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射血分数轻度降低的心力衰竭死亡影响因素分析及预测模型的构建

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临床心血管病杂志 2024年第6期40卷 467-474页

作者：郭威田晶张雅婧和紫铉武亭宇王雅靖张岩波韩清华山西医科大学第一医院心内科太原030001 山西医科大学公共卫生学院卫生统计学教研室、重大疾病风险评估山西省重点实验室山西省心脑血管病三高共管技术创新中心山西医科大学细胞生理学教育部重点实验室

目的:探讨射血分数轻度降低的心力衰竭(HFmrEF)全因死亡的影响因素,通过长期随访数据构建列线图模型,用于预测患者1年、2年、3年期的全因死亡率。方法:顺序入选2014年4月—2019年3月山西省3所三级甲等医院诊治的慢性心力衰竭且射血分数... 详细信息

目的:探讨射血分数轻度降低的心力衰竭(HFmrEF)全因死亡的影响因素,通过长期随访数据构建列线图模型,用于预测患者1年、2年、3年期的全因死亡率。方法:顺序入选2014年4月—2019年3月山西省3所三级甲等医院诊治的慢性心力衰竭且射血分数为41%~49%的患者1148例进行随访,以全因死亡为终点事件,随访截止日期为2022年4月1日。将所有研究对象按7:3比例随机分为训练集和验证集,训练集用于模型的构建,验证集用于模型性能的评估。利用Cox回归分析患者全因死亡的影响因素,R 4.3.1用于构建列线图预测模型。采用一致性指数(C-index)、受试者工作特征曲线下面积(AUC)和校正曲线评价模型的区分度和预测性能,通过临床决策曲线(DCA)评估模型的临床潜在应用价值。根据ROC曲线确定的最佳截断阈值对患者进行死亡风险分层,并采用Kaplan-Meier曲线比较高风险组和低风险组患者之间的生存差异。结果:多因素Cox回归分析显示,住院费用全自付(HR=4.722,95%CI:2.544~8.765)、入院NYHA心功能Ⅳ级(HR=2.982,95%CI:1.507~5.898)、N末端脑钠肽前体(对数值)[lg(NT-proBNP)]水平升高(HR=2.360,95%CI:1.414~3.938)、合并心房颤动(HR=2.321,95%CI:1.419~3.797)增加患者全因死亡风险;高估算肾小球滤过率(eGFR)水平(HR=0.984,95%CI:0.973~0.995)、服用血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂(ACEI/ARB)药物(HR=0.320,95%CI:0.191~0.535)及接受经皮冠状动脉介入治疗/冠状动脉旁路移植术(PCI/CABG)治疗(HR=0.503,95%CI:0.264~0.958)降低患者全因死亡风险。依此构建的列线图模型经测试集验证,C-index为0.839,1年、2年、3年生存期预测模型的AUC分别为0.864、0.860、0.857。校正曲线和DCA曲线结果显示,模型预测效果和实际生存情况拟合度较好,具有较好的临床适用性。风险分层能够有效区分高、低危患者的预后。结论:基于医保类型、NYHA心功能分级、NT-proBNP、eGFR、心房颤动、ACEI/ARB类药物及PCI/CABG治疗7个因素构建的列线图预测模型有助于高风险HFmrEF患者早期识别与治疗决策指导。

关键词：射血分数轻度降低的心力衰竭全因死亡影响因素列线图预测模型

Numerical study of the flow and dilution behaviors of round buoyant jet in counterflow

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Journal of Hydrodynamics 2017年第1期29卷 172-175页

作者：高猛槐文信李义天王伟杰 State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China

Pollutants are usually discharged into the receiving water bodies in the form of a turbulent jet or plume, and the presence of a counterflow enhances the initial dilution of the jet effluent. To understand the behaviors of jets in actual situations, a round buoyant jet issued horizontally into a uniform counterflow is simulated for different combinations of densimetric Froude number and jet-to-current velocity ratio. A two-phase mixture model is used to simulate this flow, and the renormalization group k - ε model is used to address the flow turbulence. The inter-phase interactions are described in terms of the relative slip velocity between phases. The jet features, including the trajectory of the jet centerline and the decay of the centedine velocity and the concentration, are investigated. The length scale analysis reveals the relationships between the distance and the centerline dilutions, and different flow mechanisms are revealed before and after the penetration point.

关键词： Buoyant jet counterflow mixture model velocity decay concentration dilution

Clinical efficacy and significance of serum fibroblast growth factor-21 and ghrelin in the treatment of type 2 diabetes complicated with coronary heart disease with integrated traditional Chinese and western medicine

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Journal of Hainan Medical University 2018年第22期24卷 13-17页

作者： Su Gao Xue tian wei-Na Jiang Yao Ma Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang110032Liaoning ProvinceChina Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang110000Liaoning ProvinceChina

Objective: To treat the patients with type 2 diabetes mellitus complicated with coronary heart disease, to explore the clinical efficacy and mechanism of conventional western medicine combined with Yiqi Yangyin Huoxue herbs, and to detect the level of serum fibroblast growth factor-21 (FGF-21) and Ghrelin. Changes and significance. Methods: A randomized control method was used to collect 100 patients with type 2 diabetes mellitus complicated with coronary heart disease who were diagnosed and treated in our hospital from March 2015 to March *** were randomly divided into two groups according to the random number table method: 50 patients separately. The patients in the control group were treated with conventional western medicine and basic treatment;the observation group was treated with the addition and subtraction of traditional Chinese medicine formulas on the basis of the control group;the clinical curative effect was evaluated after two months of treatment, and the treatment efficiency and scores of traditional Chinese medicine symptoms were observed in the two groups. Basic laboratory indicators were improved, and serum levels of FGF-21 and Ghrelin in patients were measured and the difference between the results of the tests was compared with the condition and efficacy. Results: After treatment, the total effective rate of the observation group (86.0%) was significantly higher than that of the control group (68.0%) (P0.05). After treatment, the symptom scores of the two groups were significantly improved after treatment (P<0.05). The observation group was better among the two groups (P<0.05).After treatment, the basic biochemical indicators were improved. The observation group was better than the control group (P<0.05);Serum FGF

关键词： Type 2 diabetes mellitus complicated coronary heart disease Integrated traditional Chinese and western medicine FGF-21 Ghrelin

基于经络理论的火龙罐综合灸在肺脾气虚型鼻鼽患者中的应用

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中华现代护理杂志 2024年第5期30卷 666-671页

作者：王智慧龙秀红丁丽云罗芬韦韩萍明爱红林思慧杨云帆冯甜广西中医药大学护理学院南宁530001 广西中医药大学附属瑞康医院护理部南宁530011 广西中医药大学附属瑞康医院耳鼻咽喉科头颈科门诊南宁530011

目的探讨火龙罐综合灸在肺脾气虚型鼻鼽患者中的应用。方法本研究为随机对照试验。采用便利抽样法,选取2022年10月—2023年4月在广西中医药大学附属瑞康医院耳鼻咽喉科头颈科门诊就诊的66例肺脾气虚型鼻鼽患者作为研究对象,随机分为试验... 详细信息

目的探讨火龙罐综合灸在肺脾气虚型鼻鼽患者中的应用。方法本研究为随机对照试验。采用便利抽样法,选取2022年10月—2023年4月在广西中医药大学附属瑞康医院耳鼻咽喉科头颈科门诊就诊的66例肺脾气虚型鼻鼽患者作为研究对象,随机分为试验组(n=33)与对照组(n=33)。两组均进行常规口服中药治疗;试验组在常规口服中药治疗基础上于督脉、膀胱经等循行部位进行火龙罐综合灸。比较干预前后两组患者鼻气道阻力指数(NAR),鼻部症状评分量表(TNSS)、视觉模拟量表(VAS)和汉化版鼻结膜炎生活质量调查问卷(RQLQ)得分。结果最终试验组、对照组各30例患者完成研究。干预后,试验组NAR评分低于对照组,差异有统计学意义(P<0.05);重复测量方差分析结果显示,随着治疗时间的增加,试验组的TNSS、VAS及RQLQ得分均低于对照组(P<0.05),且时间效应、组间效应及交互效应均具有统计学意义(P<0.05)。结论火龙罐综合灸能够降低患者鼻阻力,改善患者鼻部症状及鼻部伴随症状,提高患者的生活质量。

关键词：鼻鼽经络肺脾气虚火龙罐中医护理

基于NSGA Ⅱ的物流配送中车辆路径问题研究

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计算机集成制造系统 2008年第4期14卷 778-784页

作者：卫田范文慧清华大学国家CIMS工程技术研究中心北京100084

车辆路径问题已经被证明属于NP-Hard问题。针对这一问题建立了多目标优化的数学模型;构造了带精英策略的快速非支配排序遗传算法,以求解车辆路径问题的数学模型,针对物流配送路径优化,将该算法从解决连续问题扩展为解决离散问题;进行了... 详细信息

车辆路径问题已经被证明属于NP-Hard问题。针对这一问题建立了多目标优化的数学模型;构造了带精英策略的快速非支配排序遗传算法,以求解车辆路径问题的数学模型,针对物流配送路径优化,将该算法从解决连续问题扩展为解决离散问题;进行了算法设计,提出了离散问题的快速非支配排序和锦标赛选择结合的子代选择方法,并修正了以往的初始群体生成、交叉和变异的方法。通过实例比较证明,该算法可以更好地解决物流配送路径优化的多目标问题,较快找到更优解,避免早熟收敛并改进算法性能,达到较高的搜索效率。

关键词：物流配送车辆路径问题带精英策略的快速非支配排序遗传算法

Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift

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Acta Geologica Sinica(English Edition) 2022年第4期96卷 1451-1470页

作者： tian Xingwang LIU Guangdi LUO Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN wei YANG Dailin WANG Yunlong SUN Yiting DOU Shuang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China College of Geosciences China University of PetroleumBeijing 102249China Research Institute of Exploration and Development Southwest Oil and Gas Field CompanyPetroChinaChengdu 610041China

Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate *** results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate ***,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study ***,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic *** NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic *** profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type *** plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal *** them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weak

关键词： northern slope of paleo-uplift unconformity structural characteristics hydrocarbon accumulation Central Sichuan paleo-uplift Sichuan Basin

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中频炉生产大型高强度灰铸铁缸体增硫实践

铸造技术 2008年第2期29卷 170-173页

作者：田永维王敏刚郭敏海军驻兴平地区军事代表室陕西兴平713105 陕西柴油机重工有限公司陕西兴平713105

结合生产实践,分析了工频炉条件下生产大型高强度灰铸铁HT300缸体,厚壁部位易产生裂纹缺陷的主要原因是原铁液的含S量较低,造成孕育的效果比较差,导致厚大部位产生了大量的D、E型过冷石墨和铁素体,晶粒粗大,强度较低。介绍增S剂的使用... 详细信息

结合生产实践,分析了工频炉条件下生产大型高强度灰铸铁HT300缸体,厚壁部位易产生裂纹缺陷的主要原因是原铁液的含S量较低,造成孕育的效果比较差,导致厚大部位产生了大量的D、E型过冷石墨和铁素体,晶粒粗大,强度较低。介绍增S剂的使用方法和增S前后的实际对比结果,指出了适量的S范围。

关键词：高强度灰铸铁增硫缸体

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焦棓酸对猪链球菌体外抑菌效果试验

动物医学进展 2024年第7期45卷 76-81页

作者：高婷王艳君王雅雯袁芳艳刘泽文刘威杨克礼郭锐李畅黎璐田永祥周丹娜湖北省农业科学院畜牧兽医研究所湖北武汉430064 华中农业大学动物医学院湖北武汉430070 老河口牧原农牧有限公司湖北老河口441000

研究焦棓酸对猪链球菌的体外抗菌活性及对生物被膜的抑制作用,并初步探讨其抑菌机制。采用96孔微量稀释法测定常用抗菌药物及焦棓酸对猪链球菌的最小抑菌浓度和最小杀菌浓度;平板活菌计数法和分光光度计测定焦棓酸对猪链球菌作用的时间... 详细信息

研究焦棓酸对猪链球菌的体外抗菌活性及对生物被膜的抑制作用,并初步探讨其抑菌机制。采用96孔微量稀释法测定常用抗菌药物及焦棓酸对猪链球菌的最小抑菌浓度和最小杀菌浓度;平板活菌计数法和分光光度计测定焦棓酸对猪链球菌作用的时间-杀菌曲线;采用结晶紫染色法检测焦棓酸对猪链球菌生物被膜形成的影响;通过荧光定量PCR从转录水平分析焦棓酸对猪链球菌生长与生物被膜形成相关基因表达的情况。结果显示,猪链球菌2型HB菌株对磺胺异恶唑、磺胺甲恶唑耐药严重,焦棓酸对猪链球菌2型HB菌株的最小抑菌浓度为32μg/mL,最小杀菌浓度为64μg/mL,并且焦棓酸对猪链球菌的抑制作用呈剂量依赖性;焦棓酸在16μg/mL能显著抑制猪链球菌2型HB菌株生物被膜形成的能力;另外,经焦棓酸处理后,发现猪链球菌的生长、生物被膜形成、毒力相关基因ftsZ、stK、mrp、fbps、gapdh、ccpA、luxS下调表达。综上所述,焦棓酸可为耐药猪链球菌在临床上感染的治疗提供新思路。

关键词：焦棓酸猪链球菌抗菌活性生物被膜

Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology

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Chinese Journal of Natural Medicines 2021年第12期19卷 881-899页

作者： GAO Qiang HAN Zhen-Yun tian Dan-Feng LIU Gan-Lu WANG Zhen-Yi LIN Jing-Feng CHANG Ze ZHANG Dan-Dan XIE Ying-Zhen SUN Yi-Kun YAO Xing-wei MA Da-Yong Beijing University of Chinese Medicine Beijing 100029China Shenzhen Hospital of Beijing University of Chinese Medicine(Longgang) Shenzhen 518172China Department of Neurology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Key Laboratory of Chinese Internal Medicine of ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Clinical Laboratory Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China

The current study was designed to explore the brain protection mechanism of Xinglou Chengqi Decoction(XCD)based on gut microbiota analysis and network pharmacology. A transient middle cerebral artery occlusion(MCAO) model of mice was established, followed by behavioral evaluation, TTC and TUNEL staining. Additionally, to investigate the effects of gut microbiota on neurological function after stroke, C57BL/6 mice were treated with anti-biotic cocktails 14 days prior to ischemic stroke(IS) to deplete the gut microbiota. High-throughput 16S rDNA gene sequencing, metabonomics technique, and flow multifactor technology were used to analyze bacterial communities, SCFAs and inflammatory cytokines respectively. Finally, as a supplement, network pharmacology and molecular docking were applied to fully explore the multicomponent-multitarget-multichannel mechanism of XCD in treating IS, implicated in ADME screening, target identification, network analysis, functional annotation, and pathway enrichment *** found that XCD effectively improved neurological function, relieved cerebral infarction and decreased the neuronal ***, XCD promoted the release of anti-inflammatory factor like IL-10, while down-regulating pro-inflammatory factors such as TNF-α, IL-17A, and IL-22. Furthermore, XCD significantly increased the levels of short chain fatty acids(SCFAs), especially butyric acid. The mechanism might be related to the regulation of SCFAs-producing bacteria like Verrucomicrobia and Akkermansia, and bacteria that regulate inflammation like Paraprevotella, Roseburia, Streptophyta and Enterococcu. Finally, in the network pharmacological analysis, 51 active compounds in XCD and 44 intersection targets of IS and XCD were selected. As a validation, components in XCD docked well with key targets. It was obviously that biological processes were mainly involved in the regulation of apoptotic process, inflammatory response, response to fatty acid, and regulation of est

关键词： Xinglou Chengqi Decoction Ischemic stroke Gut microbiota Network pharmacology