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Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

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Chinese Journal of Chemical Engineering 2024年第4期68卷 65-75页

作者： Xuwei Liu wei Chen Yufei Xia Guanghui ma Reiji Noda wei Ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green manufacture Chinese Academy of SciencesBeijing 100190China

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering ***,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly *** gap in knowledge holds significant potential for enhancing vaccine *** study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell *** transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case *** factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion *** simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport ***,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single *** study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering *** insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug ***,the desired transport efficiency varies depending on the specific *** instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词： Pickering emulsion Skeletal muscular cells Transport phenomena Dissipative particle dynamics Drug delivery

Automated Vulnerability Detection of Blockchain Smart Contacts Based on BERT Artificial Intelligent Model

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China Communications 2024年第7期21卷 237-251页

作者： feng Yiting ma Zhaofeng Duan Pengfei Luo Shoushan School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing 100876China

The widespread adoption of blockchain technology has led to the exploration of its numerous applications in various *** algorithms and smart contracts are critical components of blockchain *** the benefits of virtual currency,vulnerabilities in smart contracts have resulted in substantial losses to *** researchers have identified these vulnerabilities and developed tools for detecting them,the accuracy of these tools is still far from satisfactory,with high false positive and false negative *** this paper,we propose a new method for detecting vulnerabilities in smart contracts using the BERT pre-training model,which can quickly and effectively process and detect smart *** specifically,we preprocess and make symbol substitution in the contract,which can make the pre-training model better obtain contract *** evaluate our method on four datasets and compare its performance with other deep learning models and vulnerability detection tools,demonstrating its superior accuracy.

关键词： BERT blockchain smart contract vulnerability detection

Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

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Rare Metals 2024年第2期43卷 758-769页

作者： Yu-Long Li Xi-Lang Jin Yi-Ting ma Jing-Rui Liu Fazal Raziq Peng-Yuan Zhu Zhi-feng Deng Hong-wei Zhou wei-Xing Chen Wen-Huan Huang School of materials and Chemical Engineering Xi’an Technological UniversityXi’an710021China Yulin Boyi-Jingking Research Institute of Industrial Technology Development Research Yulin719054China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China National and Local Joint Engineering Laboratory for Slag Comprehensive Utilization and Environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong723001China

Developing fluorescence porous probe for detecting and eliminating Cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable ***,improving the fluorescence detecting efficiency while enhancing the adsorption capacity of the porous probe is of great ***,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-COF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)***-COF displayed rapid detection of Cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were *** importantly,the fluorescence quenching mechanism of TTP-COF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among C=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of Cu^(2+).

关键词： Covalent organic framework(COF) Excited-state intramolecular proton transfer(ESIPT) Copper ion detection Copper ion adsorption Renewability

Enhanced cyclic stability of partially disordered spinel cathodes through direct fluorination with gaseous fluorine

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Rare Metals 2024年第4期43卷 1635-1646页

作者： Yong-Nian ma Ling-Chen Kong Shao-Shan Chen Yong Wang Li-Dong Sun Cong Peng Meng-Meng Qin Yu Li wei feng Tianjin Key Laboratory of Composite and Functional materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Institute of Advanced Technology and Equipment Beijing University of Chemical TechnologyBeijing100029China

Spinel-type cathodes are considered an optimal substitute for conventional layered oxide cathodes owing to their use of inexpensive and earth-abundant manganese as the redox-active ***,the introduction of cation disorder can effectively suppress the detrimental two-phase reaction to realize high capacities in a wide voltage ***,the continuous capacity decay during cycles has hindered the widespread application of these cathode *** fluorides exhibit excellent electrochemical stability at high voltage;therefore,in this study,the direct F2 gas reaction with a partially disordered spinel cathode(Li_(1.6)Mn_(1.6)O_(3.7)F_(0.3,)LMOF1.6)was initially applied to investigate the impacts of fluorination on the surface structure and electrochemical *** inorganic fluorinated layer,mainly containing LiF,was distributed uniformly on the surface of LMOF1.6nanoparticles after fluorination for an appropriate time without the turbulence caused by the valency of manganese cation,which improved the capacity retention and rate capability by the suppression of structural damage,parasitic reaction,and cation *** LMOF1.6cathode fluorinated for 0.5 h exhibited a capacity of283.6 mah·g^(-1)at 50 ma·g^(-1)and an enhanced capacity retention of 29.6%after 50 cycles in the voltage range of1.5-4.8 V,as compared to the pristine LMOF1.6 with only27.9%capacity retention.

