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Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome

World Journal of gastroenterology 2015年第9期21卷 2820-2825页

作者： Meghan R Flanagan Arjun Jayaraj wei Xiong Matthew M Yeh Wendy H Raskind Venu g Pillarisetty Department of Surgery University of Washington Medical Center University of washington SeattleWA 98195United States Department of Pathology and Laboratory Medicine University of British ColumbiaVancouverBritish ColumbiaVancouverBC V6Z 1Y6Canada Department of Pathology University of Washington Medical Center Departments of Medicine/Medical genetics and Pyschiatry and Behavioral Sciences University of Washington Medical Center

Intraductal papillary mucinous neoplasm(IPMN) is a mucin-producing epithelial neoplasm that carries a risk of progression to invasive pancreatic ductal *** syndrome is an autosomal dominant condition caused by germline mutations in mismatch repair genes such as MSH2 that lead to microsatellite instability and increased risk of tumor *** families with Lynch syndrome have an increased risk of pancreatic cancer, a clear connection between Lynch syndrome and IPMN has not been *** present a report of a 58 year-old Caucasian woman with multiple cancers and a germline mutation of MSH2 consistent with Lynch syndrome.A screening abdominal computed tomography scan revealed a dilated main pancreatic duct and cystic ductular structure in the uncinate process that were consistent with IPMN of the main pancreatic duct on *** and polymerase chain reaction of the patient's pancreas specimen did not reveal microsatellite instability or mismatch repair gene loss of expression or *** findings may be explained by the fact that loss of mismatch repair function and microsatellite instability is a late event in neoplastic *** the relative rarity of main duct IPMN, its appearance in the setting of somatic MSH2 mutation suggests that IPMN may fit into the constellation of Lynch syndrome related malignancies.

关键词： Intraductal papillary mucinous neoplasm Pancreatic

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A Hydrogen Iron Flow Battery with High Current Density and Long Cyclability Enabled Through Circular water Management

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Energy & Environmental Materials 2023年第6期6卷 173-178页

作者： Litao Yan Yuyan Shao wei wa.g Pacific Northwest National Laboratory 902 Battelle BoulevardRichland WA 99354USA

The hydrogen-iron(HyFe)flow cell has great potential for long-duration energy storage by capitalizing on the advantages of both electrolyzers and flow ***,its operation at high current density(high power)and over continuous cycling testing has yet to be *** this article,we discuss our design and demonstration of a water-management strategy that supports high current and long-cycling performance of a HyFe flow *** molecules associated with the movement of protons from the iron electrode to the hydrogen electrode are sufficient to hydrate the membrane and electrode at a low current density of 100 mA cm^(-2)during the charge *** higher charge current density,more aggressive measures must be taken to counter back-diffusion driven by the acid concentration gradient between the iron and hydrogen *** water-management approach is based on water vapor feeding in the hydrogen electrode and water evaporation in the iron electrode,thus enabling high current density operation of 300 mA cm^(-2).

关键词： acid concentration gradient energy storage flow battery hydrogen longcycling performance water management

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经皮椎弓根螺钉内固定治疗胸腰椎骨折的生物力学及临床研究

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中华骨科杂志 2011年第9期31卷 932-937页

作者：王洪伟周跃李长青赵卫东第三军医大学新桥医院骨科重庆400037 南方医科大学生物力学实验室

目的通过生物力学测试及临床应用对经皮跨伤椎四钉内固定（万向钉固定）与开放手术四钉内固定（单向钉固定）进行比较。方法取12具新鲜冰冻小牛腰椎标本L1～L5节段，随机分为单向钉固定组与万向钉固定组。制备腰椎前中柱损伤模型，比较... 详细信息

