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high-stability spherical lanthanide nanoclusters for magnetic resonance imaging

National Science Review 2023年第4期10卷 123-132页

作者： hai-Ling Wang Donglin Liu Jian-hua Jia Jun-Liang Liu Ze-Yu Ruan wei Deng Shiping Yang Si-Guo Wu Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of Chemistry Sun Yat-sen University College of Chemistry and Materials Science Shanghai Normal University

high-nuclear lanthanide clusters have shown great potential for the administration of high-dose mononuclear gadolinium chelates in magnetic resonance imaging(MRI). The development of high-nuclear lanthanide clusters with excellent solubility and high stability in water or solution has been challenging and is very important for expanding the performance of MRI. We used N-methylbenzimidazole-2-methanol(hL) and LnCl3·6h2O to synthesize two spherical lanthanide clusters, Ln32(Ln = ho, ho32; and Ln =Gd, Gd32), which are highly stable in solution. The 24 ligands L-are all distributed on the periphery of Ln32and tightly wrap the cluster core, ensuring that the cluster is stable. Notably, ho32can remain highly stable when bombarded with different ion source energies in hRESI-MS or immersed in an aqueous solution of different ph values for 24 h. The possible formation mechanism of ho32was proposed to be ho(Ⅲ),(L)-and h2O → ho3(L)3/ho3(L)4→ ho4(L)4/ho4(L)5→ ho6(L)6/ho6(L)7→ ho16(L)19→ho28(L)15→ ho32(L)24/ho32(L)21/ho32(L)23. To the best of our knowledge, this is the first study of the assembly mechanism of spherical high-nuclear lanthanide clusters. Spherical cluster Gd32, a form of highly aggregated Gd(Ⅲ), exhibits a high longitudinal relaxation rate(1 T, r1= 265.87 mM-1·s-1). More notably, compared with the clinically used commercial material Gd-DTPA, Gd32has a clearer and higher-contrast T1-weighted MRI effect in mice bearing 4T1 tumors. This is the first time that high-nuclear lanthanide clusters with high water stability have been utilized for MRI. high-nuclear Gd clusters containing highly aggregated Gd(Ⅲ) at the molecular level have higher imaging contrast than traditional Gd chelates; thus, using large doses of traditional gadolinium contrast agents can be avoided.

关键词： T1-weighted MRI lanthanide clusters high stability low toxicity assembly mechanism

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A review of the etched terminal structure of a 4h-SiC PiN diode

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Journal of Semiconductors 2023年第11期44卷 69-78页

作者： hang Zhou Jingrong Yan Jialin Li huan Ge Tao Zhu Bingke Zhang Shucheng Chang Junmin Sun Xue Bai Xiaoguang wei Fei Yang State Key Laboratory of Advanced Power Transmission Technology Beijing Institute of Smart EnergyBeijing 102209China

The comparison of domestic and foreign studies has been utilized to extensively employ junction termination extension(JTE)structures for power ***,achieving a gradual doping concentration change in the lateral direction is difficult for SiC devices since the diffusion constants of the implanted aluminum ions in SiC are much less than *** previously reported studies adopted many new structures to solve this ***,the JTE structure is strongly sensitive to the ion implantation ***,GA-JTE,double-zone etched JTE structures,and SM-JTE with modulation spacing were reported to overcome the above shortcomings of the JTE structure and effectively increase the breakdown *** provided a theoretical basis for fabricating terminal structures of 4h-SiC PiN *** paper summarized the effects of different terminal structures on the electrical properties of SiC devices at home and ***,the continuous development and breakthrough of terminal technology have significantly improved the breakdown voltage and terminal efficiency of 4h-SiC PiN power diodes.

