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吉林省地榆资源分布影响因素研究

时珍国医国药 2018年第1期29卷 192-194页

作者：韩曦英王哲关树光齐伟辰长春中医药大学药学院吉林长春130117

目的探讨基于多元统计方法分析在地理信息系统技术支持下研究影响地榆在吉林省分布的各个生态因子,寻找吉林省地榆分布的主要的生态因子,建立吉林省地榆分布的Logistic模型,分析地榆在吉林省的资源分布情况。方法对地榆在吉林省各地区... 详细信息

目的探讨基于多元统计方法分析在地理信息系统技术支持下研究影响地榆在吉林省分布的各个生态因子,寻找吉林省地榆分布的主要的生态因子,建立吉林省地榆分布的Logistic模型,分析地榆在吉林省的资源分布情况。方法对地榆在吉林省各地区分布进行实地调查,利用GIS技术获取地榆在各个分布点的各项生态数据和各分布点的经纬度等信息。利用主成分分析确定吉林省地榆分布主要的正态因子;利用Logistic回归分析确定对地榆分布有显著影响的生态因子。结果吉林省地榆分布的生态因子主要有三个主成分,分别为代表降水量因子、温度因子和土壤因子。海拔、纬度、年均温变化范围、温度季节性变化标准差、最干季降水量、最干月降水量、年平均降水量、季节降水量变异系数是显著影响吉林省地区地榆品种分布的因素(P<0.05)。结论主成分分析和Logistic回归分析可以对吉林省的地榆资源分布的影响因素做出有效的分析。

关键词：主成分分析 Logistic回归地榆资源分布地理信息系统

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汕头市早产儿视网膜病变筛查结果分析

国际眼科杂志 2015年第8期15卷 1455-1457页

作者：张贵华陈伟奇陈浩宇彭坤林杜生汕头大学.香港中文大学联合汕头国际眼科中心玻璃体视网膜一科中国广东省汕头市515041 汕头大学.香港中文大学联合汕头国际眼科中心玻璃体视网膜二科中国广东省汕头市515041

目的:了解汕头地区早产儿视网膜病变(retinopathy of prematurity,ROP)发病情况,探讨适合汕头地区的ROP筛查标准。方法:对2011-01/2014-12在汕头4家医院NICU住院的1 813例出生体重≤2 000g的低出生体重儿或胎龄≤34周的早产儿采用双目... 详细信息

目的:了解汕头地区早产儿视网膜病变(retinopathy of prematurity,ROP)发病情况,探讨适合汕头地区的ROP筛查标准。方法:对2011-01/2014-12在汕头4家医院NICU住院的1 813例出生体重≤2 000g的低出生体重儿或胎龄≤34周的早产儿采用双目间接眼底镜和(或)广角数码儿童成像系统(Ret CamⅡ)进行ROP筛查,所有患儿随访至视网膜完全血管化或病变退化。结果:发现ROP 202例388眼,占筛查总例数11.14%。其中重症ROP(阈值前期Ⅰ型或阈值期)43例85眼,占筛查总例数2.37%。出生体重<1 500g新生儿408例,重症ROP 34例67眼,占全部重症ROP病例的79.07%。GEE模型分析结果表明,低出生体重、小胎龄及吸氧是ROP的高危因素。结论:汕头地区ROP检出率11.14%,但重症ROP检出率较低,主要发生于出生体重<1500g低出生体重儿和出生胎龄≤34周的早产儿。低出生体重、小胎龄及吸氧是ROP的高危因素。

关键词：视网膜病早产儿/流行病学早产儿/病因学早产儿/诊断学新生儿筛查

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li wei-qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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《药用植物学》多重实践教学平台的构建

中国实验方剂学杂志 2017年第16期23卷 28-31页

作者：齐伟辰朱妮娜张天柱林喆长春中医药大学药学院长春130117 长春师范大学生命科学学院长春130032

《药用植物学》是一门理论联系实际很强的学科,实践性教学在《药用植物学》课程中占有重要的地位。传统教学模式单一,不适合本课程的教学。通过建立全方位、多层次的《药用植物学》实践性教学平台,包括综合性实验的设计,互动显微系统在... 详细信息

《药用植物学》是一门理论联系实际很强的学科,实践性教学在《药用植物学》课程中占有重要的地位。传统教学模式单一,不适合本课程的教学。通过建立全方位、多层次的《药用植物学》实践性教学平台,包括综合性实验的设计,互动显微系统在实验教学中的应用,完善以问题为导向的教学方法(PBL),网络教学平台建设,校园及野外实习基地的建立和实践技能的提高等。将多种教育信息及教学资源整合在一起,进一步提高《药用植物学》实践教学的质量和效果。对《药用植物学》的传统教学方法、教学内容和教学模式等进行改革与探索,为建立《药用植物学》的教学新模式提供参考。

关键词：《药用植物学》多重性实践教学平台构建

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运输机重装备空投鲁棒控制律设计

系统仿真学报 2008年第S2期20卷 303-306,316页

作者：张超李卫琪陈宗基王会北京航空航天大学自动化科学与电气工程学院自动控制系北京100191

分析了重装备空投对于运输机纵向运动的影响。建立了重装备空投的扰动运动模型。对于重装备空投过程设计了鲁棒H∞控制律,仿真结果表明所设计的控制器能够消除空投过程中由于运输机特性发生突变而带来的影响。

关键词：重装备空投鲁棒H∞控制飞行控制建模

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu chenxin Fang weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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空客飞控计算机系统虚拟样机验证仿真

系统仿真学报 2008年第S2期20卷 323-326,354页

作者：孙晓哲李卫琪陈宗基北京航空航天大学自动化科学与电气工程学院北京100191

为了深入分析民机Airbus系列的余度飞控计算机系统,根据飞控系统虚拟样机技术的发展趋势,设计并建立了民机飞控计算机系统虚拟样机的验证平台,介绍了此虚拟样机平台的具体硬软件实现,在此平台上对民机空客A340飞控计算机系统的简化结构... 详细信息

为了深入分析民机Airbus系列的余度飞控计算机系统,根据飞控系统虚拟样机技术的发展趋势,设计并建立了民机飞控计算机系统虚拟样机的验证平台,介绍了此虚拟样机平台的具体硬软件实现,在此平台上对民机空客A340飞控计算机系统的简化结构进行仿真分析,仿真当某一飞控计算机故障情况下舵面控制指令、舵面偏角和飞机姿态的输出情况,由仿真结果得此平台可以实现空客飞控计算机系统的余度配置,能够正确隔离故障和进行容错管理,最后总结了下一步需要进行的工作。

关键词：虚拟样机余度飞控计算机数字化验证

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing wei Chang chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses