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Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

Bioactive Materials 2023年第1期19卷 198-216页

作者： Fan Rong Tengjiao Wang Qian Zhou Haowei peng Jingtian Yang Quli Fan peng Li Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)&Xi’an Institute of Biomedical Materials and Engineering(IBME)Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’anShaanxi710072PR China National Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials(IAM) Nanjing University of Posts and TelecommunicationsNanjing210023PR China Honors College Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’anShaanxi710072PR China Queen Mary University of London Engineering School Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’anShaanxi710072PR China

Hydrogen sulfide(H_(2)S)plays an important role in regulating various pathological processes such as protecting mammalian cell from harmful injuries,promoting tissue regeneration,and regulating the process of various diseases caused by physiological *** have revealed that the physiological effects of H_(2)S are highly associated with its *** relatively low concentration,H_(2)S shows beneficial ***,long-time and high-dose donation of H_(2)S would inhibit regular biological process,resulting in cell dysfunction and *** regulate the dosage of H_(2)S delivery for precision medicine,H_(2)S delivery systems with intelligent characteristics were developed and a variety of biocompatibility polymers have been utilized to establish intelligent polymeric H_(2)S delivery systems,with the abilities to specifically target the lesions,smartly respond to pathological microenvironments,as well as real-timely monitor H_(2)S delivery and lesion conditions by incorporating imaging-capable *** this review,we focus on the design,preparation,and therapeutic applications of intelligent polymeric H_(2)S delivery systems in cardiovascular therapy,inflammatory therapy,tissue regenerative therapy,cancer therapy and bacteria-associated *** for precise H_(2)S therapies especially imaging-guided H_(2)S theranostics are *** H_(2)S donors with stimuli-responsive characters are vital components for establishing intelligent H_(2)S delivery systems,the development of H_(2)S donors is also briefly introduced.

关键词： Hydrogen sulfide prodrug Smart drug delivery Gas therapy Reactive sulfur species Precision medicine

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考虑变形影响的钢筋混凝土圆柱受剪承载力计算模型

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重庆大学学报（自然科学版） 2017年第11期40卷 72-82页

作者：张勤邴鹏韦宗延贡金鑫河海大学土木与交通学院南京210098 大连理工大学海岸和近海工程国家重点实验室大连116024

准确计算钢筋混凝土(RC)圆柱的受剪承载力是进行延性抗震设计的关键,可有效防止脆性剪切和弯剪破坏模式发生。基于已有的RC圆柱拟静力试验结果,分析了RC圆柱的地震破坏模式和受剪承载力确定方法,在理论分析的基础上提出了考虑变形(位移... 详细信息

准确计算钢筋混凝土(RC)圆柱的受剪承载力是进行延性抗震设计的关键,可有效防止脆性剪切和弯剪破坏模式发生。基于已有的RC圆柱拟静力试验结果,分析了RC圆柱的地震破坏模式和受剪承载力确定方法,在理论分析的基础上提出了考虑变形(位移延性)影响的RC圆柱受剪承载力计算模型,并与现有模型进行了比较。研究结果表明,地震作用下RC圆柱的受剪承载力随塑性铰区变形的增加而减小;弯剪破坏模式下,RC圆柱的受剪承载力取决于塑性铰区剪切破坏发生时对应的水平荷载而非骨架曲线上的峰值荷载;所提出的模型能有效反映变形对RC圆柱受剪承载力的影响,计算结果与试验数据吻合较好,可用于不同地震破坏模式RC圆柱受剪承载力计算。

关键词：钢筋混凝土圆柱弯剪破坏受剪承载力位移延性

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GCD‑L: A Novel Method for Geometric Change Detection in HD Maps Using Low‑Cost Sensors

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Automotive Innovation 2022年第3期5卷 324-332页

作者： peng Sun Yunpeng Wang peng He Xinxin Pei Mengmeng Yang Kun Jiang Diange Yang Autonomous Driving Technology Baidu IncBeijingChina School of Vehicle and Mobility Tsinghua UniversityLee Shau Kee Building No A639Beijing 100084China

Updating high-definition maps is imperative for the safety of autonomous ***,positional changes in lane lines are hard to be detected in a timely manner due to a limited number of expensive surveying vehicles over a large geo-graphic ***,a novel method is proposed to detect the geometric changes of lane lines using low-cost sensors,such as consumer-grade global navigation satellite system(GNSS)hardware receivers and *** proposed framework geometric change detection using low-cost sensors(GCD-L)and algorithm change segment compare(CSC),which are based on the lane width between the curb line and the adjacent leftmost lane line,can perceive the positional changes of the leftmost lane line on highway and expressway *** effectiveness of the proposed method is verified by evaluating it on a real-world typical urban ring road *** experimental results show that 71%detected change segments are valid with only two round crowdsourced maps.

