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New insight into Ca^(2+)-permeable channel in plant immunity

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Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： wei Wang Hang-yuan Cheng Jian-min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. We also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome

High dose glargine alters the expression profiles of microRNAs in pancreatic cancer cells

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World Journal of Gastroenterology 2012年第21期18卷 2630-2639页

作者： wei-Guang Li Yao-Zong yuan min-min Qiao Yong-Ping Zhang Department of Gastroenterology Ruijin HospitalSchoolof MedicineShanghai Jiaotong UniversityShanghai 200025China

AIM: To investigate the effect of high dose glargine on the expression profiles of microRNAs in human pancreatic cancer cells. METHODS: Real-time polymerase chain reaction array (RT-PCR) was applied to investigate miRNAs differentially expressed in Sw1990 cells treated with or without 100 IU/L glargine. Stem-loop RT-PCR was used to confirm the results of the array assay in Sw1990 and Panc-1 cells. The effects of miR-95 on cell growth, apoptosis, invasion and migration abilities were respectively examined by CCK8 assay, apoptosis assay, Matrigel invasion and migration assay in Sw1990 and Panc-1 cells. Nude mice xenograft models with Sw1990 cells were built to investigate pancreatic cancer growth in vivo after transfection by the lentivirus pGLV3-GFP-miR-95. RESULTS: Ten miRNAs were significantly up-regulated and 2 miRNAs down-regulated in glargine treated Sw1990 cells when compared with non-treated cells (2.48-fold changes on average, P < 0.01). miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells. Stem-loop RT-PCR confirmed that high dose glargine up-regulated the expression of miR-95 and miR-134 in both Sw1990 and Panc-1 cells. The most obvious change is the apparent increase of miR-95. Forced expression of miR-95 significantly increased cell proliferation (Sw1990: 2.510 ± 0.129 vs 2.305 ± 0.187, P < 0.05; Panc-1: 2.439 ± 0.211 vs 2.264 ± 0.117, P < 0.05), invasion (Sw1990: 67.90 ± 12.33 vs 47.30 ± 5.89, P < 0.01; Panc-1: 37.80 ± 8.93 vs 30.20 ± 5.14, P < 0.01), migration (Sw1990: 101 ± 6.00 vs 51.20 ± 8.34, P < 0.01; Panc-1: 91.80 ± 9.22 vs 81.50 ± 7.47, P < 0.01) and inhibited cell apoptosis (Sw1990: 22.05% ± 1.92% vs 40.32% ± 1.93%, P < 0.05; Panc-1: 20.17% ± 0.85% vs 45.60% ± 1.43%, P < 0.05) when compared with paired negative controls, whereas knockdown of miR-95 obtained the opposite effect. Nude mice xenograft models confirmed that miR-95 promoted the

关键词： Glargine MicroRNAs Pancreatic cancer Lentivirus Cancer growth

Enhancements of Passive Film and Pitting Resistance in Chloride Solution for 316LX Austenitic Stainless Steel After Sn Alloying

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Acta Metallurgica Sinica(English Letters) 2019年第1期32卷 98-106页

作者： yuan-yuan Yang yuan-yuan Liu Man-Lang Cheng Nian-wei Dai min Sun Jin Li Yi-ming Jiang Department of Materials Science Fudan University

In the present work, the electrochemical behavior and properties of the passive film of a new Sn-alloyed 316 LX austenitic stainless steel were investigated. With the increase in Sn content in 316 LX austenitic stainless steel from 0 to 0.21%, the critical pitting temperature value increased from 32.6 to 38.8 °C, and the pitting potential increased from 0.252 V_(SCE) to 0.317 V_(SCE). Electrochemical impedance spectroscopy results showed that the corrosion resistance of passive film rose with the increase in Sn content, indicating a more stable passive film. The Mott–Schottky measurement revealed an n-type passive film with a decreased carrier concentration on the 316 LX austenitic stainless steel surface. The Cr, Sn^(2+) and Sn^(4+)(SnO, SnOHCl or SnO_2) enrichments were observed in the passive layer by X-ray photoelectron spectroscopy. The enrichment of Sn and Cr in the passive film can account for the enhanced pitting resistance of 316 LX austenitic stainless steel in chloride solution.

