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实时直接分析质谱及与样品前处理技术联用的研究进展

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分析测试学报 2025年第1期44卷 43-50页

作者：林雪维姚钟平香港理工大学化学生物学及药物研发国家重点实验室未来食品研究院中医药创新研究中心应用生物与化学科技学系中国香港香港理工大学深圳研究院深圳市中药药学及分子药理学研究重点实验室深圳市食品生物污染与控制重点实验室广东深圳518057

实时直接分析质谱无需或者仅需简单的样品制备,即能对样品进行原位电离及直接快速的进样分析,已被广泛运用于食品、司法科学、药物分析、临床科学、环境等领域。尽管已有不少文献报道DART-MS的定量结果与液相/气相色谱-质谱相当,但其痕... 详细信息

实时直接分析质谱无需或者仅需简单的样品制备,即能对样品进行原位电离及直接快速的进样分析,已被广泛运用于食品、司法科学、药物分析、临床科学、环境等领域。尽管已有不少文献报道DART-MS的定量结果与液相/气相色谱-质谱相当,但其痕量分析物的检测性能仍是关键问题。为获得更准确的定量结果,研究人员开发出了一系列样品前处理技术与DART-MS联用。该文从DART-MS的原理出发,对其不同研究领域中无需样品前处理的应用进行了综述,并进一步介绍了样品预处理技术(如固相萃取、固相微萃取、顶空固相网增强吸附、分散固相萃取、分散磁性固相萃取、机械化学萃取、微波辅助萃取和热解吸)与DART-MS联用的研究成果。该综述旨在对DART-MS的样品直接分析的应用及样品前处理技术的开发提供帮助。

关键词：质谱实时直接分析直接样品分析样品预处理

ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells

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Biomedical and Environmental Sciences 2024年第8期37卷 834-849页

作者： Jing Xie Jiaxin Tang yuan Li xue kong wei Wang Haibo Wu Department of Pathology the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina

Objective Vasculogenic mimicry(VM)is a novel vasculogenic process integral to glioma stem cells(GSCs)in glioblastoma(GBM).However,the relationship between VM and ataxia-telangiectasia mutated(ATM)serine/threonine kinase activation,which confers chemoradiotherapy resistance,remains *** We investigated VM formation and phosphorylated ATM(pATM)levels by CD31/GFAPperiodic acid-Schiff dual staining and immunohistochemical staining in 145 GBM *** stem-like cells(GSLCs)derived from the formatted spheres of U87 and U251 cell lines and their pATM level and VM formation ability were examined using western blot and three-dimensional *** the examination of the function of pATM in VM formation by GSLCs,ATM knockdown by shRNAs and deactivated via ATM phosphorylation inhibitor KU55933 were *** VM and high pATM expression occurred in 38.5% and 41.8% of tumors,respectively,and were significantly associated with reduced progression-free and overall *** with VM-positive GBMs exhibited higher pATM levels(r_(s)=0.425,P=0.01).The multivariate analysis established VM as an independent negative prognostic factor(P=0.002).Furthermore,GSLCs expressed high levels of pATM and formed vascular-like networks in *** inactivation or knockdown hindered VM-like network formation concomitant with the downregulation of pVEGFR-2,VE-cadherin,and laminin *** VM may predict a poor GBM prognosis and is associated with pATM *** propose that pATM promotes VM through extracellular matrix modulation and VE-Cadherin/pVEGFR-2 activation,thereby highlighting ATM activation as a potential target for enhancing anti-angiogenesis therapies for GBM.

关键词： Glioblastoma Vasculogenic mimicry Ataxia-telangiectasia mutated(ATM) Glioma stem-like cell

Factors influencing biochemical recurrence in patients who have received salvage radiotherapy after radical prostatectomy： a systematic review and meta-analysis

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Asian Journal of Andrology 2017年第4期19卷 493-499页

作者： zhong-wei Jia Kun Chang Bo Dai Yun-Yi kong Yue Wang yuan-yuan Qu Yi-Ping Zhu Ding-wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Fudan University Shanghai Medical College Shanghai China Department of Pathology Fudan University Shanghai Cancer Center Shanghai China

Several studies have evaluated the risk factors influencing biochemical recurrence （BCR） of prostate cancer in patients receiving salvage radiotherapy （SRT） for BCR after radical prostatectomy （RP）, but the results remain conflicting. In this study, we performed a meta-analysis to resolve this conflict. We searched the following databases： PubMed, Embase, and Web of Science using the following terms in ＂All fields＂：＂salvage radiation therapy,＂＂salvage IMRT, S-IMRT, salvage radiotherapy, SRT, radical prostatectomy,＂＂RP, biochemical recurrence,＂＂BCR,＂＂biochemical relapse.＂ Eleven studies, with a total of 1383 patients, were included in our meta-analysis. Of all the variables, only Gleason score （GS）〉7 （odds ratio [OR]： 3.82; 95% confidence interval [CI]： 2.60-5.64） and pathological tumor （pT） stage 〉3a （OR： 1.82; 95% Ch 1.36-2.42） were positively correlated with BCR. However, SRT combined with androgen deprivation therapy （ADT）（OR： 0.63; 95% CI： 0.44-0.90） and radiation therapy （RT） dose 〉64 Gy （OR： 0.35; 95% CI： 0.19-0.64） were negatively correlated with BCR. Perineural invasion （OR： 2.64; 95% CI： 1.11-6.26）, preoperative prostate-specific antigen （PSA）〉10 ng m1-1 （OR： 1.36; 95% CI： 0.94-1.96）, positive surgical margin （OR： 0.92; 95% Ch 0.7-1.19）, and seminal vesicle involvement （SVI）（OR： 1.09; 95% Ch. 0.83-1.43） had no effect on BCR. Our meta-analysis indicated that pT stage, GS, RT dose, and SRT combined with ADT may influence BCR, while preoperative PSA, surgical margin, perineural invasion, and SVI have only a weak effect on BCR.

