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Fracture strength of custom-fabricated Celay all-ceramic post and core restored endodontically treated teeth

Chinese Medical Journal 2006年第21期119卷 1815-1820页

作者： ZHANG Yu-xing ZHANG wei-hong lu Zhi-yue WANG Ke-li Department of Dentistry Beijing Hospital Beijing 100730 China

Background The increased use of all-ceramic crown provides a rationale for tooth-colored core. Due to superior mechanical properties, Vita Celay infiltration ceramic developed for crown and bridge works presents the potential for fabricating all-ceramic posts and cores in one piece. This study was conducted to compare the fracture strength of endodontically treated teeth which were thereafter given different types of posts and cores and crowns restoration, respectively. The evaluated post-and-core systems are： custom-fabricated Celay all-ceramic post-core, custom cast metal post-core, and prefabricated stainless steel post （Parapost） with and without 2.0 mm dentine ferrule. Methods Sixty freshly extracted human maxillary central incisors were endodontically treated and randomly divided into five groups with 12 samples each. Group A： Celay ceramic post-cores restored teeth with 2.0 mm dentine ferrule. Group B： Celay ceramic post-cores restored teeth with no dentine ferrule. Group C： cast metal post-cores restored teeth with 2.0 mm dentine ferrule. Group D： cast metal post-cores restored teeth with no dentine ferrule. Group E： prefabricated post and composite cores restored teeth with 2.0 mm dentine ferrule. All teeth were restored with Celay ceramic crowns. Each specimen was subjected to a load at a 45-degree angle to the long axis on MTS 810 material testing machine until failure, at crosshead speed of 0.02 cm/minute. Analysis of variance followed by the Newman-Keuls pairwise multiple comparison tests were used to compare the results of the groups tested. Results There was a statistically significant difference among the five groups （P〈0.01）. Celay ceramic post-cores restored teeth with 2.0 mm dentine ferrule [（758.35± 119.26） N] and cast metal post-cores restored teeth with 2.0 mm dentine ferrule [（756.63± 166.22） N] had a significantly greater mean fracture strength than the other three groups in which no significant difference was observed. The 2.0 mm dentine fer

关键词： fracture strength ceramics post and core nonvital tooth

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Highly Efficient and Economical Baculovirus Expression System for Preparing Human Papillomavirus Type16 Virus-like Particle

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Acta Biochimica et Biophysica Sinica 2004年第8期36卷 548-552页

作者： Jin ZHENG, Jun MA, Xiao-Feng YANG, hong-Li LIU, hong-wei CHENG, lu-Sheng SI, and Yi-Li WANGThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Cancer Research,School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710061, China The Key Laboratory of Biomedical Information Engineering of Ministry of Education Institute of Cancer Research School of Life Science and Technology Xi’an Jiaotong University

To improve the existing human papillomavirus type16 (HPV16) virus-like particle (VLP) preparation, a highly efficient, economical and timesaving system was established. Sf-9 cells were infected with recombinant baculovirus containing the target gene encoding HPV16L1 protein with 6×His tag, and harvested 72 h postinfection (p.i.) at 27 °C. The ProBondTM purification system was used for protein purification. The molecular weight of expressed HPV16L1 protein was 58 kD as revealed by SDS-PAGE, and confirmed by Western blot. The purity of denatured and native HPVL1 proteins that were prepared were 91.9% and 71.5%, respectively, which corresponded to a yield of 2.26 mg denatured protein and 1.84 mg native protein per 2×107 cells. The proteins were further analyzed by mouse erythrocyte hemagglutination assay and hemagglutination inhibition assay, and there effects on VLP formation were also visualized by transmission electron microscopy. Results showed that the native protein purified was biologically active as natural HPVL1 protein, inducing the murine erythrocyte agglutination and VLP formation. In addition, the purified recombinant HPV16L1 native protein with 6×His tag could self-assemble into virions in vitro. Hopefully, the present expression and purification system is promising to be convenient, timesaving and economical for preparation of HPV16 VLP vaccine.

