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Journal of Genetics and Genomics 2024年第7期51卷 714-722页

作者： Zhitao tian Jingqi Jia Bo Yin wei Chen National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Metabolic network construction plays a pivotal role in unraveling the regulatory mechanism of biological activities,although it often proves to be challenging and labor-intensive,particularly with non-model *** this study,we develop a computational approach that employs reaction models based on the structure-guided chemical modification and related compounds to construct a metabolic network in *** construction results in a comprehensive structure-guided network,including 625 identified metabolites and additional 333 putative reactions compared with the Kyoto Encyclopedia of Genes and Genomes *** a combination of gene annotation,reaction classification,structure similarity,and correlations from transcriptome and metabolome analysis,a total of 229 potential genes related to these reactions are identified within this *** validate the network,the functionality of a hydroxycinnamoyltransferase(TraesCS3D01G314900)for the synthesis of polyphenols and a rhamnosyltransferase(TraesCS2D01G078700)for the modification of flavonoids are verified through in vitro enzymatic studies and wheat mutant tests,*** research thus supports the utility of structure-guided chemical modification as an effective tool in identifying causal candidate genes for constructing metabolic networks and further in metabolomic genetic studies.

关键词： Metabolic network Chemical modification Genetic study Wheat kernel Multi-omics

A novel interpretable multilevel wavelet decomposition deep network for actual heartbeat classification

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Science China(Technological Sciences) 2024年第6期67卷 1842-1854页

作者： JIN YanRui LI ZhiYuan tian YuanYuan wei XiaoYang LIU ChengLiang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Arrhythmias may lead to sudden cardiac death if not detected and treated in time.A supraventricular premature beat(SPB)and premature ventricular contraction(PVC)are important categories of arrhythmia ***,deep learning methods have been applied to the PVC/SPB heartbeats ***,most researchers have focused on time-domain information of the electrocardiogram and there has been a lack of exploration of the interpretability of the *** this study,we design an interpretable and accurate PVC/SPB recognition algorithm,called the interpretable multilevel wavelet decomposition deep network(IMWDDN).Wavelet decomposition is introduced into the deep network and the squeeze and excitation(SE)-Residual block is designed for extracting time-domain and frequency-domain ***,inspired by the idea of residual learning,we construct a novel loss function for the constant updating of the multilevel wavelet decomposition ***,the IMWDDN is evaluated on the Third China Physiological Signal Challenge Dataset and the MIT-BIH Arrhythmia *** comparison results show IMWDDN has better detection performance with 98.51%accuracy and a 93.75%F1-macro on average,and its areas of concern are similar to those of an expert diagnosis to a certain ***,the IMWDDN has good application value in the clinical screening of PVC/SPB heartbeats.

关键词： actual heartbeat classification electrocardiogram interpretable deep network multilevel discrete wavelet decomposition layer SE-Residual block

Selective adsorption of tetracycline by β-CD-immobilized sodium alginate aerogel coupled with ultrafiltration for reclaimed water

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Chinese Journal of Chemical Engineering 2024年第4期68卷 27-34页

作者： Xi Quan Jun Zhang Linlin Yin wei Zuo Yu tian State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or *** optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five ***,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 *** existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting *** possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory *** summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.

关键词： b-CD/NaAlg aerogel Covalent grafting Tetracycline antibiotics Ultrafiltration Selective adsorption Reclaimed water

Resource-saving scheduling scheme for centralized target tracking in multiple radar system under automatic blanket jamming

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Chinese Journal of Aeronautics 2024年第5期37卷 349-362页

作者： Zhengjie LI Yujie wei Junwei XIE Haowei ZHANG Yu tian Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China Air Force Xi’an Flying College Xi’an 710300China Air and Missile Defense Institute Air Force Research InstituteBeijing 100085China School of Economics and Management Beihang UniversityBeijing 100191China

This paper investigates the problem of Joint Radar Node Selection and Power Allocation(JRNSPA)in the Multiple Radar System(MRS)in the blanket jamming *** radar node independently tracks moving target and subsequently transmits the raw observation data to the fusion center,which formulates a centralized tracking network *** order to establish a practical blanket jamming environment,we suppose that each target carries the self-defense jammer which automatically implements blanket jamming to the radar nodes that exceed the preset interception ***,the Predicted Conditional Cramer-Rao Lower Bound(PC-CRLB)is derived and utilized as the tracking accuracy *** at ensuring both the tracking performance and the Low Probability of Intercept(LPI)performance,the resource-saving scheduling model is formulated to minimize the transmit power consumption while meeting the requirements of tracking ***,the Modified Zoutendijk Method Of Feasible Directions(MZMFD)-based two-stage solution technique is adopted to solve the formulated non-convex optimization *** results show the effectiveness of the proposed JRNSPA scheme.