目的通过生物力学测试及临床应用对经皮跨伤椎四钉内固定（万向钉固定）与开放手术四钉内固定（单向钉固定）进行比较。方法取12具新鲜冰冻小牛腰椎标本L1～L5节段，随机分为单向钉固定组与万向钉固定组。制备腰椎前中柱损伤模型，比较两组在模型上的运动范围。分别应用Sextant经皮跨伤椎四钉内固定与开放跨伤椎四钉内固定治疗无神经功能损伤的胸腰椎骨折25例和35例，观察其中随访超过12个月的11例和18例的即时复位效果、矫正度丢失情况。结果（1）生物力学试验：万向钉固定组在各个方向的运动范围均大于单向钉固定组，其中在前屈、后伸方向的差异有统计学意义；单向钉固定组在前屈、后伸、侧屈方向上的稳定性较完整标本大，差异有统计学意义；万向钉固定组在前屈、后伸方向上的稳定性与完整标本比较差异无统计学意义。（2）临床应用：两组术前、术后伤椎前缘高度、矢状位Cobb角的组间差异均无统计学意义；两组术后伤椎前缘高度、矢状面Cobb角与术前比较差异均有统计学意义；末次随访时经皮跨伤椎四钉内固定组伤椎前缘高度丢失（9．9％±5．1％）大于开放跨伤椎四钉内固定组（5．3％±6．8％）。结论应用Sextant系统经皮椎弓根螺钉内固定治疗无须神经减压的胸腰椎骨折较开放手术创伤小，但随访中伤椎前缘高度丢失明显。生物力学试验显示其在前屈、后伸运动方向上的强度较弱。

关键词：胸椎腰椎脊柱骨折内固定器生物力学

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Topological representations of crystalline compounds for the machine-learning prediction of materials properties

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npj Computational Materials 2021年第1期7卷 240-247页

作者： Yi Jiang Dong Chen Xin Chen Tangyi Li guo-wei wei Feng Pan School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhenPR China Department of Mathematics Michigan State UniversityEast LansingMIUSA

Accurate theoretical predictions of desired properties of materials play an important role in materials research and *** learning(ML)can accelerate the materials design by building a model from input *** complex datasets,such as those of crystalline compounds,a vital issue is how to construct low-dimensional representations for input crystal structures with chemical *** this work,we introduce an algebraic topology-based method,called atom-specific persistent homology(ASPH),as a unique representation of crystal *** ASPH can capture both pairwise and many-body interactions and reveal the topology-property relationship of a group of atoms at various *** with composition-based attributes,ASPH-based ML model provides a highly accurate prediction of the formation energy calculated by density functional theory(DFT).After training with more than 30,000 different structure types and compositions,our model achieves a mean absolute error of 61 meV/atom in cross-validation,which outperforms previous work such as Voronoi tessellations and Coulomb matrix method using the same ML algorithm and *** results indicate that the proposed topology-based method provides a powerful computational tool for predicting materials properties compared to previous works.

关键词： crystalline topology crystal

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Dynamic amplification factors for a system with multiple-degrees-of-freedom

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Earthquake Engineering and Engineering Vibration 2020年第2期19卷 363-375页

作者： Zhang Chao Hao hong Bi Kaiming Yan Xueyuan College of Civil Engineering Fuzhou UniversityFuzhou 350108China Centre for Infrastructure Monitoring and Protection School of Civil and Mechanical EngineeringCurtin UniversityKent StreetBentley WA 6102Australia Key Laboratory of Urban Security and Disaster Engineering of MOE Beijing University of TechnologyBeijing 100124China

It is well-known that the responses of a structure are different when subjected to a static load or a sudden step *** dynamic amplification factor(DAF),which is defined as the ratio of the amplitude of the vibratory response to the static response,is normally used to depict the dynamic *** a single-degree-of-freedom system(SDOF)subjected to a sudden dynamic load,the maximum value of DAF is *** design guidelines therefore use 2 as an upper bound to consider the dynamic *** a civil engineering structure,which is normally a multiple-degrees-of-freedom(MDOF)system,the DAF may exceed 2 in certain *** adoption of 2 as the upper bond as suggested by the design guidelines therefore may lead to unsafe structural *** limited studies systematically investigate the DAF of a MDOF sysCorrespondence to:Bi Kaiming,Centre for Infrastructure Monitoring and Protection,School of Civil and Mechanical Engineering,Curtin University,Kent Street,Bentley wa 6102,Australia Tel:(+61)892665139 E-mail:***@*** study theoretically investigates the DAF of a MDOF system when it is subjected to a step load based on the fundamental theory of structural *** condition on which the DAF may exceed 2 is *** numerical examples and one experimental study of a cable-stayed bridge subjected to sudden cable loss are presented to illustrate the problem.

