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Prevalence and risk factors of diabetes mellitus among elderly patients in the Lugu community

World Journal of Diabetes 2024年第4期15卷 638-644页

作者： li-Zhen Zhao Wei-Min Li Ying Ma Lugu Community Health Service Center West Campus Beijing Chao-yang Hospital Affiliated to Capital Medical UniversityBeijing 100043China

BACKGROUND Age is a significant risk factor of diabetes mellitus(DM).With the develop of population aging,the incidence of DM remains increasing.Understanding the epidemiology of DM among elderly individuals in a certain area contributes to the DM interventions for the local elderly individuals with high risk of DM.AIM To explore the prevalence of DM among elderly individuals in the Lugu community and analyze the related risk factors to provide a valid scientific basis for the health management of elderly individuals.METHODS A total of 4816 elderly people who came to the community for physical examination were retrospectively analyzed.The prevalence of DM among the elderly was calculated.The individuals were divided into a DM group and a non-DM group according to the diagnosis of DM to compare the differences in diastolic blood pressure(DBP)and systolic blood pressure(SBP),fasting blood glucose,body mass index(BMI),waist-to-hip ratio(WHR)and incidence of hypertension(HT),coronary heart disease(CHD),and chronic kidney disease(CKD).RESULTS DM was diagnosed in 32.70%of the 4816 elderly people.The BMI of the DM group(25.16±3.35)was greater than that of the non-DM group(24.61±3.78).The WHR was 0.90±0.04 in the non-DM group and 0.90±0.03 in the DM group,with no significant difference.The left SBP and SBP in the DM group were 137.9 mmHg±11.92 mmHg and 69.95 mmHg±7.75 mmHg,respectively,while they were 126.6 mmHg±12.44 mmHg and 71.15 mmHg±12.55 mmHg,respectively,in the non-DM group.These findings indicate higher SBP and lower DBP in DM patients than in those without DM.In the DM group,1274 patients were diagnosed with HT,accounting for 80.89%.Among the 3241 non-DM patients,1743(53.78%)were hypertensive and 1498(46.22%)were nonhypertensive.The DM group had more cases of HT than did the non-DM group.There were more patients with CHD or CKD in the DM group than in the non-DM group.There were more patients who drank alcohol more frequently(≥3 times)in the DM group than in the non-DM group.CONCLUSION Older adults in the Lugu c

关键词： Diabetes mellitus Type 2 diabetes mellitus Elderly Risk factors

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A preliminary study on photogrammetry for the FAST main reflector measurement

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Research in Astronomy and Astrophysics 2021年第7期21卷 23-30页

作者： Wei-Min Li liu-Jian Zhou Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST) is the largest single-dish radio telescope in the world. In this paper, we apply photogrammetry to measure local area surface accuracy of the FAST main reflector. Contrast with the existing photogrammetric methods that need to stick the cooperation target on the panel. In this paper, we directly detect nodes according to their natural feature. Analyzing the FAST reflector composition, we propose a two-step Hough transform method for node detection. Due to the high similarity of the neighboring area around nodes, it is hard to match two images by the feature matching method. Therefore, we apply the nodes combination approach to obtain the homography matrix between two photos for nodes matching. After nodes detection and matching,triangulation and bundle adjustment algorithms are adopted for 3 D reconstruction. During the experiment,the adjusted node position deform a local area of the FAST main reflector into a spherical cap with a radius of 300 m. The experimental result shows that the measurement accuracy of the sphere with a radius of 300 m is 12.299 mm, indicating that it is feasible to apply photogrammetry for the FAST main reflector measurement.

关键词： FAST photogrammetry node detection bundle adjustment 3D reconstruction

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Immunotherapy-related toxicity in lung cancer: clinical characteristics and managing strategy

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Chinese Medical Journal 2021年第7期134卷 780-782页

作者： Wen-Xin Luo Lan Yang Wei-Min Li Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China.

Worldwide,lung cancer is the most common malignancy and the leading cause of cancer-related death.After the era of chemotherapy,radiotherapy,and molecular-targeted therapy,the treatment of advanced lung cancer has entered a new era of immunotherapy,represented by immune checkpoint inhibitors(ICIs),including programmed cell death protein-1/programmed cell death protein ligand-1(PD-1/PD-L1)inhibitors and cytotoxic T-lymphocyte-associated antigen-4(CTLA-4)inhibitors.[1]However,patients treated with ICIs may experience unexpected systemic toxicities,some fatal.Thus,managing immunotherapy-related toxicity has become increasingly significant in patients with lung cancer.Here,we review the latest developments on the clinical features and management of immunotherapy-related toxicity in patients with lung cancer in order to promote the standardization of immunotherapy for lung cancer.

关键词： lung clinical cancer

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Evaluation method and optimization strategies of resilience for air&space defense system of systems based on kill network theory and improved self-information quantity

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Defence Technology（防务技术） 2023年第3期21卷 219-239页

作者： Qi Han Bo Pang Sen li Ning li Peng-song Guo Cheng-li Fan Wei-Min Li Air Defense and Antimissile School Air Force Engineering UniversityXi’an710051China Graduate School Air Force Engineering UniversityXi’an710051China Information and Navigation School Air Force Engineering UniversityXi’an710077China School of Automation Science and Engineering Xi'an Jiaotong UniversityXi'an710049China

Resilience of air&space defense system of systems(SoSs)is critical to national air defense security.However,the research on it is still scarce.In this study,the resilience of air&space defense SoSs is firstly defined and the kill network theory is established by combining super network and kill chain theory.Two cases of the SoSs are considered:(a)The kill chains are relatively homogenous;(b)The kill chains are relatively heterogenous.Meanwhile,two capability assessment methods,which are based on the number of kill chains and improved self-information quantity,respectively,are proposed.The improved self-information quantity modeled based on nodes and edges can achieve qualitative and quantitative assessment of the combat capability by using linguistic Pythagorean fuzzy sets.Then,a resilient evaluation index consisting of risk response,survivability,and quick recovery is proposed accordingly.Finally,network models for regional air defense and anti-missile SoSs are established respectively,and the resilience measurement results are verified and analyzed under different attack and recovery strategies,and the optimization strategies are also proposed.The proposed theory and method can meet different demands to evaluate combat capability and optimize resilience of various types of air&space defense and similar SoSs.

关键词： network optimization theory

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Moderate Deviations for Parameter Estimation in the Fractional Ornstein–Uhlenbeck Processes with Periodic Mean

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1308-1324页

作者： Hui JIANG Shi min li wei Gang WANG School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China The People's Bank of China Operations Ofice of Nanjing Branch Nanjing 210016P.R.China School of Statistics and Mathematics Zhejiang Gongshang UniversityHangzhou 310018P.R.China

In this paper,we study the asymptotic properties for the drift parameter estimators in the fractional Ornstein-Uhlenbeck process with periodic mean function and long range dependence.The Cremér-type moderate deviatio... 详细信息

关键词： Cramér-type moderate deviation fractional Ornstein-Uhlenbeck process parameter estimation multiple Wiener-Ito integrals

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The capacity of k-connectivity d-dimensional wireless networks with node failure

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Science China(Information Sciences) 2023年第10期66卷 323-324页

作者： wei li Junyu liU min SHENG Jiandong li State Key Laboratory of Integrated Service Networks Xidian University Department of Broadband Communication Peng Cheng Laboratory

In large-scale wireless networks, network structure plays a critical role in the transport process of information, especially when wireless networks encounter node failure [1]. The capability of wireless networks to carry information reliably,efficiently and timely is directly influenced by the connectivity of network structures. Meanwhile, the deployment of wireless networks has expanded from plane to space.

关键词： Wireless networks

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Construction and imaging of a neurovascular unit model

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Neural Regeneration Research 2022年第8期17卷 1685-1694页

作者： Taiwei Dong min li Feng Gao Peifeng wei Jian Wang College of Pharmacy Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinveChina

In 2001,the concept of the neurovascular unit was introduced at the Stroke Progress Review Group meeting.The neurovascular unit is an important element of the health and disease status of blood vessels and nerves in the central nervous system.Since then,the neurovascular unit has attracted increasing interest from research teams,who have contributed greatly to the prevention,treatment,and prognosis of stroke and neurodegenerative diseases.However,additional research is needed to establish an efficient,low-cost,and low-energy in vitro model of the neurovascular unit,as well as enable noninvasive observation of neurovascular units in vivo and in vitro.In this review,we first summarize the composition of neurovascular units,then investigate the efficacy of different types of stem cells and cell culture methods in the construction of neurovascular unit models,and finally assess the progress of imaging methods used to observe neurovascular units in recent years and their positive role in the monitoring and investigation of the mechanisms of a variety of central nervous system diseases.

