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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia Ming Sun Hai Huang wei-lin jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

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The updated landscape of tumor microenvironment and drug repurposing

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1052-1067页

作者： Ming-Zhu jin wei-lin jin Institute of Nano Biomedicine and Engineering Shanghai Engineering Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringKey Laboratory for Thin Film and Microfabrication Technology of Ministry of EducationSchool of Electronic Information and Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240P.R.China Shanghai Jiao Tong University School of Medicine Shanghai 200025P.R.China

Accumulating evidence shows that cellular and acellular components in tumor microenvironment(TME)can reprogram tumor initiation,growth,invasion,metastasis,and response to *** research and treatment have switched from a cancercentric model to a TME-centric one,considering the increasing significance of TME in cancer ***,the clinical efficacy of therapeutic strategies targeting TME,especially the specific cells or pathways of TME,remains *** the chemopathological characteristics of TME and crosstalk among one another can greatly benefit further studies exploring effective treating ***,we present an updated image of TME with emphasis on hypoxic niche,immune microenvironment,metabolism microenvironment,acidic niche,innervated niche,and mechanical *** then summarize conventional drugs including aspirin,celecoxib,β-adrenergic antagonist,metformin,and statin in new antitumor *** drugs are considered as viable candidates for combination therapy due to their antitumor activity and extensive use in clinical *** also provide our outlook on directions and potential applications of TME *** review depicts a comprehensive and vivid landscape of TME from biology to treatment.

关键词： microenvironment drugs metabolism

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The arsenal of TP53 mutants therapies:neoantigens and bispecific antibodies

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1935-1936页

作者： Chang Yang Ge Lou wei-lin jin Department of Gynecology Oncology The Tumor HospitalHarbin Medical UniversityHarbinP.R.China lnstitute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhouP.R.China

A recent research published in Science by Hsiue et al.1 introduced a CD3-targeting bispecific antibody that can bind to tumor cells by recognizing mutation-associated neoantigens and activate T cell-mediated tumor kil... 详细信息

关键词： TP53 antigens

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Internal Stress Distribution Model of the Magnetomechanical Hysteresis of Fe-Cr-Al Based Alloys

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Journal of Materials Science & Technology 2011年第5期27卷 471-474页

作者： Renrong lin wei jin Mingzhou Cao Rui Yang Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

The damping capacities of Fe-13Cr-6AI, Fe-12Cr-1Mo-6AI and Fe-12Cr-1Mn-6Al （at.%） alloys as a function of strain-amplitude tested in a given static load are characterized in the 3-point bending deformation mode. After being modified, Smith-Birchak model is applied to describe the results. It is shown that the modified model agrees with the experimental data much better than the original one. Finally, the influences of stress factors on the damping capacity of the alloys are analyzed.

关键词： Magnetomechanical damping Static load Smith-Birchak model 3-point bending

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Microglia in neurodegenerative diseases

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Neural Regeneration Research 2021年第2期16卷 270-280页

作者： Yu Xu Ming-Zhu jin Ze-Yong Yang wei-lin jin Department of Anesthesiology International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Embryo Original DiseaseShanghai Municipal Key Clinical SpecialtyShanghaiChina Shanghai Jiao Tong University School of Medicine ShanghaiChina Institute of Nano Biomedicine and Engineering Department of Instrument Science and EngineeringKey Laboratory for Thin Film and Microfabrication Technology of Ministry of EducationSchool of Electronic Information and Electronic EngineeringShanghai Jiao Tong UniversityShanghaiChina National Centers for Translational Medicine Shanghai Jiao Tong UniversityShanghaiChina Shaanxi Key Laboratory of Brain Disorders&Institute of Basic and Translational Medicine Xi’an Medical UniversityXi’anShaanxi ProvinceChina

A major feature of neurodegeneration is disruption of central nervous system homeostasis,during which microglia play diverse *** the central nervous system,microglia serve as the first line of immune defense and function in synapse pruning,injury repair,homeostasis maintenance,and regulation of brain development through scavenging and *** pathological conditions or various stimulations,microglia proliferate,aggregate,and undergo a variety of changes in cell morphology,immunophenotype,and *** review presents the features of microglia,especially their diversity and ability to change dynamically,and reinterprets their role as sensors for multiple stimulations and as effectors for brain aging and *** review also summarizes some therapeutic approaches for neurodegenerative diseases that target microglia.

