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超声引导下染色剂标记切缘在早期乳腺癌保乳手术中的应用效果研究

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中国现代医学杂志 2022年第2期32卷 92-96页

作者：张宏旭刘海旺胡大为刘建平申兴斌马立辉承德医学院附属医院乳腺外科河北承德067000 承德医学院附属医院病理科河北承德067000

目的探讨超声引导下染色剂标记切缘在早期乳腺癌保乳手术中的应用效果研究。方法选取2016年1月—2018年5月在承德医学院附属医院就诊的临床分期Ⅰ、Ⅱ期乳腺癌患者126例作为研究对象,根据治疗方法不同将其分为对照组和观察组。对照组采... 详细信息

目的探讨超声引导下染色剂标记切缘在早期乳腺癌保乳手术中的应用效果研究。方法选取2016年1月—2018年5月在承德医学院附属医院就诊的临床分期Ⅰ、Ⅱ期乳腺癌患者126例作为研究对象,根据治疗方法不同将其分为对照组和观察组。对照组采用传统手术治疗,观察组在超声引导下应用染色剂标记切缘,借助染色剂浸润性浸润出适当范围,沿着染色组织外切缘切除肿瘤,根据保乳治疗实践指南完整肿瘤切除,并完成3年随访,比较两组术式切缘阳性率,术后生活质量、心理状态、总生存期、无病生存期、术后并发症发生率。结果观察组手术前后精神健康、躯体疾病、生理机能、社会功能及健康状况评分的差值大于对照组(P0.05)。观察组术后3年无进展生存率高于对照组(P<0.05),复发率低于对照组(P<0.05);观察组切缘阴性率低于对照组(P<0.05)。结论超声引导下染色剂标记切缘用于早期乳腺癌保乳手术病理中能提高患者生活质量,改善患者心理状态,且与患者总生存率及无进展生存率有关。

关键词：乳腺癌保乳手术超声引导染色剂标记切缘生存质量

血清VEGF及CRP表达对肝细胞癌术后早期复发的预测

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世界华人消化杂志 2009年第33期17卷 3460-3464页

作者：马立辉周健王助新胡大为史丽民敖亚洲张海峰承德医学院附属医院肿瘤外科河北省承德市067000 承德医学院附属医院老年病科河北省承德市067000

目的:探讨肝细胞癌(HCC)患者术前周围血血清中血管内皮生长因子(VEGF)和C-反应蛋白(CRP)表达水平与肝癌术后早期复发的关系及对其预测价值进行比较.方法:运用Sandwich酶联免疫吸附测定法定量检测32例HCC术前、30例肝脏良性疾病患者和20... 详细信息

目的:探讨肝细胞癌(HCC)患者术前周围血血清中血管内皮生长因子(VEGF)和C-反应蛋白(CRP)表达水平与肝癌术后早期复发的关系及对其预测价值进行比较.方法:运用Sandwich酶联免疫吸附测定法定量检测32例HCC术前、30例肝脏良性疾病患者和20例健康人血清中VEGF的含量;运用单向免疫扩散法检测上述病例的CRP水平.结果:HCC组术前血清VEGF、CRP表达水平与肝脏良性疾病组、健康人组比较,均有显著性差异(432.32±340.57ng/Lvs158.54±120.58ng/L,124.03±51.65ng/L;9.80±0.86mg/Lvs6.48±0.98mg/L,6.12±0.80mg/L,均P<0.01).VEGF和CRP预测肝癌复发的灵敏度和特异度分别为77.27%、30%;59.09%、60%.结论:HCC患者术前血清VEGF、CRP表达水平,可能是预测HCC术后早期复发的一个较好的生物学指标.

