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Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model

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Military Medical Research 2022年第3期9卷 319-330页

作者： wei Hu Jia-Wu Liang Song Liao Zhi-Dong Zhao Yu-Xing Wang Xiao-Fei Mao si-wei Hao Yi-Fan Wang Heng Zhu Bin Guo Medical School of Chinese People’s Liberation Army(PLA) Beijing100853China Department of Stomatology the First Medical CentreChinese PLA General HospitalBeijing100853China Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing100840China

Background:The healing of bone defects can be challenging for clinicians to manage,especially after exposure to ionizing *** this regard,radiation therapy and accidental exposure to gamma(o inhibit bone formation and increase the risk of *** bone-derivγ)-ray radiation have been shown ted stem cells(CBSCs)are reportedly essential for osteogenic lineages,bone maintenance and *** study aimed to investigate the effects of melatonin on postradiation CBSCs and bone defect ***:CBSCs were extracted from C57BL/6 mice and were identified by flow *** CBSCs were subjected to 6 Gyγ-ray radiation followed by treatment with various concentrations of *** effects of exogenous melatonin on the self-renewal and osteogenic capacity of postradiation CBSCs in vitro were *** underlying mechanisms involved in genomic stability,apoptosis and oxidative stress-related signaling were further analyzed by Western blotting,flow cytometry and immunofluorescence ***,postradiation femoral defect models were established and treated with Matrigel and *** effects of melatonin on postradiation bone healing in vivo were evaluated by micro-CT and pathological ***:The decrease in radiation-induced self-renewal and osteogenic capacity were partially reversed in postradiation CBSCs treated with melatonin(Psis and intracellular oxidative stress,and enhanced expression of antioxidant-related enzymes(Psis factor alpha(TNF-α)levels via the extracellular regulated kinase(ERK)/nuclear factor erythroid 2-related factor 2(NRF2)/heme oxygenase-1(HO-1)signaling *** was also found to exhibit antioxidant effects via NRF2 *** vivo experiments demonstrated that the newly formed bone in th

关键词： Melatonin Stem cells Ionizing radiation Bone regeneration

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Clinical Study on Point-toward-Point Needling for Asthenopia

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Journal of Acupuncture and Tuina Science 2013年第2期11卷 96-100页

作者： Liu Jian Xu si-wei Zhang Ren Han Chou-ping Department of Acupuncture Branch of Shanghai First People's Hospital Shanghai First People's Hospital Shanghai Literature Institute of Traditional Chinese Medicine

Objective:To observe the effect of point-toward-point needling on ***:A total of 60 asthenopia cases were randomized into an observation group and a control group,30 cases in each ***-point needling was used in the observation group;whereas point injection was used in the control *** signs and symptoms including visual tasks and eye fatigue were observed before and after *** was followed by an inter-group comparison of eye discomfort symptom score and therapeutic ***:After treatment,the symptoms and signs in both groups were significantly improved,showing a statistical significance(Psion:Both treatment protocols can help alleviate the clinical symptoms of asthenopia;point-toward-point needling can obtain better effect than point injection.

关键词： Point-toward-point Method Acupuncture Therapy Hydro-acupuncture Asthenopia

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Combustion Characteristics of Polyethylene and Coal Powder at High Temperature

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Journal of Iron and Steel Research International 2008年第1期15卷 6-9页

作者： LONG Shi-gang CAO Feng WANG si-wei SUN Liu-heng PANG Jian-ming SUN Yu-ping School of Metallurgy and Resource Anhui University of Technology Ma＇anshan 243002 Anhui China

To study the combustion characteristics of the polyethylene（PE）particle and coal powder at blast temperature of the blast furnace,the contents of CO and CO2 of off-gas during the combustion of PE particle and coal powder at the 1 200 ℃ and 1 250 ℃ were measured using carbon monoxide and carbon dioxide infrared analyzer,and then the corresponding combustion ratio was *** results showed that when the temperature is high,the combustion speed of PE and coal powder is high and the corresponding combustion ratio is ***,the combustion speed and ratio of PE are much higher than those of coal powder.

关键词： polyethylene coal powder combustion characteristic

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Research progress of traditional medicine to improve colorectal tumor from the perspective of intestinal flora

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Microenvironment & Microecology Research 2022年第3期4卷 19-26页

作者： wei-Chen si School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China

Colorectal cancer(CRC)is one of the cancers with a high mortality *** and more scientific researches have found that intestinal flora can directly interact with *** can also be involved in the development of CRC by regulating metabolites such as bile acids,short-chain fatty acid and amino *** traditional medicine has unique advantages in the treatment of CRC by correcting microbiome,restoring intestinal microecology,improving intestinal immune function and enhancing intestinal barrier *** author combines the global scientific research in this direction for analysis and report,to make a summary.

