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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

国产与进口雷帕霉素洗脱支架在冠状动脉粥样硬化性心脏病中的疗效比较

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中国临床医学 2016年第6期23卷 744-748页

作者：毕春辉魏盟沈虹陆志刚上海交通大学附属上海市第六人民医院心内科上海200233

目的：比较国产雷帕霉素药物洗脱支架（Firebird 2）和进口雷帕霉素药物洗脱支架（Cypher Select）在冠状动脉粥样硬化性心脏病（冠心病）患者经皮冠状动脉介入术中的临床疗效。方法：选择2010年5月—2011年12月在上海市第六人民医院心... 详细信息

目的：比较国产雷帕霉素药物洗脱支架（Firebird 2）和进口雷帕霉素药物洗脱支架（Cypher Select）在冠状动脉粥样硬化性心脏病（冠心病）患者经皮冠状动脉介入术中的临床疗效。方法：选择2010年5月—2011年12月在上海市第六人民医院心内科采用雷帕霉素药物洗脱支架治疗的冠心病患者。根据植入支架种类分为Firebird 2组和Cypher组。随访时间25-40个月,平均（32.54±3.90）个月,其中Firebird 2组完成随访139例,Cypher组完成随访125例。比较两组患者随访期间主要心血管不良事件（MACE,包括心源性死亡、非致死性心肌梗死、靶血管再次血运重建）以及支架内再狭窄、确定的支架内血栓发生情况。结果：Firebird 2组男性患者比例低于Cypher组（P〈0.05）。Firebird 2组患者血浆N末端B型钠尿肽前体（NTproBNP）含量、靶病变长度、每处病变植入支架数大于Cypher组（P〈0.05）。Firebird 2组患者和Cypher组患者在心源性死亡（4.3%vs 3.2%）、非致死性心肌梗死（1.4%vs 1.6%）、靶血管再次血运重建（4.3%vs 5.6%）、MACE（9.4%vs 8.8%）方面差异均无统计学意义。Firebird 2组患者和Cypher组患者支架内再狭窄、确定的支架内血栓发生差异亦无统计学意义。Logistic回归分析显示：年龄（OR=1.11,95%CI 1.05-1.18,P=0.000）、糖尿病（OR=2.70,95%CI 1.02-7.15,P=0.045）是随访期间MACE发生的独立危险因素;支架种类（OR=0.88,95%CI 0.34-2.24,P=0.782）不是MACE发生的独立危险因素。结论：Firebird 2雷帕霉素药物洗脱支架和Cypher雷帕霉素药物洗脱支架在冠心病治疗中的长期临床疗效及安全性基本类似。

关键词：冠状动脉粥样硬化性心脏病经皮冠状动脉介入术药物洗脱支架疗效

七氟醚减轻心脏骤停大鼠心肌水肿及水通道蛋白1作用的探讨

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中国急救医学 2017年第1期37卷 76-80页

作者：李恒杰魏红艳卢远征杨焰黎博毛慧蔡文伟廖晓星浙江省人民医院急诊科浙江杭州310014 中山大学附属第一医院急诊科广东广州510080

目的探讨七氟醚是否可以减轻大鼠心脏骤停（CA）后心肌水肿及水通道蛋白1（AQP-1）的作用。方法窒息法建立心脏骤停模型。78只大鼠随机分为假手术组、七氟醚组和对照组，假手术组仅予麻醉及置管，七氟醚组在心肺复苏时予以1MAC七氟醚吸... 详细信息

目的探讨七氟醚是否可以减轻大鼠心脏骤停（CA）后心肌水肿及水通道蛋白1（AQP-1）的作用。方法窒息法建立心脏骤停模型。78只大鼠随机分为假手术组、七氟醚组和对照组，假手术组仅予麻醉及置管，七氟醚组在心肺复苏时予以1MAC七氟醚吸入5min，对照组进行常规心肺复苏。实验一：七氟醚组及对照组大鼠分别于造模前及自主循环恢复（ROSC）6h、12h、18h、24h五个时间点（每个时间点4只）分别处死取材测心肌含水量；实验二：假手术组、七氟醚组、对照组大鼠于造模前、ROSC1h、ROSC24h行心脏超声检查，并于ROSC24h处死（每组6只）测各组大鼠心肌AQP-1蛋白及mRNA表达量。结果ROSC后心肌含水量明显增加，但七氟醚组心肌含水量低于对照组（P〈0．05）；ROSC 1h射血分数下降，但七氟醚组高于对照组（P〈0．05）；ROSC24h室壁肥厚、左室容量下降，但七氟醚组室壁厚度小于对照组、左室容量高于对照组（P〈0．05）；心脏骤停后心肌AQP-1蛋白及mRNA表达均下降，但七氟醚组高于对照组（P〈0．05）。结论七氟醚可以改善复苏后心功能不全，减轻心肌水肿，但APQ-1在缺血后心肌水肿形成与消退中的作用尚不完全明确。

关键词：七氟醚心脏骤停复苏后心功能不全心肌水肿水通道蛋白1(AQP-1)

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian Xu lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Shear flow induced vibrations of long slender cylinders with a wake oscillator model

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Acta Mechanica Sinica 2011年第3期27卷 330-338页

作者： Fei Ge wei lu Lei Wang You-Shi hong State Key Laboratory of Nonlinear Mechanics Institute of Mechanics CAS 100190 Beijing China

