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Integrated therapeutic plasma exchange and traditional Chinese medicine treatment in a patient with severe COVID-19:A case report

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Journal of Integrative Medicine 2022年第6期20卷 575-580页

作者： Chia-wei Lin wei-chen hsu Chien-Lu Lu Su-Hsing cheng cheng-Pin chen Yu-Chang Hou Department of Chinese Medicine Taoyuan General HospitalTaoyuan City 330TaiwanChina Department of Nephrology Taoyuan General HospitalTaoyuan City 330TaiwanChina Department of Infectious Disease Taoyuan General HospitalTaoyuan City 330TaiwanChina School of Public Health Taipei Medical UniversityTaipei City 110TaiwanChina Department of Bioscience Technology Chung Yuan Christian UniversityTaoyuan City 320TaiwanChina School of Chinese Medicine College of Chinese MedicineChina Medical UniversityTaichung City 404TaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan City 333TaiwanChina

This report presents the case of a 59-year-old man with severe COVID-19 that gradually progressed to cytokine release syndrome and then acute respiratory distress syndrome;he was successfully treated via integration of therapeutic plasma exchange and traditional Chinese *** patient initially presented with a sore throat,severe muscle aches,productive cough and *** the worsening of symptoms,remdesivir was ***,as the symptoms continued to worsen and a cytokine release syndrome was suspected,oxygen was provided through a high-flow nasal cannula(50 L/min)and therapeutic plasma exchange was performed to prevent worsening of the acute respiratory distress *** the same day,a course of traditional Chinese medicine was introduced in consultation with the infectious house *** patient’s symptoms gradually improved;the levels of C-reactive protein and D-dimers reduced,and the patient was weaned to a simple oxygen mask and eventually to room *** is the first reported case of the integration of these ***,they prevented the patient from requiring intubation,played a role in cytokine management,and also improved the clinical symptoms,including productive purulent sputum,cough,frequent stool passage and intermittent fever,with no adverse *** a result,the patient was discharged within two weeks of the integration of these ***,the integration of therapeutic plasma exchange and traditional Chinese medicine is an effective therapy for patients with severe COVID-19.

关键词： COVID-19 Therapeutic plasma exchange Traditional Chinese medicine

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激光多普勒检测口服六味地黄丸对体表微循环血流的影响(英文)

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中西医结合学报 2011年第10期9卷 1101-1109页

作者：许昕徐维侦黄世铭林家庆林鸿文国立台湾科技大学医学工程研究所台北市立联合医院仁爱院区中医科元智大学电机系

目的:通过分析健康受试者口服六味地黄丸后数个重要穴位激光多普勒血流信号的频谱成分,了解口服六味地黄丸对体表微循环血流的影响。方法:对两组男性健康受试者进行激光多普勒血流信号测量。六味地黄丸实验组42名受试者,平均年龄(27.8±... 详细信息

目的:通过分析健康受试者口服六味地黄丸后数个重要穴位激光多普勒血流信号的频谱成分,了解口服六味地黄丸对体表微循环血流的影响。方法:对两组男性健康受试者进行激光多普勒血流信号测量。六味地黄丸实验组42名受试者,平均年龄(27.8±3.8)岁;空白实验组28名受试者,平均年龄(27.3±3.4)岁。每次测量实验包含一次20min的基础测量与3次药效测量,其中两次于服药当天进行(口服5g六味地黄丸的浓缩药粉,配合250mL28℃温水服用),另一次测量于服药后第2天进行。结果:在服药后第2天,太溪穴处测量到最明显的平均血流量与脉波血流量增大,此外由频谱分析可发现,0.02～0.06Hz频带的能量比例显著降低,而在其他测量位置,则无任何显著的效应。结论:在口服六味地黄丸之后,体表微循环血流会进行重新分配调整,这可能因于不同体表穴位的血管床和交感神经作用强度不同从而引发微动脉小开口的血流阻力不同。这一非侵入式与实时监控的技术,有助于证实中药的生理效应及其生理作用机制。

