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Neonatal feeding of an estrogen receptor β agonist induces external adenomyosis-like lesions in ICR mouse

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Reproductive and Developmental Medicine 2022年第3期6卷 144-151页

作者： Yun-Lei Cao Xi wang Xi-Shi Liu Tasuku Harada Sun-wei guo Shanghai Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases Fudan UniversityShanghai 200011China Department of Obstetrics and Gynecology Tottori University Faculty of MedicineYonagoTottori 683-8504Japan

Objective:Despite the fact that adenomyosis is a fairly common gynecological disorder,its pathogenesis remains *** theories on the pathogenesis of adenomyosis have been proposed,but none of them has been proven *** far,the most used one is the neonatal feeding of tamoxifen(TAM)in Institute of Cancer Research/cryopreserved(ICR/CD-1)***,its underlying mechanism of action is *** further delineate the mechanism of TAM-induced adenomyosis in ICR/CD-1 mouse with regard to specific estrogen receptor(ER),we conducted an experiment that neonatal mice were fed with either TAM,or 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol(PPT;an ERαagonist),or 2,3-bis(4-hydroxyphenyl)-propionitrile(DPN;an ERβagonist),or G-1(a G-protein coupled receptor 30 agonist),or just vehicle,in an attempt to tease out which specific receptor plays a dominant role in the genesis of adenomyosis induced by neonatal feeding of ***:Forty female neonatal mice were randomly divided into 5 equal-sized groups:CTL(control),TAM,PPT,DPN,and *** months later,all mice were sacrificed and their uterine horns were harvested,weighed,and processed for histological ***:All mice in the TAM group developed adenomyosis,so did 4 mice(50%)in the DPN group,a result that should be considered significant given that mice in the CTL group would not develop *** mouse in the PPT or G-1 group developed ***,all lesions in the DPN group were seen exclusively near the uterine serosa,which are dramatically different from that of TAM mice and reminiscent of extrinsic or external adenomyosis in ***:Neonatal feeding of DPN induces adenomyosis,but the adenomyotic lesions appear to be different from those induced by ***,the cause of TAM-induced adenomyosis in ICR/CD-1 mouse cannot be attributable to one specific ER *** suggests that the extrinsic/external adenomyosis may have a pathogenesis that is differen

关键词： Adenomyosis Estrogen receptor a agonist Estrogen receptorβagonist Mouse model Neonatal Tamoxifen

混合教学法应用于神经内科住院医师规范化培训电生理带教探索

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中国高等医学教育 2024年第1期 87-88,90页

作者：聂田魏婉卲雪瑛赵晓燕唐波蒋敏海杭州市第一人民医院浙江杭州310006

目的:探讨混合教学法应用于神经内科住院医师规范化培训电生理带教中的探索及效果评价。方法:选取杭州市第一人民医院2010年9月至2020年8月参加神经内科住院医师规范化培训的88名住院医师,对照组46名在神经电生理轮转期间采用传统教学法... 详细信息

目的:探讨混合教学法应用于神经内科住院医师规范化培训电生理带教中的探索及效果评价。方法:选取杭州市第一人民医院2010年9月至2020年8月参加神经内科住院医师规范化培训的88名住院医师,对照组46名在神经电生理轮转期间采用传统教学法,试验组42名采用CBL联合PBL混合教学方法。对两组进行电生理操作及结果判读考核,并对比两组成绩差别及教学满意度。结果:试验组操作考核(P=0.000)、电生理结果判读考核(P=0.003)、教学满意度(P=0.001)均优于对照组,差别有统计学意义。结论:混合教学法在神经内科住院医师规范化培训神经电生理带教中可以促进教学质量。

关键词：住院医师规范化培训神经电生理 CBL教学法 PBL教学法混合教学法

The fractal or scaling perspective on progressively generated intra-urban clusters from street junctions

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International Journal of Digital Earth 2023年第1期16卷 1944-1961页

作者： Biao He Renzhong guo Minmin Li Ying Jing Zhigang Zhao wei Zhu Chen Zhang Chengyue Zhang Ding Ma Research Institute for Smart Cities School of Architecture and Urban PlanningShenzhen University&MNR Technology Innovation Center of Territorial&Spatial Big Data&MNR Key Laboratory of Urban Land Resources Monitoring and Simulation&Guangdong-Hong Kong-Macao Joint Laboratory for Smart CitiesShenzhenPeople’s Republic of China Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ) ShenzhenPeople’s Republic of China Ningbo Institute of Technology School of EconomicsZhejiang UniversityNingboPeople’s Republic of China School of Resource and Environmental Sciences Wuhan UniversityWuhanPeople’s Republic of China

