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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang Lei Gui-Lin Pi Ting He Rui Xiong Jing-Ru Lv Jia-Le Liu Dong-Qin Wu Meng-Zhu Li Kun Shi Shi-Hong Li Na-Na Yu Yang Gao Hui-Ling Yu Lin-Yu wei Xin Wang Qiu-Zhi Zhou Pei-Lin Zou Jia-Yang Zhou Ying-Zhou Liu Nai-Ting Shen jie Yang Dan Ke Qun Wang gong-Ping Liu Xi-Fei Yang Jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

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水稻种植业的资金运作管理及财务风险控制

北方水稻 2025年第1期55卷 84-86页

作者：龚婕西安医学院西安710000

水稻种植业正在经历一场数字化与智能化的深刻变革,推动资金运作与风险控制的全面创新。通过智能化工具和数据驱动的决策支持系统,种植者可以实现高效的资金使用与风险管理,提高对市场动态的敏感度。内控与合规机制的优化,加之外部合作... 详细信息

水稻种植业正在经历一场数字化与智能化的深刻变革,推动资金运作与风险控制的全面创新。通过智能化工具和数据驱动的决策支持系统,种植者可以实现高效的资金使用与风险管理,提高对市场动态的敏感度。内控与合规机制的优化,加之外部合作与知识共享网络的拓展,进一步提升了企业的抗风险能力和灵活应变能力。创新文化的培育与激励机制的实施,推动了学习型组织的建设,使水稻种植者在实践中不断探索新技术与新模式,开创出可持续发展的新局面,不仅提升了资源配置的效率,更为整个行业注入了持续发展的动力。

关键词：水稻种植业资金运作财务风险

Effect of GaInP and GaAsP inserted into waveguide/barrier interface on carrier leakage in InAlGaAs quantum well 808-nm laser diode

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中国光学(中英文) 2025年第1期18卷 186-197页

作者： FU Meng-jie DONG Hai-liang JIA Zhi-gang JIA wei LIANG Jian XU Bing-she Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Institute of Atomic and Molecular Science Shaanxi University of Science&TechnologyXi’an 710021China

There is nonradiative recombination in waveguide region owing to severe carrier leakage,which in turn reduces output power and wall-plug *** this paper,we designed a novel epitaxial structure,which suppresses carrier leakage by inserting n-Ga_(0.55)In_(0.45)P and p-GaAs_(0.6)P_(0.4) between barriers and waveguide layers,respectively,to modulate the energy band structure and to increase the height of *** results show that the leakage current density reduces by 87.71%,compared to traditional *** nonradiative recombination current density of novel structure reduces to 37.411 A/cm^(2),and the output power reaches 12.80 W with wall-plug efficiency of 78.24%at an injection current density 5 A/cm^(2) at room *** addition,the temperature drift coefficient of center wavelength is 0.206 nm/℃at the temperature range from 5℃to 65℃,and the slope of fitted straight line of threshold current with temperature variation is *** novel epitaxial structure provides a theoretical basis for achieving high-power laser diode.

关键词： 808-nm laser diode Ga_(0.55)In_(0.45)P and GaAs_(0.6)P_(0.4)insertion layers InAlGaAs quantum well carrier leakage

Diagnosis and treatment of lung cancer:A molecular perspective

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World Journal of Clinical Oncology 2025年第3期16卷 1-7页

作者： Yuan Xiong Long Cheng Yu-jie Zhou wei-Hong Ge Ming Qian Hui Yang Department of Pharmacy Nanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210009Jiangsu ProvinceChina Nanjing Drum Tower Hospital Clinical College Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Nanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina

This editorial comments on the review by Da Silva et al,published in the World Journal of Clinical Oncology which focuses on the molecular perspectives of lung *** the rapid development of molecular technology,new diagnostic methods are constantly emerging,including liquid biopsy,the identification of gene mutations,and the monitoring biomarkers,thus providing precise in-formation with which to identify the occurrence and development of lung ***,such as circulating tumor cells,circulating tumor DNA,and cir-culating RNA can provide helpful information for clinical *** types of genetic mutations and immune checkpoints include epidermal growth factor receptor,anaplastic lymphoma kinase,c-ROS proto-oncogene 1,progra-mmed death-1 and cytotoxic T-lymphocyte-associated *** to specific biomarkers,targeted therapy and immunotherapy can improve survival outcomes based on the types of gene mutation and immune *** application of molecular approaches can facilitate our ability to control the progression of disease and select appropriate therapeutic strategies for patients with lung cancer.

