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Clinical significance of changes in the Th17/Treg ratio in autoimmune liver disease

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World Journal of Gastroenterology 2017年第21期23卷 3832-3838页

作者： Ting-Ting feng Ting Zou Xin Wang wei-feng zhao Ai-Lan Qin Department of Infectious Diseases the First Affiliated Hospital of Soochow University

AIM To investigate the levels, ratios, and clinical significance of T helper 17(Th17) cells and regulatory T(Treg) cells in the peripheral blood of patients with autoimmune liver disease(AILD). METHODS F o r t y-t w o A I L D p a t i e n t s w e r e i n c l u d e d i n t h e experimental group(group E), and 11 healthy subjects were recruited as the control group(group C). Flow cytometry was performed to determine the percentages of Th17 and Treg cells in peripheral blood lymphocytes. Furthermore, a range of biochemical indices was measured simultaneously in the blood of group E patients. RESULTS The percentage of Th17 cells and the Th17/Treg ratio were higher in group E than in group C(P < 0.01), whereas the percentage of Tregs was lower in the group E patients(P < 0.05). Patients in group E who were admitted with AILD in the active stage showed significantly higher Th17 percentages and Th17/Treg ratios than those measured in patients with AILD in remission(P < 0.05). In addition, among patients with AILD in the active stage, individuals that remained unhealed after hospitalization showed significantly higher baseline values of the Th17 percentage and the Th17/Treg ratio than those detected in patients who improved after treatment(P < 0.05). The results suggested that imbalance in the Th17/Treg ratio plays an important role in the pathogenesis and development of *** A high Th17/Treg ratio appears to predict poor shortterm prognosis in patients with AILD in the active stage.

关键词： Autoimmune liver disease Helper T cell 17 Regulatory T cells Short-term prognosis

Recombinant human thrombopoietin treatment in patients with chronic liver disease-related thrombocytopenia undergoing invasive procedures:A retrospective study

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1260-1271页

作者： Jing-Nuo Ding Ting-Ting feng wei Sun Xin-Yi Cai Yun Zhang wei-feng zhao Department of Infectious Diseases The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Chronic liver disease(CLD)related thrombocytopenia increases the risk of bleeding and poor *** liver disease patients require invasive procedures or surgeries,such as liver biopsy or endoscopic variceal ligation,and most of them have lower platelet counts,which could aggravate the risk of bleeding due to liver dysfunction and coagulation ***,there is no defined treatment modality for CLD-induced *** human thrombopoietin(rhTPO)is commonly used to treat primary immune thrombocytopenic purpura and thrombocytopenia caused by solid tumor chemotherapy;however,there are few reports on the use of rhTPO in the treatment of CLD-related *** To evaluate the efficacy of rhTPO in the treatment of patients with CLDassociated thrombocytopenia undergoing invasive *** All analyses were based on the retrospective collection of clinical data of patients with CLD who were treated in the Department of Infectious Diseases at The First Affiliated Hospital of Soochow University between June 2020 and December ***-nine male and 41 female patients with liver disease were enrolled in this study to assess the changes in platelet counts and parameters before and after the use of rhTPO for *** events related to treatment,such as bleeding,thrombosis,and disseminated intravascular coagulation,were also *** Among the enrolled patients,78(78%)showed a platelet count increase after rhTPO use,while 22(22%)showed no significant change in platelet *** mean platelet count after rhTPO treatment in all patients was 101.53±81.81×10^(9)/L,which was significantly improved compared to that at baseline(42.88±16.72×10^(9)/L),and this difference was statistically significant(P50×10^(9)/L).Subgroup analyses showed that the medi

关键词： Recombinant human thrombopoietin Invasive procedures Chronic liver disease Liver cirrhosis Thrombocytopenia Platelet transfusion

Elevated serum prostaglandin E2 predicts the risk of infection in hepatitis B virus-related acute-on-chronic liver failure patients

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 916-920页

作者： Xiao-Ping Huang Yan Wang Li Chen wei Sun Yan Huang Ying Xu Ting-Ting feng Er-Ping Luo Ai-Lan Qin wei-feng zhao Jian-He Gan Department of Infectious Diseases The First Affiliated Hospital of Suzhou UniversitySuzhouChina

Objective: To evaluate the serum Prostaglandin E2(PGE2) level in Acute-on-chronic liver failure(ACLF) and determine its predicative value for ***: From April 2014 to April 2015, ninety-one patients with hepatitis B virus and ACLF but without infection were enrolled into this prospective study that was carried out at our Hospital. Twenty patients with stable chronic hepatitis B were enrolled from the outpatient department and twenty healthy control subjects without any disease were enrolled from hospital staff. Serum PGE2 levels were determined using ELISA at enrollment. Clinical and laboratory parameters were collected. Receiver operating characteristic(ROC) curves were used to determine optimal cut-off values to predict ***: Significantly higher PGE2 levels were found in patients with ACLF in comparison with healthy controls and patients with stable CHB(P < 0.000 1). In ACLF patients, PGE2 levels were significantly higher in patients that eventually developed infection than those without this complication(P < 0.000 1). ROC analysis showed that serum PGE2(area under the ROC curve, 0.83) could predict infection in patients with ACLF with sensitivity of 78.4% and specificity of 81.5% using a threshold of 141 pg/m ***: Serum PGE2 is associated with the susceptibility to secondary infections for patients with ACLF. Increased PGE2 serum levels may serve as a potential biomarker for developing infections in ACLF patients.