关键词： 3D printing blood-brain barrier computational biology encephalopathy imaging techniques microfluidic on-chip methods nerve cell co-culture neurovascular unit review stem cells

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Research on tune feedback of the Hefei light SourceⅡbased on machine learning

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Nuclear Science and Techniques 2022年第3期33卷 45-52页

作者： Yong-Bo Yu Gong-Fa liu wei Xu Chuan li Wei-Min Li Ke Xuan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029AnhuiChina

The theory of tune feedback correction and the principle of a feedback algorithm based on machine learning are introduced,with a focus on the application of lasso regression for tune feedback correction.Simulation verification and online feedback correction results are presented.The results show that,after applying machine learning,the feedback accuracy of the tune feedback system was higher,and the betatron tune stability was further improved.

关键词： Storage ring Tune feedback Machine learning Lasso regression

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Effect of sevoflurane preconditioning on astrocytic dynamics and neural network formation after cerebral ischemia and reperfusion in rats

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Neural Regeneration Research 2019年第2期14卷 265-271页

作者： Qiong Yu li li Wei-Min Liang Department of Anesthesiology Huashan Hospital Fudan University

Astrocytes, the major component of blood-brain barriers, have presented paradoxical profiles after cerebral ischemia and reperfusion in vivo and in vitro. Our previous study showed that sevoflurane preconditioning improved the integrity of blood-brain barriers after ischemia and reperfusion injury in rats. This led us to investigate the effects of sevoflurane preconditioning on the astrocytic dynamics in ischemia and reperfusion rats, in order to explore astrocytic cell-based mechanisms of sevoflurane preconditioning. In the present study, 2,3,5-triphenyltetrazolium chloride staining and Garcia behavioral scores were utilized to evaluate cerebral infarction and neurological outcome from day 1 to day 3 after transient middle cerebral artery occlusion surgery. Using immunofluorescent staining, we found that sevoflurane preconditioning substantially promoted the astrocytic activation and migration from the penumbra to the infarct with microglial activation from day 3 after middle cerebral artery occlusion. The formation of astrocytic scaffolds facilitated neuroblasts migrating from the subventricular zone to the lesion sites on day 14 after injury. Neural networks increased in the infarct of sevoflurane preconditioned rats, consistent with decreased infarct volume and improved neurological scores after ischemia and reperfusion injury. These findings demonstrate that sevoflurane preconditioning confers neuroprotection, not only by accelerating astrocytic spatial and temporal dynamics, but also providing astrocytic scaffolds for neuroblasts migration to ischemic regions, which facilitates neural reconstruction after brain ischemia.

关键词： nerve regeneration sevoflurane ischemia and reperfusion neuroprotection astrocytes dynamics neuroblast glial scar neural network stroke inhalational anesthetics neural regeneration

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Deformation Behavior and Microstructure Evolution of AZ31 Mg Alloy by Forging-Bending Repeated Deformation with Multi-pass Lowered Temperature

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金属学报:英文版 2023年第8期36卷 1317-1335页

作者： minhao li liwei Lu Yuhui wei min Ma weiying Huang School of Mechanical Engineering Hunan University of Science and TechnologyXiangtan411201China Hunan Jinfeng Mechanical Technology Co. Ltd.Loudi417700China School of Materials Science and Engineering Hunan University of Science and TechnologyXiangtan411201China Jiangsu Dayang Precision Forging Co. Ltd.Yancheng224000China Key Laboratory of Efficient and Clean Energy Utilization School of Energy and Power EngineeringChangsha University of Science and TechnologyChangsha410114China

In this study, AZ31 Mg alloy was processed by a new severe plasticity deformation methodology with multi-pass lowered temperature, and the deformation behavior and microstructure evolution were investigated by finite element method and electron back-scattered diffraction technique and hardness. The results show that with the increase of deformation pass, the strain gradually springs, and its interval distribution tends to homogenize. Meanwhile, the effective strain increases dramatically with the shear force sudden upgrade in the deformation process. Moreover, the new deformation technique can refine grain size remarkably. With the passes on, {10-12} tensile twins behavior and the pyramidal slip are triggered more frequently, leading to the completeness of dynamic recrystallization (DRX) gradually, which weaken and disperse the basal texture obviously. Besides, the standard deviation of hardness is getting smaller, and the maximum can reach 78.40 HV on average, which can be attributed to the even large strain distribution, complete DRX, and the high geometrically necessary dislocation.

关键词： AZ31 magnesium alloy sheet Forging-bending repeated deformation-Characterization Microstructure evolution Deformationbehavior

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