关键词：肝细胞癌血管内皮生长因 C-反应蛋白

合作的收益与风险:发明人外部合作网络对核心技术和颠覆性技术形成的不同影响

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管理工程学报 2025年第1期39卷 155-169页

作者：胡谍佘茂艳杨雪魏丽灿福州大学经济与管理学院福建福州350108 成都理工大学管理科学学院四川成都610059 四川大学商学院四川成都610065

本研究基于合作的收益和风险,利用1980年—2017年的美国医药发明专利数据进行实证分析,探索发明人外部合作网络对核心技术和颠覆性技术形成的不同影响。研究表明,发明人外部直接合作对核心技术和颠覆性技术的形成均存在“倒U型”作用,... 详细信息

本研究基于合作的收益和风险,利用1980年—2017年的美国医药发明专利数据进行实证分析,探索发明人外部合作网络对核心技术和颠覆性技术形成的不同影响。研究表明,发明人外部直接合作对核心技术和颠覆性技术的形成均存在“倒U型”作用,但效果有所差异:在达到最优外部直接合作数量(“倒U型”拐点)之前,外部直接合作对核心技术的正向作用强于对颠覆性技术的正向作用,达到最优合作数量(“倒U型”拐点)之后,外部直接合作对核心技术的负向作用强于对颠覆性技术的负向作用;发明人外部间接合作对核心技术的形成存在负向作用,对颠覆性技术的形成存在正向作用;外部间接合作会减弱外部直接合作与核心技术的“倒U型”曲线关系,增强外部直接合作与颠覆性技术的“倒U型”曲线关系。研究结论从合作的收益与风险视角为管理者有效利用发明人外部合作网络来促成不同类型技术创新的产生提供决策参考。

关键词：发明人外部合作网络核心技术颠覆性技术收益与风险

Strength and Chloride Diffusion Behaviour of Three Generations of Repeated Recycled Fine Aggregate Concrete

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Journal of Wuhan University of Technology(Materials Science) 2018年第5期33卷 1113-1120页

作者： Zhu Pinghua LIU Wenying NIU Zhigang wei da hu Kun Department of Civil Engineering Changzhou UniversityChangzhou 213164China State Key Laboratory GeoMechanics and Deep Underground Engineering China University of Mining ＆ TechnologyXuzhou 221116China

The feasibility of using different generations of recycled fine aggregate（RFA） in structural concrete in a chloride environment was evaluated by studying the performance of the RFA and the corresponding concrete. The different generations of RFA were recycled by following the cycle of ‘concrete-waste concrete-fine aggregate-concrete＇. The properties of three generations of repeatedly recycled fine aggregate（RRFA） were systematically investigated, and we focused on the compressive strength and splitting tensile strength and chloride ion permeability of the related structural concretes with 25%, 75%, and 100% replacement of natural fine aggregates with RFA. The results indicated that the quality of RRFA presents a trend of slow deterioration, but the overall performance of all RRFA still fulfils the quality requirements of recycled fine aggregate for structural concrete. All RRFA concretes achieved the target compressive strength of 40 MPa after 28 days except for the second generation of the recycled aggregate concrete and the third generation of the recycled aggregate concrete with 100% replacement, and all the concrete mixes achieved the target compressive strength after 90 days. The insights obtained in this study demonstrate the feasibility of using at least three generations of RRFA for the production of normal structural concrete with a design service life of 100 years in a chloride environment.

关键词： repeated recycled concrete repeatedly recycled fine aggregate compressive strength chloride ion diffusion

High Accuracy Gene Signature for Chemosensitivity Prediction in Breast Cancer

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Tsinghua Science and Technology 2015年第5期20卷 530-536页

作者： wei hu Department of Computer Science Houghton College

Neoadjuvant chemotherapy for breast cancer patients with large tumor size is a necessary *** this treatment patients who achieve a pathologic Complete Response（p CR） usually have a favorable prognosis than those without. Therefore, p CR is now considered as the best prognosticator for patients with neoadjuvant chemotherapy. However, not all patients can benefit from this treatment. As a result, we need to find a way to predict what kind of patients can induce p CR. Various gene signatures of chemosensitivity in breast cancer have been identified, from which such predictors can be built. Nevertheless, many of them have their prediction accuracy around 80%. As such, identifying gene signatures that could be employed to build high accuracy predictors is a prerequisite for their clinical tests and applications. Furthermore, to elucidate the importance of each individual gene in a signature is another pressing need before such signature could be tested in clinical settings. In this study, Genetic Algorithm（GA） and Sparse Logistic Regression（SLR） along with t-test were employed to identify one signature. It had 28 probe sets selected by GA from the top 65 probe sets that were highly overexpressed between p CR and Residual Disease（RD） and was used to build an SLR predictor of p CR（SLR-28）. This predictor tested on a training set（n = 81） and validation set（n = 52） had very precise predictions measured by accuracy,specificity, sensitivity, positive predictive value, and negative predictive value with their corresponding P value all zero. Furthermore, this predictor discovered 12 important genes in the 28 probe set signature. Our findings also demonstrated that the most discriminative genes measured by SLR as a group selected by GA were not necessarily those with the smallest P values by t-test as individual genes, highlighting the ability of GA to capture the interacting genes in p CR prediction as multivariate techniques. Our gene signature produced superior per