关键词： Acute-on-chronic liver failure Immune paralysis Infection Prostaglandin E2

Feasibility and safety of vaginal myomectomy:analysis of 90 cases

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Chinese Medical Journal 2006年第21期119卷 1790-1793页

作者： wei feng-hua zhao Xiao-dong ZHANG Yi Department of Obstetrics and Gynecology Beijing Hospital Beijing 100730 China

Background Vaginal myomectomy was firstly reported in 1994, however, it is a relatively new technique in China. The feasibility and safety of the procedure is still controversial in this country. The aim of this study was to analyze the outcomes of vaginal myomectomy in 90 patients and to investigate the feasibility and safety of the surgery. Methods From June 2001 to June 2004, 90 patients with uterine leiomyoma were treated with vaginal myomectomy in our hospital （vaginal group）. The indications, operative performance, postoperative complications, and recovery of the patients were analyzed and compared with those of 93 patients with uterine leiomyoma treated by laparotomic myomectomy from January 2000 to January 2001 （laparotomy group）. The Student＇s t test was used to compare the continuous variables between the two groups, and the chi-square test was used to compare the categorical variables. The vaginal and laparotomy groups were followed up for 10-34 months （median, 21） and 15-24 months （median, 30）, respectively. Results Vaginal myomectomy was performed successfully in 87 of the 90 patients （96.7%）. In the other 3 patients, the procedure failed and laparotomy was carded out. In both groups, the uterus was enlarged to 8-16 weeks gestational size （median, 10 gestational weeks）. The number of resected tumors was 1 - 12 （median, 2） in the vaginal group and 1-15 （median, 4） in the laparotomy group, respectively （P〉0.05）. The mean operating time, intraoperative blood loss, and postoperative hospital stay were （52± 21） minutes, （230± 44） ml, and （7.0±1.2） days in the vaginal group, and （654±32） minutes, （200±56） ml, and （7.04±1.5） days in the laparotomy group （P〉0.05）. The mean top postoperative temperature was （38.44±1.1）℃ and （37.8±0.6）℃ in the two groups respectively （P〈0.05）. Both groups had one recurrent case during the follow-up （P〉0.05）. Condusions Vaginal myomectomy is feasible and safe in treating uterine leiomyoma. To some extent, it is superior to laparot

关键词： uterine neoplasms leiomyoma surgical procedures, minimally invasive

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加快吉林电网发展的若干思考

电网技术 2006年第13期30卷 1-7页

作者：魏昭峰吉林省电力有限公司吉林省长春市130021

通过对吉林电网现状的分析,指出了电网存在的主要问题,根据电源规划和负荷预测的结果,提出了吉林电网“十一五”发展的指导思想,明确了电网的发展目标,阐述了吉林省500kV电网、220kV电网、重点城市电网、城乡电网和电网二次系统的发展... 详细信息

通过对吉林电网现状的分析,指出了电网存在的主要问题,根据电源规划和负荷预测的结果,提出了吉林电网“十一五”发展的指导思想,明确了电网的发展目标,阐述了吉林省500kV电网、220kV电网、重点城市电网、城乡电网和电网二次系统的发展思路以及加大使用高新技术的力度、提高电网科技含量的建议,最后探讨了在吉林电网发展过程中需要注意的若干问题。

关键词：电力系统吉林电网发展规划

DIFFERENTIATION BETWEEN MALIGNANT AND BENIGN OVARIAN TUMORS BY MAGNETIC RESONANCE IMAGING

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Chinese Medical Sciences Journal 2006年第4期21卷 270-275页

作者： Min Chen Wen-chao Wang Cheng Zhou Ni-na Zhou Kui Cai Zheng-han Yang wei-feng zhao Sa-ying Li Guo-zhen Li Department of Radiology Beijing Hospital Beijing 100730

