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Skeletal muscle-derived cells repair peripheral nerve defects in mice

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Neural Regeneration Research 2020年第1期15卷 152-161页

作者： Zi-Xiang Chen Hai-Bin Lu Xiao-Lei Jin wei-feng feng Xiao-Nan Yang Zuo-Liang Qi The 16^th Department Plastic Surgery HospitalChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)BeijingChina Yu Tian Cheng Plastic Surgery Clinic ShanghaiChina

Skeletal muscle-derived cells have strong secretory function,while skeletal muscle-derived stem cells,which are included in muscle-derived cells,can differentiate into Schwann cell-like cells and other cell ***,the effect of muscle-derived cells on peripheral nerve defects has not been *** this study,5-mm-long nerve defects were created in the right sciatic nerves of mice to construct a peripheral nerve defect *** female C57BL/6 mice were randomly divided into four *** the muscle-derived cell group,muscle-derived cells were injected into the catheter after the cut nerve ends were bridged with a polyurethane *** external oblique muscle-fabricated nerve conduit and polyurethane groups,an external oblique muscle-fabricated nerve conduit or polyurethane catheter was used to bridge the cut nerve ends,*** the sham group,the sciatic nerves on the right side were separated but not *** 8 and 12 weeks post-surgery,distributions of axons and myelin sheaths were observed,and the nerve diameter was calculated using immunofluorescence *** number,diameter,and thickness of myelinated nerve fibers were detected by toluidine blue staining and transmission electron *** fiber area ratios were calculated by Masson’s trichrome staining of gastrocnemius muscle *** functional index was recorded using walking footprint analysis at 4,8,and 12 weeks after *** results showed that,at 8 and 12 weeks after surgery,myelin sheaths and axons of regenerating nerves were evenly distributed in the muscle-derived cell *** number,diameter,and myelin sheath thickness of myelinated nerve fibers,as well as gastrocnemius muscle wet weight and muscle area ratio,were significantly higher in the muscle-derived cell group compared with the polyurethane *** 4,8,and 12 weeks post-surgery,sciatic functional index was notably increased in the muscle-derived cell group compared with the polyurethane

关键词： muscle nerve conduit myokine nerve regeneration nerve repair peripheral nerve regeneration polyurethane catheter seed cells skeletal muscle skeletal muscle-derived cells tissue-engineered nerve

Apelin-13 promotes H9c2 rat cardiomyocyte hypertrophy and autophagy mediated by PI3K pathway

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中国病理生理杂志 2012年第11期 2073-2074页

作者： XIE feng,LIU wei,feng feng,LI Xin,YANG Li,LU Qi-xuan,QIN Xu-ping,LI Lan-fang,CHEN Lin-Xi(Institude of Pharmacy and Pharmacology,University of South China,Learning Key Laboratory for Pharmaco-proteomics,Hengyang 421001,China)

AIM:APJ is an orphan G protein-coupled receptor and its endogenous ligand is *** objective of this work is to study whether apelin can promote rat myocardial hypertrophy and autophagy regulated by PI3k-Akt-ERK1/2-p70S... 详细信息

关键词： PI ERK Apelin-13 promotes H9c2 rat cardiomyocyte hypertrophy and autophagy mediated by PI3K pathway

Influence of insulin resistance on long-term outcomes in patients with coronary artery disease after sirolimus-eluting stent implantation

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Chinese Medical Journal 2010年第6期123卷 651-657页