The underlying complexity of urban space can be manifested by its fractal forms and scaling *** paper examines these characteristics at the intra-urban scale through the lens of clustered street junctions(including road ends)in two Chinese metropolitan areas:Beijing and *** derived the cluster sets with Euclidean distance thresholds starting at 100 meters(m)and ending at 1000 m,and outlined each cluster using a concave-hull method to maintain their original irregular *** each delimited cluster,we examined four urban attributes:gross domestic product,number of street nodes,polygon area,and *** analysis revealed that power law distribution applied to almost every cluster set in terms of the four attributes,but varied from one attribute to another or from city to city,represented primarily byfluctuated power law exponents and ht-index values whose profiles along with the cluster growth can effectively characterize the urban ***,we computed the spectrum of intra-urban scaling exponents with cluster size increments,contributing new insights into the allometric relationships between urban configuration and function.

关键词： Spatial clustering urban structure urban function power law intra-urban scaling law

Neglected acidity pitfall: boric acid-anchoring hole-selective contact for perovskite solar cells

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National Science Review 2023年第5期10卷 221-231页

作者： Huanxin guo Cong Liu Honglong Hu Shuo Zhang Xiaoyu Ji Xiao-Ming Cao Zhijun Ning wei-Hong Zhu He Tian Yongzhen Wu Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterInstitute of Fine ChemicalsFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and Technology School of Physical Science and Technology Shanghai Tech University

The spontaneous formation of self-assembly monolayer(SAM) on various substrates represents an effective strategy for interfacial engineering of optoele ctronic ***-selective SAM is becoming popular among high-performance inverted perovskite solar cells(PSCs),but the presence of strong acidic anchors(such as-PO3H2) in state-of-the-art SAM is detrimental to device ***,we report for the first time that acidity-weakened boric acid can function as an alternative anchor to construct efficient SAM-based hole-sele ctive contact(HSC) for *** calculations reve al that boric acid spontaneously chemisorbs onto indium tin oxide(ITO) surface with oxygen vacancies facilitating the adsorption *** and electrical measurements indicate that boric acid anchor significantly mitigates ITO *** excess boric acid containing molecules improves perovskite deposition and results in a coherent and well-passivated bottom interface,which boosts the fill factor(FF) performance for a variety of perovskite *** optimal boric acid-anchoring HSC(MTPA-BA) can achieve power conversion efficiency close to 23% with a high FF of 85.2%.More importantly,the devices show improved stability:90% of their initial efficiency is retained after 2400 h of storage(ISOS-D-1) or 400 h of operation(ISOS-L-1),which are 5-fold higher than those of phosphonic acid SAM-based ***-weakened boric acid SAMs,which are friendly to ITO,exhibits well the great potential to improve the stability of the interface as well as the device.

关键词： perovskite solar cells hole-selective contact boric acid anchor acid-induced degradation long-term stability

Anomalous refinement and uniformization of grains in metallic thin films

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Nano Research 2023年第12期16卷 13358-13365页

作者： Lei wang Shu wang Xiaofeng wang Jianming Zhang Jianjie Dong Bin wei Haiguang Yang Zhongchang wang Ziyang Zhang ChuanFei guo Qian Liu Chinese Academy of Sciences(CAS)Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology&University of Chinese Academy of SciencesBeijing 100190China College of Mathematics and Physics Qingdao University of Science and TechnologyQingdao 266061China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Materials Sun Yat-Sen UniversityGuangzhou 510275China International Iberian Nanotechnology Laboratory(INL) Department of Quantum and Energy MaterialsBraga 4715-330Portugal School of Electronic and Information Engineering Qingdao UniversityQingdao 266071China The MOE Key Laboratory of Weak-Light Nonlinear Photonics and TEDA Applied Physics Institute and School of Physics Nankai UniversityTianjin 300457China