Objective To determine the magnetic resonance （MR） imaging findings of an ovarian mass which are most predictive of malignancy and assess the value of intravenous gadolinium administration in the characterization of an ovarian mass. Methods Totally 74 consecutive patients with a clinically or sonographicaUy indeterminate adnexal mass underwent MR imaging, of whom 59 had subsequent surgical resection of 70 adnexal masses. These 59 patients formed the study population. MR imaging studies were prospectively and independently reviewed by a senior and a junior radiologist. The senior radiologist also reevaluated the studies in a blind fashion after a minimum 6 months interval. The sensitivity, specificity, positive predictive value, and negative predictive value of contrast-enhanced and unenhanced MR im- aging were evaluated Results The most predictive MR imaging findings for malignancy were presence of vegetations in a cystic lesinn and presence of necrosis in a solid lesion. The odds ratio was even higher when the ancillary finding of peritoneal metastasis or ascites was present. Contrast media contributed significantly to lesinn characterization. Total 70 ovarian masses were detected by contrast-enhanced MR imaging including 37 malignant ovarian masses and 33 benign ovarian masses with 87% （61/70）accuracy, 86% （32/37）sensitivity, 88% （29/33）specificity, 89% （32/36）positive predictive value, and 85% （29/34） negative predictive value, whereas 70 ovarian masses were detected by unenhanced MR imaging with 74% （52/70） accuracy, 73 % （27/37） sensitivity, 76 % （ 25/33 ） specificity, 77% （27/35） positive predictive value, and 71% （ 25/35 ） negative predictive value. There were significant differences in accuracy （ P 〈 0. 01 ）, sensitivity （ P 〈0. 01 ）, specificity （ P 〈0. 01 ） between contrast-enhanced and unenhanced MR imaging. Conclusion Contrast-enhanced MR imaging is highly accurate in detection and characterization of complex adnexal masses.

关键词： ovarian tumor malignancy magnetic resonance imaging

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21世纪中国基础教育的传统文化使命

教育学报 2010年第4期6卷 37-42页

作者：魏兆锋华东师范大学教育学系上海200062 西藏民族学院教育学院陕西咸阳712082

21世纪中国基础教育的传统文化使命既包括培养学生对中国传统文化的感恩情怀,又包括培养学生对中国传统文化的自觉意识。为了顺利实现此一使命,我们应该将中国传统文化系统而又连续地纳入现代课程体系,使之成为能够反映中国传统文化特... 详细信息

21世纪中国基础教育的传统文化使命既包括培养学生对中国传统文化的感恩情怀,又包括培养学生对中国传统文化的自觉意识。为了顺利实现此一使命,我们应该将中国传统文化系统而又连续地纳入现代课程体系,使之成为能够反映中国传统文化特质和精神的中国传统文化综合课程。与此同时,我们还应该注重基础教育阶段的隐性课程建设:其一,教师尤其是历史、语文等人文学科教师自身首先应该努力加强中国传统文化修养;其二,每个学校可以根据自己的特殊情况着意营造一种深富中国传统文化特色的校园文化氛围。

关键词： 21世纪巾围基础教育传统文化使命

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风电在我国能源发展中的定位

中国电力 2011年第4期44卷 1-5页

作者：魏昭峰中国电力企业联合会北京100761

我国在能源结构调整和积极开发可再生能源等方面取得了显著成绩,尤其是风力发电实现了倍增式发展。但风电的高速发展与电力系统、产业体系和政策机制之间存在诸多不协调,需要理清根本原因,进一步深化解决。基于我国风电发展的既有特点... 详细信息

我国在能源结构调整和积极开发可再生能源等方面取得了显著成绩,尤其是风力发电实现了倍增式发展。但风电的高速发展与电力系统、产业体系和政策机制之间存在诸多不协调,需要理清根本原因,进一步深化解决。基于我国风电发展的既有特点和现实问题,从能源利用、能源发展的角度和风电发展的最终目标3个方面进行逻辑论证,提出了风电的能源定位问题,论述了当前风电发展应立足于风电产业化体系的完善以及智能电网建设和新储能技术研究,为未来风电大规模发展打下坚实基础。

关键词：风电定位能源品位能源发展替代能源

2017年四川九寨沟M_s7.0地震前区域重力场变化

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地球物理学报 2017年第10期60卷 4124-4131页

作者：祝意青梁伟锋赵云峰刘芳隗寿春徐云马中国地震局第二监测中心西安710054

利用南北地震带2014-2017年期间的流动重力观测资料,系统分析了区域重力场变化及其与2017年8月8日四川九寨沟7.0级地震发生的关系.结果表明:①区域重力场异常变化与北西西向塔藏断裂和南北向岷江断裂带在空间上关系密切,反映了沿控震断... 详细信息

利用南北地震带2014-2017年期间的流动重力观测资料,系统分析了区域重力场变化及其与2017年8月8日四川九寨沟7.0级地震发生的关系.结果表明:①区域重力场异常变化与北西西向塔藏断裂和南北向岷江断裂带在空间上关系密切,反映了沿控震断裂在2013-2017年期间发生了引起地表重力变化效应的地壳变形和构造活动.②九寨沟地震前,测区内出现了大空间范围的区域性重力异常,而震源区附近产生了局部重力异常,沿塔藏断裂带形成了重力变化高梯度带,其中,甘肃玛曲、迭部、青海河南蒙古族自治县、四川若尔盖、九寨沟一带重力差异变化达100×10^(-8)m·s^(-2)以上;这些可能反映九寨沟地震前,区域及震源区附近均产生与该地震孕育、发生有关的构造运动或应力增强作用.③九寨沟地震震中位于重力差异运动剧烈的鞍部等值线附近,与断裂走向基本一致的重力变化高梯度带零值线上,这一观测事实进一步佐证了重力场动态变化图像对强震地点预测具有重要的指示意义.

关键词：南北地震带重力观测重力变化九寨沟地震中期前兆