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颈动脉粥样硬化斑块形成及其血管重塑的力学机制

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国外医学（脑血管疾病分册） 2005年第1期13卷 63-65页

作者：贾伟华田桂玲天津医科大学总医院神经内科 300052

目前公认的颈动脉粥样硬化斑块形成及其血管重塑的机制有3种:机械力学、炎症和理化因素。文章主要以力学因素为线索,介绍血流动力切应力在颈动脉斑块形成及其血管重塑进程中的作用和机制。

关键词：颈动脉粥样硬化斑块形成血管重塑力学机制内皮细胞

基于GEE云平台的三江源湖泊面积提取及动态变化

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长江科学院院报 2023年第7期40卷 179-185,190页

作者：祁昌贤任燕彭海月魏加华王永强李琼青海大学水利电力学院西宁810016 青海大学三江源生态与高原农牧国家重点实验室西宁810016 青海大学黄河上游生态保护与高质量发展实验室西宁810016 清华大学水沙科学与水利水电工程国家重点实验室北京100084 长江科学院水资源综合利用研究所武汉430010

基于GEE(Google Earth Engine)遥感云计算平台和Landsat TM、ETM+和OLI卫星影像数据,采用修正归一化水体指数(MNDWI)、归一化植被指数(NDVI)和增强植被指数(EVI)等多个指数的综合水体识别算法,提取三江源区1990—2020年大于1 km^(2)的... 详细信息

基于GEE(Google Earth Engine)遥感云计算平台和Landsat TM、ETM+和OLI卫星影像数据,采用修正归一化水体指数(MNDWI)、归一化植被指数(NDVI)和增强植被指数(EVI)等多个指数的综合水体识别算法,提取三江源区1990—2020年大于1 km^(2)的湖泊面积,结合气象、冰川编目、冻土分布等数据分析了湖泊面积变化及其影响因素。结果表明:1990年以来,三江源区湖泊增加了46个,湖泊面积从10811.8 km 2增加到12449.53 km^(2),增长了15%;其中,黄河源区湖泊面积增长了10%,长江源区湖泊面积增长了29%,长江源区较黄河源湖泊面积增幅更明显。平均气温升高和降水量增加是湖泊面积增加的主要因素;气温升高导致冰川退缩和冻土退化,使得冰川补给型湖泊和冻土区湖泊面积增加更快,这就是长江源区湖泊增长更为明显的主因,而黄河源湖泊面积增长与降水变化联系更为紧密。

关键词：三江源 GEE遥感云计算平台湖泊面积湖泊动态变化气候变化

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-wei Pu Xin-Yian Guo jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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中医护理方案对胸痹心痛病患者的影响

护理实践与研究 2017年第4期14卷 134-136页

作者：乔小平袁玮杨桂华聊城市人民医院聊城市252000

目的:探讨综合医院如何实施胸痹心痛病中医护理方案,推广中医特色护理技术。方法:成立中医护理方案管理小组,对护理人员进行系统培训。对胸痹胸痛病患者应用中医护理技术改善患者症状,并进行效果评价。结果:中医护理方案有助于改善患者... 详细信息

目的:探讨综合医院如何实施胸痹心痛病中医护理方案,推广中医特色护理技术。方法:成立中医护理方案管理小组,对护理人员进行系统培训。对胸痹胸痛病患者应用中医护理技术改善患者症状,并进行效果评价。结果:中医护理方案有助于改善患者的临床症状,推广中医特色护理技术,提高了患者对中医护理服务的满意度。结论:综合医院推广中医优势病种护理方案具有重大意义,能够满足患者的中医护理技术需求。

关键词：中医护理方案胸痹心痛病症状

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加利福尼亚州水银行及水权转让

南水北调与水利科技 2006年第6期4卷 17-22,30页

作者：魏加华张远东黄跃飞清华大学水沙科学与水利水电工程国家重点实验室北京100084

水银行是促进地表水、地下水和其它形式水的合法转让和交易的一种形式,并引起广泛关注。加利福尼亚州政府倡导建立的、著名的加州水银行,通过临时水权转让成功地应对了1991、1992和1994年持续的干旱。介绍加利福尼亚州水银行运转情况和... 详细信息

