检索结果-南通市图书馆

Cyclohexanol optimizes Pt/ionomer interface in fuel cell cathodes

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第2期67卷 417-419页

作者： Lei Tong hai-wei Liang Hefei National Research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei230026China

This highlight is based on a recent article published in Nature Catalysis, in which wei's group [1] from Chongqing University proposes a novel approach to enhance the performance of proton exchange membrane fuel cells(PEMFCs)by adjusting the interface between Pt and ionomer in the cathode catalyst layer. Their strategy involves adding cyclohexanol to the cathode catalyst ink to impede the adsorption of sulfonate groups from the ionomer onto Pt nanoparticles, which results in the release of Pt activity sites and a significant improvement in the mass transport efficiency.

关键词： interface catalyst adding

Nanocrystalline WSe_(2)excels at high-performance anode for Na storage via a facile one-pot hydrothermal method

在线全文

学校读者我要写书评

暂无评论

Tungsten 2024年第1期6卷 248-258页

作者： hai-Yan Zou Lei fang Gang Yu Dong Wang State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Changxing County Quality and Technology Supervision and Testing Center Huzhou 313100China

For the next large-scale energy storage systems,sodium-ion batteries(SIBs)with excellent electrochemical performance are promising.However,the exploration of anode materials with high specific capacity,fascinating cycling stability and rate capability is still restricted.Among transition metal dichalcogenides(TMDs),tungsten diselenide(WSe_(2))has been regarded as an effective anode material for SIBs and has been extensively studied,due to high theoretical capacity and unique twodimensional layered structure.Herein,nanocrystalline WSe_(2)is prepared by a facile one-pot hydrothermal method.Compared with the micro-scale WSe_(2),benefiting from the high specific surface area of highly ordered nano-flake structures and short ion/electron transport paths,nanocrystalline WSe_(2)shows excellent electrochemical performance in Na storage.After 1000 cycles at a current density of 2 A·g^(-1),a high specific capacity of 264.4 mA·h·g^(-1)is still maintained.The full cell matched with the Na_(3)V_(2)(PO_(4))_(3) cathode can deliver an excellent reversible specific capacity of 196.5 mA·h·g^(-1)after 100 cycles at 0.5 A·g^(-1).

关键词： Tungsten diselenide Transition metal dichalcogenides Hydrothermal Sodium-ion batteries Layered structure

Protein succinylation,hepatic metabolism,and liver diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第3期16卷 344-352页

作者： Shuang Liu Rui Li Ya-Wen Sun hai Lin hai-fang Li College of Animal Science and Veterinary Medicine Shandong Agricultural UniversityTai’an 271018Shandong ProvinceChina College of Life Sciences Shandong Agricultural UniversityTai’an 271018Shandong ProvinceChina

Succinylation is a highly conserved post-translational modication that is processed via enzymatic and non-enzymatic mechanisms.Succinylation exhibits strong effects on protein stability,enzyme activity,and transcriptional regulation.Protein succinylation is extensively present in the liver,and increasing evidence has demonstrated that succinylation is closely related to hepatic metabolism.For instance,histone acetyltransferase 1 promotes liver glycolysis,and the sirtuin 5-induced desuccinylation is involved in the regulation of the hepatic urea cycle and lipid metabolism.Therefore,the effects of succinylation on hepatic glucose,amino acid,and lipid metabolism under the action of various enzymes will be discussed in this work.In addition,how succinylases regulate the progression of different liver diseases will be reviewed,including the desuccinylation activity of sirtuin 7,which is closely associated with fatty liver disease and hepatitis,and the actions of lysine acetyltransferase 2A and histone acetyltransferase 1 that act as succinyltransferases to regulate the succinylation of target genes that influence the development of hepatocellular carcinoma.In view of the diversity and significance of protein succinylation,targeting the succinylation pathway may serve as an attractive direction for the treatment of liver diseases.