关键词： biochemical recurrence prostate cancer radical prostatectomy risk factors salvage radiotherapy

Effect of tempering on carbides and hydrogen embrittlement in E690 high strength marine structural steel

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Journal of Iron and Steel Research International 2022年第10期29卷 1669-1682页

作者： Yi Luo wei Li Peng-wei Zhou yuan-tao Xu Hui-yong Pang Ning zhong Hui-sheng Jiao xue-jun Jin Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Institute of Advanced Steels and Materials School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China China Wuyang Iron and Steel Co. Ltd.Pingdingshan462500HenanChina School of Materials Science and Engineering Shanghai Maritime UniversityShanghai200120China TESCAN CHINA Shanghai200240China

The effect of tempering on carbides and hydrogen embrittlement in E690 high strength marine structural steel has been *** steel was tempered at 600℃ for 1–3 *** characterization was carried out to characterize the microstructure,especially the dislocation density and grain *** hydrogen permeation test and thermal desorption spectroscopy test were also *** dislocation density decreases,the amount of carbide increases,and carbides(M_(23)C_(6) and MX)coarsen with the tempering time *** tempered at 600℃ for 3 h,the diffusible hydrogen trapped by lattice and dislocation decreases while the non-diffusible hydrogen trapped by carbides increases,leading to the best hydrogen embrittlement resistance,although hydrogen diffuses rapidly due to the reduction of dislocation *** the fracture mode changes from a combination of brittle cleavage and ductile dimpled fracture to fully ductile dimple fracture under hydrogen charging ***,a phenomenon that hydrogen accelerates the dislocations movement of the steel during deformation was observed,which is related to the fact that hydrogen enhanced localized plasticity mechanism.

关键词： High strength marine structural steel Carbide Tempering Hydrogen embrittlement Thermal desorption spectroscopy

Slight Structural Disorder in Bithiophene-based Random Terpolymers with Improved Power Conversion Efficiency for Polymer Solar Cells

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Chinese Journal of Polymer Science 2018年第10期36卷 1129-1138页

作者： Meng-Han Wang zhong-yuan xue Zhi-wei Wang wei-Hua Ning Yu zhong Ya-Nan Liu Chun-Feng Zhang Sven Huettner You-Tian Tao Key Lab for Flexible Electronics &Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Macromolecular Chemistry Ⅰ Universitat Bayreuth 30 Universitatsstr 95447 Bayreuth Germany

A series of random terpolymers P2-P5 were designed and synthesized by randomly embedding 5 mol%, 10 mol%, 15 mol% and 25 mol% feed ratios of low cost 2,2-bithiophene as the third monomer to the famous donor-acceptor （D-A） type copolymer PTBT-Th （P1）. All polymers showed similar molecular weight with number-average molecular weight （Mn） and weight-average molecular weight （Mw） in the range of （59-74） and （93-114） kg·mol-1, respectively, to ensure a fair comparison on the structure-property relationships. Compared with the control copolymer PTBT-Th, the random terpolymers exhibited enhanced absorption intensity in a wide range from 400 nm to 650 nm in both solution and film as well as in polymer/PC71BM blends. From grazing incident wide-angle X-ray diffraction （GIWAXS）, compared with the regularly alternated copolymer PTB7-Th, the random terpolymers demonstrated mild structural disorder with reduced （100） lamellar stacking and slightly weakened （010） π-π stacking for the polymers as well as slightly reduced PC71BM aggregation in polymer/PC71BM blends. However, the measured hole mobility for terpolymers （（1.20-3.73） × 10 -4 cm2·V-1·s-1） was evaluated to be comparable or even higher than 1.35 × 10 -4 cm2·V-1 ·s-1 of the alternative copolymer. Enhanced average power conversion efficiency （PCE） from 7.35% to 8.11% and 7.79% to 8.37% was observed in both conventional and inverted device architectures from copolymer P1 to terpolymers P4, while further increasing the 2,2-bithiophene feed ratio decreased the PCE.