关键词： colorectal cancer intestinal flora traditional Chinese medicine pathogenesis therapeutic mechanism

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Etomidate protects retinal ganglion cells from hydrogen peroxide-induced injury via Nrf2/HO-1 pathway

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1606-1613页

作者： Xuan Zhao De-Gang Fan Xin-Chao Zhang si-wei You Fang Kuang Ming-Mei Wu Department of Histology and Embryology School of Basic Medical SciencesXi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Neurobiology the Basic Medical Science Academythe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina College of Life Sciences Northwestern UniversityXi’an 710069Shaanxi ProvinceChina

AIM:To determine whether etomidate(ET)has a protective effect on retinal ganglion cells(RGCs)injured with hydrogen peroxide(H_(2)O_(2))and to explore the potential mechanism underlying the antioxidative stress effect of ***:Cultured RGCs were identified by double immunofluorescent labeling of microtubule-associated protein 2 and *** injury model of H_(2)O_(2)-induced RGCs oxidative stress was established in *** were pretreated with different concentrations of ET(1,5,and 10μmol/L)for 4h,followed by further exposure to H_(2)O_(2)at 1000μmol/*** counting kit 8 and Annexin V/propidium iodide assays were applied to detect the viabilities and apoptosis rates of the RGCs at 12,24,and 48h after H_(2)O_(2)*** levels of nitric oxide,malondialdehyde,and glutathione in culture media were measured at these time *** reverse transcription polymerase chain reaction(qRT-PCR)and Western blot were performed to observe the effects of ET on the messenger RNA and protein expression of inducible nitric oxide synthase(iNOS),nuclear factor erythroid 2-related factor 2(Nrf2),heme oxygenase 1(HO-1),glutathione peroxidase 1 and the level of conjugated acrolein in RGCs at 12,24,and 48h after H_(2)O_(2)stimulation and in the retina at 12h after optic nerve transection(ONT).RESULTS:The applications of 5 and 10μmol/L of ET significantly increased the viability of *** from qRT-PCR indicated a decrease in the expression of iNOS and an increase in the expressions of Nrf2 and HO-1 in ETpretreated RGCs at 12,24 and 48h after H_(2)O_(2)stimulation,as well as in ET-treated retinas at 12h after *** blot analysis revealed a decrease in the expression of iNOS and levels of conjugated acrolein,along with an increase in the expressions of Nrf2 and HO-1 in ET-pretreated RGCs in vitro and ET-treated retinas in ***:ET is a neuroprotective agent in primary cultured RGCs injured by H_(2)O_(2).The effect of ET is dosedependent with the

关键词： etomidate retinal ganglion cell neuroprotection hydrogen peroxide-induced injury nuclear factor erythroid 2-related factor 2 heme oxygenase 1

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An AEE-active Polymer Containing Tetraphenylethene and 9,10-Distyrylanthracene Moieties with Remarkable Mechanochromism

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Chinese Journal of Polymer Science 2017年第2期35卷 282-292页

作者： Jun-ru Chen Juan Zhao Bing-jia Xu 杨志涌 si-wei Liu Jia-rui Xu 张艺 Yuan-chun Wu Po-yen Lv 池振国 Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education Guangdong Provincial Key Laboratory for High Performance Polymer-based CompositesGuangdong Engineering Technology Research Center for High-performance Organic and Polymer Photoelectric Functional FilmsState Key Laboratory of Optoelectronic Material and TechnologiesSchool of ChemistrySun Yat-sen University Shenzhen China Star Optoelectronics Technology Co. Ltd

A polymer （poly（9,10）anthracenevinylene-alt-4,4＇-（9,9-bis（4-（4＇-（1,2,2＇-triphenyviny）phenoxy）butyl）-9H- fluorene-2,7-diyl） dibenzaldehyde）, P1） was successfully synthesized through the Wittig-Horner reaction by employing fluorene and 9,10-distyrylanthracene moieties as building blocks for backbone and tetraphenylethenes as pendant groups. Photophysical and thermal properties of the resulting polymeric emitter were fully characterized by ultraviolet-visible （UV- Vis） absorption and photoluminescence （PL） spectra, thermogravimetric analysis （TGA） and differential scanning calorimetry （DSC）. While P1 emits an orange-light centered at 567 nm in dilute tetrahydrofuran （THF） solution, the solid powder of the polymer exhibits strong yellow emission peaked at 541 nm. It is also found that the as-synthesized polymer shows unique property of aggregation-enhanced emission （AEE）. In addition, P1 possesses high thermal stability with a decomposition temperature （Td,5%） of 430 ℃ and high morphological stability with a glass transition temperature （Tg） of 171℃. Under the stimulus of mechanical force, the emission of P1 can be changed from yellow to red （△λmax = 61 rim）, showing a remarkable mechanochromism. The results from XRD analysis suggest that such mechanochromic phenomenonof PI is probably caused by the destruction of crystalline structure, which leads to the conformational planarization of the distyrylanthracene moieties forming by the polymerization and the increase of molecular conjugation of the backbone.

