确双季早稻机械穴直播合理的穴距和穴播量。结果表明,机直播穴距均以11 cm处理产量最高。穴距11 cm条件下,株两优819播种量3和5粒处理的产量分别为9 671.19 kg/hm^2和9 461.46 kg/hm^2;中早35播种量3和5粒处理的产量分别为7 942.47 kg/hm^2和8 786.0 kg/hm^2。株两优819的分蘖早、分蘖量大、分蘖峰值高;中早35分蘖力较弱,分蘖平均峰值比株两优819低40.15%。中早35平均成穗率比株两优819高9.45%。直播穴距为11 cm处理产量高,主要由于有效穗数多;其前期干物质生产量占全生育期的比重相对较小,中后期干物质生产量占全生育期的比重高于其它穴距处理。说明此机播穴距的群体发育相对更为合理。在平均行距25 cm条件下,减小穴距以提高基本苗数比提高播种量更利于高产。早稻的最佳直播穴距为11 cm;分蘖力强的品种适宜穴播量3粒谷左右,分蘖弱的品种适宜穴播量5粒谷左右。

关键词：早稻机械直播穴距播种量产量

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