关键词： Spinel-type cathodes Direct fluorination Capacity retention ability High rate capability

Extreme precipitation detection ability of four high-resolution precipitation product datasets in hilly area:a case study in Nepal

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Advances in Climate Change Research 2024年第3期15卷 390-405页

作者： Sunil Subba Yao-Ming ma wei-Qiang ma Cun-Bo Han Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakista

Given Nepal's vulnerability to extreme precipitation(EP),it is imperative to conduct a comprehensive analysis to comprehend the historical trends of such ***,acquiring precise precipitation data for EP remains challenging in mountainous countries like Nepal owing to the scarcity of densely gauged *** limitation impedes the dissemination of knowledge pertaining to EP variability events in *** current research on this topic is deficient for two main reasons:1)there is a lack of studies leveraging recently released high-resolution precipitation products to identify their EP detection capabilities,which further hinders the usability of those products in data-scarce regions like Nepal,and 2)most studies have focused on the characterisation of EP events in Nepal rather than their spatial and temporal *** address these issues,this study evaluated the EP detection capabilities of four high-resolution precipitation product datasets(PPDs)across Nepal from 1985 to *** datasets include the ERA5 Land reanalysis data,satellite-based precipitation data(PERSIANN_CCS_CDR and CHIRPS_V2.0)and a merged dataset(TPHiPr).We used various statistical and categorical indices to assess their ability to capture the spatial and temporal variability of EP *** annual EP events were characterised by 11 indices divided into frequency and intensity *** TPHiPr merged dataset offered a robust depiction of monthly precipitation estimates,achieving the highest critical success index,accuracy,probability of detection and a low false alarm ratio for daily precipitation detection of 0.1 mm in ***,the PERSIANN_CCS_CDR dataset exhibited poor *** PPDs showed increasing trends in EP ***,the TPHiPr dataset showcased those trends with fewer errors and stronger correlations for many frequency(R10mm,R20mm and R25mm)and intensity(RX1day,RX5day,PRCPTOT and R99p)*** results indicate that TPHiPr outperformed ot

关键词： Extreme precipitation Precipitation product Nepal TPHiPr ERA5 land PERSIANN_CCS_CDR CHIRPS_V2.0

Double DQN Method For Botnet Traffic Detection System

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Computers, materials & Continua 2024年第4期79卷 509-530页

作者： Yutao Hu Yuntao Zhao Yongxin feng Xiangyu ma School of Information Science and Engineering Shenyang Ligong UniversityShenyang110159China Graduate School Shenyang Ligong UniversityShenyang110159China

In the face of the increasingly severe Botnet problem on the Internet,how to effectively detect Botnet traffic in realtime has become a critical *** the existing deepQnetwork(DQN)algorithminDeep reinforcement learning can solve the problem of real-time updating,its prediction results are always higher than the actual *** Botnet traffic detection,although it performs well in the training set,the accuracy rate of predicting traffic is as high as%;however,in the test set,its accuracy has declined,and it is impossible to adjust its prediction strategy on time based on new data ***,in the new dataset,its accuracy has declined ***,this paper proposes a Botnet traffic detection system based on double-layer DQN(DDQN).Two Q-values are designed to adjust the model in policy and action,respectively,to achieve real-time model updates and improve the universality and robustness of the model under different data *** show that compared with the DQN model,when using DDQN,the Q-value is not too high,and the detectionmodel has improved the accuracy and precision of Botnet ***,when using Botnet data sets other than the test set,the accuracy and precision of theDDQNmodel are still higher than DQN.

关键词： DQN DDQN deep reinforcement learning botnet detection feature classification

Conductive edge-warping graphite mesas for robust structural superlubricity

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Science China(Technological Sciences) 2024年第7期67卷 2040-2049页

作者： feng weiJia LIU Ying ma Ming PENG DeLi NIE JinHui State Key Laboratory of Tribology in Advanced Equipment&Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Center for Nano and Micro Mechanics Tsinghua UniversityBeijing 100084China Institute of Superlubricity Technology Research Institute of Tsinghua University in ShenzhenShenzhen 518057China

Structural superlubricity(SSL) refers to a state of ultralow friction and zero wear when two solid surfaces slide against each other. Recent investigations have identified amorphous carbon at the edge of the graphite mesa as the primary source of friction in such SSL systems. Here, the tensile stress of metal thin film is exploited to engineer vertically conductive edge-warping graphite mesas(EWGM). Through this approach, robust SSL performance is realized, demonstrated by sliding an 8 μm side length square EWGM on an atomically smooth Au substrate for 10000 cycles at a constant voltage of 1 m V. In this SSL system,differential friction coefficients lower than 1.5 × 10^(-4) are achieved, with static contact resistance between EWGM and Au substrate as low as 28Ω and sliding contact resistance as low as 32Ω. Moreover, the EWGM exhibits SSL behavior on polished Si wafer substrates. Furthermore, because of the no-edge contact with the substrate during sliding, friction is independent of the sliding speed of the EWGM. This study presents the first successful fabrication of conductive EWGM. Remarkably, in both EWGM-Au and EWGM-Si SSL systems, the measured frictions are more than one order of magnitude lower than those of ordinary self-retracting graphite mesas with no-edge warping, and no wear is observed during extended current-carrying ***, these findings establish a solid groundwork for the future realization of macroscale conductive SSL systems.