关键词： Autonomous driving HD Maps Lane line Change detection

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Microstructure and mechanical properties of transient liquid phase bonding DD5 single-crystal superalloy to CrCoNi-based medium-entropy alloy

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Journal of Materials Science & Technology 2022年第1期96卷 140-150页

作者： Shiwei Li Jinglong Li Junmiao Shi Yu peng Xuan peng Xianjun Sun Feng Jin Jiangtao Xiong Fusheng Zhang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical UniversityXi’an 710072China

This study focuses on the transient liquid phase(TLP)bonding of DD5 single-crystal superalloy to Cr Co Nibased medium-entropy alloy(MEA)using a BNi-2 filler *** microstructure and mechanical properties of the TLP-bonded DD5/MEA joint were evaluated,and the microstructural evolution mechanism was *** formation of the isothermal solidification zone(ISZ)depended on the diffusion of the melting-point depressants(Si and B elements)from the liquid filler into the DD5 and MEA substrates,as well as the dissolution of the *** diffused along theγchannel of DD5 and reacted to form M_(5)B_(3)boride,herein referred to as the diffusion-affected zone(DAZ I).Similarly,the Cr_(5)B_(3)boride precipitated in the Ni-rich MEA matrix adjacent to the MEA substrate(i.e.,DAZ II).Additionally,a coherent orientation of[0]_(BCY)//[011]_(FCC)and(002)_(BCY)//(200)_(FCC)was detected between M_(5)B_(3)boride with a body-centered tetragonal(BCT)structure and the face-centered cubic(FCC)*** performance of the joint was dominated by the properties of the bonding *** the bonding time increased from 20to 80 min,the athermal solidification zone(including eutectic microstructure)was gradually replaced by the ISZ exhibiting excellent plastic deformation capability,and the shear strength of the joint was *** maximum shear strength(752 MPa)was achieved when the eutectic-free joint was bonded at 1050℃ for 80 *** fracture morphology revealed a mixture mode,indicating the initiation of cracks in the DAZ II,mainly propagating in the ISZ,and passing through the DAZ I.

关键词： Microstructure Mechanical properties Transient liquid phase bonding Single-crystal superalloy Medium-entropy alloy

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Effect of Aspergillus niger NBC001 on the soybean rhizosphere microbial community in a soybean cyst nematode-infested field

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Journal of Integrative Agriculture 2021年第12期20卷 3230-3239页

作者： JIN Na LIU Shi-ming peng Huan HUANG Wen-kun KONG Ling-an peng De-liang Department of Horticulture Beijing Vocational College of AgricultureBeijing 102442P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Soybean cyst nematode(SCN,Heterodera glycines Ichinohe)is one of the most important pests causing considerable damage to soybean(Glycine max(L.)Merr.)around the *** provides a strategy for sustainable nematode ***,Aspergillus niger NBC001 was isolated from the cysts Heterodera *** able to control *** and promote the growth of soybean in a pot *** this study,the effects of NBC001 on *** density and on the soybean rhizosphere microbial community in a soybean cyst nematode-infested field were *** results showed that NBC001 could suppress *** by 31.7%in the ***-throughput sequencing analysis showed that NBC001 had no significant influence on soybean rhizosphere microbial community structure,indicating that seed coatdressing with the concentrated culture filtrate of NBC001 was safe for the soil ecological *** addition,high-throughput sequencing results demonstrated that at 10 days post transplantation,NBC001 increased the abundances of Actinobacteria and Acidobacteria,but decreased the abundances of Bacteroidetes and Gemmatimonadetes at the phylum ***,the abundances of Phyllobacterium,Ralstonia and H16 were increased,while the abundances of Adhaeribacter,Gemmatimonas,Sphingomonas,Flavisolibacter\Nere suppressed by application of ***,at 90 days post transplantation,NBC001 only increased the abundances oi Aeromicrobium and RB41 whereas it decreased the abundance of *** results indicated that application of NBC001 increased the relative abundances of the beneficial microorganisms such as Actinobacteria,Acidobacteria,Aeromicrobium and Phyllobacterium in the *** summary,NBC001 is an eco-friendly biocontrol agent for *** control.

关键词： Aspergillus niger NBC001 biocontrol Heterodera glycines high-throughput sequencing microbial community

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二维全向无线充电信息物理融合系统建模与优化方法

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电子学报 2019年第3期47卷 568-575页

作者：孙朋朋董云卫西北工业大学计算机学院陕西西安710129

本文解决两相交流电源供电下二维全向无线充电信息物理融合系统的能量传输效率优化问题,发现了系统的频率分叉现象及其能量传输机理,利用混成自动机理论建立了系统的形式化模型.制定了一种面向不同负载区间的多供电模式的最优输电控制... 详细信息

本文解决两相交流电源供电下二维全向无线充电信息物理融合系统的能量传输效率优化问题,发现了系统的频率分叉现象及其能量传输机理,利用混成自动机理论建立了系统的形式化模型.制定了一种面向不同负载区间的多供电模式的最优输电控制策略和能量传输频率优化算法.论文对共振条件下的频率分叉现象进行仿真实验,验证了两相交流电源供电下能量的最优传输理论模型,可用于电动汽车、智能手机等移动装置的充电系统.

关键词：二维全向无线充电能量传输信息物理融合系统频率分叉两相交流电源混成自动机供电模式

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陕南豇豆绿色生产集成技术

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长江蔬菜 2025年第1期 43-45页

作者：闫东林崔玲王鹏洋县农产品质量安全监测检验中心陕西汉中723300 宜昌市秭归县公共检验检测中心洋县磨子桥镇农业综合服务站

豇豆被列入食用农产品“治违禁、控药残、促提升”3年行动的重点治理品种,其根本原因在于豇豆花果同期,豇豆采摘期会发生病虫害,如用药不当,安全间隔无法有效落实,易造成农药残留超标。因此,在豇豆生产过程中,应采取选用抗病品种、培育... 详细信息

豇豆被列入食用农产品“治违禁、控药残、促提升”3年行动的重点治理品种,其根本原因在于豇豆花果同期,豇豆采摘期会发生病虫害,如用药不当,安全间隔无法有效落实,易造成农药残留超标。因此,在豇豆生产过程中,应采取选用抗病品种、培育壮苗、配方施肥、作畦栽培、绿色防控等措施,探索绿色种植技术,从而实现豇豆病虫害防治与质量安全双达标。

关键词：豇豆绿色生产技术

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Fault Identification for Shear-Type Structures Using Low-Frequency Vibration Modes

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2769-2791页

作者： Cuihong Li Qiuwei Yang Xi peng School of Civil Engineering Shaoxing UniversityShaoxing312000China School of Civil and Transportation Engineering Ningbo University of TechnologyNingbo315211China Engineering Research Center of Industrial Construction in Civil Engineering of Zhejiang Ningbo University of TechnologyNingbo315211China

Shear-type structures are common structural forms in industrial and civil buildings,such as concrete and steel frame *** diagnosis of shear-type structures is an important topic to ensure the normal use of *** main drawback of existing damage assessment methods is that they require accurate structural finite element models for damage ***,for many shear-type structures,it is difficult to obtain accurate *** order to avoid finite elementmodeling,amodel-freemethod for diagnosing shear structure defects is developed in this *** method only needs to measure a few low-order vibration modes of the *** proposed defect diagnosis method is divided into two *** the first stage,the location of defects in the structure is determined based on the difference between the virtual displacements derived from the dynamic flexibility matrices before and after *** the second stage,damage severity is evaluated based on an improved frequency sensitivity *** innovations of this method lie in two *** first innovation is the development of a virtual displacement difference method for determining the location of damage in the shear *** second is to improve the existing frequency sensitivity equation to calculate the damage degree without constructing the finite *** has been verified on a numerical example of a 22-story shear frame structure and an experimental example of a three-story steel shear *** on numerical analysis and experimental data validation,it is shown that this method only needs to use the low-order modes of structural vibration to diagnose the defect location and damage degree,and does not require finite element *** proposed method should be a very simple and practical defect diagnosis technique in engineering practice.