关键词： PiN diode terminal structure mesa-JTE reverse breakdown voltage etching process

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浙江沿海潜在区域地震海啸风险分析

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海洋学报 2015年第3期37卷 37-45页

作者：毛献忠祝倩 wei Yong 清华大学深圳研究生院海洋学部广东深圳518055 NOAA Center for Tsunami Research Pacific Marine Environmental LaboratoryNOAA

采用COMCOT海啸模型建立三重网格模型模拟了2011年3月11日日本东北部9.0级地震引发的海啸发生、发展以及在我国东南沿海传播过程。震源附近浮标站以及浙江沿海的潮位站实测资料验证结果显示,大部分监测站首波到达时间和海啸波的计算值... 详细信息

采用COMCOT海啸模型建立三重网格模型模拟了2011年3月11日日本东北部9.0级地震引发的海啸发生、发展以及在我国东南沿海传播过程。震源附近浮标站以及浙江沿海的潮位站实测资料验证结果显示,大部分监测站首波到达时间和海啸波的计算值相差在15%以内,表明模型可较好的模拟海啸在计算域内的传播过程。研究表明日本南海海槽、冲绳海槽以及琉球海沟南部是影响浙江沿海主要的区域潜在震源,通过情景计算分别模拟3个潜在震源9.1级、8.0级和8.7级地震引发的海啸对浙江沿海的海啸风险,计算结果表明,海啸波产生后可在3~8h内传至浙江省沿岸,海啸波达1~3m,最大可达4m,此时浙江沿岸面临Ⅲ~Ⅳ级海啸风险,达到淹没至严重淹没等级。

关键词： COMCOT模型地震海啸日本南海海槽冲绳海槽琉球海沟浙江沿海

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Ionoprinting controlled information storage of fluorescent hydrogel for hierarchical and multi-dimensional decryption

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Science China Materials 2019年第6期62卷 831-839页

作者： Xiao-Xia Le wei Lu Jiang he Michael J. Serpe Jia-wei Zhang Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of Sciences University of Chinese Academy of Sciences Department of Chemistry University of Alberta

Information storage and corresponding encryption/decryption are highly important owing to the prevalence of counterfeit activities and information leakage in the current age. herein, we propose a novel method to store information via controllable ionoprinting onto fluorescent hydrogel for hierarchical and multi-dimensional *** incorporating pyrene moieties and carboxylic groups into polymeric hydrogel network, fluorescence changing and controllable shape deformation behaviors could be achieved and integrated by ionoprinting of Fe3+ions. The diffusion of Fe^3+ions into fluorescent hydrogel can quench the fluorescence of pyrene moieties, and chelate with carboxylic groups to generate anisotropic structures for shape deformation simultaneously. Thus, fluorescence quenching-based 2D information and actuation-based 3D information could be hierarchically decrypted when exposed to UV light and being put into water, respectively. Importantly, the stored information could be erased by replacing Fe^3+with h^+, which allows the fluorescent hydrogel as a recyclable information storage material. This work may provide new insights in designing and fabricating novel soft devices for hierarchical and multidimensional information encryption, against the rising problems of counterfeiting and confidential information disclosure.

关键词： information storage information decryption hydrogel actuator fluorescence quenching anisotropic structures

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三氧化二砷对慢性髓系白血病细胞hedgehog通路的影响

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中国实验血液学杂志 2015年第4期23卷 971-975页

作者：何晓薇燕玮杨威中国医科大学附属盛京医院血液内科辽宁沈阳110022

目的:探讨三氧化二砷对慢性髓系白血病(CML)细胞hedgehog信号通路的影响。方法:采用MTT法及流式细胞术测定细胞的凋亡,Western blot检测hedgehog通路中PTCh及SMO蛋白表达,real-time PCR检测PTCh及SMO基因mRNA的表达。结果:三氧化二砷可... 详细信息

目的:探讨三氧化二砷对慢性髓系白血病(CML)细胞hedgehog信号通路的影响。方法:采用MTT法及流式细胞术测定细胞的凋亡,Western blot检测hedgehog通路中PTCh及SMO蛋白表达,real-time PCR检测PTCh及SMO基因mRNA的表达。结果:三氧化二砷可诱导K562细胞凋亡,最佳浓度为2μmol/L,最佳作用时间为24 h。在该浓度及时间点作用下hedgehog通路中PTCh及SMO蛋白和mRNA表达下调。结论:三氧化二砷可降低hedgehog通路中PTCh及SMO基因表达。