关键词：六味地黄汤中草药微循环激光多普勒流量测定人体

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-hsun Lin Ying-Yi chen Yuan-Ming Tsai Ti-Hui Wu hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

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Isothermal section of ternary Sn-Zn-Ni phase equilibria at 250℃

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Progress in Natural Science:Materials International 2011年第5期21卷 386-391页

作者： Sinn-wen chen Chia-ming hsu Chin-yi CHOU Che-wei hsu Department of Chemical Engineering National Tsing Hua University

Ternary Sn-Zn-Ni alloys were prepared and equilibrated at 250℃for 4-15 *** phases formed in these equilibrated alloys were determined *** isothermal section of Sn-Zn-Ni system was constructed,based on the phase diagrams of the three constituent binary systems and the ternary phase equilibria data,determined in this study and referenced in literatures.12 single-phase regions were identified in the Sn-Zn-Ni ternary system at 250℃,including the three ternary compounds,δ,τ1andτ*** were 13 ternary phase regions and 23 binary phase regions in the 250℃Sn-Zn-Ni isothermal *** solubility of Zn in the binary Sn-Ni compounds is significant,and is 15.1%（mole fraction） in the Ni3Sn phase.

关键词： Pb-free solder phase equilibria Sn-Zn Ni

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Thickness bound for nonlocal wide-field-of-view metalenses

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Light(Science & Applications) 2022年第12期11卷 3018-3027页

作者： Shiyu Li Chia wei hsu Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA

Metalenses—flat lenses made with optical metasurfaces—promise to enable thinner,cheaper,and better imaging *** a sufficient angular field of view(FOV)is crucial toward that goal and requires a tailored incidentangle-dependent ***,we show that there is an intrinsic trade-off between achieving a desired broad-angle response and reducing the thickness of the *** the memory effect in disordered media,this thickness bound originates from the Fourier transform duality between space and *** can write down the transmission matrix describing the desired angle-dependent response,convert it to the spatial basis where its degree of nonlocality can be quantified through a lateral spreading,and determine the minimal device thickness based on such a required lateral *** approach is *** applied to wide-FOV lenses,it predicts the minimal thickness as a function of the FOV,lens diameter,and numerical *** bound is tight,as some inverse-designed multi-layer metasurfaces can approach the minimal thickness we *** work offers guidance for the design of nonlocal metasurfaces,proposes a new framework for establishing bounds,and reveals the relation between angular diversity and spatial footprint in multi-channel systems.

关键词： desired angular field

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Improving bagging performance through multi-algorithm ensembles

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Frontiers of Computer Science 2012年第5期6卷 498-512页

作者： Kuo-wei hsu Jaideep SRIVASTAVA Department of Computer Science Chengchi University Taipei 11605 China Department of Computer Science and Engineering University of Minnesota Minneapolis MN 55455 USA

Working as an ensemble method that establishes a committee of classifiers first and then aggregates their out- comes through majority voting, bagging has attracted consid- erable research interest and been applied in various applica- tion domains. It has demonstrated several advantages, but in its present form, bagging has been found to be less accurate than some other ensemble methods. To unlock its power and expand its user base, we propose an approach that improves bagging through the use of multi-algorithm ensembles. In a multi-algorithm ensemble, multiple classification algorithms are employed. Starting from a study of the nature of diver- sity, we show that compared to using different training sets alone, using heterogeneous algorithms together with different training sets increases diversity in ensembles, and hence we provide a fundamental explanation for research utilizing het- erogeneous algorithms. In addition, we partially address the problem of the relationship between diversity and accuracy by providing a non-linear function that describes the relation- ship between diversity and correlation. Furthermore, after re- alizing that the bootstrap procedure is the exclusive source of diversity in bagging, we use heterogeneity as another source of diversity and propose an approach utilizing heterogeneous algorithms in bagging. For evaluation, we consider several benchmark data sets from various application domains. The results indicate that, in terms of Fl-measure, our approach outperforms most of the other state-of-the-art ensemble meth- ods considered in experiments and, in terms of mean margin, our approach is superior to all the others considered in experiments.