关键词： Tetraphenylethene 9,10-Distyrylanthracene Aggregation-enhanced emission High thermal stability Mechanochromic polymer

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Incidence and mortality of liver cancer in China, 2010

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Chinese Journal of Cancer 2014年第8期33卷 388-394页

作者： Kuang-Rong wei Xia Yu Rong-Shou Zheng Xia-Biao Peng si-wei Zhang Ming-Fang Ji Zhi-Heng Liang Zhi-Xiong Ou Wan-Qing Chen Cancer Institute Zhongshan Municipal People’s HospitalZhongshan Guangdong National Central Cancer Registry National Cancer CenterBeijing Digestive Internal Department Zhongshan Municipal People’s HospitalZhongshan Guangdong

Liver cancer is a common malignant tumor in China and a major health concern. We aimed to estimate the liver cancer incidence and mortality in China in 2010 using liver cancer data from some Chinese cancer registries and provide reference for liver cancer prevention and treatment. We collected and evaluated the incidence and mortality data of liver cancer in 2010 from 145 cancer registries, which were included in the 2013 Chinese Cancer Registry Annual Report, calculated crude, standardized, and truncated incidences and mortalities, and estimated new liver cancer cases and deaths from liver cancer throughout China and in different regions in 2010 from Chinese practical population. The estimates of new liver cancer cases and deaths were 358,840 and 312,432, respectively, in China in 2010. The crude incidence, age-standardized rate by Chinese standard population(ASR China), and age-standardized rate by world standard population(ASR world) were 27.29/100,000, 21.35/100,000, and 20.87/100,000, respectively; the crude, ASR China, and ASR world mortalities were 23.76/100,000, 18.43/100,000, and 18.04/100,000, respectively. The incidence and mortality were the highest in western regions, higher in rural areas than in urban areas, and higher in males than in females. The age-specific incidence and mortality of liver cancer showed a rapid increase from age 30 and peaked at age 80-84 or 85+. Our results indicated that the 2010 incidence and mortality of liver cancer in China, especially in undeveloped rural areas and western regions, were among high levels worldwide. The strategy for liver cancer prevention and treatment should be strengthened.

关键词：中国标准死亡率肝癌世界人口死亡病例恶性肿瘤西部地区农村地区

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Autophagy prevents autophagic cell death in Tetrahymena in response to oxidative stress

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Zoological Research 2015年第3期36卷 167-173页

作者： si-wei ZHANG Jiang-Nan FENG Yi CAO Li-Ping MENG Shu-Lin WANG State Key Laboratory of Genetic Engineering Institute of GeneticsSchool of Life SciencesFudan University

Autophagy is a major cellular pathway used to degrade long-lived proteins or organelles that may be damaged due to increased reactive oxygen species（ROS） generated by cellular stress. Autophagy typically enhances cell survival, but it may also act to promote cell death under certain conditions. The mechanism underlying this paradox, however, remains unclear. We showed that Tetrahymena cells exerted increased membranebound vacuoles characteristic of autophagy followed by autophagic cell death（referred to as cell death with autophagy） after exposure to hydrogen peroxide. Inhibition of autophagy by chloroquine or 3-methyladenine significantly augmented autophagic cell death induced by hydrogen peroxide. Blockage of the mitochondrial electron transport chain or starvation triggered activation of autophagy followed by cell death by inducing the production of ROS due to the loss of mitochondrial membrane potential. This indicated a regulatory role of mitochondrial ROS in programming autophagy and autophagic cell death in Tetrahymena. Importantly, suppression of autophagy enhanced autophagic cell death in Tetrahymena in response to elevated ROS production from starvation, and this was reversed by antioxidants. Therefore, our results suggest that autophagy was activated upon oxidative stress to prevent the initiation of autophagic cell death in Tetrahymena until the accumulation of ROS passed the point of no return, leading to delayed cell death in Tetrahymena.