关键词： dynamic amplification factors(DAF) multiple-degrees-of-freedom(MDOF) step load

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四川龙泉山断裂带及其活动性与潜在地震危险性讨论

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西北地震学报 2012年第1期34卷 50-56页

作者：黄伟江娃利中国地震局地壳应力研究所北京100085

龙泉山构造带是四川盆地内川西强烈断陷区和川中稳定隆起区之间的一条区域性断裂。2008年汶川地震后该断裂带未来的强震潜势备受关注。本文对该断裂带的展布、晚第四纪活动性、深部构造形成机制以及断裂带未来的地震危险潜势进行了讨论... 详细信息

龙泉山构造带是四川盆地内川西强烈断陷区和川中稳定隆起区之间的一条区域性断裂。2008年汶川地震后该断裂带未来的强震潜势备受关注。本文对该断裂带的展布、晚第四纪活动性、深部构造形成机制以及断裂带未来的地震危险潜势进行了讨论。断裂带北段位于德阳东侧龙泉山脉西缘;龙泉山脉中段的山体两翼存在断裂;断裂带的南段以向西倾斜的断裂为主。这些断裂在晚更新世以来曾有活动,前人阶地调查显现该断裂带全新世存在活动。考虑到该断裂带未来的地震潜势评估,值得对该断裂带的活动性及断裂带深部构造和运动方式开展进一步的调查。

关键词：四川盆地龙泉山构造带晚第四纪活动前陆盆地前隆未来地震潜势

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研究生招生考试报考中的“偏好误识”分析——基于公共部门理论的视角

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中国地质大学学报（社会科学版） 2009年第4期9卷 113-117页

作者：米红李小娃厦门大学高等教育研究中心福建厦门361005 浙江大学公共管理学院浙江杭州310058

随着我国研究生教育规模的扩大,研究生招生的报考过程中出现区域集中、专业集中、学校集中、招生单位宣传加剧等现象。这些现象的出现不仅在于扩招的大背景,还在于研究生教育的公共物品的本质属性,以及研究生招生考试管理中的偏好误识... 详细信息

随着我国研究生教育规模的扩大,研究生招生的报考过程中出现区域集中、专业集中、学校集中、招生单位宣传加剧等现象。这些现象的出现不仅在于扩招的大背景,还在于研究生教育的公共物品的本质属性,以及研究生招生考试管理中的偏好误识和考生"经济人"角色的偏好选择。因此,从公共部门理论的视角分析并解决上述问题成为解决报考中不合理现象的一条重要途径。

关键词：研究生教育报考偏好误识公共部门

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Acupuncture transcutaneous electrical nerve stimulation reduces discomfort associated with barostat-induced rectal distension:A randomized-controlled study

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World Journal of gastroenterology 2013年第3期19卷 381-388页

作者： Wing-wa Leung Alice YM Jones Simon SM Ng Cherry YN Wong Janet FY Lee Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Faculty of Health Sciences The University of SydneySydneyNSW 2006Australia Division of Colorectal Surgery Department of SurgeryThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong 999077China