关键词： Bithiophene-based random terpolymers Structural disorder Polymer solar cells Photovoltaic properties

“Charging”the cigarette butt:heteroatomic porous carbon nanosheets with edge-induced topological defects for enhanced oxygen evolution performance

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Frontiers of Chemical Science and Engineering 2023年第11期17卷 1755-1764页

作者： Qing-Hui kong Xian-wei Lv Jin-Tao Ren Hao-Yu Wang Xin-Lian Song Feng Xu zhong-Yong yuan School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China Tianjin Workstation Technology Center of Shanghai Tobacco Group Co.Ltd.Tianjin 300163China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

Owing to the complexity of electron transfer pathways,the sluggish oxygen evolution reaction process is defined as the bottleneck for the practical application of Zn-air *** this effort,metal nanoparticles(Co,Ni,Fe,etc.)encapsulated within nitrogen-doped carbon materials with abundant edge sites were synthesized by one-step pyrolysis treatment using cigarette butts as raw materials,which can drastically accelerate the overall rate of oxygen evolution reaction by facilitating the adsorption of oxygenated intermediates by the edge-induced topological *** prepared catalyst of nitrogen-doped carbon porous nanosheets loaded with Co nanoparticles(Co@NC-500)exhibits enhanced catalytic activity toward oxygen evolution reaction,with a low overpotential of 350 mV at the current density of 10 mA·cm^(-2).Furthermore,the Zn-air battery assembled with Co@NC-500 catalyst demonstrates a desirable performance affording an open-circuit potential of 1.336 V and power density of 33.6 mW·cm^(-2),indicating considerable practical application potential.

关键词： oxygen evolution reaction porous carbon nanosheets Co nanoparticles edge-induced topological defects Zn-air batteries

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang weimin yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert kong Erik Kuulkers weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang zhongxiang Wang Qingwen Wu xuefeng Wu Dong Xu Yanjun Xu Suijian xue Yongquan xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen wei Chen Yehai Chen Yifan Chen Chenzhou Cui weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin xue Yulong xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Novel liver-specific nitric oxide(NO) releasing drugs with bile acid as both NO carrier and targeting ligand

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Chinese Chemical Letters 2014年第5期25卷 787-790页

作者： xue-yuan Jin Shi-Yong Fan Hong-Wu Li wei-Guo Shi wei Chen Hui-Fen Wang Bo-Hua zhong Chinese PLA General Hospital & Chinese PLA Medical School Beijing Institute of Pharmacology and Toxicology

Novel liver-specific nitric oxide（NO） releasing drugs with bile acid as both the NO carrier and targeting ligand were designed and synthesized by direct nitration of the hydroxyl group in bile acids or the 3-Ohydroxyl alkyl derivatives,with the intact 24-COOH being preserved for hepatocyte specific *** biological evaluation revealed that oral administrated targeted conjugates could protect mice against acute liver damage induced by acetaminophen or carbon *** nitrate level in the liver significantly increased after oral administration of 1e while nitrate level in the blood did not significantly ***-administration of ursodeoxycholic acid（UDCA） significantly antagonized the increase of nitrate in the liver resulted by administration of 1e.

关键词： Liver-specific Nitric oxide releasing drugs Hepatoprotective activity Bile acid

Effects of reclaimed water irrigation and nitrogen fertilization on the chemical properties and microbial community of soil

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Journal of Integrative Agriculture 2017年第3期16卷 679-690页

作者： GUO wei Mathias N Andersen QI xue-bin LI Ping LI zhong-yang FAN Xiang-yang ZHOU yuan Farmland Irrigation Research Institute Chinese Academy of Agricultural Sciences (CAA S) Xinxiang 453003 P.R. China Graduate School of Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China Department of Agroecology Faculty of Science and Technology Aarhus University Tjele 8830 Denmark Key Laboratory of High-efficient and Safe Utilization of Agriculture Water Resources of CAAS Xinxiang 453003 P.R. China

The ecological effect of reclaimed water irrigation and fertilizer application on the soil environment is receiving more *** microbial activity and nitrogen（N）levels are important indicators of the effect of reclaimed water irrigation on *** study evaluated soil physicochemical properties and microbial community structure in soils irrigated with reclaimed water and receiving varied amounts of N *** results indicated that the reclaimed water irrigation increased soil electrical conductivity（EC）and soil water content（SWC）.The N treatment has highly significant effect on the ACE,Chao,Shannon（H）and Coverage *** on a 16S ribosomal RNA（16S rRNA）sequence analysis,the Proteobacteria,Gemmatimonadetes and Bacteroidetes were more abundant in soil irrigated with reclaimed water than in soil irrigated with clean *** clustering of microbial communities using either clean or reclaimed water for irrigation indicated that the type of irrigation water may have a greater influence on the structure of soil microbial community than N fertilizer *** on a canonical correspondence analysis（CCA）between the species of soil microbes and the chemical properties of the soil,which indicated that nitrate N（NO3-–-N）and total phosphorus（TP）had significant impact on abundance of Verrucomicrobia and Gemmatimonadetes,meanwhile the p H and organic matter（OM）had impact on abundance of Firmicutes and Actinobacteria *** was beneficial to the improvement of soil bacterial activity and fertility under 120 mg kg^-1 N with reclaimed water irrigation.

关键词： reclaimed water nitrogen soil chemical properties 16S rRNA sequence soil microbe community