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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu Hui Hong wei Quan Xinyu qiao Chun Cui Chenmeng qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si Rna-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review

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World Journal of Gastroenterology 2025年第2期31卷 27-41页

作者： Jing Ye Jian-Guo Wang Rong-Qiang Liu qiao Shi wei-Xing Wang Department of General Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pancreatic Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

Intrapancreatic fat deposition(IPFD)has garnered increasing attention in recent *** prevalence of IPFD is relatively high and associated with factors such as obesity,age,and ***,the pathophysiological mechanisms underlying IPFD remain unclear,with several potential contributing factors,including oxida-tive stress,alterations in the gut microbiota,and hormonal *** was found to be highly correlated with the occurrence and prognosis of exocrine pan-creatic *** imaging techniques remain the primary diagnostic approach for IPFD,an expanding array of biomarkers and clinical scoring systems have been identified for screening ***,effective treatments for IPFD are not available;however,existing medications,such as glucagon-like peptide-1 receptor agonists,and new therapeutic approaches explored in animal models have shown considerable potential for managing this *** paper reviews the pathogenesis of IPFD,its association with exocrine pancreatic disea-ses,and recent advancements in its diagnosis and treatment,emphasizing the significant clinical relevance of IPFD.

关键词： Intrapancreatic fat deposition Pancreatic steatosis Nonalcoholic fatty pancreas disease Pancreatitis Pancreatic cancer

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan wei Yaru qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

丝素蛋白在甲醇-水混合溶剂中构象变化的光谱学研究

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光谱学与光谱分析 2010年第11期30卷 3047-3051页

作者：马林何维仁黄爱民李立硕童张法韦俏娜黄子伦广西大学化学化工学院广西南宁530004

应用圆二色谱、内源荧光和外源荧光探针研究了丝素蛋白在甲醇-水混合溶剂中的构象变化及机理。结果显示,在浓度低于30%(V/V)的甲醇-水混合溶剂中,处于无规卷曲状态的丝素蛋白可以通过疏水相互作用形成小的疏水区域,随着甲醇浓度的增加,... 详细信息

应用圆二色谱、内源荧光和外源荧光探针研究了丝素蛋白在甲醇-水混合溶剂中的构象变化及机理。结果显示,在浓度低于30%(V/V)的甲醇-水混合溶剂中,处于无规卷曲状态的丝素蛋白可以通过疏水相互作用形成小的疏水区域,随着甲醇浓度的增加,丝素蛋白发生由无规卷曲向β-折叠的构象转变,削弱了疏水侧链的相互作用。分析表明,丝素蛋白的构象变化与溶剂体系的微观结构密切相关,其稳定性主要由肽键单元与混合溶剂中的分子簇之间的相互作用决定。低浓度的甲醇-水混合溶剂保持水固有的氢键结构,对丝素蛋白肽键单元的溶剂化和丝素蛋白构象的影响较小,而随着甲醇浓度的增加,溶剂结构出现由四面体结构的水分子簇向链状结构的甲醇分子簇的转变,丝素蛋白通过形成分子内氢键减少肽键单元与溶剂分子的接触,从而引发丝素蛋白的构象转变。

关键词：丝素蛋白甲醇构象变化荧光光谱圆二色谱

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya Cheng Duan-Rui qiao Yi-Ying Liu Wen-na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-Dna Immune tolerance Antiviral therapy

Exploring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies

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World Journal of Gastroenterology 2025年第2期31卷 147-156页

作者： Tong qiao Xian-Hui Wen Department of Clinical Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Life Science and Technology Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Extensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental ***,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of *** paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and exploring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic *** fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut *** characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD ***,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary *** elucidating the complex interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关键词： Crohn’s disease Gut microbiome Dysbiosis Creeping fat Fecal microbiota transplantation

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan Fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu wei Han qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

基于化学识别模式的金花三宝口服液HPLC指纹图谱及多成分含量测定研究

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化学研究与应用 2024年第10期36卷 75-85页

作者：林婧梁洁莫迎陈睿韦宏官孙良广韦俏娜广西中医药大学药学院广西南宁530200 广西农业职业技术大学食品药品工程学院广西南宁530007

基于化学识别模式,建立HPLC指纹图谱及多成分含量测定,为金花三宝口服液的质量评价提供参考。采用HPLC法,以Capcell Pak C_(18)(250mm×4.6mm,5μm)为色谱柱,流速为0.8mL·min^(-1),流动相是甲醇(A)-0.1%磷酸水(B),柱温为30℃,进样量为1... 详细信息

基于化学识别模式,建立HPLC指纹图谱及多成分含量测定,为金花三宝口服液的质量评价提供参考。采用HPLC法,以Capcell Pak C_(18)(250mm×4.6mm,5μm)为色谱柱,流速为0.8mL·min^(-1),流动相是甲醇(A)-0.1%磷酸水(B),柱温为30℃,进样量为10μL,检测波长为266nm;建立指纹图谱并同时测定6个成分的含量,采用聚类分析(CA),主成分分析(PCA)以及偏最小二乘-判别分析(PLS-DA)对数据进行分析。指纹图谱共确定了13个共有峰,并指认了6个成分;相似度值为0.958以上;聚类分析,主成分分析将样品划分为2类,偏最小二乘-判别分析筛选出峰12,新绿原酸,芦丁等8个质量差异标志成分。含量测定结果表明:10批金花三宝口服液中新绿原酸、绿原酸、隐绿原酸、异绿原酸A、芦丁、异绿原酸C的平均含量依次为:0.2183,0.8465,0.1644,0.3790,0.0749,0.1701mg·mL^(-1)。本研究所建立的HPLC指纹图谱及多成分的含量测定准确,稳定可行,可为质量控制提供参考依据。

关键词：金花三宝口服液化学识别模式指纹图谱多成分含量测定^(*)

知识溢出、技术创新对军民融合产业产值的影响研究———以航空航天制造业为例

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价值工程 2016年第28期35卷 55-56页

作者：张维娜王华侨西北工业大学人文与经法学院西安710129

本文以航空航天制造业为例,运用我国2008-2013年19个省份的面板数据,采用逐步回归分析的方法,研究了知识溢出、技术创新对军民融合产业产值的影响以及知识溢出与技术创新之间的相互作用。结果表明:对于航空航天制造业而言,产业内的知识... 详细信息

本文以航空航天制造业为例,运用我国2008-2013年19个省份的面板数据,采用逐步回归分析的方法,研究了知识溢出、技术创新对军民融合产业产值的影响以及知识溢出与技术创新之间的相互作用。结果表明:对于航空航天制造业而言,产业内的知识溢出更有利于其产值的增长,且知识溢出对技术创新有很大的促进作用。因此,对于航天航空制造业而言,提高产业集中度更有利于其发展。

关键词：知识溢出技术创新航空航天产业产值