关键词： Multiple Radar System(MRS) Centralized target tracking Resource scheduling Blanket jamming Low Probability of Intercept(LPI)

Impact of Mo/Ni alloying on microstructural modulation and low-temperature toughness of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1746-1762页

作者： wei Liu Hong-li Zhao Bing-xing Wang Yong tian State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

The high-strength low-alloy steel plates with varying Ni/Mo contents were manufactured using the thermos-mechanical control *** investigation was conducted to explore the effect of Ni/Mo microalloying on microstructure evolution and mechanical properties of the *** results revealed that the increase in Ni content from 1 to 2 wt.%reduced the transition temperature of ferrite and the growth range of ferritic grain was narrowed,which promoted grain *** optimized combination of grain size,high-angle grain boundaries(HAGBs),and martensite-austenite(M-A)islands parameter contributed to the excellent impact toughness of S1 steel at-100℃(impact absorbed energy of 218.2 J at-100℃).As the Mo increases from 0 to 2 wt.%,the matrix structure changes from multiphase structure to granular bainite,which increases the average effective grain size to~4.62 pm and reduces HAGBs proportion to~36.22%.With these changes,the low-temperature impact toughness of S3 steel is *** addition,based on the analysis of the characteristics of crack propagation path,it was found that M-A islands with low content(~2.21%)and small size(~1.76 pm)significantly retarded crack propagation,and the fracture model of M-A islands with different morphologies was further ***,correlation between behaviour of delamination and toughness was further analysed by observing delamination size and impact energy parameters.

关键词： High-strength low-alloy steel Microstructural regulation Ni addition Mo addition Crack propagation Low-temperature toughness

Steady-state multiscale CFD simulation of a circulating fluidized bed riser

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Particuology 2024年第10期93卷 54-64页

作者： Zhaojie Ke Yujie tian Fei Li Bona Lu wei Wang State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Compared to transient simulation,steady-state simulation of circulating fluidized bed risers is more efficient,but is also harder to perform due to the complex scale-dependency of dense gas-solid *** this work,steady-state computational fluid dynamics(CFD)simulation of a riser is performed using the steady energy-minimization multi-scale(EMMS)*** is found that the steady state corresponds to an extremely large scale of length and time,thus the grid size required in steady-state simulation is larger than that in transient *** time-averaged two-fluid model(TFM)coupled with the steady-state EMMS/1M drag model enables a good prediction of the S-shaped,axial solids distribution and the choking transition,whereas the two-phase turbulence and solids stress models are important in predicting the radially core-annular distribution of *** far as we know,this is the first time that one can predict the choking transition in a steady-state CFD *** improvement may need an EMMS modeling of the time-averaged solid stresses.

关键词： Fluidization Drag force Steady state Simulation Mesoscale

Ovarian function in patients with systemic lupus erythematosus:Pathogenesis,drug application and prospective therapies

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World Journal of Experimental Medicine 2024年第2期14卷 29-34页

作者： min Xu Li-Li tian Xiao-Liu Li Cheng Bao Hai-wei Zhang Hong-wei Chen Department of Rheumatology and Immunology Nanjing Drum Tower HospitalClinical College of Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina School of Life Science Nanjing Normal UniversityNanjing 210023Jiangsu ProvinceChina Department of Rheumatology and Immunology Nanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina Department of Rheumatology and Immunology Nanjing Pukou People’s HospitalNanjing 211800Jiangsu ProvinceChina Department of Rheumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of School of MedicineNanjing UniversityNanjing 210008Jiangsu ProvinceChina

Systemic lupus erythematosus(SLE)is a chronic autoimmune disease in which multiple organs are damaged that prevails in fertile ***,glucocorticoids and immunosuppressants are widely used to treat SLE ***,ovarian dysfunction occurs following the use of these drugs in women with ***,we summarize recent progress in terms of understanding ovarian injury,the effects of drug application and strategies to improve ovarian function in women with *** review could be helpful to precisely cure SLE in women desiring to have offspring.

