检索结果-南通市图书馆

Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled maLDI-Q-TOF/MS imaging

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第2期14卷 284-286页

作者： Lixing Nie Lieyan Huang Xiaofei Jia Shuai Kang Lingwen Yao Yanpei Wu Hao Yuan Yongli Liu feng wei Hongyu Jin Xiang Li Shuangcheng ma National Institutes for Food and Drug Control Beijing102629China Chinese Academy of Medical Science and Peking Union Medical College Beijing100006China Waters Corporation Beijing102600China Hebei Institute for Drug and Medical Device Control Shijiazhuang050227China Department of Pharmacy Medical Supplies Center of the PLA General HospitalBeijing100853China

Unraveling the distribution of metabolites in traditional Chinese medicine(TCM)provides direct indications for understanding their regulatory and functional basis,which is of paramount significance for better utilization and quality control of medicinal plants[1].Recently,imaging techniques such as near-infrared spectroscopy,Raman spectroscopy,and mass spectrometry(MS)were explored to reveal the spatial context of component accumulation and localization[2,3].

关键词： medicine(TCM) Radix Scutellaria

Response of soil nutrients to terracing and environmental factors in the Loess Plateau of China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geography and Sustainability 2024年第2期5卷 230-240页

作者： Die Chen wei wei Liding Chen Bojun ma Hao Li Department of Soil and Water Conservation Changjiang River Scientific Research InstituteWuhan 430010China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Research Center on Mountain Torrent&Geologic Disaster Prevention of Ministry of Water Resources Wuhan 430010China

Terracing is a widely adopted agricultural practice in mountainous regions around the world that aims to conserve soil and water *** nutrients play a crucial role in determining soil quality,particularly in landscapes prone to *** are influenced by factors such as land-use type,slope aspect,and *** this study,we sought to examine the impact of terracing on soil nutrients(soil organic content(SOC),total nitrogen(TN),nitrate-nitrogen(NO_(3)^(-)-N),ammonium nitrogen(NH_(4)^(+)-N),total phosphorus(TP),available phosphorus(AP),total potassium(TK),and available potassium(AK))and how they vary with environmental factors in the Chinese Loess *** the growing season,we collected 540 soil samples from the 0 to 100 cm soil layer across five major land-use types,different slope aspects,and varying ***,a meta-analysis of literature data further corroborated the effective accumulation of soil nutrients through terracing in the Loess *** findings are as follows:(1)Terraced fields,regardless of land-use type,showed a significant improvement in SOC and TN content.(2)Soil nutrient contents within terraced fields were predominantly higher on sunny slopes.(3)Terraces at lower altitudes are characterized by elevated SOC concentrations.(4)A meta-analysis of literature data pertaining to terracing and soil nutrients in this region confirmed the effective accumulation of soil nutri-ents through *** elucidated outcomes of this study offer a profound theoretical underpinning for the accurate planning and management of terraces,the scientific utilization of land resources,and the enhancement of land productivity.

关键词： Terrace Soil nutrients Land-use Slope aspect Altitude Loess Plateau

The combined effect of bromadiolone and ivermectin (iBr) in controlling both rodents and their fleas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第1期19卷 156-164页

作者： Ming LIU Xinrong WAN wei LIU Xingan ma Zhibin ZHANG State Key Laboratory of Integrated Pest management Institute of ZoologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina Inner Mongolia Minzu University TongliaoInner MongoliaChina International Society of Zoological Sciences BeijingChina