关键词： genetic algorithm gene signature breast cancer sparse logistic regression predictor chemosensitivity

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天然和饱水红砂岩三轴压缩蠕变变形试验研究

三峡大学学报（自然科学版） 2025年第1期47卷 9-15页

作者：刘桃根胡凯李玲王伟湖南工学院土木与建筑工程学院湖南衡阳421002 河海大学岩土工程科学研究所南京210098 江西职业技术大学建筑工程学院江西九江332007

蠕变特性和长期强度是红砂岩地区岩体工程安全评价的关键要素,饱水软化效应对红砂岩蠕变特性和长期强度具有重要影响.采用全自动岩石三轴压缩伺服流变仪,开展天然与饱水红砂岩的三轴压缩试验和三轴压缩蠕变试验.试验结果表明:峰值强度... 详细信息

蠕变特性和长期强度是红砂岩地区岩体工程安全评价的关键要素,饱水软化效应对红砂岩蠕变特性和长期强度具有重要影响.采用全自动岩石三轴压缩伺服流变仪,开展天然与饱水红砂岩的三轴压缩试验和三轴压缩蠕变试验.试验结果表明:峰值强度、弹性模量和蠕变破坏应力因饱水软化效应而降低,围压对其降幅有削弱作用,蠕变破坏应力与峰值强度的比值在0.75~0.98之间;饱水软化效应能增强蠕变瞬时变形,减弱蠕变变形及蠕变应变速率;环向应变比轴向应变更早进入稳态蠕变阶段和加速蠕变阶段;稳态蠕变速率与偏压的变化关系符合指数函数关系;长期强度因饱水软化作用而降低,却因围压增加而增大,长期强度与峰值强度的比值在0.62~0.92之间;裂纹损伤应力与长期强度相差较大,裂纹损伤应力视为长期强度有待进一步考究.

关键词：红砂岩蠕变特性长期强度饱水软化效应裂纹损伤应力

Profiling the pattern of the human T-cell receptorγδcomplementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis

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Cellular & Molecular Immunology 2019年第3期16卷 250-259页

作者： hui Chen Mingjin Zou da Teng Yu hu Jianmin Zhang wei He Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeState Key Laboratory of Medical Molecular BiologyBeijing 100005China Department of Clinical Laboratory Qilu Hospital of Shandong University107 Wenhua Xi RoadJinan 250012China

γδT cells function as sentinels in early host responses to infections and ***,γδT cells recognize tumor-associated stress antigens via T-cell receptor(TCR)γδand play important roles in the antitumor immune *** this study,we characterized the pattern of the human TCRγδcomplementary determinant region 3(CDR3)repertoire in patients with lung carcinoma(LC)via high-throughput *** results showed that the diversity of CDR3δwas significantly reduced,and that of CDR3γwas unchanged in LC patients compared with healthy individuals;in addition,LC patients shared significantly more CDR3δsequences with each other than healthy *** CDR3 length distribution and N-addition length distribution did not significantly differ between LC patients and healthy *** addition,the CDR3 repertoire tended to use more Vδ2 and fewer Vδ1 germline gene fragments among LC ***,we found a combination of four TCRγδrepertoire features that focus on CDR3δand can be used as a biomarker for LC *** research suggests that the TCRγδCDR3 repertoire changed in LC patients due to the antitumor immune response byγδT cells in vivo,and these changes primarily focus on the amplification of certain tumor-specific CDR3δclones among *** study demonstrates the role ofγδT cells from the TCRγδCDR3 repertoire in tumor immunity and lays the foundation for elucidating the mechanism underlying the function ofγδT cells in antitumor immunity.

