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三种空心钉构型踝关节融合的有限元分析

中国矫形外科杂志 2024年第8期32卷 744-749页

作者：张宁康颂科李伟延李强朱涛山东第一医科大学附属人民医院手足外科山东济南271199

[目的]通过有限元分析,研究空心钉不同构型对镜下踝关节融合稳定性的影响。[方法]选择1例37岁男性志愿者为研究对象,螺旋CT自膝关节至足底进行薄层扫描,获得DICOM图像导入到Mimics中分割跟骨、距骨、胫骨、腓骨三维点云,Geomagic、Hyper... 详细信息

[目的]通过有限元分析,研究空心钉不同构型对镜下踝关节融合稳定性的影响。[方法]选择1例37岁男性志愿者为研究对象,螺旋CT自膝关节至足底进行薄层扫描,获得DICOM图像导入到Mimics中分割跟骨、距骨、胫骨、腓骨三维点云,Geomagic、Hypermesh中模拟构建踝关节有限元模型,分别建立正常对照模型和双钉平行、双钉交叉和三钉交叉的踝关节融合模型。观察模型中胫距关节面相对位移、Mises应力峰值及平均Mises应力。[结果]载荷下双钉平行组位移显著大于双钉交叉组和三钉交叉组,包括跖屈[(106.2±8.6)μm vs (58.9±4.5)μm vs (58.5±4.1)μm, P0.05)。双钉平行组空心钉的应力峰值大于双钉交叉组和三钉交叉组,其中站立状态下(65.5MPa, 51.3 MPa, 50.5 MPa),双钉平行组胫距关节平均Mises应力显著小于双钉交叉组、三钉交叉组(P0.05)。[结论]双钉交叉组、三钉交叉组空心钉构型的稳定性优于双钉平行组,有利于提高镜下踝关节融合的成功率。

关键词：踝关节融合关节镜内固定有限元分析

Enantioseparation of Racemic Anti-hepatitis New Drug Bicyclol with Crystallization

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Chinese Chemical Letters 2005年第11期16卷 1471-1473页

作者： wei HU yan li Chun Zhen ZHANG Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050

The enantioseparation of anti-hepatitis new drug （±）-bicyclol was performed by optically active alkaloid. The alcoholic acid, the hydrolysate of bicyclol was reacted with optically active alkaloid, such as brucine, strychnine, quinidine etc., the diastereoisomeric salts were obtained by fractional recrystallization, then separately decomposed and esterified to obtain the two enantiomers of bicyclol. The pharmacological study showed that the effect of （-）-bicyclol was more potent than racemic bicyclol two times and the potency of （＋）-bicyclol was incative.

关键词： (±)-Bicyclol,4,4'-dimethoxy-2,3,2 3'-bis(methylenedioxy)-6-hydroxymethyl-6'-methoxy-carbonyl biphenyl anti-hepatitis resolution.

Radar target recognition based on micro-Doppler effect

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Optoelectronics Letters 2008年第6期4卷 456-459页

作者： DONG wei-guang li yan-jun College of Astronautics Northwestern Polytechnical University Xi ＇an 710072 China

Mechanical vibration of target structures will modulate the phase function of radar backscattering,and will induce the frequency modulation of returned signals from the target. It generates a side bands of the target body Doppler frequency shift,which is helpful for target recognition. Based on this,a micro-Doppler atomic storehouse is built for the target recognition,and four kinds of common classifiers are used separately to perform the classified recognition. The simulation experimental results show that this method has high recognition rate above 90%.