关键词： Protein succinylation Hepatic metabolism Fatty liver Hepatitis Hepatocellular carcinoma

Drug repurposing for cancer therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia Ming Sun hai Huang wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global health.Despite significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic strategy.However,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer therapeutics.One promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved drugs.Drug repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety profiles.In light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat cancer.We describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor microenvironment.In addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug delivery.We also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy regimen.To conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

Endoscopic treatment of extreme esophageal stenosis complicated with esophagotracheal fistula: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第1期16卷 239-247页

作者： Jia-Heng fang wei-Min Li Cheng-hai He Jian-Liang Wu Yun Guo Zhi-Chao Lai Guo-Dong Li Department of Gastroenterology Hangzhou Normal University Affiliated HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND At present,there is no unified and effective treatment for extreme corrosive esophageal stenosis(CES)with esophagotracheal fistula(ETF).This case had extreme and severe esophageal stenosis(ES)and ETF after ingesting an enzyme-based chemical detergent,resulting in a serious pulmonary infection and severe malnutrition.Upper gastrointestinal imaging showed that he had an ETF,and endoscopy showed that he had extreme and severe esophageal stricture.This case was complex and difficult to treat.According to the domestic and foreign lite-rature,there is no universal treatment that is low-risk.CASE SUMMARY A patient came to our hospital with extreme ES,an ETF,and severe malnutrition complicated with pulmonary tuberculosis 1 mo after the consumption of an enzy-me-based detergent.The ES was serious,and the endoscope was unable to pass through the esophagus.We treated him by endoscopic incision method(EIM),esophageal stent placement(ESP),and endoscopic balloon dilation(EBD)by using the bronchoscope and gastroscope.This treatment not only closed the ETF,but also expanded the esophagus,with minimal trauma,greatly reducing the pain of the patient.According to the literature,there are no similar reported cases.CONCLUSION We report,for the first time,a patient with extreme CES complicated with ETF,where the endoscope could not be passed through his esophagus but he could be examined by bronchoscopy and treated by EIM,ESP,and EBD.

关键词： Extreme corrosive esophageal stenosis Esophagotracheal fistula Endoscopic incision method Esophageal stent placement Endoscopic balloon dilation Case report

Enhanced hydrogen evolution performance by 3D ordered macroporous Ru-CoP@NC electrocatalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 1095-1107页

作者： Chen-Chen Zhang Sheng wei Li-Xian Sun Yi-fang Ouyang Fen Xu hai-Liang Chu Hong-GePan Li-Xin Chen Xue-Zhang Xiao School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Guangxi UniversityNanning530004China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055GuangdongChina Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an710021China School of Materials Science and Engineering Zhejiang UniversityHangzhou310058China

Electrocatalytic water splitting coupled with sustainable energies is identified as an environmentally friendly and renewable strategy to generate high-quality hydrogen for the fuel cells.However,the main challenge is to develop high performance,low cost and chemically stable electrocatalysts to decline the energy barriers and enhance the sluggish kinetics of hydrogen evolution reaction(HER).Herein,a three-dimensional hierarchically ordered macroporous Ru-CoP@NC electrocatalyst(3DOM Ru-CoP@NC)derived from ordered macro-microporous metal-organic frameworks has been prepared using the precursor@template and double-solvent methods.The prepared 3DOM Ru-CoP@NC catalyst exhibits an overpotential of 15 mV(j=10 mA·cm^(-2))and a reaction Tafel slope of 38 mV·dec^(-1)in alkaline electrolyte,which are superior to commercial Pt@C catalyst.Additionally,the overpotential and reaction Tafel slope of this catalyst in acidic media are 45 mV and 50 mV·dec^(-1),respectively.The outstanding HER activities of 3DOM Ru-CoP@NC catalysts are ascribed to the 3D highly interconnectedreticular nanospaces that can increase effective reaction active sites.The N dope d carbon framework improves the electronic properties and conductivity.Moreover,the strong interaction of Ru and CoP nanoparticles also boosts the HER process.These results indicate that 3DOM Ru-CoP@NC catalysts with high catalytic activities have a broad application prospect in the future.