关键词： CDR3δ high-throughput sequencing LC TCRγδrepertoire

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不同来流条件下急弯段环流结构演化过程研究

Dynamic Theory of Die Swell for Entangled Polymeric Liquids in Tube Extrusion： Correlations of Total and Ultimate Extrudate Swell Effects to Growth Time, Shear Stress and Aspect Ratio Under the Free States

工程力学 2025年第1期42卷 259-272页

作者：胡呈维余明辉渠庚长江科学院河流研究所武汉430010 长江科学院水利部长江中下游河湖治理与防洪重点实验室武汉430010 武汉大学水资源与水电工程科学国家重点实验室武汉430072

弯道环流是弯道水流运动的典型特征之一，一直以来都是众多学者关注的重点。弯道环流主要分为两类：第一类由水流经过弯道时受到的径向压差力差而引起，流速较大;第二类主要由紊流各向异性引起，尽管流速很小，但其与弯道岸坡冲刷过程... 详细信息

弯道环流是弯道水流运动的典型特征之一，一直以来都是众多学者关注的重点。弯道环流主要分为两类：第一类由水流经过弯道时受到的径向压差力差而引起，流速较大;第二类主要由紊流各向异性引起，尽管流速很小，但其与弯道岸坡冲刷过程密切相关。然而当前成果较少关注第二类弯道环流发展演化过程。因此，该文采用弯道水槽试验与数值模拟方法得到的高精度三维流速数据，研究弯道环流结构的变化规律及其动力特性，特别是第二类弯道环流的发展变化。研究结果表明：对于高雷诺数的急弯水流，由于紊动各向异性特征明显，弯道水流常会出现多个环流;对于纵向流速，当水流流经弯顶断面后，纵向流速沿垂向的分布已经明显偏离对数流速分布;当水流经过弯顶断面后，纵向流速沿着垂线存在着显著的均匀化趋势;当弗劳德数较大时，大尺寸涡体在不断分解中，使得原来的各向异性影响越来越小，凹岸附近的小尺寸环流趋近于各向同性状态，造成凹岸小环流逐渐微弱并最后消失;急弯段中环流与纵向水流互馈作用十分显著，弯道环流将对断面内的动量进行重分配，携带某些高速流体到断面内的其他区域，因此，在出现弯道环流的区域其纵向流速也一般比较小。

关键词：弯曲型河流急弯河段弯道环流水槽试验数值模拟

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Chinese Journal of Chemical Physics 2008年第1期21卷 55-68页

作者： Jing Zhao Ming-shi Song Chang-wei Zhu Gui-xian hu Ke-jian Wang da-ming Wu School of Mechanical and Electrical Engineering Belting University of Chemical and TechnologyBeijing 100029 China School of Materials Science and Engineering Beifing University of Chemical and TechnologyBeijing 100029 China

The dynamic theory of die swell deduced in a previous paper was extensively applied to study the extrudate swelling behaviors of two entangled polymeric liquids （HDPE and PBD） in a simple shear flow at steady shear stress. The mechanism and dynamics for the recoils and the recoveries of viscoelastic strains in the extrudate were investigated under the free recovery and dynamic states. It was found that in the course of recovery the free recoil and the growth of die swell in the extrudate may be divided into two recovery regions （instantaneous and delayed regions） and three growth stages （instantaneous, delayed, and ultimate extrudate swelling stages）. The free recoil and the extrudate swelling behaviors may be expressed as a function of shear stress. The correlations of instantaneous, delayed, total and ultimate extrudate swell effects to the molecular parameters and the operational variables in the simple shear flow at steady shear stress were derived from the dynamic theory of die swell. Also, two sets of new universal equations on the total extrudate swelling effect （TESE） and ultimate extrudate swelling effect （UESE） were deduced. The first is the universal equation of the logarithmic correlation between the TESE and the growth time under the free and dynamic states; the second is the universal equation of the logarithmic correlation between the UESE and the operational variables under the free and equilibrium states. The first equation was verified by experimental data of PBD with different molecular weights at different operational variables. The second equation was verified by experimental data of HDPE at two temperatures and different operational variables. An excellent agreement result was obtained. The excellent agreement shows that the two universal equations can be used directly to predict the correlations of the TESE and UESE to the growth time, the molecular parameters, and the operational variables under the dynamic and equilibrium states.

关键词： Die swell Entanglement Viscoelastic recoil