When a laser beam writes on a metallic film,it usually coarsens and deuniformizes grains because of Ostwald ripening,similar to the case of *** we show an anomalous refinement effect of metal grains:A metallic silver film with large grains melts and breaks into uniform,close-packed,and ultrafine(~10 nm)grains by laser direct writing with a nanoscale laser spot size and nanosecond pulse that causes localized heating and adaptive *** method exhibits high controllability in both grain size and uniformity,which lies in a linear relationship between the film thickness(h)and grain size(D),D∝*** linear relationship is significantly different from the classical spinodal dewetting theory obeying a nonlinear relationship(D∝h5/3)in common laser *** also demonstrate the application of such a silver film with a grain size of~10.9 nm as a surface-enhanced Raman scattering chip,exhibiting superhigh spatial-uniformity and low detection limit down to 10-15 *** anomalous refinement effect is general and can be extended to many other metallic films.

关键词： laser direct writing anomalous refinement localized heating ripening linear relationship

基于生信分析与实验验证探讨黄芩素改善癫痫后认知障碍的分子机制

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中医药信息 2024年第6期41卷 1-8,18页

作者：李晨阳赵姣娇郭晗陈思软郝雪南张炜河北医科大学河北石家庄050017

目的:采用网络药理学与实验验证研究黄芩素(Baicalein)对癫痫后认知障碍小鼠模型谷氨酸代谢水平的影响,探讨其防治癫痫后认知障碍的作用机制。方法:基于文献检索与网络药理学分析,应用STRING、DAVID在线平台与Cytoscape 3.8.2软件构建蛋... 详细信息

目的:采用网络药理学与实验验证研究黄芩素(Baicalein)对癫痫后认知障碍小鼠模型谷氨酸代谢水平的影响,探讨其防治癫痫后认知障碍的作用机制。方法:基于文献检索与网络药理学分析,应用STRING、DAVID在线平台与Cytoscape 3.8.2软件构建蛋白-蛋白互作(PPI)网络,京都基因和基因组百科全书(KEGG)信号通路和基因本体论(GO)功能富集分析。利用分子对接技术预测Baicalein与GRIA2、SLC1A1和SLC1A2基因之间的结合力。体内实验:40只雄性C57BL/6J小鼠随机分为Model组、Baicalein组、VPA组和Baicalein+VPA组,每组10只。给予相应干预后检测小鼠海马组织的炎性浸润情况与SLC1A1、SLC1A2的表达水平变化。体外实验:CHO-GRIA2细胞灌注不同剂量的Baicalein,观察其电流变化。结果:PPI网络中发现兴奋性氨基酸载体1(SLC1A1)、兴奋性氨基酸转运体2(SLC1A2)等40个靶点。KEGG与GO富集分析发现谷氨酸能突触、尼古丁成瘾、离子型谷氨酸受体信号通路、AMPA谷氨酸受体活性、突触后致密膜等与谷氨酸强相关的信号通路。分子对接结果表明,Baicalein与GRIA2、SLC1A1、SLC1A2基因具有较强的结合亲和力。给药后,与Model组比较,Baicalein组与Baicalein+VPA组海马组织炎性浸润率显著降低,各给药组SLC1A1与SLC1A2水平显著升高。CHO-GRIA2灌注1、5、10、20、50μmol/L不同剂量的Baicalein后,其抑制作用逐渐增强,IC50为9.353μmol/L。结论:Baicalein可通过上调谷氨酸转运体SLC1A1和SLC1A2的表达,降低GRIA2受体的表达,改善癫痫后认知障碍的海马炎性浸润情况。

关键词：网络药理学黄芩素谷氨酸癫痫后认知障碍谷氨酸转运体

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Conformal Human–Machine Integration Using Highly Bending‑Insensitive,Unpixelated,and Waterproof Epidermal Electronics Toward Metaverse

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纳微快报:英文版 2023年第11期15卷 140-156页

作者： Chao wei wansheng Lin Liang wang Zhicheng Cao Zijian Huang Qingliang Liao Ziquan guo Yuhan Su Yuanjin Zheng Xinqin Liao Zhong Chen Department of Electronic Science Xiamen UniversityXiamen 361005People’s Republic of China Department of Engineering Mechanics School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Key Laboratory for Advanced Energy Materials and Technologies School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

Efficient and flexible interactions require precisely converting human intentions into computer-recognizable signals,which is critical to the breakthrough development of *** electronics face common dilemmas,which realize highprecision and stable touch detection but are rigid,bulky,and thick or achieve high flexibility to wear but lose ***,we construct highly bending-insensitive,unpixelated,and waterproof epidermal interfaces(BUW epidermal interfaces)and demonstrate their interactive applications of conformal human–machine *** BUW epidermal interface based on the addressable electrical contact structure exhibits high-precision and stable touch detection,high flexibility,rapid response time,excellent stability,and versatile“cut-and-paste”*** of whether being flat or bent,the BUW epidermal interface can be conformally attached to the human skin for real-time,comfortable,and unrestrained *** research provides promising insight into the functional composite and structural design strategies for developing epidermal electronics,which offers a new technology route and may further broaden human–machine interactions toward metaverse.