关键词： Lung cancer Molecular Oncogenic mutations Biomarkers Liquid biopsy Targeted therapy Immunotherapy

Assessing the possibility of using large language models in ocular surface diseases

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 1-8页

作者： Qian Ling Zi-Song Xu Yan-Mei Zeng Qi Hong Xian-Zhe Qian Jin-Yu Hu Chong-Gang Pei Hong wei jie Zou Cheng Chen Xiao-Yu Wang Xu Chen Zhen-Kai Wu Yi Shao Department of Ophthalmology the First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburgNetherlands Changde Hospital Xiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To assess the possibility of using different large language models(LLMs)in ocular surface diseases by selecting five different LLMS to test their accuracy in answering specialized questions related to ocular surface diseases:ChatGPT-4,ChatGPT-3.5,Claude 2,PaLM2,and ***:A group of experienced ophthalmology professors were asked to develop a 100-question singlechoice question on ocular surface diseases designed to assess the performance of LLMs and human participants in answering ophthalmology specialty exam *** exam includes questions on the following topics:keratitis disease(20 questions),keratoconus,keratomalaciac,corneal dystrophy,corneal degeneration,erosive corneal ulcers,and corneal lesions associated with systemic diseases(20 questions),conjunctivitis disease(20 questions),trachoma,pterygoid and conjunctival tumor diseases(20 questions),and dry eye disease(20 questions).Then the total score of each LLMs and compared their mean score,mean correlation,variance,and confidence were ***:GPT-4 exhibited the highest performance in terms of *** the average scores of the LLMs group with the four human groups,chief physician,attending physician,regular trainee,and graduate student,it was found that except for ChatGPT-4,the total score of the rest of the LLMs is lower than that of the graduate student group,which had the lowest score in the human *** ChatGPT-4 and PaLM2 were more likely to give exact and correct answers,giving very little chance of an incorrect ***-4 showed higher credibility when answering questions,with a success rate of 59%,but gave the wrong answer to the question 28% of the ***:GPT-4 model exhibits excellent performance in both answer relevance and ***2 shows a positive correlation(up to 0.8)in terms of answer accuracy during the *** terms of answer confidence,PaLM2 is second only to GPT4 and surpasses Claude 2,SenseNova,and *** the fact t

关键词： ChatGPT-4.0 ChatGPT-3.5 large language models ocular surface diseases

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen jie Ying Ge Tian Yu-Xuan Xiao Yi Lu Si-Ming Wu wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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清热化瘀法治疗多囊肾发热浅析

山东中医杂志 2011年第6期30卷 372-374页

作者：郑炜贞龚婕宁南京中医药大学江苏南京210029

认为多囊肾在合并感染或出血情况下的高热不退,其病机特点是邪热与瘀血相结合,可采用温病清热化瘀法进行治疗。运用该法的关键是以准确辨证为前提,并根据病程之久暂、血瘀之轻重灵活变化,施治得法,则可收明显疗效。

关键词：多囊肾发热病因病机清热化瘀法

In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-Yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng Wu Mei-Yu Lv Zhi-Jia Wang Xing-jie Hu Jian-Xiao Liang Hong-Lei Wang Yue-Ze Wang Hui-Hui You Hong-wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

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量子信息法规政策及标准现状浅析

中国标准化 2025年第4期 55-59页

作者：陈卫杜健安洁陈珂公伟山东国家标准技术审评中心山东省标准化研究院

本文从政策和标准化的角度,详细介绍了美国、英国、德国、日本、俄罗斯等发达国家和国内量子信息相关的法规政策现状,ISO/IEC JTC 1/WG 14(量子信息工作组)、ISO/IEC JTC 1/SC 27(信息安全、网络安全和隐私保护分技术委员会)、ISO/IEC J... 详细信息

本文从政策和标准化的角度,详细介绍了美国、英国、德国、日本、俄罗斯等发达国家和国内量子信息相关的法规政策现状,ISO/IEC JTC 1/WG 14(量子信息工作组)、ISO/IEC JTC 1/SC 27(信息安全、网络安全和隐私保护分技术委员会)、ISO/IEC JTC 3、国际电信联盟ITU-T、欧洲电信标准研究院(ETSI)等国际标准组织和国内量子信息标准化现状,从制度、组织、标准供给等层面分析我国量子信息政策及标准化方面存在的问题,提出我国量子信息政策及标准化工作建议。

关键词：量子信息法规政策标准

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