水银行是促进地表水、地下水和其它形式水的合法转让和交易的一种形式,并引起广泛关注。加利福尼亚州政府倡导建立的、著名的加州水银行,通过临时水权转让成功地应对了1991、1992和1994年持续的干旱。介绍加利福尼亚州水银行运转情况和特点,分析总结了加利福尼亚州水银行和水权转让的经验。

关键词：水银行水权转让加利福尼亚州

Invariant Sets and Exact Solutions to Nonlinear Diffusion Equations with x-Dependent Convection and Absorption

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Communications in Theoretical Physics 2008年第10期50卷 821-826页

作者： jia hua-Bing XU wei Department of Applied Mathematics Northwestern Polytechnical University Xi＇an 710072 China Department of Matheinatics Baoji University of Arts and Sciences Baoji 721013 China

In this paper, we introduce a new invariant set Eo={u：ux=f＇（x）F（u）＋ε[g＇（x）-f＇（x）g（x）]F（u）×exp（-∫^u1/F（z）dz）}where f and g are some smooth functions of x, ε is a constant, and F is a smooth function to be determined. The invariant sets and exact sohltions to nonlinear diffusion equation ut = （ D（u）ux）x ＋ Q（x, u）ux ＋ P（x, u）, are discussed. It is shown that there exist several classes of solutions to the equation that belong to the invariant set Eo.

关键词： invariant set exact solution nonlinear diffusion equations rotation group scaling group

Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing Xin-Ran Liu Xing-hua Wang Hui Han Sha-Sha Liang Xi-Meng Chen Dong-Hui wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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考虑ESG行为类别的碳减排与经济增长均衡机制研究

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经济问题 2025年第1期 15-26页

作者：曲卫华孙娜曲国华山西大学经济与管理学院山西太原030006 山西大学管理与决策研究所山西太原030006 山西财经大学管理科学与工程学院山西太原030006

“双碳”目标视域下,探究企业ESG(Environmental、Social and Governance)行为对碳排放的作用机理具有重要意义。考虑ESG行为存在表面上顺应迎合而实质上“言行不一”,构建了划分ESG行为类别的动态随机一般均衡(DSGE)模型,研究实质性ES... 详细信息

“双碳”目标视域下,探究企业ESG(Environmental、Social and Governance)行为对碳排放的作用机理具有重要意义。考虑ESG行为存在表面上顺应迎合而实质上“言行不一”,构建了划分ESG行为类别的动态随机一般均衡(DSGE)模型,研究实质性ESG行为与策略性ESG行为对碳排放等宏观经济因素的动态传导机制。研究发现:相比难以实现碳减排的策略性ESG行为,企业采取实质性ESG行为能够显著降低碳排放量且对宏观经济有正向影响,推动经济向低碳绿色转型,实现减排与经济发展的“共赢”。企业实质性ESG行为对碳减排与经济增长的影响机制为:(1)内部资本投入机制:企业采取实质性ESG行为对碳减排技术研发投入形成溢出效应,且实质性ESG行为激励企业将生产要素投入由高碳产品转移到低碳产品,以实现“增低碳降高碳”,达到碳减排与经济增长的协调统一;(2)外部政策激励机制:企业采取实质性ESG行为可获得更多的政府碳减排补贴,促使企业增加低碳产出投入,实现外部政策激励与内部低碳转型的协同效应;(3)金融机构信贷优惠机制:企业采取实质性ESG行为能够激发金融机构对其实行差异化信贷优惠利率,增加企业碳减排技术的研发投入,推动绿色金融与绿色技术的协同发展。研究为辨识ESG行为类别推动企业低碳转型发展提供理论依据与政策启示。

关键词：实质性ESG行为策略性ESG行为绿色金融碳排放动态随机一般均衡模型