关键词：雷达目标显微多普勒效应信息处理后向散射

Trajectories of oxygen saturation within 6–72 hours after birth in neonates at moderate altitude:a prospective longitudinal cohort study

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World Journal of Pediatrics 2023年第9期19卷 894-901页

作者： Qu‑Ming Zhao Hong‑yan Chen Shi‑Xiu li wei‑li yan Xiao‑Jing Hu Guo‑Ying Huang Children’s Hospital of Fudan University National Children’s Medical Center399 Wan Yuan RoadShanghai 201102China Shanghai Key Laboratory of Birth Defects 399 Wan Yuan RoadShanghai 201102China Luchun County People’s Hospital LuchunChina Research Unit of Early Intervention of Genetically Related Childhood Cardiovascular Diseases(2018RU002) Chinese Academy of Medical SciencesShanghaiChina

Trajectories of pulse oxygen saturation(SpO_(2))within the first few days after birth are important to inform the strategy for identifying asymptomatic hypoxemic disease but remain poorly substantiated at higher *** We performed a longitudinal cohort study with consecutive neonates at a local hospital in Luchun County,China,at an altitude of 1650 m between January and July *** repeatedly measured the pre-and post-ductal SpO_(2)values at 6,12,18,24,36,48,and 72 hours after birth for neonates without oxygen *** neonates underwent echocardiography and were followed up to 42 days after *** included neonates without hypoxemic diseases to characterize the trajectories of SpO_(2)over time using a linear mixed *** considered the 2.5th percentile as the reference value to define hypoxemic *** A total of 1061 neonates were ***-five had non-cardiac hypoxemic diseases,with 84%(21/25)presenting with abnormal SpO_(2)within 24 *** had tetralogy of Fallot identified by *** the 1035 asymptomatic neonates,SpO_(2)values declined from 6 hours after birth,reached a nadir at 48 hours,and tended to level off thereafter,with identical patterns for both pre-and post-ductal SpO_(2).The reference percentile was 92%for both pre-and post-ductal SpO_(2)and was time *** A decline within 48 hours features SpO_(2)trajectories within the first 72 hours at moderate *** findings suggest that earlier screening may favorably achieve a benefit–risk balance in identifying asymptomatic hypoxemic diseases in this population.

关键词： Critical congenital heart disease Hypoxemic disease Pulse oximetry screening Pulse oxygen saturation

Changes of Cu, Zn, and Cd speciation in sewage sludge during composting

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Journal of Environmental Sciences 2005年第6期17卷 957-961页

作者： GAO Ding ZHENG Guo-di CHEN Tong-bin LUO wei GAO wei ZHANG Yi-an li yan-xia Center for Environmental Remediation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

The potential toxicity risks from heavy metals depend on their chemical speciation. The four stages of the Tessier sequential extraction method were employed to investigate changes in heavy metal speciation （Cu, Zn, and Cd） of sewage sludge during forced aeration composting, and then to identify whether the composting process would reduce or enhance their toxicities. Throughout the composting process, the exchangeable, carbonate-bound, Fe-Mn oxide-bound, and organic matter-bound fractions of Cu were converted to the residual Cu fraction. The organic matter-bound Cu fraction greatly contributed to this transformation. Residual Zn fraction was transformed to the Fe-Mn oxide-bound and organic matter-bound fractions after composting. The residual Zn fraction was a major contributor to the organic matter-bound Zn fraction. The availability of Cu and Zn was reduced by composting such that the risk of heavy metal toxicity decreased with prolonged treatment times. Additionally, attention should be paid to the increased availability of Cd in sewage sludge after composting treatment.

关键词： composting distribution heavy metal sewage sludge speciation

Robust Interval State Estimation for Distribution Systems Considering Pseudo-measurement Interval Prediction

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 179-188页

作者： Xu Zhang wei yan Meiqing Huo Hui li the School of Electrical Engineering Chongqing UniversityChongqing 400044China

