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High Accuracy Gene Signature for Chemosensitivity Prediction in Breast Cancer

Tsinghua Science and Technology 2015年第5期20卷 530-536页

作者： wei hu Department of Computer Science Houghton College

Neoadjuvant chemotherapy for breast cancer patients with large tumor size is a necessary *** this treatment patients who achieve a pathologic Complete Response（p CR） usually have a favorable prognosis than those without. Therefore, p CR is now considered as the best prognosticator for patients with neoadjuvant chemotherapy. However, not all patients can benefit from this treatment. As a result, we need to find a way to predict what kind of patients can induce p CR. Various gene signatures of chemosensitivity in breast cancer have been identified, from which such predictors can be built. Nevertheless, many of them have their prediction accuracy around 80%. As such, identifying gene signatures that could be employed to build high accuracy predictors is a prerequisite for their clinical tests and applications. Furthermore, to elucidate the importance of each individual gene in a signature is another pressing need before such signature could be tested in clinical settings. In this study, Genetic Algorithm（GA） and Sparse Logistic Regression（SLR） along with t-test were employed to identify one signature. It had 28 probe sets selected by GA from the top 65 probe sets that were highly overexpressed between p CR and Residual Disease（RD） and was used to build an SLR predictor of p CR（SLR-28）. This predictor tested on a training set（n = 81） and validation set（n = 52） had very precise predictions measured by accuracy,specificity, sensitivity, positive predictive value, and negative predictive value with their corresponding P value all zero. Furthermore, this predictor discovered 12 important genes in the 28 probe set signature. Our findings also demonstrated that the most discriminative genes measured by SLR as a group selected by GA were not necessarily those with the smallest P values by t-test as individual genes, highlighting the ability of GA to capture the interacting genes in p CR prediction as multivariate techniques. Our gene signature produced superior per

关键词： genetic algorithm gene signature breast cancer sparse logistic regression predictor chemosensitivity

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Mutations in Hemagglutinin of a Novel Avian-Origin H7N9 Virus That Are Critical for Receptor Binding Specificity

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Tsinghua Science and Technology 2013年第5期18卷 522-529页

作者： wei hu the Department of Computer Science Houghton College

A novel avian-origin H7N9 influenza virus was discovered in March in China and has caused a total of131 people infected including 39 deaths in China as of June 9, 2013. Adaptation of avian viruses to efficiently infect humans requires the viral hemagglutinin（HA） binding switches from avian to human type receptors with help of some mutations in HA. As such it is critical for pandemic assessment to discover these mutations as hallmarks of adaptation. To continue our previous study of this novel H7N9 virus, we identified two sets of mutations in HA. The first set of mutations are present in the current circulating strains of 2013 H7N9 in China, and the second set are potential mutations that were found when compared to the HAs of previous human H7 subtype. These two sets of mutations exhibited unique features. The first group of mutations, on average, enhanced the HA binding to human type receptors whereas reduced that to avian types. Further the reduction of avian binding was almost three times of the increase of the human binding. The second group increased the binding to both human and avian *** the increase in human types was almost three times of that in the avian types. Though different in their way of changing the binding preference, these two sets of mutations both contained more mutations to decrease the avian binding and increase the human binding than those that did the opposite. Our research highlighted the pandemic potential of this novel virus by showing the important mutations that could potentially help it to adapt to human hosts. Our findings offered new insights into the current state of evolution of this virus, which might be helpful for the continued surveillance of the emergence of H7N9 strains having the ability of human-to-human transmission.

关键词： H7N9 influenza receptor binding specificity mutation HA gene

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The contrast between defect solitons in parity-time symmetric superlattice and simple-lattice complex potentials

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Chinese Physics B 2012年第2期21卷 362-367页

作者： hu Su-Mei hu wei Laboratory of Photonic Information Technology South China Normal UniversityGuangzhou 510631China Department of Physics Guangdong University of Petrochemical TechnologyMaoming 525000China

The existence and stability of defect superlattice solitons in parity-time （PT） symmetric superlattice and simplelattice complex potentials are reported. Compared with defect simple-lattice solitons in similar potentials, the defect soliton in superlattice has a wider stable range than that in simple-lattice. The solitons＇ power increases with increasing propagation constant. For the positive defect, the solitons are stable in the whole region where solitons exist in the semi-infinite gap. For the zero defect, the solitons are unstable at the edge of the band. For the negative defect, the solitons propagate with the shape of Y at low propagation constant and propagate stably at the large one.