关键词： Austenitic stainless steel Sn alloying Pitting Chloride solution

Application of Optimal-Jerk Trajectory Planning in Gait-balance Training Robot

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 50-61页

作者： Fu yuan Diansheng Chen Chenghang Pan Jun Du Xiaodong wei min Wang Robotics Institute Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China

To accommodate the gait and balance disorder of the elderly with age progression and the occurrence of various senile diseases,this paper proposes a novel gait balance training robot(G-Balance)based on a six degree-of-freedom parallel *** the platform movement and IMU wearable sensors,two training modes,i.e.,active and passive,are developed to achieve vestibular *** reality technology is applied to achieve visual *** the active training mode,the elderly actively exercises to control the posture change of the platform and the switching of the virtual *** the passive training mode,the platform movement is combined with the virtual scene to simulate bumpy environments,such as earthquakes,to enhance the human anti-interference *** achieve a smooth switching of the scene,continuous speed and acceleration of the platform motion are required in some scenarios,in which a trajectory planning algorithm is *** paper describes the application of the trajectory planning algorithm in the balance training mode and the optimization of jerk(differential of acceleration)based on cubic spline planning,which can reduce impact on the joint and enhance stability.

关键词： Gait and balance training robot Balance training mode Optimal trajectory planning

Dense pair plasma generation and its modulation dynamics in counter-propagating laser field

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Chinese Physics B 2018年第10期27卷 433-439页

作者： wei-yuan Liu Wen Luo Tao yuan Ji-Ye Yu min Chen School of Nuclear Science and Technology University of South ChinaHengyang 421001China Key Laboratory for Laser Plasmas（MoE） School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China

With two-dimensional quantum electrodynamics（QED） particle-in-cell simulations, a dense electron-positron（e^-e~＋） pair generation from laser-solid interactions is demonstrated. When the interaction of two linearly polarized laser pulses with a thin target enters into the relativistic transparency regime, a stable standing wave（SW） field can be formed by the overlap of the two counter-propagating laser pulses directly. The present study aims to clarify the effects of the S W field on the dynamics of e^-e^＋ pair plasmas. Our results indicate that under the combined effect of the SW field and radiation reaction（RR） effect, the created e^-e^＋ pairs can be trapped into the electric field nodes when the field strength is *** trapping effect contributes to the generation of γAV≥400 and ultra-dense pair plasmas in the two-side irradiation scheme. Despite different laser intensities, these pair plasmas have a Maxwellian spectral distribution with a peak energy of 150 MeV. Besides, the periodical modulation of the average energy, spatial, phase-space, and angular patterns of the e^-e^＋ pair plasmas can be triggered. In the angular patterns, as long as the SW field exists, pair plasmas can be pinched along the laser polarization direction. These results may offer a better understanding of the laser-solid interactions in the experiments when 10-PW laser facilities come into operation in the future.

关键词： PIC simulation laser-plasma interaction standing wave radiation reaction

Fitness of F1 hybrids between stacked transgenic rice T1c-19 with cry1C*/bar genes and weedy rice

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Journal of Integrative Agriculture 2019年第12期18卷 2793-2805页

作者： HUANG Yao WANG yuan-yuan QIANG Sheng SONG Xiao-ling DAI wei-min Weed Research Laboratory College of Life Sciences Nanjing Agricultural University