AIM:To explore the effectiveness of acupuncture transcutaneous electrical nerve stimulation(Acu-TENS), a non-invasive modality in reduction of rectal discomfort during barostat-induced rectal distension. METHODS:Forty healthy subjects were randomized to receive 45 min of either Acu-TENS or placebo-TENS(no electrical output)over acupuncture points Hegu(largeintestine 4),Neiguan(pericardium 6)and Zusanli(stomach 36).A balloon catheter attached to a dual-drive barostat machine was then inserted into the subjects'rectum.A step-wise(4 mmHg)increase in balloon pressure was induced until maximal tolerable or 48 *** analogue scale and a 5-point subjective discomfort scale(no perception,first per-ception of distension,urge to defecate,discomfort/ pain and extreme pain)were used to assess rectal discomfort at each distension *** beta-endorphin levels were measured before,immediately after intervention,at 24 mmHg and at maximal toler- able distension pressure. RESULTS:There was no difference in the demographic data and baseline plasma beta-endorphin levels between the two *** threshold levels were higher in the Acu-TENS group when compared to the placebo group,but the difference reached statistical significance only at the sensations"urge to defecate"and"pain".The distension pressures recorded at the"urge to defecate"sensation for the Acu-TENS and placebo-TENS groups were 28.0±4.5 mmHg and 24.6±5.7 mmHg,respectively(P=0.043);and the pressures recorded for the"pain"sensation for these two groups were 36.0±4.2 mmHg and 30.5± 4.3 mmHg respectively(P=0.002).Compared to the placebo group,a higher number of participants in the Acu-TENS group tolerated higher distension pressures (>40 mmHg)(65%in Acu-TENS vs 25%in placebo, P=0.02).The plasma beta-endorphin levels of the Acu-TENS group were significantly higher than that of the placebo group at barostat inflation pressure of 24 mmHg(1.31±0.40 ng/mL vs 1.04±0.43 ng/mL,P= 0.044)and at maximal inflation p

关键词： Colonoscopy Rectal discomfort Transcu-taneous electrical nerve stimulation Acupuncture Visceral pain

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Cortisol and uncomplicated Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 146-147页

作者： Ibrahim EA Kheir MM Elhardello OA Almahi wa Ali NI Elbashir MI Ishag Adam Faculty of Medicine University of KhartoumSudan New Halfa Teaching Hospital Sudan Sudan Atomic Energy Commission Sudan

Objective:To investigate the levels of serum Cortisol in patients with uncomplicated Plasmodium falciparum(***) malaria in an area of unstable malaria transmission in eastern Sudan. Methods:The concentrations of Cortisol were measured in sera of 25 patients with uncomplicated *** malaria(at presentation,24 h and 7 d later) and 25 healthy volunteers using radioimmunoassay gamma ***:There was no significant difference in mean(SD) of total Cortisol levels in patients with malaria in comparison with the control group;602.2(369.6) vs. 449.2(311.7) ng/mL,P=*** patients with uncomplicated *** malaria,the mean(SD) presenting Cortisol levels were significantly higher in comparison to the levels on day 7;602.2 (369.6) vs.373.6(139.1) ng/mL,P=*** the patients with uncomplicated *** malaria (on presentation) Cortisol levels were not correlated with initial temperature or the presenting ***:Thus,Cortisol levels were not significantly different between the patients and the controls.

关键词： Pathogenesis Falciparum Malaria Cortisol Sudan

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消落带土壤铁的形态变化及其对有效磷的影响

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土壤通报 2008年第1期39卷 66-70页

作者：王改改傅瓦利魏朝富袁红西南大学资源环境学院重庆400715

Fe3+还原为Fe2+的过程中会增加磷酸铁的溶解,影响磷的化学行为及有效性。本文采用室内模拟试验研究了三峡库区消落带土壤铁的形态变化及其对有效磷的影响。消落带旱地和水田土壤经淹水和落水处理后,活性铁、水溶性铁增加,其他各形态铁... 详细信息

Fe3+还原为Fe2+的过程中会增加磷酸铁的溶解,影响磷的化学行为及有效性。本文采用室内模拟试验研究了三峡库区消落带土壤铁的形态变化及其对有效磷的影响。消落带旱地和水田土壤经淹水和落水处理后,活性铁、水溶性铁增加,其他各形态铁变化较小。旱地土壤在不同的有机质和淹水落水处理下,其活化铁、游离铁、络合铁、水溶性亚铁、和交换性亚铁均为淹水处理高于落水处理,其中活性铁在各处理间呈现出显著性差异,其他则各处理间差异均未达到显著性水平;水田下层活性铁高于上层,且落水处理间呈显著差异。氧化铁及亚铁之间总处于不断的相互转化中,活性铁、络合铁和有机质正相关。旱地土壤中的有效磷各处理间差异显著,水田有效磷淹水处理高于落水处理。

关键词：铁的形态有效磷消落带

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