关键词： structural superlubricity graphite mesa contact resistance tensile stress edge warping

Future Changes in Various Cold Surges over China in CMIP6 Projections

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Advances in Atmospheric Sciences 2024年第9期41卷 1751-1768页

作者： Li ma Zhigang wei Xianru LI Shuting WU Key Laboratory of Environmental Change and Natural Disasters of Chinese Ministry of Education Beijing Normal UniversityBeijing 100875China State Key Laboratory of Earth Surface Processes and Resource Ecology(ESPRE) Beijing Normal UniversityBeijing 100875China Academy of Disaster Reduction and Emergency management Ministry of Emergency Management and Ministry of EducationBeijing 100875China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Cold surges(CSs)often occur in the mid-latitude regions of the Northern Hemisphere and have enormous effects on socioeconomic *** report that the occurrences of CSs and persistent CSs(PCSs)have rebounded since the 1990s,but the trends related to the frequencies of strong CSs(SCSs)and extreme CSs(ECSs)changed from increasing to decreasing after *** highest-ranked model ensemble approach was used to project the occurrences of various CSs under the SSP1-2.6,SSP2-4.5,and SSP5-8.5 *** frequencies of the total CSs show overall decreasing ***,under the SSP1-2.6 scenario,slight increasing trends are noted for SCSs and ECSs in *** circulations that are characterized by an anomalous anticyclonic circulation with a significantly positive 500-hPa geopotential height(Z500)anomaly at high latitudes along with significant negative anomalies in China were favorable for cold air intrusions into *** addition,the frequencies of all CS types under the SPP5-8.5 scenario greatly decreased in the long term(2071-2100),a finding which is thought to be related to negative SST anomalies in the central and western North Pacific,differences in sea level pressure(SLP)between high-and mid-latitude regions,and a weaker East Asian *** terms of ECSs,the decreasing trends observed during the historical period were maintained until 2024 under the SSP1-2.6 *** to the SSP1-2.6 scenario,the Z500 pattern showed a trend of strengthened ridges over the Ural region and northern East Asia and weakened troughs over Siberia(60°-90°E)under the SSP2-4.5 and SSP5-8.5 scenarios,contributing to the shift to increasing trends of ECSs after 2014.

关键词： cold surge “highest-ranked”model ensemble anticyclonic circulation geopotential height China

Reduced-order modeling and vibration transfer analysis of a fluid-delivering branch pipeline that consider fluid–solid interactions

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Frontiers of Mechanical Engineering 2024年第2期19卷 75-97页

作者： Wenhao JI Hongwei ma wei SUN Yinhang CAO School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero-Propulsion Systems(Ministry of Education) Northeastern UniversityShenyang 110819China College of Power and Energy Engineering Harbin Engineering UniversityHarbin 150001China

The efficient dynamic modeling and vibration transfer analysis of a fluid-delivering branch pipeline(FDBP)are essential for analyzing vibration coupling effects and implementing vibration reduction ***,this study proposes a reduced-order dynamic modeling method suitable for FDBPs and then analyzes the vibration transfer *** the modeling method,the finite element method and absorbing transfer matrix method(ATMM)are integrated,considering the fluid–structure coupling effect and fluid *** dual-domain dynamic substructure method is developed to perform the reduced-order modeling of FDBP,and ATMM is adopted to reduce the matrix order when solving fluid ***,the modeling method is validated by experiments on an H-shaped branch ***,transient and steady-state vibration transfer analyses of FDBP are performed,and the effects of branch locations on natural characteristics and vibration transfer behavior are *** show that transient vibration transfer represents the transfer and conversion of the kinematic,strain,and damping energies,while steady-state vibration transfer characteristics are related to the vibration *** addition,multiple-order mode exchanges are triggered when branch locations vary in frequency-shift regions,and the mode-exchange regions are also the transformation ones for vibration transfer patterns.

关键词： fluid-delivering branch pipeline vibration transfer analysis reduced-order modeling fluid-solid interactions finite element method absorbing transfer matrix method