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A peptide-based near-infrared fluorescence probe for dynamic monitoring senile plaques in Alzheimer＇s disease mouse model

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Science Bulletin 2017年第23期62卷 1593-1601页

作者： chen-wei wang Dou-Dou Nan Xin-Meng wang zun-Ji Ke Guo-Jun chen Jiang-Ning Zhou CAS Key Laboratory of Brain Function and Disease School of Life Sciences University of Science and Technology of China Hefei 230026 China Department of Biochemistry Shanghai University of Traditional Chinese Medidne Shanghai 201203 China Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Neurology Chongqing 400016 China

In vivo monitoring neuropathological changes in Alzheimer＇s disease （AD） animal model is critical for drug development. Here, by integrating blood-brain barrier penetrable peptide, we have developed a peptide probe which based on angiopep-2. Angiopep-based probe exhibited high binding affinity to Aβ aggregates and labeled senile plaques in vivo. Remarkably, the in vivo near-infrared imaging data revealed that fluorescence signals of this probe were nearly 3-fold higher in the brains of 16-monthold APP/PSI transgenic mice compared to C57 mice and exhibited linear correlation with the senile plaques load process in 4-, 8-, 16-month-old APP/PSI transgenic mice. Moreover, senile plaques load was detected in vivo as early as 4 months of age that even at the very beginning of plaques developed in APP/PS1 transgenic mice. Taken together, this novel peptide-based probe achieved dynamic monitoring senile plaques in APP/PS1 transgenic mice and have been ready to use in drug development in AD mouse model.

关键词： Alzlaelmer's diseaseSenile plaquesAmyloid-β LRP-1 Angiopep In vivo imaging AD animal model

INTERFERENCE ESTIMATION AND ITS APPLICATIONS IN COGNITIVE RADIO NETWORKS

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Journal of Electronics(China) 2010年第5期27卷 630-638页

作者： chen Ronghao chen wei wang Jun Li Shaoqian National key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 61173China

Cognitive Radio(CR) has been proposed as a system-level means to improve the spectrum utilization *** most significant premise for CR networks is to avoid harmful interference to the licensed ***,it is very important to estimate the potential inter-ference introduced by the deployment of CR networks so that CR networks can be coexistence with Licensed User(LU) networks by designing proper system *** this paper,two statistical models of potential interference due to CR networks are developed based on transmitter and receiver oriented spectrum sensing schemes,*** approximate probability dis-tributions of aggregate interference introduced by CR networks are then derived with respect to the obtained *** the help of these probability distributions,a method is further pre-sented to get the critical system parameter,i.e.,sensing distance and user density of the CR networks,so that the introduced interference can be controlled to predefined *** results validate the proposed interference estimation method and confirm the effectiveness of in-terference distribution based system parameter design.

关键词： Cognitive Radio (CR) Spectrum sensing Interference estimation

Effect of mutant p27^(kip1) gene on human cholangiocarcinoma cell line, QBC_(939)

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World Journal of Gastroenterology 2008年第34期14卷 5344-5348页

作者： Jian Luo Yong-Jun chen wei-Yu wang Sheng-Quan Zou Department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM：To investigate the effects of exogenously mutated p27^kip1 （p27） on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC939 in ***： Adenviral vectors were used to transfect mutated p27 cDNA into human QBC939 cell line. Expression of p27 was detected by RT-PCR. Western blot. Cell growth, morphological change, cell cycle, apoptosis and cloning formation were determined by MTT assay and flow ***： The expression of p27 protein and mRNA was increased signifi cantly in QBC939 cell line transfected with Ad-p27mt. The transfer of Ad-p27mt could signifi cantly inhibit the growth of QBC939 cells, decrease the cloning formation rate and induce apoptosis. p27 over expression caused cell cycle arrest at G0/G1 phase 72 h after infection with ***： p27 may cause cell cycle arrest at G0/G1 phase and subsequently lead to apoptosis. Recombinant adenovirus expressing mutant p27 may be potentially useful in gene therapy for cholangiocarcinoma.

关键词： Adenovirus Cholangiocarcinoma Gene therapy Cell cycle Apoptosis

Novel photoelectrochromic cells fabricated with wirelike photo-electrode

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Chinese Science Bulletin 2008年第20期53卷 3173-3177页

作者： LIU Yong SHEN Hui chen wei wang Hai DENG YouJun wang DongHai State Key Laboratory of Optoelectronic Materials and Technologies Institute for Solar Energy Systems School of Physics and Engineering Sun Yat-sen University Guangzhou 510275 China

A novel structure of photoelectrochromic cell fabricated with titanium wirelike photo-electrode is introduced in this paper. The transmittance spectra show that average transmittance of devices is 68.0% (from 400 to 1100 nm) at bleached state and 26.1% (from 400 to 1100 nm) at colored state, respectively. And the maximal photopic transmittance of the device varies from 81.9% (bleached state) to 30.3% (colored state) at 736 nm. Compared with traditional devices, the spectral response range is improved obviously, which solves the problem of lower transmittance at bleached state for traditional devices.

关键词：光电铬电池染料敏化纳米晶光电极太阳能电池

Numerical Simulation of Methane Distribution and Sensor Placement in 2-Dimension Roadway

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Journal of China University of Mining and Technology 2007年第3期17卷 372-375页

作者： SUN Ji-ping TANG Liang chen wei wang Fu-zeng State Key Laboratory of Coal Resources and Safe Mining China University of Mining ＆ Technology Beijing 100083 China

In order to provide a theoretical basis for methane sensor placement in the vertical direction of a tunnel,the software Fluent was used to simulate methane distribution. A geometric roadway model was established and divided by grids. Methane distribution in both level and vertical sections was simulated using a realizable k-ε model with the Fluent software according to a conservation equation in a turbulent state,a turbulent kinetic energy equation and a turbulent dissipation rate equation. The realizable k-ε model and the Fluent software were used to simulate methane distribution according to the principle of the conservation equation in a state of turbulent flow. The results show that after overflow-ing,a methane level with a certain thickness is formed. Methane density curves at three specific levels were internally consistent and methane density at higher levels is denser than that at lower levels. Methane distribution becomes thinner in the direction of wind and methane in the vertical direction becomes uniform if wind speed is high. The distance be-tween sensors and roof should be less than 300 mm which is in agreement with mine safety regulations.

关键词： numerical simulation methane sensor placement methane distribution realizable k-ε model

Noninfectious Fever Following Aortic Surgery:Incidence,Risk Factors,and Outcomes

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Chinese Medical Sciences Journal 2009年第4期24卷 213-219页

作者： Yun-tai Yao Li-huan Li Qian Lei Lei chen wei-peng wang wei-ping chen Department of Anesthesiology Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 China

Objective To determine the incidence, course, potential risk factors, and outcomes of noninfectious fever developed in patients after aortic surgery. Methods Patients who received operation for aortic aneurysm or dissection in our center from January 2006 to January 2008 were reviewed. Patients who met one of the following criteria were excluded： having a known source of infection during hospitalization; having a preoperative oral temperature greater than or equal to 38.0℃; undertaking emergency surgery; having incomplete data. Univariate analysis was performed in patients with noninfectious postoperative fever and those without, with respect to demographics, intraoperative data, etc. Risk factors for postoperative fever were considered for the muhivariate logistic regression model if they had a P value less than 0.10 in the univariate analysis. Results Totally 463 patients undergoing aortic surgery were enrolled for full review. Among them, 345 （74.5%） patients had noninfectious postoperative fever, the other 118 （25.5%） patients didn＇t develop postoperative fever. Univariate analysis demonstrated that several risk factors were associated with the development of noninfectious postoperative fever, including weight, surgical procedure, minimum intraoperative bladder temperature, temperature upon intensive care unit （ICU） admission, discharge, and during ICU stay, as well as blood transfusion. In a further multivariate analysis, surgical site of thoracic and thoracoabdominal aorta （odds ratio： 4.861; 95% confidence interval： 3.029-5.801; P=0.004）, lower minimum intraoperative bladder temperature （odds ratio： 1.117; 95% confidence interval： 1.01-1.24; P=0.04）, and higher temperature on admission to the ICU （odds ratio： 2.57; 95% confidence interval： 1.28-5.18; P=0.008） were found to be significant predictors for noninfectious postoperative fever. No difference was found between the febrile and afebrile patients with regard to postoperative hospitalization duration （P