作者： ZHAO Liang-ping LU An-kang SHEN wei-feng LIU Hai-feng MA Xiao-ye FAN Xiao-ming ZHANG Qi Department of Cardiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background Insulin resistance（IR）is significantly associated with coronary artery disease and cardiovascular events in patients with or without type 2 diabetes *** study aimed to evaluate the influence of IR on long-term outcomes of patients undergoing percutaneous coronary intervention（PCI）with sirolimus-eluting stent（SES）*** A total of 467 consecutive patients undergoing SES-based PCI were divided into lR group（n=104）and non-IR group（n=363）.The patients were followed up for one *** rate of major adverse cardiac events（MACEs） including death, non-fatal myocardial infarction and recurrent angina pectoris was compared by the log-rank test,and the independent risk factors were identified by the Cox regression *** MACEs occurred more frequently,and cumulative survival rate was lower in the IR group than in the non-IR group during the follow-up （all P〈0.05）.IR was an independent risk factor for the occurrence of cardiac death and non-fatal myocardial infarction（OR=2176,95% CI=1.35-5.47,P=0.034）.Old age,diabetes,and multi-vessel disease were determinants for recurrent angina pectoris after PCI（P〈0.05）.Subgroup analysis revealed that IR（OR=3.35,95% CI=1.07-13.59,P=0.013）and multi-vessel disease（OR=2.19,95%CI=1.01-5.14,P=0.044）were independent risk predictors for recurrent angina pectoris in patients with diabetes after *** IR is associated with reduced MACE-free survival and remains an independent predictor for recurrent angina pectoris after PCI with SES implantation.

关键词： insulin resistance coronary artery disease sirolimus-eluting stent long-term prognosis

Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： wei-Tong Cui Hua-Ru Xue Dian-Fang wei Xiao-Yu feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

2017年四川九寨沟M_s7.0地震前区域重力场变化

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地球物理学报 2017年第10期60卷 4124-4131页

作者：祝意青梁伟锋赵云峰刘芳隗寿春徐云马中国地震局第二监测中心西安710054

利用南北地震带2014-2017年期间的流动重力观测资料,系统分析了区域重力场变化及其与2017年8月8日四川九寨沟7.0级地震发生的关系.结果表明:①区域重力场异常变化与北西西向塔藏断裂和南北向岷江断裂带在空间上关系密切,反映了沿控震断... 详细信息

利用南北地震带2014-2017年期间的流动重力观测资料,系统分析了区域重力场变化及其与2017年8月8日四川九寨沟7.0级地震发生的关系.结果表明:①区域重力场异常变化与北西西向塔藏断裂和南北向岷江断裂带在空间上关系密切,反映了沿控震断裂在2013-2017年期间发生了引起地表重力变化效应的地壳变形和构造活动.②九寨沟地震前,测区内出现了大空间范围的区域性重力异常,而震源区附近产生了局部重力异常,沿塔藏断裂带形成了重力变化高梯度带,其中,甘肃玛曲、迭部、青海河南蒙古族自治县、四川若尔盖、九寨沟一带重力差异变化达100×10^(-8)m·s^(-2)以上;这些可能反映九寨沟地震前,区域及震源区附近均产生与该地震孕育、发生有关的构造运动或应力增强作用.③九寨沟地震震中位于重力差异运动剧烈的鞍部等值线附近,与断裂走向基本一致的重力变化高梯度带零值线上,这一观测事实进一步佐证了重力场动态变化图像对强震地点预测具有重要的指示意义.

关键词：南北地震带重力观测重力变化九寨沟地震中期前兆

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang feng Miao Peifeng wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-wei Niu Guo-Chao Zhang Wu Ning Hai-Bin Liu Hua Yang Chao-feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-feng Zhou wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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动力锂离子电池的极柱去氧化方法

电池 2017年第6期47卷 343-346页

作者：曹乃锋冯伟峰温灿国中航锂电(洛阳)有限公司河南洛阳471000

采用激光清洗去除电池极柱表面氧化层。获得50 W功率激光去氧化的最优工艺参数:扫描速度(5 000±100)mm/s、脉冲频率50 k Hz及扫描线间距0.06 mm。连接性能和防腐蚀性能测试表明:极柱接触电阻显著降低,普遍小于0.02 mΩ;动态连接一致性... 详细信息

采用激光清洗去除电池极柱表面氧化层。获得50 W功率激光去氧化的最优工艺参数:扫描速度(5 000±100)mm/s、脉冲频率50 k Hz及扫描线间距0.06 mm。连接性能和防腐蚀性能测试表明:极柱接触电阻显著降低,普遍小于0.02 mΩ;动态连接一致性良好,充电1 min最大电压差不超过0.025 V。与传统人工打磨方式相比,激光清洗能提升极柱表面耐腐蚀性能1倍以上,在清洗效率和成本方面也有优势。

关键词：动力锂离子电池极柱氧化激光清洗接触电阻防腐蚀性