Compared to single-trait transgenic crops, stacked transgenic plants may be more prone to become weedy, and transgene flow from stacked transgenic plants to weedy relatives may pose a potential environmental risk because these hybrids could be more advantageous under specific environmental conditions. Evaluation of the potential environmental risk caused by stacked transgenes is essential for assessing the environmental consequences caused by crop-weed transgene flow. The agronomic performance of fitness-related traits was assessed in F1+(transgene positive) hybrids(using the transgenic line T1 c-19 as the paternal parent) in monoculture and mixed planting under presence or absence glufosinate pressure in the presence or absence of natural insect pressure and then compared with the performance of F1–(transgene negative) hybrids(using the non-transgenic line minghui 63(MH63) as the paternal parent) and their weedy rice counterparts. The results demonstrated that compared with the F1– hybrids and weedy rice counterparts, the F1+ hybrid presented higher performance(P0.05) under natural insect pressure, respectively, lower performance(P0.05) in the absence of insect pressure in monoculture planting, respectively. And compared to weedy rice counterparts, the F1+ hybrid presented higher performance(P0.05) in the presence or absence of insect pressure in mixed planting, respectively. The F1+ hybrids presented nonsignificant changes(P>0.05) under the presence or absence glufosinate pressure under insect or non-insect pressure in monoculture planting. The all F1+ hybrids and two of three F1– hybrids had significantly lower(P<0.05) seed shattering than the weedy rice counterparts. The potential risk of gene flow from T1 c-19 to weedy rice should be prevented due to the greater fitness advantage of F1 hybrids in the majority of cases.

关键词： weedy rice hybrids stacked transgenes safety assessment fitness

Agricultural Market Name Geo-Locating System Based on an Administrative Ontology and Web Search Engine

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Journal of Integrative Agriculture 2012年第5期11卷 849-857页

作者： HU Yi-min SONG Liang-tu wei yuan-yuan HUANG He WANG Xue Institute of lntelligent Machines Chinese Academy of Sciences Hefei 230031 P.R.China School of Information Science and Teehnology University of Science and Technology of China Hefei 230026 P.R.China

The problem of associating the agricultural market names on web sites with their locations is essential for geographical analysis of the agricultural products. In this paper, an algorithm which employs the administrative ontology and the statistics from the search results were proposed. The experiments with 100 market names collected from web sites were conducted. The experimental results demonstrate that the algorithm proposed obtains satisfactory performance in resolving the problem above, thus the effectiveness of the method is verified.

关键词： agriculture markets geo-locating ontology search engine Pearson's chi-square test

Developments of mucus penetrating nanoparticles

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Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 275-282页

作者： min Liu Jian Zhang wei Shan yuan Huang Key Laboratory of Drug Targeting and Drug Delivery System Ministry of EducationWest China School of PharmacySichuan UniversityNo.17Block 3Southern Renmin RoadChengdu 610041China

Mucus can effectively protect the exposed mucosal surfaces due to its adhesive and viscoelastic *** foreign particulates are efficiently trapped in mucus layers via steric obstruction and *** particles are typically removed from the mucosal tissue within seconds to a few hours depending on their location *** article focuses on describing the tenacious mucus barrier properties,the strategies to investigate the interaction of nanoparticles with the mucus as well as the novel developments of mucus penetrating nanoparticles.

关键词： Mucus barrier Mucus penetrating nanoparticles Mucus properties Experimental strategies

A New Approach to 2,3-Dihydro-1H-1,5-Benzodiazepines from the Reaction of o-Nitrophenylazide with α,β-Unsaturated Ketones Promoted by Samarium Diiodide

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Chinese Chemical Letters 2001年第1期12卷 5-6页

作者： Xiao yuan CHEN wei Hui ZHONG Yong min ZHANG Department of Chemistry Zhejiang University at Xixi CampusHangzhou 310028 Laboratory of Organometallic Chemistry Chinese Academy of SciencesShanghai 200032 Department of Chemistry Hunan Jishou UniversityJishou416000

o-Nitrophenylazide was reduced by SmI2 in anhydrous THF at room temperature to produce active intermediate 2 (samarium amide), "living" double-anion in situ which reacted smoothly with α，β-unsaturated ketones to af... 详细信息

关键词： Samarium diiodide reduction nitro group azide 2 3-dihydro-1H-1 5-benzodiazepine.