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Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 670-675页

作者： De-Shuang Li Hong-Xia Liao Chuan-He Zhang Jian-guo Huang wei Chen Jing-Lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Department of Ophthalmology the University of Hong Kong-Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this *** were randomly assigned to receive either aflibercept or a combination of aflibercept and *** once a month for a total of three *** macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly ***:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both ***:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and ***,both aflibercept and combination therapy show no significant change in the area of FAZ.

关键词： diabetic macular edema optical coherence tomography optical coherence tomography angiography hyperreflective foci subretinal fluid foveal avascular zone aflibercept

Upstream-downstream cooperation approach in Guanting Reservoir watershed

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Journal of Environmental Sciences 2005年第4期17卷 676-680页

作者： YANGZhi-feng ZHANGWen-guo StateKeyJointLaboratoryofEnvironmentalSimulationandPollutionControl BeijingNormalUniversityBeijing100875China. StateKeyJointLaboratoryofEnvironmentalSimulationandPollutionControl BeijingNormalUniversityBeijing100875China.／／DepartmentofNatureandEcologyConservationofSEPABeijing100035China

A case study is introduced and discussed concerning water dispute of misuse and pollution between up\| and down\|stream parts. The relations between water usage and local industrial structures are analyzed. Results show it is important to change industrial structures of the target region along with controlling water pollution by technical and engineering methods. Three manners of upstream-downstream cooperation are presented and discussed based on the actual conditions of Guangting Reservoir watershed. Two typical scenarios are supposed and studied along with the local plan on water resources development. The best solution for this cooperation presents a good way to help the upstream developing in a new pattern of eco-economy.

关键词： watershed cooperation upstream-downstream industrial structures Guanting Reservoir

HYDRAULIC PRESSURE SIGNAL DENOISING USING THRESHOLD SELF-LEARNING WAVELET ALGORITHM

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Journal of Hydrodynamics 2008年第4期20卷 433-439页

作者： guo Xin-lei YANG Kai-lin guo Yong-xin Department of Hydraulics China Institute of Water Resources and Hydropower Research Beijing 100044 China

A pre-filter combined with threshold self-learning wavelet algorithm is proposed for hydraulic pressure signals denoising. The denoising threshold is self-learnt in the steady flow state, and then modified under a given limit to make the mean square errors between reconstruction signals and desirable outputs minimum, so the corresponding optimal denoising threshold in a single operating case can be obtained. These optimal thresholds are used for the whole signal denoising and are different in various cases. Simulation results and comparative studies show that the present approach has an obvious effect of noise suppression and is superior to those of traditional wavelet algorithms and back-propagation neural networks. It also provides the precise data for the next step of pipeline leak detection using transient technique.

关键词： hydraulic pressure signal wavelet threshold denoising self-learning neural network

Inhibition of retinal angiogenesis by gold nanoparticles via inducing autophagy

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1269-1276页

作者： Ni Shen Rui Zhang Hao-Rui Zhang Hao-Yang Luo wei Shen Xin Gao Da-Zhi guo Jie Shen Department of Ophthalmology Shanghai Renji HospitalShanghai Jiao Tong University School of Medicine Department of Ophthalmology Changhai Hospitalthe Second Military Medical Univerisity Company 6 of Basic Medical School the Second Military Medical University School of Life Science Fudan University Department of Hyperbaric Oxygen Navy General Hospital

AIM： To investigate the effect of gold nanoparticles on retinal angiogenesis in vitro and in vivo, and to reveal the possible ***： Seed growth method was used to synthesize gold nanoparticles（GNPs）. The size, zeta potential, absorption spectrum and morphology of GNPs were identified using Malvern nano-ZS, multimode reader（Bio Tek synergy2） and transmission electron microscope. Cell viability was analyzed using cell counting kit-8 method and cell growth was assessed with EdU kit. Transwell chamber was used to investigate cell migration. Tube formation method was used to assess the angiogenic property in vitro. Oxygen induced retinopathy（OIR） model was used to investigate the effect of GNPs on retinal angiogenesis. Confocal microscope and Western blot were used to study the possible mechanism of GNPs inhibited ***： The GNPs synthesized were uniform and well dispersed. GNPs of 10 μg/mL and 20 μg/mL were able to inhibit human umbilical vein endothelial cells proliferation（50% and 72% separately, P〈0.001）, migration（54% and 83% separately, P〈0.001） and tube formation（52% and 90% separately, P〈0.001）. Further data showed that GNPs were able to improve the retinopathy in an OIR model. The possible mechanism might be that GNPs were able to induce autophagy significantly（P〈0.05）.CONCLUSION： The present study suggests that GNPs are able to inhibit retinal neovascularization in vitro and in vivo. GNPs might be a potential nanomedicine for the treatment of retinal angiogenesis.