关键词： defect superlattice solitons parity time symmetry

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Simulating coupled dynamics of a rigid-flexible multibody system and compressible fluid

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Science China(Physics,Mechanics & Astronomy) 2018年第4期61卷 54-68页

作者： wei hu Qiang Tian HaiYan hu Ministry of Education Key Laboratory of Dynamics and Control of Flight Vehicle School of Aerospace Engineering Beijing Institute of Technology

As a subsequent work of previous studies of authors, a new parallel computation approach is proposed to simulate the coupled dynamics of a rigid-flexible multibody system and compressible fluid. In this approach, the smoothed particle hydrodynamics(SPH) method is used to model the compressible fluid, the natural coordinate formulation(NCF) and absolute nodal coordinate formulation(ANCF) are used to model the rigid and flexible bodies, respectively. In order to model the compressible fluid properly and efficiently via SPH method, three measures are taken as follows. The first is to use the Riemann solver to cope with the fluid compressibility, the second is to define virtual particles of SPH to model the dynamic interaction between the fluid and the multibody system, and the third is to impose the boundary conditions of periodical inflow and outflow to reduce the number of SPH particles involved in the computation process. Afterwards, a parallel computation strategy is proposed based on the graphics processing unit(GPU) to detect the neighboring SPH particles and to solve the dynamic equations of SPH particles in order to improve the computation efficiency. Meanwhile, the generalized-alpha algorithm is used to solve the dynamic equations of the multibody system. Finally, four case studies are given to validate the proposed parallel computation approach.

关键词： smoothed particle hydrodynamics(SPH) compressible flow Riemann solver absolute nodal coordinate formulation(ANCF) graphics processing unit(GPU)

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Characteristics of dry deposited mineral particles associated with weather conditions in the adjacent sea areas of East China during a cruise in spring 2011

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Particuology 2016年第5期14卷 86-92页

作者： Hongya Niu wei hu wei Pian Min hu Daizhou Zhang Key Laboratory of Resource Exploration Research of Hebei Province Hebei University of Engineering Handan 056038 China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sdences and Engineering Peking UniversityBeijing 100871 China Faculty of Environmental and Symbiotic Sdences Prefectural University of Kumamoto Kumamoto 862-8502 Japan

Dry deposited particles, larger than 1.3 μm, were collected under clear, cloudy, and foggy conditions during a cruise, traversing the Yellow Sea and the East China Sea from 23 March to 8 April 2011. In these areas, air masses are influenced by pollution outflows from the Asian continent. The size and elemental composition of dry deposited particles were investigated using a scanning electron microscope. Number-size distributions of these particles were approximately lognormal. Under clear conditions, the mode size was about 5.0 μm, with a mean diameter of 6.9 μm. Under cloudy and foggy conditions, the mean diameters were 5.7 and 6.0 μm, respectively, but the mode sizes were vague. Non-mixed mineral particles, sea salt, and mixed mineral-sea salt particles were the major particle types. Correspondingly, Al and Si were the most frequently detected elements. Frequencies of K-, Ca-, and S-containing particles were highest under foggy conditions, while the frequency of Na-containing particles was lowest. These results indicate that fog favored sulfate production on the particles and led to the deposited mineral particles more abundant in secondary salt, suggesting the importance to consider the dependence of the comoosition of deoosited mineral narticles on weather as well as narticle size.

关键词： Dry deposition Mixture Sea salt Sulfate Single particle analysis Marine aerosols

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DISPOSING THE LEFTOVERS UNDER THE CONSIGNMENT CONTRACT WITH REVENUE SHARING:RETAILER VS SUPPLIER

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Journal of Systems Science & Complexity 2012年第2期25卷 262-274页

作者： wei hu Jianbin LI School of Mathematical Sciences and LPMC Nankai University School of Management Huazhong University of Science and Technology

This paper studies the consignment contract with revenue sharing where the retailer offers two revenue share schemes between himself and his supplier from the viewpoint of inventory ownership: One is that the retailer takes charge of the unsold items,the other one is that the retailer returns the unsold items to the supplier at the end of the selling period,and the supplier disposes those *** each contract,the retailer deducts a percentage from the selling price for each sold item and transfers the balance to the *** supplier solves a two-stage problem:She first chooses contract,then decides retail price and delivery quantity according to the terms of the contract *** an iso-price-elastic demand model,the authors derive the retailer and suppliers’ optimal decisions for both *** addition,the authors characterize how they are affected by disposing *** authors compare the decisions between the two schemes for disposing cost turn out to be holding cost or salvage value,*** authors use numerical examples to show the supplier’s first-stage optimal decision depends critically on demand price elasticity,the disposing cost and the retailer’s share for channel cost.

关键词： Consignment sales revenue sharing stackelberg game supply chain management.

