检索结果-南通市图书馆

Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

World Journal of Clinical Cases 2024年第14期12卷 2359-2369页

作者： wei-ming xu Hai-Fu Zhang Yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle *** studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty *** To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this *** Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant *** After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric ***,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,P<0.01),bipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,P<0.01),and PTSD(OR:5.66,95%CI:5.33-6.01,P<0.01).Meanwhile,NAFLD significantly increased the risk of developing bipolar disorder(OR:55.08,95%CI:3.59-845.51,P<0.01),OCD(OR:61.50,95%CI:6.69-565.45,P<0.01),and PTSD(OR:52.09,95%CI:4.24-639.32,P<0.01).CONCLUSION Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders,namely bipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psy

关键词： Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis of Chemically Recyclable Polyesters via Dehydrogenative Copolymerization of Diols

引用

Chinese Journal of Polymer Science 2023年第8期41卷 1206-1214,I0006页

作者： wei-ming xu Yuan-Dong Yu Meng-Xiang Ma Hui-Du xu Rui-Qin Wang Yu-Peng Pan Ke-Qin Wu wei-Ran Yang Chang-Guang Yao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China School of Resource&Environment Nanchang UniversityNanchang 330031China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Preparation of chemically recyclable polyesters by ring-opening polymerization(ROP)has made a considerable progress over the past few ***,this method involves cumbersome synthesis and minimal functional diversity of cyclic ***,it is of great significance to develop novel polymerization methods for direct polymerization of commercially available monomers to prepare recyclable polyesters with versatile *** present work,we report dehydrogenative copolymerization of commercialα,ω-diols to afford high molecular weight chemically recyclable aliphatic copolyesters(65.7 kg·mol^(-1))by using commercially available Milstein catalyst *** thermal properties of the obtained copolymers could be finely tuned by simply adjusting the feeding ratio of two *** incorporation of aliphatic or aromatic rings into polyester mainchain via copolymerization of 1,10-decanediol with 1,4-cyclohexanedimethanol and 1,4-benzenedimethanol could significantly improve the thermal properties of the resulting *** importantly,the obtained copolyesters were able to completely depolymerize back to original diols via hydrogenation by the same catalyst in solvent-free and mild conditions,thus offering a green and cost-effective route toward the preparation of widely used polyesters.

关键词： Chemically recyclable Dehydrogenative copolymerization Polyester Diol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quality assessment of friction-stir-welded aluminum alloy welds via three-dimensional force signals

引用

Advances in Manufacturing 2024年第1期12卷 61-75页

作者： Ji-Hong Dong Yi-ming Huang Jia-Lei Zhu wei Guan xu-Kai Ren Huan-wei Yu Lei Cui Beijing Institute of Petrochemical Technology Beijing102617People’s Republic of China Beijing Academy of Safety Engineering and Technology Beijing102617People’s Republic of China AVIC Manufacturing Technology Institute Beijing100024People’s Republic of China Tianjin Key Laboratory of Advanced Joining Technology School of Materials Science and EngineeringTianjin UniversityTianjin300350People’s Republic of China Shaoxing Special Equipment Testing Institute Shaoxing Key Laboratory of Special Equipment Intelligent Testing and EvaluationShaoxing312071ZhejiangPeople’s Republic of China

An online detection technology must be developed for realizing the real-time control of friction stir *** this study,the three-dimensional force exerted on a material during friction stir welding was collected synchronously and the relationship between the forces and welding quality was *** results indicated that the fluctuation period of the traverse force was equal to that of the lateral force during the stable welding *** phase difference between two horizontal forces wasπ/*** values of the horizontal forces increased with welding speed,whereas their amplitudes remained the *** proposed force model showed that the traverse and lateral forces conformed to an elliptical curve,and this result was consistent with the behavior of the measured *** variational mode decomposition was used to process the plunge *** intrinsic mode function that represented the real fluctuation in the plunge force varied at the same frequency as the spindle rotational *** tunnel defects occurred,the fluctuation period features were consistent with those obtained during normal welding,whereas the ratio parameter defined in this study increased significantly.