关键词： gold nanoparticles retinal angiogenesis oxygen induced retinopathy autophagy nanomedicine

Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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Current Medical Science 2024年第4期44卷 741-747页

作者： Su-guo WANG Yong-gang WANG guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN Gao-zhong HUANG Hong-tao LI Department of General Medicine Shenzhen Third People's HospitalShenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China

Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant *** After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant *** The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,*** values;P<0.01).The mean levels of LDL-C and ApoE were also 19%and 16%higher,respectively(P<0.05).No correlation was found between the pretreatment lipid profile and the histologic response to *** increase in Lp(a)was strongly correlated with the Ki-67 index(R=0.31,P=0.023).Moreover,a trend toward longer disease-free survival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： osteosarcoma neoadjuvant chemotherapy serum lipids

Using “management mosaics” to mitigate the impacts from extreme wildfires

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Ecological Processes 2021年第1期10卷 579-581页

作者： Qinfeng guo USDA FS Eastern Forest Environmental Threat Assessment Center3041 Cornwallis RoadResearch Triangle ParkNC 27709USA

Human activities and global change have resulted in more severe and destructive megafires in forest ecosystems ***,I introduce and discuss the concept of“management mosaics”and how to use it over both space and time... 详细信息

关键词： Disturbance refuges Fire frequency and severity Fuel treatment Human activities Megafires

Property of three-dimensional silica composites

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Journal of University of Science and Technology Beijing 2007年第1期14卷 85-88页

作者： Guangyao Jia Zhimeng guo Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China

Silica fibers-reinforced, fused silica composites were fabricated with repeated vacuum-assisted liquid-phase infiltration. The mechanical properties, thermal properties, and ablative properties of the samples were evaluated. The effect of the silica fiber content and treatment temperature on the flexural strength of the three-dimensional SiO2 （3-D SiO2） composites also was investigated. The SiO2 composites show good mechanical properties and excellent ablative performance. The flexural strength increases with an increase in silica fiber content, and decreases with an increase in treatment temperature. When the volume fraction of the silica fiber is 50vo1% and the treatment temperature is 700℃ the flexural strength of the composites reaches a maximum value of 78 MPa. By adding cyclohexanone surfactant, the infiltration property can be largely improved, resulting in the density of SiO2 composites increasing up to 1.65 g/cm^3. The fracture surfaces of the flexural specimens observed using SEM, show that the pseudoplasticity and the toughening mechanisms of the composites are caused by absorption of a lot of energy by interface debonding and fiber pulling out.

关键词： silica ceramics composites three-dimensional woven property

Plasma Enhanced Chemical Vapor Deposition Synthesizing Carbon Nitride Hard Thin Films

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Chinese Physics Letters 1998年第12期15卷 913-915页

作者： ZHANG Zhi-hong guo Huai-xi MENG Xian-quan YE Ming-sheng ZHANG wei FAN Xiang-jun Department of Physics Wuhan UniversityWuhan 430072

Using plasma enhanced chemical vapor deposition and SiC and carbon buffer layers,we have obtained carbon nitride thin films on Si(100)and Si(111).The x-ray diffraction and x-ray photoelectron spectroscopy are used to characterize the thin *** Vickers hardness of the carbon nitride thin films is more than 5100kgf/mm2 and comparable to that of diamond.

关键词： Si(111) carbon films

UNREDUCED MEGAGAMETOPHYTE FORMATION VIA SECOND DIVISION RESTITUTION CONTRIBUTES TO TETRAPLOID PRODUCTION IN INTERPLOIDY CROSSES WITH/ORAH/MANDARIN(CITRUS RETICULATA)

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Frontiers of Agricultural Science and Engineering 2021年第2期8卷 302-313页

作者： Qiangming XIA wei WANG Kaidong XIE Xiaomeng WU Xiuxin DENG Jude WGROSSER Wenwu guo Key Laboratory of Horticultural Plant Biology(Ministry of Education) College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Citrus Research and Education Center University of Florida/IFASLake AlfredUSA.

Seedless fruits are desirable in the citrus fresh fruit *** production via diploid x tetraploid interploidy crosses is thought to be the most efficient and widely-used strategy for the breeding of seedless ***'Orah'mandarin has desirable organoleptic qualities,seeds in the fruits weaken its market *** produce new seedless cultivars that are similar to'Orah'mandarin,we performed three 2x x 4x crosses using'Orah'mandarin as the seed parent to regenerate triploid plantlets.A total of 182 triploid and 36 tetraploid plantlets were *** analyzing their genetic origins using nine novel single nucleotide polymorphism(SNP)markers,all of the triploids and tetraploids derived from these three crosses were proven to be ***,we demonstrated that 2n megagametophyte formation in'Orah'mandarin result in tetraploid production in these three interploidy *** tetraploid plantlets were genotyped using eight pericentromeric SNP markers and nine centromere distal SNP *** on the genotypes of the 2n megagametophytes,the parental heterozygosity rates in 16 SNP loci and all 2n megagametophytes were less than 50%,indicating that second division restitution was the mechanism underlying 2n megagametophyte formation at both the population and individual *** triploid hybrids enrich the germplasm available for seedless ***,the tetraploid hybrids are valuable as parents for ploidy breeding for the production of seedless citrus fruits.

关键词： Citrus 2n gamete interploidy hybridization pericentromeric SNP marker second division restitution