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Study of Model-free Adaptive Data-driven SMC Algorithm

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International Journal of Automation and computing 2016年第2期13卷 183-190页

作者： wei hu Jie Tang School of Electrical Engineering & Automatic Henan Polytechnic University Yima Coal Group Co. Ltd

A kind of adaptive sliding model control algorithm is developed to solve and improve the mathematical model dependency and un-modeled dynamics of a controlled system. The control strategy derived from a kind of data-driven control method in essence, thereby the input and output data are utilized by the controller with no information about the control system model. Theoretical analysis proves that this proposed control algorithm can improve the utilization of the estimated pseudo partial derivative information and accelerate the velocity of the convergence. The stability of the control system is further verified by rigorous mathematical analysis. This new discrete-time nonlinear systems model-free control algorithm obtained better control performance through the simulations for the linear motor position and the information tracking speed, which also achieved robust and accurate traceability.

关键词： Nonlinear system model-free adaptive control sliding mode control control law pseudo partial derivative

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An overview of the environmental finance policies in China： retrofitting an integrated mechanism for environmental management

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 316-328页

作者： wei LI Mengze hu State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China

Considering the significant roles of the policies in developing environmental finance, an overview is conducted on the environmental finance policies （EFPs） in China. This paper analyzed the definition, scope, evolution and main instruments of EFPs. The implementation progress of financial activities on each instrument are investigated respectively. Then the experiences learned from and failures discovered in the development of the EFPs are discussed well recommendations for further improvement of the EFPs and their implementation are provided. Our study found that the EFPs have been established in China after a four-phase evolution since the early 1980s. The policies have played a critical role in leading to a rapid development in environmental finance by involving more financial instruments to accomplish the objective-led environmental plans. Driven by the policies, the new green credit （GC）, green security （GS）, and green insurance （GI） instruments have been phased in as supplements to the conventional command and control approaches to improve the environmental governance of financial activities and pollution sources. However, the market mechanism of financial institution is limited due to their defensive and incapable performance on implementation some of EFP instruments. To further strengthen the effectiveness of EFPs in facilitating environmental man- agement, recommendations are made mainly on the aspects including developing more specific policy guidelines, enhancing information sharing and disclosure, providing sufficient economic incentives, establishing environmental liabilities with financial activities, and involving issues related to climate change, and biodiversity and ecosystem service.

关键词： environmental finance policy integrated mechanism phased evolution implementation progress,financial institution environmental management

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Artificial Bee Colony Algorithm-based Parameter Estimation of Fractional-order Chaotic System with Time Delay

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IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 107-113页

作者： Wenjuan Gu Yongguang Yu wei hu School of Economics and Management Beijing Jiaotong University School of Science Beijing Jiaotong University

It is an important issue to estimate parameters of fractional-order chaotic systems in nonlinear science, which has received increasing interest in recent years. In this paper, time delay and fractional order as well as system's parameters are concerned by treating the time delay and fractional order as additional parameters. The parameter estimation is converted into a multi-dimensional optimization problem. A new scheme based on artificial bee colony ABC algorithm is proposed to solve the optimization problem. Numerical experiments are performed on two typical time-delay fractional-order chaotic systems to verify the effectiveness of the proposed method. © 2014 Chinese Association of Automation.

关键词： Chaos theory Chaotic systems Numerical methods Optimization Time delay Timing circuits

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Applicability of LIVE/DEAD BacLight stain with glutaraldehyde fixation for the measurement of bacterial abundance and viability in rainwater

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Journal of Environmental Sciences 2017年第1期29卷 202-213页

作者： wei hu Kotaro Murata Daizhou Zhang Faculty of Environmental and Symbiotic Sciences Prefectural University of KumamotoKumamoto 862-8502Japan

Rainwater contains substantial bacteria and rain is an efficient pathway for the dissemination of bacteria from the atmosphere to land and water ***,quantitative information on rainwater bacteria is very limited due to the lack of a reliable *** this study,the epifluorescence microscopy enumeration with the LIVE/DEAD BacLight Bacterial Viability Kit stain was verified to quantify the abundance of viable and non-viable bacterial cells in rainwater,with the 4＇,6-diamidino-2-phenylindole（DAPI） stain for the reference of total cell *** showed that the total counts of bacterial cells by LIVE/DEAD BacLight staining were consistent with those by DAPI staining,and the average detection efficiency was（109 ± 29）%.The ratio of cell count with glutaraldehyde fixation to that without fixation was（106 ± 5）%on *** bacterial concentration in negative control was usually an order of magnitude lower than that in rainwater ***,in case of small precipitation,the abundance in negative control could be more than that in rainwater *** results indicate that the enumeration with LIVE/DEAD BacLight bacterial viability assay coupled with glutaraldehyde fixation and careful negative control investigation is an approach applicable to the measurement of the concentration and viability of bacterial cells in rainwater.

关键词： Bacterial abundance Viability Rainwater LIVE/DEAD BacLight stain Fluorescent enumeration

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