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Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway

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Current Medical Science 2024年第1期44卷 93-101页

作者： li-wei zhang Hong-qi FENG Song-bo FU Dian-jun SUN Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityNHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University)Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin 150086China

Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein *** induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the *** study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial *** A low Se and low protein animal model was *** hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).EliSA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)***-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(P<0.05 for all).The mRNA and protein expression levels of PINK1,Parkin and MAP1LC3B were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(P<0.05 for all).Conclusion Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.

关键词： Keshan disease low selenium and low protein myocardial mitochondrial injury PTEN induced putative kinase 1(PINK1)/Parkin mitochondrial autophagy

Digital generation of super-Gaussian perfect vortex beams via wavefront shaping with globally adaptive feedback

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High Power Laser Science and Engineering 2024年第1期12卷 42-51页

作者： Rui Ma Ke Hai Luo Jing Song He wei li zhang Dian Yuan Fan Anderson S.L.Gomes Jun liu International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhenChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Fiber Optics Research Centre School of Information and Communication EngineeringUniversity of Electronic Science and Technology of ChinaChengduChina Departamento de Física Universidade Federal de PernambucoRecife-PEBrazil

High-intensity vortex beams with tunable topological charges and low coherence are highly demanded in applications such as inertial confinement fusion(ICF) and optical communication. However, traditional optical vortices featuring nonuniform intensity distributions are dramatically restricted in application scenarios that require a high-intensity vortex beam owing to their ineffective amplification resulting from the intensity-dependent nonlinear effect. Here, a low-coherence perfect vortex beam(PVB) with a topological charge as high as 140 is realized based on the super-pixel wavefront-shaping technique. More importantly, a globally adaptive feedback algorithm(GAFA) is proposed to efficiently suppress the original intensity fluctuation and achieve a flat-top PVB with dramatically reduced beam speckle contrast. The GAFA-based flat-top PVB generation method can pave the way for high-intensity vortex beam generation,which is crucial for potential applications in ICF, laser processing, optical communication and optical trapping.

关键词： digital micromirror device flat-top beam orbital angular momentum perfect vortex beam random fiber laser

Application of alginate in inflammatory bowel disease

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Biomedical Engineering Communications 2024年第2期3卷 10-16页

作者： Rui-Xue Kang Ying Zhuang Ming-Jie liu Qi Han wei-li zhang wei-Yu Fan Xue Gao Jia-Zheng Zhou Jian-Bin zhang Collage of Pharmacy Dalian Medical UniversityDalian 116044China Laboratory Animal Center Dalian Medical UniversityDalian 116044China

Inflammatory bowel disease(IBD)represents a chronic inflammatory condition profoundly impacting the gastrointestinal *** prevalence has markedly risen in both developed and developing nations over recent *** the absence of definitive etiological elucidation,therapeutic strategies predominantly revolve around pharmacological interventions aimed at symptom ***(AG)is a polysaccharide of marine origin that has garnered significant attention due to its inherent biocompatibility,pH sensitivity,and *** exploration within drug delivery systems for IBD treatment stems from its natural sourcing,non-cytotoxic nature,and economic ***,AG demonstrates facile interpolymeric cross-linking,facilitating the formation of a cohesive network conducive to sustained drug release ***-based carrier systems for sustained drug release,and targeted drug delivery have been widely *** article reviews the pathogenesis of IBD and the current drugs,AG-based drug delivery systems and their properties in alleviating *** prospect of further development of AG in the field of biopharmaceutical and drug delivery is prospected.

关键词： alginate inflammatory bowel disease drug delivery

Analysis of operational parameters affecting denitrification rate of sintering flue gas in cross-flow activated coke purification facility

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Journal of Iron and Steel Research International 2020年第8期27卷 887-897页

作者： wei-li zhang Sheng-li Wu Zhong-jie Hu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Baoshan Iron and Steel Co. Ltd.Shanghai 201999China

The denitrification rate of the cross-flow activated coke flue gas purification facility varies with operational parameters. According to the simulated experiments, the denitrification rate with the height drop of the denitrification unit experiences 100%, rapid decreasing, and gradual rising to the equilibrium. According to the correlation analysis results based on production data, several operational parameters affecting the denitrification rate have been obtained. The denitrification rate has negative relationships with the activated coke bed temperature, the flue gas flow, the H2O content, the SO2 content and the NH3 slip, and has positive relationships with the O2 content, the NOx content, the NH3–NOx molar ratio, the flue gas pressure and the regeneration temperature. Properly increasing the sintering air leakage or the cooling air added into flue gas is beneficial to increase the denitrification rate. Priority should be given to O2, NH3–NOx molar ratio and flue gas flow to improve the denitrification rate. Additionally, a linear model, which had been validated, was developed and can be used to predict and control the denitrification rate.

关键词： Denitrification Activated coke Operational parameter Sintering flue gas Statistical analysis

Properties change of activated coke for sintering flue gas purification in cyclic removal of SO_(2) and NO_(x)

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Journal of Iron and Steel Research International 2021年第6期28卷 641-650页

作者： Sheng-li Wu wei-li zhang Zhong-jie Hu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Ironmaking Plant Baoshan Iron and Steel Co.Ltd.Shanghai 201999China