关键词： Fault diagnosis shear steel structure vibration mode dynamic flexibility frequency sensitivity

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Effect of Salivary Antimicrobial Factors on Microbial Composition of Tongue Coating in Patients with Coronary Heart Disease with Phlegm-Stasis Syndrome

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World Journal of Traditional Chinese Medicine 2022年第1期8卷 123-130页

作者： Juan Ye Ke-Lei Su Yue-Hua Xu Yang Yang Qian Zhou wei Gao Xue-Ting Cai Qing-Yun wei Meng Cao peng Cao Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing 210023 Institute of Comparative Medicine College of Veterinary MedicineJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and ZoonosesJoint International Research Laboratory of Agriculture and Agri-Product SafetyThe Ministry of Education of ChinaYangzhou UniversityYangzhou225009China

Objective: Phlegm-stasis syndrome is one of the most common traditional Chinese medicine(TCM) syndromes and found in 59% of patients with coronary heart disease(CHD) in routine TCM clinical practice in China. One of the diagnostic criteria of phlegm-stasis syndrome is its characteristic white-greasy and thin tongue coating. We have previously reported that different types of tongue coating have different microbiome characteristics that can be used as diagnostic markers. However, the microbial characteristics of tongue coating of CHD patients with phlegm-stasis syndrome, including coating feature and underlying reason of formation, have rarely been reported. Herein, we examined the characteristic microbiome of tongue coating, and discussed the cause of tongue coating formation via salivary proteins in patients with phlegm-stasis syndrome. Methods: We examined white-greasy and thin tongue coatings obtained from 10 patients with CHD having phlegm-stasis syndrome(n = 10), and compared with those of patients with almost no coating – patients with Qi-Yin deficiency syndrome(n = 10) – and healthy controls(n = 10). 16S r RNA sequencing of tongue coating microbiome and isobaric tags for relative and absolute quantitation(i TRAQ)-based quantitative analysis of salivary proteins were used to detect tongue coating and salivary protein separately. Salivary levels of s Ig A, lysozyme, and amylase were detected by ELISA. Results: We identified Candidatus_Saccharimonas and Candidate_division_TM7_norank as the prominent members of tongue coating in patients with CHD having phlegm-stasis syndrome. Salivary proteins involved in biological processes, pentose phosphate pathway, and complement and coagulation cascades were among the differentially expressed proteins identified in patients with CHD having phlegm-stasis syndrome on i TRAQ analysis. Moreover, the formation of microbiota in tongue coating was associated with salivary s Ig A, lysozyme, and saliva flow rate. Conclusions: We ex

关键词： Coronary heart disease oral microbiome salivary proteins traditional Chinese medicine syndrome tongue diagnosis

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铌锑酸镁陶瓷的烧结和微波介电性能

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电子元件与材料 2005年第8期24卷 11-13页

作者：苏未安刘鹏边小兵陕西师范大学物理学与信息技术学院江西理工大学理学院江西赣州341000

用固相反应法制备了一系列铌锑酸镁(Sb含量x≤2)陶瓷,研究了该陶瓷的烧结性能、物相结构和微波介电性能。结果表明,当x≤1.6时,铌锑酸镁形成了连续固溶体,少量Sb5+对Nb5+的取代(0.4≤x≤0.8),使得陶瓷最佳烧结温度从1400℃降到1300℃,... 详细信息

用固相反应法制备了一系列铌锑酸镁(Sb含量x≤2)陶瓷,研究了该陶瓷的烧结性能、物相结构和微波介电性能。结果表明,当x≤1.6时,铌锑酸镁形成了连续固溶体,少量Sb5+对Nb5+的取代(0.4≤x≤0.8),使得陶瓷最佳烧结温度从1400℃降到1300℃,而材料εr和Q·f值没有降低。1300℃,5h烧结的铌锑酸镁陶瓷具有优异的微波介电性能:εr为11.61,Q·f为169820GHz,τf为–54.4×10–6℃–1。

关键词：无机非金属材料微波介质陶瓷铌锑酸镁(MNS)陶瓷连续固溶体

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