A time domain model is presented to study the vibrations of long slender cylinders placed in shear flow. Long slender cylinders such as risers and tension legs are widely used in the field of ocean engineering. They are subjected to vortex-induced vibrations（VIV） when placed within a transverse incident flow. A three dimensional model coupled with wake oscillators is formulated to describe the response of the slender cylinder in cross-flow and in-line directions. The wake oscillators are distributed along the cylinder and the vortex-shedding frequency is derived from the local current velocity. A non-linear fiuid force model is accounted for the coupled effect between cross-flow and in-line vibrations. The comparisons with the published experimental data show that the dynamic features of VIV of long slender cylinder placed in shear flow can be obtained by the proposed model,such as the spanwise average displacement,vibration frequency,dominant mode and the combination of standing and traveling waves. The simulation in a uniform flow is also conducted and the result is compared with the case of nonuniform flow. It is concluded that the flow shear characteristic has significantly changed the cylinder vibration behavior.

关键词： Vortex-induced vibration Vortex-induced wave Shear flow Wake oscillator Long slender cylinder

Why Was the Strengthening of Rainfall in Summer over the Yangtze River Valley in 2016 Less Pronounced than that in 1998 under Similar Preceding El Nino Events？Role of Midlatitude Circulation in August

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Advances in Atmospheric Sciences 2017年第11期34卷 1290-1300页

作者： chaofan li wei chen xiaowei hong riyu lu center for monsoon system research institute of atmospheric physicschinese academy of sciencesBeijing 100029China state key laboratory of numerical modelling for atmospheric sciences and geophysical fluid dynamics institute of atmospheric physicschinese academy of sciencesBeijing 100029China climate change research center chinese academy of sciencesBeijing 100029China

It is widely recognized that rainfall over the Yangtze River valley （YRV） strengthens considerably during the decaying summer of E1 Nifio, as demonstrated by the catastrophic flooding suffered in the summer of 1998. Nevertheless, the rainfall over the YRV in the summer of 2016 was much weaker than that in 1998, despite the intensity of the 2016 E1 Nifio having been as strong as that in 1998. A thorough comparison of the YRV summer rainfall anomaly between 2016 and 1998 suggests that the difference was caused by the sub-seasonal variation in the YRV rainfall anomaly between these two years, principally in August. The precipitation anomaly was negative in August 2016--different to the positive anomaly of 1998.

关键词： Yangtze River valley summer rainfall super El Nio sub-seasonal variation Silk Road Pattern

防抱制动中AUDI盘式制动器动态特性的系统辨识

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吉林大学学报（工学版） 2002年第2期32卷 33-39页

作者：王铁山陈宏伟任露泉笪光艳吉林大学机电设备研究所吉林长春130025

在JF 1 32型汽车制动器试验台上进行了AUDI盘式制动器的动态测试 ,建立了该制动器的带外生变量的自回归 (ARX)模型。根据试验中获得的数据 ,确定了模型的结构 ,采用最优辅助变量法对所建模型的参数进行了辨识 ,通过残差白色性检验以及... 详细信息

在JF 1 32型汽车制动器试验台上进行了AUDI盘式制动器的动态测试 ,建立了该制动器的带外生变量的自回归 (ARX)模型。根据试验中获得的数据 ,确定了模型的结构 ,采用最优辅助变量法对所建模型的参数进行了辨识 ,通过残差白色性检验以及不同观测数据的比较 ,验证了所建模型的精确程度。

关键词：防抱制动系统 AUDI盘式制动器动态特性系统辨识 ABS 自回归模型汽车

Fractal analysis of small-micro pores and estimation of permeability of loess using mercury intrusion porosimetry

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第7期24卷 584-595页

作者： Tuo lu Yaming TANG Yongbo TIE Bo hong wei FENG Chinese Academy of Geological Sciences Beijing 100037China School of Water Resources and Environment China University of GeosciencesBeijing 100083China Xi'an Center of China Geological Survey Xi'an 710054China Chengdu Center of China Geological Survey Chengdu 610081China

Many popular models have been proposed to study the fractal properties of the pores of porous materials based on mercury intrusion porosimetry(MIP).However,most of these models do not directly apply to the small-micro pores of loess,which have a significant impact on the throat pores and tunnels for fluid ***,in this study we used a combination of techniques,including routine physical examination,MIP analysis,and scanning electron microscope(SEM)image analysis,to study these small-micro pores and their saturated water permeability *** techniques were used to determine whether the fractal dimensions of six MIP fractal models could be used to evaluate the microstructure types and permeability properties of *** results showed that the Neimark model is suitable for analysis of small-micro *** applied to saturated water permeability,the results from this model satisfied the correlation significance test and were consistent with those from SEM analysis.A high clay content and density cause an increase in the number of small-micro pores,leading to more roughness and heterogeneity of the pore structure,and an increase in the fractal *** process further leads to a decrease in the content of macro-meso pores and saturated water ***,we propose new parameters:the*Ellipse and its area ratios(*EAR).These parameters,coupled with 2D-SEM and 3D-MIP fractal dimensions,can effectively and quantitatively be used to evaluate the types of loess microstructures(from typeⅠto typeⅢ)and the saturated water permeability(magnitude from 1×10^(-4)cm/s to 1×10^(-5)cm/s).

关键词： Malan loess Fractal models Small-micro pores Mercury intrusion porosimetry(MIP) Microstructure Saturated waterpermeability

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan hongbin lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2