关键词： Autophagy Autophagic cell death Lysosome Mitochondria Reactive oxygen species Tetrahymena

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Environmentally friendly expanded graphite-doped ZnO superhydrophobic coating with good corrosion resistance in marine environment

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Rare Metals 2023年第9期42卷 3075-3087页

作者： si-wei Wu Quan-Tong Jiang Shuai Yuan Qing-Kun Zhao Chang Liu Heng Tang Qiang Sun Ji-Zhou Duan Bao-Rong Hou Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou510301China CAS Key Laboratory of Marine Environmental Corrosion and Bio-Fouling Institute of OceanologyChinese Academy of SciencesQingdao266071China Sanya Institute of Ocean Eco-Environmental Engineering Sanya572000China University of Chinese Academy of Sciences Beijing100049China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266071China

Designing and fabricating the marine anti-corrosion materials without fluorine by superhydrophobic method is a huge challenge. In this study, an environmentally friendly composite coating was prepared by combing modified expanded graphite(EAG) with nano zinc oxide(ZnO). This coating showed superhydrophobic surface and good corrosion resistance. Fourier transform infrared spectroscopy(FITR), X-ray diffraction(XRD),and scanning electron microscopy(SEM) were used to characterize the materials in fabricating process of the coating. The properties of three composite coatings(ZnO,EAG, and EAG@ZnO) were analyzed, including surface roughness, water contact angle, corrosion resistance, selfcleaning and anti-fouling. The combination of ZnO and EAG caused a big water contact angle, leading superhydrophobic surface of the composite coatings. The electrochemical results showed that the superhydrophobic EAG@ZnO coating had a larger capacitive arc diameter and charge transfer resistance, indicating the enhanced anti-corrosion resistance. Meanwhile, the EAG@ZnO coating also showed good self-cleaning and anti-fouling performance according to solid and liquid pollutants *** addition, the mechanical properties and stability of the superhydrophobic EAG@ZnO coatings were evaluated by knife peeling and finger scratch tests. In summary, these superhydrophobic and anti-fouling EAG@ZnO composite coatings provide a potential application in marine corrosion and protection field.

关键词： Coating Superhydrophobic Anti-corrosion Anti-fouling Environmentally friendly

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Sodium butyrate protects against lipopolysaccharideinduced liver injury partially via the GPR43/b-arrestin-2/NF-кB network

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Gastroenterology Report 2021年第2期9卷 154-165,I0002页

作者： Qian-Jiang Luo Mei-Xing Sun Yun-wei Guo si-wei Tan Xiao-Ying Wu Kodjo-Kunale Abassa Li Lin Hui-Ling Liu Jie Jiang Xiu-Qing wei Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Eighth Affiliated Hospital of Sun Yat-sen University(Shenzhen Futian Hospital)ShenzhenGuangdongP.R.China

Background Butyrate acts as a regulator in multiple inflammatory organ ***,the role of butyrate in acute liver injury has not yet been fully *** the present study,we aimed to investigate the association between butyrate and lipopolysaccharide(LPS)-induced acute liver injury and the signaling pathways *** LPS-induced acute liver injury was induced by intraperitoneal injection of LPS(5 mg/kg)in G-protein-coupled receptor 43(GPR43)-knockout(KO)and wild-type female C57BL/6 *** butyrate(500mg/kg)was administered intraperitoneally 30min prior to LPS *** injury was detected by serum markers,tissue morphology,and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).Pro-inflammatory-factor levels were detected by enzyme-linked immunosorbent assay and real-time polymerase chain reaction(RT-PCR).Cell models were first treated with sodium butyrate(4μmol/mL),followed by LPS(1μg/mL)half an hour later in GPR43 small interfering RNA(siRNA)-transfected or control RAW264.7 ***-inflammation status was evaluated through detecting pro-inflammatory-factor expression by RT-PCR and also through checking toll-like receptor 4/nuclear factor-кB(TLR4/NF-кB)-element levels including TLR4,TRAF6,IKKb,IкBα,phospho-IкBα,p65,and phospho-p65 by Western *** interaction between GPR43 and barrestin-2 was tested by *** Sodium butyrate reversed the LPS-induced tissue-morphology changes and high levels of serum alanine aminotransferase,aspartate transaminase,myeloperoxidase,TUNEL,and pro-inflammatory cytokines such as tumor necrosis factor-a and *** ameliorating effect of sodium butyrate was weakened in GPR43-KO mice and GPR43 siRNA RAW264.7 cells,compared with those of GPR43-positive *** butyrate downregulated some elements of the TLR4/NF-кB pathway,including phospho-IкBαand phospho-p65,in RAW264.7 *** interactions between GPR43 and b-arrestin-2,and betw

关键词： sodium butyrate short-chain fatty acids lipopolysaccharide-induced liver injury G-protein-coupled receptor 43 b-arrestin-2 NF-кB

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