关键词： Friction stir welding(FSW) Three-dimensional force model Variational mode decomposition Tunnel defect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction of metallo-complexes with 2,2′:6′,2″-terpyridine substituted triphenylamine in different modified positions and their photophysical properties

引用

Chinese Chemical Letters 2024年第7期35卷 301-305页

作者： Shengwen Guan Zhaotong wei Ningxu Han Yude wei Bin xu ming Wang Junjuan Shi State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

The stable coordinated metallo-complexes based on 2,2′:6′,2″-terpyridine(tpy)and its derivatives have been widely researched for various wide-ranging applications in photoelectronics,catalysis,sensor,photoluminescence,and so ***,the most reported studies ignored the comprehensive comparison between structures modified by different positions and ***,we design a series of metallo-complexes which were assembled with tpy substituted triphenylamine(TPA)at different positions and metal ions and explored their photophysical *** the solution state,MLE_(2)based on the 5,5″-positions modification showed the highest PLQYs and PL *** the increase of solvent polarity,MLB2exhibit the largest *** the solid state,from MLA_(2)to MLE_(2),the emission colours are gradually red-shifted from yellow to *** findings in this work may pave a new way to design functional metallo-complexes,not just for PL properties.

关键词： Metallo-complexes 2 2′:6′ 2″-terpyridine Triphenylamine Different modified positions Photophysical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-Fidelity Simulation of Gas Turbine Overall Performance by Directly Coupling High-Fidelity Models of Multiple Rotating Components

引用

Journal of Thermal Science 2024年第4期33卷 1357-1378页

作者： DENG weimin xu Yibing NI ming wei Zuojun GAN Xiaohua REN Guangming Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055China School of Aerospace Engineering Tsinghua UniversityBeijing100084China Shenzhen Key Laboratory of Wide-Speed-Range and Variable-Density Continuous Wind Tunnel Shenzhen Science and Technology Innovation CommitteeShenzhen518000China

Multi-fidelity simulations incorporate computational fluid dynamics(CFD) models into a thermodynamic model,enabling the simulation of the overall performance of an entire gas turbine with high-fidelity *** iterative coupled methods rely on characteristic maps,while fully coupled methods directly incorporate high-fidelity ***,fully coupled methods face challenges in simulating rotating components,including weak convergence and complex *** address these challenges,a fully coupled method with logarithmic transformations was developed to directly integrate high-fidelity CFD models of multiple rotating *** developed fully coupled method was then applied to evaluate the overall performance of a KJ66 micro gas turbine across various off-design *** developed fully coupled method was also compared with the traditional iterative coupled ***,experimental data from ground tests were conducted to verify its *** convergence history indicated that the proposed fully coupled method exhibited stable convergence,even under far-off-design *** experimental verification demonstrated that the multi-fidelity simulation with the fully coupled method achieved high accuracy in off-design *** analysis revealed inherent differences in the coupling methods of CFD models between the developed fully coupled and traditional iterative coupled *** inherent differences provide valuable insights for reducing errors between the component-level model and CFD models in different coupling *** developed fully coupled method,introducing logarithmic transformations,offers more realistic support for the detailed and optimal design of high-fidelity rotating components within the overall performance platform of gas turbines.

关键词： multi-fidelity fully coupled method iterative coupled method gas turbine component-level model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Calibrating the linearity between grayscale and element content for X-ray KES imaging of alloys

引用

Nuclear Science and Techniques 2022年第1期33卷 1-12页

作者： Xiao-Lu Ju Biao Deng Ke Li Fu-Cheng Yu Hai-Peng Zhang ming-wei xu Guo-Hao Du Hong-Lan Xie Bin Li Ti-Qiao Xiao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China University of Chinese Academy of Sciences Beijing 100049China

Doped elements in alloys significantly impact their *** methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor penetration *** X-ray K-edge subtraction(KES)method exhibits great potential for the nondestructive in situ detection of element contents in ***,the signal of doped elements usually deteriorates because of the strong absorption of the principal component and scattering of crystal *** in turn prevents the extensive application of X-ray KES imaging to *** this study,methods were developed to calibrate the linearity between the grayscale of the KES image and element *** methods were aimed at the sensitive analysis of elements in ***,experiments with phantoms and alloys demonstrated that,after elaborate calibration,X-ray KES imaging is capable of nondestructive and sensitive analysis of doped elements in alloys.