关键词： human papillomavirus HPV16L1 protein purification virus-like particle (VLP)

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Experimental Study on Springback of Sheet Metal Single Point Incremental Forming

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International Journal of Plant Engineering and Management 2011年第1期16卷 60-64页

作者： LIANG Ying GAO Lin wei hong-yu lu Ren-wei College of Mechanical and Electrical Engineering Nanjing University of Aeronautics & Astronautics Nanjing 210016 P.R. China

Sheet metal single point incremental forming （SPIF） is a new technology for flexible process. The springback phenomenon in single point incremental forming has been discussed. Effects of forming angle and shape of the part are analysed using simple experimental method. Tool diameter, sheet thickness, step size, material parameters and the interaction of them are also analysed by using orthogonal test. The results show that the primary factor af- fecting springback is forming angle. In addition, springback is decreased when the specimen has a larger forming angle. The order of the four factors that influence springback is tool diameter, sheet thickness, step size and material parameters. The forming precision will increase if springabck is decreased by optimizing the forming parameters.

关键词： incremental forming springback orthogonal test forming parameters

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Sequential vs simultaneous revascularization in patients undergoing liver transplantation:A meta-analysis

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World Journal of Gastroenterology 2015年第22期21卷 7036-7046页

作者： Jia-Zhong Wang Yang Liu Jin-Long Wang Le lu Ya-Fei Zhang hong-wei lu Yi-Ming Li Department of General Surgery Second Affiliated Hospital Xi’an Jiaotong University School of Medicine

AIM: We undertook this meta-analysis to investigate the relationship between revascularization and outcomes after liver ***: A literature search was performed using MeSH and key words. The quality of the included studies was assessed using the Jadad Score and the NewcastleOttawa Scale. Heterogeneity was evaluated by the χ 2and I 2 tests. The risk of publication bias was assessed using a funnel plot and Egger's test, and the risk of bias was assessed using a domain-based assessment tool.A sensitivity analysis was conducted by reanalyzing the data using different statistical ***: Six studies with a total of 467 patients were included. Ischemic-type biliary lesions were significantly reduced in the simultaneous revascularization group compared with the sequential revascularization group(OR = 4.97, 95%CI: 2.45-10.07; P < 0.00001),and intensive care unit(ICU) days were decreased(MD = 2.00, 95%CI: 0.55-3.45; P = 0.007) in the simultaneous revascularization group. Although warm ischemia time was prolonged in simultaneous revascularization group(MD =-25.84, 95%CI:-29.28-22.40; P < 0.00001), there were no significant differences in other outcomes between sequential and simultaneous revascularization groups. Assessment of the risk of bias showed that the methods of random sequence generation and blinding might have been a source of bias. The sensitivity analysis strengthened the reliability of the results of this ***: The results of this study indicate that simultaneous revascularization in liver transplantation may reduce the incidence of ischemic-type biliary lesions and length of stay of patients in the ICU.

关键词： Revascularization Liver transplantation Outcomes Biliary complications Meta-analysis

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原位负载稀土三元催化剂催化环氧丙烷和二氧化碳的共聚合研究

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高分子学报 2012年第4期22卷 446-452页

作者：路宏伟秦玉升王献红赵晓江王佛松中国科学院长春应用化学研究所中国科学院生态环境高分子材料重点实验室长春130022 中国科学院研究生院北京100039

采用2种方法制备了原位负载稀土三元催化剂,即先将均相的Y(CCl3OO)3-Glycerin体系负载在载体上,后逐滴加入ZnEt2(标记为Y(CCl3OO)3-Glycerin/γ-Al2O3/ZnEt2);或先将ZnEt2与载体反应,再与均相的Y(CCl3OO)3-Glycerin体系反应(标记为ZnEt2/γ-Al2O3/Y(CCl3OO)3-Glycerin).研究发现原位负载催化剂催化环氧丙烷和二氧化碳共聚合反应的活性比未负载前低24%～36%,通过分析催化剂制备过程中所生成的乙烷量的变化,证明原位负载时催化剂组分如Y(CCl3OO)3、Glycerin或ZnEt2发生了向载体孔隙内的扩散渗透,使得催化剂各组分配比与未负载催化剂相比发生了偏差,从而降低了催化活性;另一方面,表面羟基与ZnEt2反应形成了低效率的活性种,也是原位负载催化剂活性不高的原因之一.提出了影响原位负载稀土三元催化剂活性的2个主要因素,即活性种的反应活性和活性种的数量.通过调节催化剂组分配比、负载化阶段的振荡研磨时间、原位负载时的活性种状态、载体的表面状态等,可使负载催化剂的活性比未负载的稀土三元催化剂提高3.5%.