关键词： fever noninfectious aortic surgery

Dative B–N bonds weaven toward two-dimensional purely organic materials for single crystals

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Science China Chemistry 2025年第1期68卷 12-14页

作者： wei-Lei Zhou Siwei wang Yong chen College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional Molecules Innovation Team of Optical Functional Molecular Devices Inner Mongolia Minzu University College of Chemistry Nankai University

Molecular topology is one of the important topics to study and understand the relationship between molecular structure and properties [1]. Particularly, two-dimensional (2D) materials with extremely high surface area and ultra-thin morphology have attracted considerable attention due to their unexpected properties in materials and chemistry [2,3].

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Improvement of clinical parameters in patients with gastroesophageal reflux disease after radiofrequency energy delivery

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World Journal of Gastroenterology 2011年第39期17卷 4429-4433页

作者： Hai—Feng Liu Jian-Guo Zhang Jun Li Xiao-Guang chen wei-An wang Department of Gastroenterology General Hospital of Chinese People＇s Armed Police Forces Beijing 100039 China

AIM:To evaluate the efficacy of Stretta procedure with gastroesophageal reflux disease(GERD)based on symptom control,medication changes and oesophagitis ***:Ninety patients with a history of GERD underwent Stretta procedure from June 2007 to March *** patients with GERD diagnosed by the pres-ence of endoscopically evidenced oesophagitis or abnormal esophageal pH *** evaluated GERD-health-related quality of life,satisfaction,medication use and endoscopy at baseline,6,12 mo after *** of the procedure were ***:We found that patients experienced significant changes in symptoms of GERD after Stretta *** onset of GERD symptom relief was less than 2 mo(70.0%)or 2 to 6 mo(16.7%).The mean GERD-HRQL score was 25.6(baseline),7.3(6 mo,P<0.01),and 8.1(12 mo,P<0.01).The mean heartburn scorewas 3.3(baseline),and 1.2(12 mo,P<0.05).The percentage of patients with satisfactory GERD control improved from 31.1%at baseline to 86.7%after treat-ment,and patient satisfaction improved from 1.4 at baseline to 4.0 at 12 mo(P<0.01).Medication usage decreased significantly from 100%of patients on pro-ton pump inhibitors therapy at baseline to 76.7%of patients showing elimination of medications or only as needed use of antacids/H2-RA at 12 *** improvement in endoscopic grade of oesophagitis was seen in 33 of the 41 *** patients had either no erosions or only mild erosive disease(grade A)at 6 ***:The experience with Stretta procedure confirms that it is well tolerated,safe,effective and durable in the treatment of *** Stretta procedure provides the drug-refractory patients with a new mini-mally invasive method.

关键词： Gastroesophageal reflux disease Clinical parameters Stretta procedure Radiofrequency

Characterization of surface EMG signals using improved approximate entropy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第10期7卷 844-848页

作者： chen wei-ting wang Zhi-zhong REN Xiao-mei Department of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200240 China

An improved approximate entropy (ApEn) is presented and applied to characterize surface electromyography (sEMG) signals. In most previous experiments using nonlinear dynamic analysis, this certain processing was often confronted with the problem of insufficient data points and noisy circumstances, which led to unsatisfactory results. Compared with fractal dimension as well as the standard ApEn, the improved ApEn can extract information underlying sEMG signals more efficiently and accu- rately. The method introduced here can also be applied to other medium-sized and noisy physiological signals.

关键词： Surface EMG (sEMG) signal Nonlinear analysis Approximate entropy (ApEn) Fractal dimension