Rodent pests not only cause severe agricultural loss but also spread zoonotic pathogens to human ***-agulant rodenticides are widely used to decrease the population densities of rodents but often lead to the spillover of ectoparasites becausefleas and ticks may gather on surviving ***,it is necessary to killfleas and ticks before culling rodents to minimize the risk of pathogen *** this study,we used a mixture of ivermectin(an antiparasitic drug)and bromadiolone(an anticoagulant rodenticide)to control both rodent andflea/tick *** found that in a laboratory test,0.01%ivermectin bait was not lethal for greater long-tailed hamsters after 7 days of treatment,while 0.1%ivermectin bait was lethal for approximately 33%of treated *** afield test,bait containing 0.001%,0.005%,0.01%,and 0.05%ivermectin decreased the number offleas per vole of Brandt’s voles to 0.42,0.22,0.12,and 0.2,respectively,compared with 0.77 in the control group,indicating that 0.01%ivermectin bait performed best in *** another laboratory test,bait containing a 0.01%ivermectin and 0.005%bromadiolone mixture caused the death of all voles within 6–14 days after the intake of the *** thefield test,the bait containing 0.01%ivermectin and 0.005%bromadiolone reduced the average number offleas per vole to 0.35,which was significantly lower than the 0.77 of the control *** results indicate that a 0.01%ivermectin and 0.005%bromadiolone mixture could be used to control both rodents andfleas to minimize the spillover risk of disease transmission when using traditional rodenticides.

关键词： bromadiolone flea iBr ivermectin rodent synergistic control

In situ thermoresponsive supramolecular assembly for switchable circularly polarized luminescence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第7期67卷 2362-2372页

作者： Menghan Pan Gong Zhang Haotian ma Xiaoxiao Cheng Jieai Li wei Zhang State and Local Joint Engineering Laboratory for Novel Functional Polymeric materials Jiangsu Engineering Laboratory of Novel Functional Polymeric MaterialsSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu 241000China

The dynamic regulation of circularly polarized luminescence(CPL)holds profound significance in various fields,such as highlevel information storage and *** we developed a chiral amphiphilic molecule,CPSB-GLU-PEG350(CGP),composed of aggregation-induced emission(AIE)chromophores(Z)-4-(1-cyano-2-phenylvinyl)benzoic acid(CPSB),a chiral linker Glutamic acid and polyethylene glycol(PEG)thermoresponsive *** the self-assembled supramolecular system formed by CGP,we have achieved in-situ temperature-responsive chiral structures,facilitating the thermal control switch of the CPL *** dynamics simulations demonstrate the distinct behaviors of AIE and PEG units during the temperature-variable assembly ***,by co-assembling achiral dye molecules with CGP,we have expanded the color range of the temperature-responsive CPL assembly system in situ and confirmed the occurrence of circularly polarizedF?rster resonance energy transfer(C-FRET)phenomenon in this process,which successfully enriched the strategies for in-situ CPL control in aqueous *** addition,the contactless radiative energy transfer of CPL can also be realized in this system,exhibiting more flexible temperature regulation of the CPL *** study provides a convenient and universal strategy for the construction of dynamically smart chiroptical materials.

关键词： circularly polarized luminescence in-situ thermoresponsive supramolecular assembly energy transfer

Reinforcement Learning Based Quantization Strategy Optimal Assignment Algorithm for Mixed Precision

在线全文

学校读者我要写书评

暂无评论

Computers, materials & Continua 2024年第4期79卷 819-836页

作者： Yuejiao Wang Zhong ma Chaojie Yang Yu Yang Lu wei Xi’an Microelectronics Technology Institute Xi’an710065China

The quantization algorithm compresses the original network by reducing the numerical bit width of the model,which improves the computation speed. Because different layers have different redundancy and sensitivity to databit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determinethe optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantizationcan effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In thispaper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bitwidth is proposed, and reinforcement learning is used to automatically predict the mixed precision that meets theconstraints of hardware resources. In the state-space design, the standard deviation of weights is used to measurethe distribution difference of data, the execution speed feedback of simulated neural network accelerator inferenceis used as the environment to limit the action space of the agent, and the accuracy of the quantization model afterretraining is used as the reward function to guide the agent to carry out deep reinforcement learning training. Theexperimental results show that the proposed method obtains a suitable model layer-by-layer quantization strategyunder the condition that the computational resources are satisfied, and themodel accuracy is effectively *** proposed method has strong intelligence and certain universality and has strong application potential in thefield of mixed precision quantization and embedded neural network model deployment.