关键词： central nervous system microglia neurodegeneration neuroinflammation plasticity

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Cell perturbation in choroid plexus and cortex aiding COVID-19 neurological symptoms

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Science Bulletin 2021年第24期66卷 2442-2444页

作者： Xiao-Yuan Mao wei-lin jin Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha 410008China Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of PharmacogeneticsChangsha 410078China Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of EducationChangsha 410078China National Clinical Research Center for Geriatric Disorders Changsha 410008China Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000China

Patients with coronavirus disease 2019 (COVID-19) often succumb to neurological manifestations such as loss of smell, headache, disturbed consciousness, seizure, and stroke. In a recent paper published in Nature, Yang et al.[1] reported substantial cellular perturbations in the choroid plexus and cortex, notably an infiltration of peripheral T cells into the parenchyma and microglial activation and astrogliosis with distinct transcriptional profiles. These findings provide a complex view of the cellular and molecular processes underlying COVID-19-related neurological abnormalities.

关键词：神经症状 al. cortex

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Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells

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Protein & Cell 2016年第5期7卷 351-361页

作者： Jie Gao Yue Ma Hua-lin Fu Qian Luo ZhenWang Yu-Huan Xiao Hao Yang Da-Xiang Cui wei-lin jin School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China institute of Nano Biomedicine and Engineering Department of Instrument Science and Engineering School of Electronic Information and Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China Department of Experimental Surgery Tangdu Hospital Fourth Military Medical University Xi'an 710038 China Clinical Stem Cell Research Center Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

The methylcytosine dioxygenases TET proteins （TET1, TET2, and TET3） play important regulatory roles in neural function. In this study, we investigated the role of TET proteins in neuronal differentiation using Neuro2a cells as a model. We observed that knockdown of TET1, TET2 or TET3 promoted neuronal differentiation of Neuro2a cells, and their overexpression inhibited VPA （valproic acid）-induced neuronal differentiation, suggesting all three TET proteins negatively regulate neu- ronal differentiation of Neuro2a cells. Interestingly, the inducing activity of TET protein is independent of its enzymatic activity. Our previous studies have demon- strated that srGAP3 can negatively regulate neuronal differentiation of Neuro2a cells. Furthermore, we revealed that TET1 could positively regulate srGAP3 expression independent of its catalytic activity, and srGAP3 is required for TET-mediated neuronal differentiation of Neuro2a cells. The results presented here may facilitate better understanding of the role of TET proteins in neuronal differentiation, and provide a possible therapy target for neuroblastoma.

关键词： methylcytosine dioxygenase TET1,srGAP3 neuronal differentiation neuroblastoma cells

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The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

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Towards sustainable adversarial training with successive perturbation generation

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 527-539页

作者： wei lin Lichuan LIAO College of Computer Science and Mathematics Fujian University of TechnologyFuzhou 350118China College of Economics and Management Xi’an University of TechnologyXi’an 710048China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fujian University of TechnologyFuzhou 350118China

Adversarial training with online-generated adversarial examples has achieved promising performance in defending adversarial attacks and improving robustness of convolutional neural network ***,most existing adversarial training methods are dedicated to finding strong adversarial examples for forcing the model to learn the adversarial data distribution,which inevitably imposes a large computational overhead and results in a decrease in the generalization performance on clean *** this paper,we show that progressively enhancing the adversarial strength of adversarial examples across training epochs can effectively improve the model robustness,and appropriate model shifting can preserve the generalization performance of models in conjunction with negligible computational *** this end,we propose a successive perturbation generation scheme for adversarial training(SPGAT),which progressively strengthens the adversarial examples by adding the perturbations on adversarial examples transferred from the previous epoch and shifts models across the epochs to improve the efficiency of adversarial *** proposed SPGAT is both efficient and effective;e.g.,the computation time of our method is 900 min as against the 4100 min duration observed in the case of standard adversarial training,and the performance boost is more than 7%and 3%in terms of adversarial accuracy and clean accuracy,*** extensively evaluate the SPGAT on various datasets,including small-scale MNIST,middle-scale CIFAR-10,and large-scale *** experimental results show that our method is more efficient while performing favorably against state-of-the-art methods.

关键词： Adversarial training Adversarial attack Stochastic weight average Machine learning Model generalization

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Non-convexity Pricing and Allocating Costs in Stochastic Electricity Markets

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1466-1477页

作者： wei lin Zhifang Yang Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology College of Electrical EngineeringChongqing UniversityChongqing 400030China

Stochastic electricity markets have drawn attention due to fast increase of renewable *** results in two issues:one is to reduce uplift payments arising from non-convexity under renewable uncertainties,and the other one is to allocate reserve costs based on renewable *** resolve the first issue,a convex hull pricing method for stochastic electricity markets is *** dual variables of system-wide constraints in a chance-constrained unit commitment model are shown to reduce expected uplift payments,together with developing a linear program to efficiently calculate such *** resolve the second issue,an allocation method is proposed to allocate reserve costs to each renewable power plant by explicitly investigating how renewable uncertainties of each renewable power plant affect reserve *** proposed methods are validated in a 24-period 3-unit test example and a 24-period 48-unit utility example.

关键词： Convex hull pricing cost allocation non-convexity renewable uncertainty stochastic electricity market

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