关键词： X-ray KES imaging Grayscale calibration Element analysis for alloy Nondestructive imaging of elements

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polystyrene-supported Benzyl Selenide: An Efficient Reagent for Highly Stereocontrolled Synthesis of Substituted Olefins

引用

Chinese Chemical Letters 2003年第4期14卷 335-337页

作者： wei ming xu Li ming YU Xian HUANG Department of Chemistry Zhejiang University(Xixi Campus)Hangzhou 310028

Polystyrene-supported benzyl selenide has been prepared. This novel reagent was treated with LDA to produce a selenium stabilized carbanion, which reacted with alkyl halide, followed by selenoxide syn-elimination, to... 详细信息

关键词： Solid phase synthesis polystyrene-supported benzyl selenide substituted olefins.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between dietary niacin intake and erectile dysfunction:a population-based study

引用

Asian Journal of Andrology 2024年第4期26卷 382-388页

作者： wei-Long Lin Cheng Zheng Hao-xu Wang wei Zhang ming-En Lin Department of Urology The First Affiliated Hospital of Shantou University Medical CollegeMedical College of Shantou UniversityShantou 515041China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510260China.

Existing research on the precise link between dietary niacin intake and erectile dysfunction(ED)is ***,this study aimed to investigate the potential association between dietary niacin intake and the risk of *** logistic regression and restricted cubic splines(RCSs)were used to examine the relationship between dietary niacin intake and *** interaction analysis was performed to assess the impact of different subgroups on the study *** addition,1:1 propensity score matching(PSM)was employed to adjust for potential confounding factors,ensuring the reliability of the *** analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey(NHANES)in the *** study encompassed 3184 adults,among whom 863 participants were identified as having *** adjustments for potential confounders,the findings revealed that higher niacin intake,specifically in the highest tertile,was associated with a decreased risk of ED compared to that in the lowest tertile,showing an odds ratio(OR)of 0.56(95%confidence interval[CI]:0.37–0.85).Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of *** and interaction analyses fortified the consistency of these ***,PSM corroborated the validity of the *** study suggests an inverse association between dietary niacin intake and the risk of ***,establishing a cause-and-effect relationship remains elusive,and defining the safe threshold of niacin intake to prevent ED requires further investigation.

关键词： dietary niacin erectile dysfunction National Health and Nutrition Examination Survey propensity score matching

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development characteristics and controlling factors of fractures in lacustrine shale and their geological significance for evaluating shale oil sweet spots in the third member of the Shahejie Formation in the Qikou Sag, Bohai Bay Basin

引用

Petroleum Science 2024年第2期21卷 791-805页

作者： xu Zeng Tao Yang Jian-wei Feng Cong-Sheng Bian ming Guan wei Liu Bing-Cheng Guo Jin Dong Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing100083China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China School of Earth Sciences China University of PetroleumQingdao266400ShandongChina

Natural fractures are critical for shale oil and gas enrichment and development. Due to the extremely high heterogeneity of shale, the factors controlling the formation of internal fractures, especially horizontal fractures, remain controversial. In this study, we integrate thin section analysis and microcomputed tomography(CT) data from several lacustrine shale samples from the third member(Es3) of the Shahejie Formation, Qikou Sag, Bohai Bay Basin, to assess the fractures in detail. The goal is to reveal the development characteristics, controlling factors, and geological significance for evaluating sweet spots in a shale oil play. The fractures in the Es3contain high-angle structural and horizontal bed-parallel fractures that are mostly shear and extensional. Various factors influence fracture development,including lithofacies, mineral composition, organic matter content, and the number of laminae. Structural fractures occur predominantly in siltstone, whereas bed-parallel fractures are abundant in laminated shale and layered mudstone. A higher quartz content results in higher shale brittleness, causing fractures, whereas the transformation between clay minerals contributes to the development of bedparallel fractures. Excess pore pressure due to hydrocarbon generation and expulsion during thermal advance can cause the formation of bed-parallel fractures. The density of the bed-parallel and structural fractures increases with the lamina density, and the bed-parallel fractures are more sensitive to the number of laminae. The fractures are critical storage spaces and flow conduits and are indicative of sweet spots. The laminated shale in the Es3with a high organic matter content contains natural fractures and is an organic-rich, liquid-rich, self-sourced shale play. Conversely, the siltstone, massive mudstone, and argillaceous carbonate lithofacies contain lower amounts of organic matter and do not have bed-parallel fractures. However, good reservoirs can form in th

关键词： Fractures Development characteristics Controlling factors Shale oil Sweet spot

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2

引用

Science China(Life Sciences) 2024年第6期67卷 1305-1307页

作者： Songlin Gan Wen-Si Yang Liting wei Zhiguo Zhang Rui-ming xu Key Laboratory of Epigenetic Regulation and Intervention Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Cancer Genetics Department of Pediatrics and Department of Genetics and DevelopmentColumbia University Irving Medical CenterNew York 10032USA School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin ***... 详细信息

关键词： structure nucleosome passage

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：