关键词：二氧化碳,共聚,稀土三元催化剂,负载催化剂

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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斋堂水库混凝土剥蚀及防碳化处理设计

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北京水务 2009年第1期 42-44页

作者：魏陆宏北京市水利规划设计研究院 100044

斋堂水库溢洪道混凝土剥蚀、碳化严重,对剥蚀破坏混凝土凿除表面松动层,植筋挂钢筋网浇筑微膨胀混凝土加固。对于混凝土表面碳化,采用了2种处理方式,方法1为植筋挂铅丝网和钢丝网再抹微膨胀硅粉水泥砂浆,方法2为植筋挂铅丝网再抹聚合物... 详细信息

斋堂水库溢洪道混凝土剥蚀、碳化严重,对剥蚀破坏混凝土凿除表面松动层,植筋挂钢筋网浇筑微膨胀混凝土加固。对于混凝土表面碳化,采用了2种处理方式,方法1为植筋挂铅丝网和钢丝网再抹微膨胀硅粉水泥砂浆,方法2为植筋挂铅丝网再抹聚合物水泥砂浆。就斋堂水库溢洪道混凝土剥蚀、碳化不同处理方法进行了论述,并提出了施工中应注意的问题。

关键词：剥蚀碳化处理

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迈克全自动化学发光仪测定促甲状腺激素的性能验证

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检验医学与临床 2015年第4期12卷 473-475页

作者：王萍魏红璐重庆市第五人民医院检验科 400062

目的通过对迈克IS1200全自动化学发光测定仪进行性能验证及评价,探讨迈克IS1200全自动化学发光测定仪临床应用的可行性。方法参考ISO15189:2007《医学实验室质量和能力认可准则》的国际标准和相关文献,同时结合实际工作,对IS1200的稳定... 详细信息

目的通过对迈克IS1200全自动化学发光测定仪进行性能验证及评价,探讨迈克IS1200全自动化学发光测定仪临床应用的可行性。方法参考ISO15189:2007《医学实验室质量和能力认可准则》的国际标准和相关文献,同时结合实际工作,对IS1200的稳定性、精密度、正确度、线性相关性、携带污染率、仪器间的比对等分析性能进行验证及评价。结果迈克IS1200仪器性能稳定,稳定性试验4h后的相对偏倚为3.43%,8h后的相对偏倚为5.04%,批内不精密度小于5%,总不精密度小于10%,携带污染率小于2ppm,线性相关系数为0.999 92。结论迈克IS1200仪器稳定性较好,线性良好,携带污染率低,良好的精密度和正确度,可应用于临床。

关键词：全自动化学发光测定仪精密度携带污染率正确度

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妊娠期肝内胆汁淤积症相关指标的临床意义

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检验医学与临床 2012年第10期9卷 1169-1170,1172页

作者：王萍魏红璐重庆市第五人民医院检验科 400062

目的探讨生化指标与妊娠期肝内胆汁淤积症(ICP)的相关性及临床意义。方法筛选678例正常妊娠者及102例妊娠期ICP患者,分别测定血清总胆汁酸(TBA)、总胆红素(TB)、直接胆红素(DB)、甘胆酸(CG)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移... 详细信息

目的探讨生化指标与妊娠期肝内胆汁淤积症(ICP)的相关性及临床意义。方法筛选678例正常妊娠者及102例妊娠期ICP患者,分别测定血清总胆汁酸(TBA)、总胆红素(TB)、直接胆红素(DB)、甘胆酸(CG)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)和乳酸脱氢酶(LDH)。将正常妊娠者与妊娠期ICP患者的静脉血、脐血及羊水分别进行比较。结果 ICP组静脉血TBA、TB、DB、CG、ALT、AST、ALP、GGT、LDH与正常妊娠者静脉血比较差异有统计学意义(P<0.05),ICP组脐血TBA、TB、DB、CG、ALT、AST、ALP、LDH与正常妊娠者静脉血比较差异有统计学意义(P<0.05),ICP组羊水TBA、TB、CG、ALT、ALP、GGT、LDH与正常妊娠者静脉血比较差异也有统计学意义(P<0.05)。结论 CG、TBA、AST、ALT、ALP可作为ICP诊断可靠而实用的指标,可帮助终止妊娠时机的选择。

关键词：妊娠期肝内胆汁淤积症实验室检测

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua lu Jun Shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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