Interval state estimation(ISE)can estimate state intervals of power systems according to confidence intervals of predicted pseudo-measurements,thereby analyzing the impact of uncertain pseudo-measurements on ***,predicted pseudo-measurements have prediction errors,and their confidence intervals do not necessarily contain the truth values,leading to estimation biases of the *** solve this problem,this paper proposes a pseudo-measurement interval prediction framework based on the Gaussian process regression(GPR)model,thereby improving the prediction accuracy of pseudo-measurement confidence ***,a weight assignment strategy for improving the robustness of weighted least squares(WLS)ISE is *** strategy quantifies the deviation between the pseudo-measurement intervals and their estimated intervals and assigns smaller weights to the pseudo-measurement intervals with larger deviations,thereby improving the estimation accuracy and robustness of the *** paper adopts the data from the supervisory control and data acquisition(SCADA)system of the New York Independent System Operator(NYISO).It verifies the advantages of the GPR method for pseudo-measurement interval prediction by comparing it with the quantile regression and neural network *** addition,this paper demonstrates the effectiveness of the proposed weight assignment strategy through the IEEE 14-bus ***,the differences in the estimation accuracy and the bad data identification between the robust interval state estimation and deterministic state estimation are discussed.

关键词： Interval state estimation interval analysis pseudo-measurement Gaussian process regression(GPR)

Dynamic Response Impact of Vehicle Braking on Simply Supported Beam Bridges with Corrugated Steel Webs Based on Vehicle-Bridge Coupled Vibration Analysis

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3467-3493页

作者： yan Wang Siwen li Na wei School of Civil Engineering Zhengzhou UniversityZhengzhou450001China

A novel approach for analyzing coupled vibrations between vehicles and bridges is presented,taking into account spatiotemporal effects and mechanical phenomena resulting fromvehicle *** modeling and solution of bridge vibrations induced by vehicle deceleration are realized using this *** method’s validity and reliability are substantiated through numerical examples.A simply supported beam bridge with a corrugated steel web is taken as an example and the effects of parameters such as the initial vehicle speed,braking acceleration,braking location,and road surface roughness on the mid-span displacement and impact factor of the bridge are *** results show that vehicle braking significantly amplifies mid-span displacement and impact factor responses in comparison to uniform vehicular motion across the ***,the influence of wheelto-bridge friction forces is of particular significance and cannot be *** the vehicle initiates braking near the middle of the span,both the mid-span displacement and impact factor of the bridge exhibit substantial increases,further escalating with higher braking *** favorable road surface conditions,the midspan displacement and the impact factor during vehicle braking may exceed the design values stipulated by *** is important to note that road surface roughness exerts a more pronounced effect on the impact factor of the bridge in comparison to the effects of vehicle braking.

关键词： Corrugated steel web girder bridges simply supported beam bridges vehicle-bridge coupled vibration braking impact factor

PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： yan Wang Feng li Shuang Wang Jiaqi Meng Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(lipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and lipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

Common SNPs of APM1 Gene Are Not Associated With Hypertension or Obesity in Chinese Population

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Biomedical and Environmental Sciences 2006年第3期19卷 179-184页

作者： wei-li yan SHU-FENG CHEN JIAN-FENG HUANG yan SHENA BO-QIN QIANG DONG-HAI liU DONG-FENG GU Division of Population Genetics and Prevention Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 167 Beilishi Road Beijing 100037 China National Human Genome Center North Yongchang Rd 3-707 Beijing 100176 China

Objective To investigate whether the common variants 45T/G and 276G/T in APM1 gene were associated with hypertension combined with obesity （HO） and related clinical features in Chinese Han population. Methods A case-control study design was applied. Common polymorphisms of 45T/G and 276G/T were genotyped by PCR product sequencing in 484 cases with HO and 502 controls with normal blood presure and BMI 〈 25. Results The genotype and allele frequencies of 45T/G, 276G/T, and haplotype defined by the two variants in cases did not differ from those in controls. The means of blood pressure, BMI and waist-hip ratio did not differ among genotypes of the two polymorphisms and haplotypes. Among lipid profiles, only serum high-density lipoprotein cholesterol （HDL-C） levels were significantly lower in T allele carders than that in non-T carriers after adjusting possible confounding factors （1.21 vs 1.32 mmol/L, P=0.0001）. Condusion Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population. Common polymorphism of 45T/G might be associated with serum HDL-C levels in Chinese.

关键词： Adiponectin HDL-C Hypertension Obesity