关键词： Mixed precision quantization quantization strategy optimal assignment reinforcement learning neural network model deployment

Acupoint Selection Standards of Auricular Therapy in the Treatment of maintenance Hemodialysis Insomnia Based on Data Mining

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2024年第1期10卷 53-64页

作者： Jun-Xin Wang Bing-Qian Zou Yu-feng Chen Cheng-Long Wang wei-Hong Li Xue-Ling ma Xiang-Di Liu Department of TCM Nursing School of NursingBeijing University of Chinese MedicineBeijingChina Department of Healthcare Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesP.R.China Pharmacology of Integrated Chinese and Western Medicine School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Beijing Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijingChina Key Laboratory of TCM Syndrome and Formula School of Traditional Chinese MedicineBeijing University of Chinese MedicineMinistry of EducationBeijingChina

Background:Insomnia is a high-incidence complication in patients undergoing maintenance hemodialysis(MHD).Auricular therapy can effectively improve sleep with few adverse *** selection affects the impact of auricular ***,there is currently a lack of analysis on the standards of acupoint *** study used data mining technology to investigate the acupoint selection principles and characteristics of auricular therapy for the treatment of MHD-related ***:The objective of the study is to explore the standards of acupoint selection in auricular therapy for the treatment of MHD-related insomnia through data mining *** and Methods:We searched three English(PubMed,WOS,and Embase)and four Chinese(CNKI,VIP,Wangfang,and CBM)databases for studies on auricular therapy for MHD-related insomnia from self-establishment to November 14,***:Eighty-one publications were involved,which included 33 *** most common auricular points in patients with MHD-related insomnia were the Shenmen,heart,and kidney *** applications involved the visceral,nervous system,and specific *** effective clusters and two clusters were obtained through cluster analysis,including specific auricular points for insomnia,such as the multi-dream area,neurasthenia area,deep sleep point,and anterior ear *** network analysis showed that the core auricular acupoint combinations for the intervention of MHD-related insomnia were Shenmen with kidney,Shenmen with heart,heart with kidney,heart with Shenmen,and heart and Shenmen with ***:The selection of auricular points for the treatment of MHD-related insomnia was guided by the heart theory of traditional Chinese *** treatment attaches importance to the use of the multi-dream area,neurasthenia area,and other acupoints.

关键词： Acupoint selection standards auricular therapy data mining insomnia maintenance hemodialysis

Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue XIAO Yan-wei ma Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Fast charge transfer kinetics in Sv-ZnIn_(2)S_(4)/Sb_(2)S_(3)S-scheme heterojunction photocatalyst for enhanced photocatalytic hydrogen evolution

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 533-542页

作者： wei Li Jia-Jun Li Zhi-Fei Liu Hong-Yu ma Peng-Fei Fang Rui Xiong Jian-Hong wei Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan430072China

Constructing a S-scheme heterojunction with tight interface contact and fast charge transfer is beneficial to improving the photocatalytic hydrogen evolution ***,a unique one-dimensional(1D)/two-dimensional(2D)S-scheme heterojunction containing 1D Sb_(2)S_(3) nanorods and 2D ZnIn_(2)S_(4) with affluent sulfur vacancies(denoted as Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3)) was *** introduced sulfur vacancy can promote the effective adsorption of H+for the following interfacial hydrogen-evolution ***,the larger contact area and stronger electron interaction between Sb_(2)S_(3) and ZnIn_(2)S_(4) effectively inhibits the recombination of photo-generated electron–hole pairs and abridges the migration distance of *** a result,the optimal Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) sample achieves H_(2) evolution activity of 2741.3 mol·h^(−1)·g^(−1),which is 8.6 times that of pristine ZnIn_(2)S_(4) and 3.0 times that of the Sv-ZnIn_(2)S_(4) *** on the experimental result,the photo-reactivity S-scheme mechanism of hydrogen evolution from water splitting with Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) is *** work provides an effective method for developing S-scheme heterojunction composites of transition metal sulfide with high hydrogen evolution performance.

关键词： ZnIn_(2)S_(4) nanosheets S-scheme heterojunction Sulfur vacancy Charge transfer and separation Photocatalytic H_(2)evolution

Human influence on the duration of extreme temperature events in Asia's hotspot regions

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： Zi-Meng WANG Hong-Yun ma wei LI Hai-Shan CHEN Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global ***,changes in the duration of extreme temperature events and their association with human influence have not been considered in most ***,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)*** projection based on these attribution results was also *** optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 *** show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas ***,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast *** influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme *** attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast ***,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions