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Chinese Chemical Letters 1992年第10期3卷 767-770页

作者： Pei Qiang HUANG wei shan zhou shanghai Institute of Organic Chemistry Academia Sinica345 Lingling LuShanghai 200032 Department of Chemistry Xiamen UniversityXiamen 361005

An efficient synthesis of functionalized 6-decalone 16, starting from a dienolate anion 3a via a tandem Michael reaction, is described. 16 could be used as a potential intermediate for synthesis of drimane related ses... 详细信息

关键词： Vita SYNTHESIS OF A POTENTIAL ANTIFEEDANT SESOUITERPENE INTERMEDIATE FROM A NEW TERPENOID A B-RING SYNTHON BY TANDEM NICHAEL REACTION

STUDIES ON STEROIDAL PLANT GROWTH REGULATOR 24. STEREOCONTROLLED CONSTRUCTION OF THE SIDE CHAIN OF BRASSINOLIDE AND HOMOBRASSINOLIDE VIA A TANDEM VICINAL DIALKYLATION OF PYRANONE MOIETY

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Chinese Chemical Letters 1991年第12期2卷 929-932页

作者： wei shan zhou Li Qiang SUN Xin Fu PAN shanghai Institute of Organic Chemistry Chinese Academy of Sciences345 LingLing Lu200032 Department of Chemistry Lanzhou University Lanzhou730000

A stereocontrolled construction of the side chain of brassinclide and homobrassinolide has been achieved via the tandem vicinal dialkylation of the pyranone moiety as a key step.

关键词： STUDIES ON STEROIDAL PLANT GROWTH REGULATOR 24 STEREOCONTROLLED CONSTRUCTION OF THE SIDE CHAIN OF BRASSINOLIDE AND HOMOBRASSINOLIDE VIA A TANDEM VICINAL DIALKYLATION OF PYRANONE MOIETY VIA

STUDIES ON THE SYNTHESIS OF RABDOSIA DITERPENOID Ⅱ,PREPARATION OF A KEY BUILDING BLOCK,α,β-UNSATURATED LACTONE

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Chinese Chemical Letters 1990年第1期1卷 71-74页

作者： Zhi Min WANG wei shan zhou shanghai Institute of Organic Chemistry,Academia Sinica,345 Lingling Lu,shanghai 200032

The main half molecule(4a)of the trichorabdal B(1) was synthesized from pentadienol(6).The key step is the intramolecular Diels-Alder reaction of 8.

关键词： THF PREPARATION OF A KEY BUILDING BLOCK STUDIES ON THE SYNTHESIS OF RABDOSIA DITERPENOID UNSATURATED LACTONE

STUDIES ON STEROID PLANT-GROWTH REGULATOR *** PRODUCT DIASTEREOMERIC EXCESSES IN ASYMMETRIC DIHYDROXYLATION OF THE(22E,24R)-AND THE(22E,24S)-24-ALKYL STEROIDAL UNSATURATED SIOECHAIN BY USING THE SHARPLESS IMPROVED CHIRAL LIGAND

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Chinese Chemical Letters 1992年第12期3卷 969-970页

作者： Liang Fu HUANG wei shan zhou shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,shanghai 200032

The osmium tetroxide catalyzed asymmetric dihydroxylation of the(22E)- steroidal sidechain is described and an unexpected 8:1 ratio of(22R,23R)and (22S,23S)was obtained from the(22E,24S)-24-ethyl substituted sidechain.

关键词： Chen ALKYL STEROIDAL UNSATURATED SIOECHAIN BY USING THE SHARPLESS IMPROVED CHIRAL LIGAND AND THE STUDIES ON STEROID PLANT-GROWTH REGULATOR 27.ENHANCED PRODUCT DIASTEREOMERIC EXCESSES IN ASYMMETRIC DIHYDROXYLATION OF THE

STUDY ON THE SYNTHESIS OF TETRACYCLIC DITERPENOID 7 Preparation of the Key Intermediate 5 for the Synthesis of Grandiflorenic Acid and its Analogues

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Chinese Chemical Letters 1993年第4期4卷 291-294页

作者： Yun Xing CHENG wei shan zhou shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,shanghai 200032

The key intermediate 5 for synthesis of the contragestationally active diterpenoid grandiflorenic acid(1)and its analogues 2 and 3 was prepared and an acetyl transposition reaction occurred in the SeO_2 oxida- tion of 8.

关键词： In STUDY ON THE SYNTHESIS OF TETRACYCLIC DITERPENOID 7 Preparation of the Key Intermediate 5 for the Synthesis of Grandiflorenic Acid and its Analogues

CHBMISTRY OF HYODEOXYCHOLIC ACID 5. CONCISE SYNTHESIS OF 25-HYDROXYCHOLESTEROL FROM HYODEOXYCHOLIC ACID, A KEY INTERMEDIATE OF 25-HYDROXYVITAMIN D_3

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Chinese Chemical Letters 1992年第6期3卷 409-410页

作者： Zhong Qi WANG Li Zhong JIANG wei shan zhou shanghai Institute of Organic Chemistry, Academia Sinica 345, Lingling Lu, shanghai 200032

25-Hydroxycholesterol, which is an important intermediate for the synthesis of 25-hvdroxyvitamin D_3 and 1α, 25-dihydroxyvitamin D_3, was prepared efficiently from hyodeoxycholic acid in 31% overall yield in seven st... 详细信息

关键词： CONCISE SYNTHESIS OF 25-HYDROXYCHOLESTEROL FROM HYODEOXYCHOLIC ACID CHBMISTRY OF HYODEOXYCHOLIC ACID 5 A KEY INTERMEDIATE OF 25-HYDROXYVITAMIN D3 CHC

REGIOSELECTIVE OXIDATION OF KETONE BY AN OXIDATIVE REAGENT SYSTEM KH/O_2/18-CROWN-6/THF:APPLICATION TO SYNTHESIS OF VARIOUS LACTONES

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Chinese Chemical Letters 1991年第7期2卷 505-508页

作者： wei shan zhou Biao JIANG shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,shanghai 200032.Xin Fu PAN Department of Chemistry,Lanzhou University,Lanzhou 730000.

the regioselectivity in the oxidation of different types of ketone compounds 1--6 with an oxidative reagent system,KH/O_2/18- Crown-6/THF is *** these oxidative products,the various lactones have been prepared.

关键词： THF REGIOSELECTIVE OXIDATION OF KETONE BY AN OXIDATIVE REAGENT SYSTEM KH/O2/18-CROWN-6/THF KH

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

CATALYTIC　ASYMMETRIC　EPOXIDATION　OF　a－FURFURYLAMINE　IN　THE　PRESENCE　OF　MOLECULAR　SIEVE　AND　CaH_2

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Chinese Chemical Letters 1994年第7期5卷 567-568页

作者： Zhi Hut LU Xue You ZHU and wei shan zhou(shanghai Institute of Organic Chemistry ,Chinese Academ of Sciences.354 Fengling Lu. shanghai 200032)(Department of Bio-engineering Sichuan University. Chengdu 610064)

The modified procedure of the catalytic asvmmetric epoxidation of the a-furfurylamines(dl)-1a-d in the presenceof molecular sieve and CaH2 provides the slow-reacting enantiomers (S)-1a-d and the fast-reacting enantiom...

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混沌系统隐含频率检测方法研究及其在海洋资料分析中的应用

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海洋学报 2001年第1期23卷 29-34页

作者：魏恩泊田纪伟许金山周发诱上海理工大学动力工程学院上海200093 青岛海洋大学海洋环境学院山东青岛266003

利用Ｇｕｉｌｌｅｒｍｏ的单时间序列重构相空间点概率密度的功率谱分析方法，对赤道日表层水温和青岛月气温的九点滑动平均资料进行了隐含频率检测，结果表明，赤道日表层水温隐含周期为２３．３，１０．５，７．７ｄ，其他物理参... 详细信息

利用Ｇｕｉｌｌｅｒｍｏ的单时间序列重构相空间点概率密度的功率谱分析方法，对赤道日表层水温和青岛月气温的九点滑动平均资料进行了隐含频率检测，结果表明，赤道日表层水温隐含周期为２３．３，１０．５，７．７ｄ，其他物理参量的震荡及青岛气温隐含周期１０．６，５．７，４．５，２．９ａ，３个月其他物理参量的震荡．

关键词：相空间嵌入维数概率密度混沌系统单时间序列海洋资料海洋物理学