关键词： Carbon-based functional composite Multifunctional epidermal interface Property modulation Addressable electrical contact structure Conformal human–machine integration

Coercivity enhancement of hot-deformed Nd-Fe-B magnets with Pr-Cu alloy addition

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Rare Metals 2023年第4期42卷 1403-1407页

作者： Jun-Ming wang Zhao-Hui guo Zheng Jing Xiao Du Neng-Jun Yu Meng-Yu Li Ming-Gang Zhu wei Li Division of Functional Materials Central Iron&Steel Research InstituteBeijing100081China

Effects of low-melting Pr-Cu alloy addition on the microstructure and magnetic properties of the hot-deformation Nd-Fe-B magnets were investigated.A small amount of Pr-Cu addition enhances the coercivity of the hot-deformation Nd-Fe-B magnets *** coercivity of the hotdeformation Nd-Fe-B magnets with 4.0 wt%Pr_(85)Cu_(15)addition increases to 1271 kA·m^(-1),75.69%higher than that of Pr-Cu-free magnet(723 kA·m^(-1)),and then decreases with5 wt%Pr_(85)Cu_(15)*** is observed that there a uniform RE-rich phase is formed wrapping the Nd2Fe14B main phase in the sample with 4.0%Pr_(85)Cu_(15)addition by scanning electron microscopy(SEM),which promotes the *** angular dependence of coercivity for the hot-deformation Nd-Fe-B magnets indicates that the coercivity mechanism is nucleation combined with domain wall *** domain wall pinning is weakened,while the nucleation is enhanced after Pr-Cu ***,intrinsic coercivity,and maximum magnetic energy product of the original Nd-Fe-B magnet are 1.45 T,723 kA·m^(-1),and 419.8 kJ·m^(-3),respectively,and those of the sample with 4.0%Pr_(85)Cu_(15)alloy addition are 1.30 T,1271 kA·m^(-1),and 330.0 kJ·m^(-3),respectively.

关键词： Nd-Fe-B Low-melting alloy Hot-deformation Microstructure Coercivity mechanism

关节腔注射联合“经筋”手法治疗早中期冻结肩的疗效观察

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西部中医药 2024年第4期37卷 150-154页

作者：易志勇韩清民魏合伟杨威黄旭东郑维蓬万雷刘治军广州中医药大学第三附属医院广东广州510405

目的:观察关节腔注射联合“经筋”手法治疗早中期冻结肩的临床疗效及安全性。方法:选择62例早中期冻结肩患者,按照治疗方法不同分为观察组和对照组,每组31例。对照组予以口服美洛昔康片,外用温性经筋通贴膏、经筋通凝胶剂,观察组予以关... 详细信息

目的:观察关节腔注射联合“经筋”手法治疗早中期冻结肩的临床疗效及安全性。方法:选择62例早中期冻结肩患者,按照治疗方法不同分为观察组和对照组,每组31例。对照组予以口服美洛昔康片,外用温性经筋通贴膏、经筋通凝胶剂,观察组予以关节腔注射联合“经筋”手法治疗,分别于治疗前后比较疼痛视觉模拟量表(visual analogue score,VAS)评分、肩痛和功能指数(shoulder pain and function index,SPADI)、Fugl-Meyer肩关节活动范围量表评分和Constant-Murley肩功能评分,并对临床疗效及不良反应进行评价。结果:治疗后,两组VAS、SPADI评分较治疗前降低(P0.05)。观察组不良事件发生率[22.6%(7/31)]低于对照组[45.2%(14/31)](P<0.05)。结论:关节腔注射联合“经筋”手法治疗早中期冻结肩疗效明显,安全性好。

关键词：冻结肩关节腔注射经筋手法临床疗效