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ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS

World Journal of Traditional Chinese Medicine 2016年第2期 81-81页

作者： Grace Gar-Lee Yue Julia Kin-Ming Lee Hin-Fai Kwok Da-Rong Wu Shao-Hua Liu wei-lie xiao.clara bik-san lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Chengdu No.1 Pharmaceutical Group Co. Ltd. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Introduction:Heteronone B(HB)is a labdane diterpene isolated from Leonurus heterophyllus Sweet which is known as Yimucao in Chinese medicines and is traditionally used for the treatment of gynaecological *** was first... 详细信息

关键词： HB ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS RNA

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AN IN VITRO PLATFORM FOR SCREENING CHINESE HERBAL MEDICINES THAT INHIBIT CANCER STEM-LIKE CELLS IN BREAST CANCER

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World Journal of Traditional Chinese Medicine 2016年第2期 81-81页

作者： Hoi-Wing Leung Chun-Hay Ko Grace Gar-Lee Yue clara bik-san lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong

Introduction:With the high recurrence rate of breast cancer,cancer stem-like cells(CSCs)are believed to be one of the possible cause of cancer *** are subpopulation among cancer cells that possess stem cell characteri... 详细信息

关键词： AN IN VITRO PLATFORM FOR SCREENING CHINESE HERBAL MEDICINES THAT INHIBIT CANCER STEM-LIKE CELLS IN BREAST CANCER

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Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-sang W ang Shun-Wa Tsang King-lau Chow Philip Chun Yeung John Wong Paul Bo-san Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell

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