关键词： Hydrogen evolution reaction Template method 3D ordered macroporous Ru-CoP@NC

Penetrating canaloplasty in corticosteroid-induced glaucoma:a report of two cases

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第4期17卷 770-772页

作者： fang Liu Liu-Shan Zhou wei-wei Zhang Department of Ophthalmology Daqing Longnan Hospitalthe Fifth Affiliated Hospital of Qiqihar Medical CollegeDaqing 163453Heilongjiang ProvinceChina

Dear Editor,We have treated two patients of glucocorticoid-induced glaucoma with penetrating canaloplasty(PCP)since 2021.PCP is a new type internal drainage surgery for glaucoma,which is a bleb-independent filtering surgery combined canaloplasty with trabeculectomy,and the surgery shows a great efficacy of intraocular pressure(IOP)reduction with no surgical complication.PCP surgery started with a fornix-based conjunctival flap and double scleral flap,and Schlemm’s canal was opened,a 10-0 prolene suture was positioned and tensioned within Schlemm’s canal,trabucular meshwork segment was excised and peripheral iridectomy was performed,the scleral flap and the conjunctival flap were closed watertight with 10-0 prolene sutures.

关键词： glaucoma surgery glucocorticoid

Chemical passivation of methylammonium fragments eliminates traps,extends charge lifetimes,and restores structural stability of CH_(3)NH_(3)PbI_(3) perovskite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第5期15卷 4765-4772页

作者： Xi Zhao wei-hai fang Run Long Oleg V.Prezhdo College of Chemistry Key Laboratory of Theoretical&Computational Photochemistry of Ministry of EducationBeijing Normal UniversityBeijing 100875China Department of Chemistry University of Southern CaliforniaLos AngelesCalifornia 90089USA

Hybrid organic-inorganic perovskites are currently considered the most promising next-generation photovoltaic material.However,poor stability,arising from structural degradation under exposure to moisture,heat,and strong current,remains a critical challenge for their device applications.Using ab initio nonadiabatic molecular dynamics,we demonstrate that methylamine fragments deriving from the dissociation of the methylammonium cation can undermine structural stability,produce deep hole traps,and decrease charge carrier lifetimes by 1-3 orders of magnitude.Both stability and charge lifetime can be restored by methylamine passivation with chlorines,which withdraw electrons from the lone electron pair of methylamine and bring the trap levels down into the valence band.The charge lifetime of the passivated system is even longer than that of the pristine perovskite.The simulations reveal the detailed microscopic mechanism underlying deterioration of perovskite performance due to molecular defects,and demonstrate an effective defect passivation strategy to obtain highly efficient and stable perovskite solar cells.

关键词： hybrid organic-inorganic perovskites structural stability methylammonium dissociation chlorine passivation time-domain density functional theory nonadiabati cmolecular dynamics

Overlapping infections of Mycobacterium canariasense and Nocardia farcinica in an immunocompetent patient:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第12期12卷 2079-2085页

作者： hai-Yan Huang Kun-Peng Bu Jin-wei Liu Jing wei Department of Comprehensive Internal Medicine The Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Doppler Ultrasound The Second Nanning People's HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since then.Nocardia is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales order.Conventional methods for diagnosis of NTM are inefficient.Metagenomic next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare species.Most NTM and Nocardia infections occur in immunocompromised patients with atypical clinical symptoms.There are no previous reports of infection by M.canariasense and Nocardia farcinica(N.farcinica),especially in immunocompetent patients.This case report describes an immunocompetent 52-year-old woman who had overlapping infections of M.canariasense,N.farcinica,and Candida parapsilosis(C.parapsilosis)based on mNGS.CASE SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 wk.She received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain persisted.We collected samples of a lung lesion and alveolar lavage fluid for mNGS.The lung tissue was positive for M.canariasense,N.farcinica,and C.parapsilosis,and the alveolar lavage fluid was positive for M.canariasense.The diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the patient.CONCLUSION Etiological diagnosis is critical for patients with infectious diseases.mNGS can identify rare and novel pathogens,and does not require a priori knowledge.

关键词： Overlapping infection Mycobacterium canariasense Nocardia farcinica Metagenomic next-generation sequencing technology Case report