The properties of activated coke(AC)for sintering flue gas purification greatly affect the efficiency of desulfurization and denitration,but they gradually change during *** change in properties of coal-based AC during cycles was studied to clarify the change law and AC optimization *** AC oxygen content rapidly increases 13.49 to 17.87 wt.%in the early cycles to form phenol,which promotes the denitration rate 55.63%to 78.20%.The denitration performance slowly increases in subsequent cycles becaof the generation of quinone AC slow ***,the oxygen-containing groups are not conducive to adsorption capacity of AC for *** adsorbed NO species which can be replaced SO2 is the main NO species on AC,and its amount decreases with the decrease in CC content of *** AC chemical loss leads to the opening of closed pores,expansion of original pores and formation of new pores,causing micropore volume to increase 0.085%to 0.152%,compressive strength to decrease 472 to 336 N,and abrasive resistance to decrease 97.87%to 94.16%during *** low oxygen content and high micropore volume are favorable to the initial desulfurization performance,and the former is more *** a while,the desulfurization rate is linearly positively correlated with the micropore volume regardless of the chemistry.4-h desulfurization rate increased 69.03%to 85.91%during 25 cycles due to the increasing micropore *** AC properties change in cycles will greatly affect the desulfurization and denitration rate in the height direction of the flue gas purification *** the coal-based AC with moderate micropore volume,easy oxidation surface and less original oxygen-containing groups facilitates the better purification efficiency at lower cost for sintering plants.

关键词： Activated coke Sintering flue gas Purification Desulfurization Denitration Cycle

Parametrization of the Quadratic Function Fields Whose Divisor Class Numbers are Divisible by Three

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Acta Mathematica Sinica,English Series 2009年第4期25卷 593-596页

作者： wei li Xian Ke zhang Department of Mathematical Sciences Tsinghua University Beijing 100084 P. R. China

A parametrization of quadratic function fields whose divisor class numbers are divisible by 3 is obtained by using free parameters when the characteristics of the fields are not 3.

关键词： quadratic function fields divisor class numbers

2D Co metal-organic framework nanosheet as an oxidase-like nanozyme for sensitive biomolecule monitoring

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Rare Metals 2023年第3期42卷 797-805页

作者： Jia-wei Guo Zhong-wei Yang Xiu-li liu li-wei zhang wei-Bo Guo Jian zhang Long-Hua Ding Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China School of Chemistry and Chemical Engineering Linyi UniversityLinyi276005China Department of Biology and Biological Engineering Chalmers University of Technology41296 GoteborgSweden

Nanozyme-based biomolecules sensitive and quantitative detection is an attractive strategy due to their high chemical,thermal stability and reactive ***,we have synthesized a significant number of two-dimensional(2D)cobalt-metal-organic framework(Co-MOF)nanosheets with oxidase(OXD)-like activity using a facile solvothermal method in one pot for biomolecule monitoring.

关键词： attractive cobalt facile

Estimation of interfacial damage in composites with reinforced particles based on ultrasonic data

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Journal of University of Science and Technology Beijing 2007年第3期14卷 280-285页

作者： Xiqiang liu Peijun wei li zhang Hang Wang Applied Science School University of Science and Technology Beijing Beijing 100083 China

The scattering of elastic waves by a spherical particle with imperfect interface and the nondestructive detection of interfacial damage were studied. First, the scattering of elastic waves by a spherical particle with imperfect interface, i.e. spring interface model, was studied. Then, multiple scattering by random distributed particles was investigated and the equations to evaluate the velocity and attenuation of effective waves defined by statistic averaging were given. Furthermore, on the basis of the established relation between the velocity and interfacial constants, a method to evaluate the interfacial damage nondestructively from the ultrasonic data was pro- posed. Numerical simulation was performed for the SiC-Al composites. The velocities of the effective waves were computed to show the influence of the interface constants. Using the genetic algorithm, the interfacial damage was evaluated from the synthetic experi- mental data with various noise levels. The numerical results showed the feasibility of the method proposed.

关键词： spring model average waves scattering genetic algorithm inverse problem

Clinical utility of automated platelet clump count in the screening for ethylene diamine tetraacetic acid-dependent pseudothrombocytopenia

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Chinese Medical Journal 2011年第20期124卷 3353-3357页

作者： WU wei GUO Ye zhang lin CUI wei li wei zhang Shuo Department of Laboratory Peking Union Medical College Hospitaland Chinese Academy of Medical Sciences Be~iing 100730 China

Background Platelet （PLT） clumping occurring in pseudothrombocytopenia （PTCP） can result in inaccurate PLT. Automated platelet clump count （APCC） is a quantitative parameter of platelet aggregation. In this study, we evaluated the clinical utility of APCC in the screening for platelet aggregation related ethylene diamine tetraacetic acid （EDTA）-dependent PTCP （EDTA-PTCP）. Methods A total of 105 patients and 200 healthy individuals were enrolled in this study. Blood samples were collected with dipotassium EDTA and sodium citrate respectively. ADVIA 2120 hematology analyzer was used to perform complete blood count （CBC） and APCC. Blood smears of both EDTA- and citrate-anticoagulated samples were made for microscope observation and manual PLT counting. Results In 25 patients with EDTA-PTCP patients, for EDTA-2K anticoagulated-blood, PLT was （55±6）×10^9/L, significantly lower than citrate anticoagulated blood （（186±13）×10^9/L））. APCC was （905±694）×10^9/L, significantly higher than citrate anticoagulated blood （98±37）×10^9/L. In true thrombocytopenia and healthy control groups, APCC was （63±60）×10^9/L and （69±59）×10^9/L respectively and there was no significant difference between EDTA and citrate anticoagulants. Receiver operator characteristic （ROC） curve showed both sensitivity and specificity of APCC were 96% when the cutoff value of APCC was set as 182×10^9/L. Other platelet parameters had poor performance. Conclusion The APCC has a good sensitivity and specificity in differentiating EDTA-PTCP from true thrombocytopenia compared with other platelet parameters.

关键词： automated platelet clump count thrombocytopenia hematology analyzers