关键词： Systemic lupus erythematosus Ovarian reserve Ovarian insufficiency Mesenchymal stem cells Fertility Autoimmune disease

Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research

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Chinese Journal of Integrative Medicine 2024年第6期30卷 551-558页

作者： HU Xiao-yi tian Zi-yu CHEN Huan HU Xiang-yu minG tian-yu PENG Hao-xuan JIAO Rui-min SHI Lan-jun XIU Wen-cui YANG Ji-wei GANG wei-juan JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina Department of Traditional Chinese Medicine Beijing Puren HospitalBeijing100062China

Objective To assess the use of evidence-based research(EBR)approach in randomized controlled trials(RCTs)of acupuncture-related therapies for primary dysmenorrhea(PD).Methods PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Database,and China Science and Technology Journal Database were searched from January 2013 to December 2022 for RCTs of acupuncture on *** full text and references of each RCT were read to assess whether systematic reviews(SRs)or other types of studies with similar research questions and end-users’perspectives were cited to justify and design the *** addition,the discussion section were analyzed to evaluate whether trials placed the new result in the existing SRs to draw a *** logistic regression was used to find variables that associated with 3 aspects of EBR approach:(1)citing clinical studies for justification,(2)citing relevant studies that obtain the perspectives of end users,and(3)citing clinical studies for results *** Of 473 RCTs included,45.67%(216)of the trials cited relevant similar studies,21.56%(102)referenced to the studies that collected end-users’perspectives,and 10.99%(52)placed result in the context of the previous *** RCTs appropriately applied EBR *** all the included studies,3.17%(15)of the trials used SRs to inform study questions but none of them used updated SRs with acceptable quality;1.05%(5)of the trials cited SRs of end-user’s perspectives in the justification and design of the study,and only 1 trial added results in existing SR to draw a *** of publication,language,funding,registration,ethical approval and number of sites were significantly associated with 1 of the 3 aspects of EBR *** Few RCTs in acupuncture-related therapies for PD used the EBR approach to minimize research ***,research institutes,funding agencies,ethics committees,journals and peer

关键词： evidence-based research acupuncture therapy primary dysmenorrhea randomized controlled trial systematic review end-usersperspective meta-research

Regulating CRISPR/Cas9 Using Streptavidin-Biotin Interactions

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Chinese Journal of Chemistry 2024年第12期42卷 1387-1393页

作者： wei Shen wei Xiong Qianqian Qi Xingyu Liu Zhongpao Xie Yuanyuan Zhang Jinxuan Hou tian tian Xiang Zhou College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China Department of Thyroid&Breast Surgery Zhongnan Hospitalof Wuhan University Wuhan Hubei43001Chin

Comprehensive Summary Currently,CRISPR/Cas9 technology has found widespread applications across various ***,the utility of CRISPR/Cas9 is encumbered by issues pertaining to its reliability and safety,primarily stemming from the uncontrolled activity of the ***,the design and development of CRISPR/Cas9 systems with controllable activity is of paramount ***,characterized by its small molecular weight,and streptavidin,distinguished by its substantial spatial steric hindrance,can be harnessed as an ideal OFF switch(termed a"bioactivity brake")due to their interaction *** this work,we present a strategy that employs the streptavidin-biotin interaction as a"brake system"for CRISPR/Cas9,effectively allowing for the shutdown of the enzymatic activity of CRISPR/Cas9.

关键词： Streptavidin-biotin CRISPR/Cas9 CRISPR-OFF Guide RNA 2'-OH acylation Gene technology DNA cleavage

Core-shell nanoparticle enhanced Raman spectroscopy in situ probing the composition and evolution of interfacial species on PtCo surfaces

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Nano Research 2024年第6期17卷 4687-4692页

作者： Jing Liu Han-Liang Zhong Xiangyu Li Mu-Fei Yue wei-min Yang Xueqiu You Jing-Hua tian Yao-Hui Wang Jian-Feng Li Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing School of Ocean Information EngineeringJimei UniversityXiamen 361021China College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China

The composition and evolution of interfacial species play a key role during electrocatalytic *** the structural evolution and intermediate during catalytic process by in situ characterization can shed new light on the electrocatalytic reaction mechanism and develop highly efficient ***,directly probing the interfacial species is extremely difficult for most spectroscopic techniques due to complicated interfacial environment and ultra-low surface ***,electrochemical core-shell nanoparticle enhanced Raman spectroscopy is utilized to probe the composition and evolution processes of interfacial species on Au@Pt,Au@Co,and Au@PtCo core-shell nanoparticle *** spectral evidences of interfacial intermediates including hydroxide radical(OH*),superoxide ion(O_(2)^(−)),as well as metal oxide species are directly captured by in situ Raman spectroscopy,which are further confirmed by the both isotopic experiment and density functional theory *** results provide a mechanistic guideline for the rational design of highly efficient electrocatalysts.

关键词： in situ Raman core-shell nanoparticle PtCo interfacial species composition and evolution