关键词： bagging classification diversity ensemble

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Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8880-8886页

作者： Chia-Chi hsu Hsin-chen Lee Yau-Huei wei Institute of Pharmacology School of MedicineNational Yang-Ming University Department of Biochemistry and Molecular Biology National Yang-Ming University Department of Medicine Mackay Medical College

Hepatocellular carcinoma(HCC)is one of the most common malignancies and is ranked third in mortality among cancer-related *** are intracellular organelles that are responsible for energy metabolism and cellular homeostasis,and mitochondrial dysfunction has been regarded as a hallmark of *** the past decades,several types of mitochondrial DNA(mtDNA)alterations have been identified in human cancers,including ***,the role of these mtDNA alterations in cancer progression is *** this review,we summarize the recent findings on the somatic mtDNA alterations identified in HCC and their relationships with the clinicopathological features of *** advances in understanding the potential roles of somatic mtDNA alterations in the progression of HCC are also *** suggest that somatic mtDNA mutations and a decrease in the mtDNA copy number are common events in HCC and that a mitochondrial dysfunction-activated signaling cascade may play an important role in the progression of *** of the retrograde signaling pathways in HCC and the quest for strategies to block some of these pathways will be instrumental for the development of novel treatments for this and other malignancies.

关键词： Hepatocellular carcinoma Somatic mitochondrial DNA mutations Mitochondrial dysfunction

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A family of explicit algorithms for general pseudodynamic testing

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Earthquake Engineering and Engineering Vibration 2011年第1期10卷 51-64页

作者： Shuenn-Yih Chang Chi-wei hsu Department of Civil Engineering Taipei University of Technology (NTUT) NTUT Box 2653

A new family of explicit pseudodynamic algorithms is proposed for general pseudodynamic testing. One particular subfamily seems very promising for use in general pseudodynamic testing since the stability problem for a structure does not need to be considered. This is because this subfamily is unconditionally stable for any instantaneous stiffness softening system, linear elastic system and instantaneous stiffness hardening system that might occur in the pseudodynamic testing of a real structure. In addition, it also offers good accuracy when compared to a general second-order accurate method for both linear elastic and nonlinear systems.

关键词： pseudodynamic test explicit method unconditional stability dominant mode structural dynamics instantaneous degree of nonlinearity

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Comparison of capability of time integration methods in capturing dynamic loading

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 409-423页

作者： Shuenn-Yih Chang Chi-wei hsu Department of Civil Engineering Taipei University of Technology

Numerical properties of the time integration method proposed by the first author of this paper in 2007 are the same as those of the constant average acceleration method （AAM） for linear elastic systems, except that the capability to capture dynamic loading was not explored. It was found that there were different quadrature equations to predict the next step displacement increment. A modified quadrature equation of this method was derived so that the equation to determine the next step displacement was numerically equivalent to the equation used in the constant AAM. It was verified that the original form of this method, in general, had a better capability to capture dynamic loadings than the constant AAM. This excellent property, in addition to computational efficiency, will help to make this method competitive with general secondorder accurate integration methods.

关键词： equations of motion quadrature equation constant average acceleration method integration methods

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Synthesis and Characterization of Small Band-gap Conjugated Polymers - Poly(pyrrolyl methines)

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Chinese Chemical Letters 2002年第10期13卷 988-990页

作者： wei YAN Chain Shu hsu Yu wei School of Environmental&Chemical Engineering Jiaotong UniversityXi'an 710049 Department of Applied Chemistry National Chiao Tung UniversityHsinchuTaiwan English Department Xi抋n University of Science&TechnologyXi'an 710049

A kind of small band-gap conjugated polymers-poly (pyrrolyl methines) and their precursors-(poly pyrrolyl methanes) have been synthesized by a simple method and characterized by (HNMR)-H-1, FT-IR, TGA and UV-Vis. These polymers can be dissolved in high polar solvents such as DMSO, DMF or NMP. The results reveals that the band-gap of the synthesized conjugated polymers are in the range of 0.96similar to1.14 eV and they all belong to the small band-gap polymers. The conductivity of doped products with iodine is in the range of semiconductor.

关键词： Small band-gap conducting polymer poly( pyrrolyl methine).

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