关键词：慢性粒细胞白血病三氧化二砷 hedgehog信号通路

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数码相机与全站仪集成原理与方法

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测绘通报 2006年第10期 5-8页

作者：徐进军 h.Ingensand 张民伟武汉大学测绘学院湖北武汉430079 苏黎世联邦理工学院

普通数码相机以其价廉、灵活的特点在实际工程中得到广泛的应用。但物镜畸变较大而且内外方位元素求解复杂,从一定程度上限制了其进一步的应用。结合数码相机的特点,讨论数码相机与全站仪集成的有关原理、方法及实现过程,使非量测相机... 详细信息

普通数码相机以其价廉、灵活的特点在实际工程中得到广泛的应用。但物镜畸变较大而且内外方位元素求解复杂,从一定程度上限制了其进一步的应用。结合数码相机的特点,讨论数码相机与全站仪集成的有关原理、方法及实现过程,使非量测相机量测化。通过室内实验,说明这种集成是可行的,能满足工程上的测量要求。

关键词：数码相机全站仪集成

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Utilization of aggregation-induced emission materials in urinary system diseases

Aggregate

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Aggregate 2024年第5期5卷 135-158页

作者： haodong Xu Xin Chen he Wang Chaozhong Wang Yunjie Guo Yuxin Lin Yuhua huang Jianquan hou Xuedong wei Department of Urology The First Afﬁliated Hospital of Soochow UniversitySuzhouChina Department of Urology Dushu Lake Hospital Afﬁliated to Soochow UniversityMedical Center of Soochow UniversitySuzhou Dushu Lake HospitalSuzhouChina

With the development of aggregation-induced emission(AIE)materials,the draw-backs of conventionalﬂuorescence materials subjected to aggregation-caused quenching(ACQ)have been *** has allowed for the improvement of novel AIEﬂuorescent materials that exhibit enhanced photostability,a higher signal-to-noise ratio,and better imaging ***,the enhanced phototherapeutic effect of AIE materials has garnered widespread attention in the realm of tumor *** distinct physiological and anatomical characteristics of the urinary system make it suitable for the use of AIE ***,AIE-based pho-totherapy provides a superior solution to deal with the weaknesses of conventional treatments for urologic *** this review,the scientiﬁc advancement on the use of AIE materials in urinary system diseases since the emergence of the AIE con-cept is reviewed in *** review highlights the promise of AIE materials for biomarkers detection,ﬂuorescence imaging(FLI)in vivo and in vitro,AIE-based phototherapy,and synergistic therapy from both diagnostic and therapeutic *** isﬁrmly believed that AIE materials hold immense untapped potential for the diagnosis and treatment of urologic disease,as well as all diseases of the human body.

关键词： aggregation-induced emission AIEgens cancer therapy ﬂuorescence imaging urinary system diseases

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AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone h3 acetylation

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Cancer Communications 2022年第11期42卷 1185-1206页

作者： Rongfang wei Yan Zhu Yuanjiao Zhang Wene Zhao Xichao Yu Ling Wang Chunyan Gu Xiaosong Gu Ye Yang Nanjing hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine NanjingJiangsu 210001P.R.China School of Medicine&holistic Integrative Medicine Nanjing University of Chinese MedicineNanjingJiangsu 210023P.R.China Department of Analytical and Testing Center Nanjing Medical UniversityNanjingJiangsu 211112P.R.China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Nantong UniversityNantongJiangsu 226019P.R.China

Background:Multiple myeloma(MM)is the second most common hematological *** overwhelming majority of patients with MM progress to serious osteolytic bone ***-tRNA synthetase-interacting multifunctional protein 1(AIMP1)participates in several steps during cancer development and osteoclast *** study aimed to explore its role in ***:The gene expression profiling cohorts of MM were applied to determine the expression of AIMP1 and its association with MM patient ***-linked immunosorbent assay,immunohistochemistry,and Western blotting were used to detect AIMP1 *** chip analysis,RNA-sequencing,and chromatin immunoprecipitation and next-generation sequencing were employed to screen the interacting proteins and key downstream targets of *** impact of AIMP1 on cellular proliferation was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in vitro and a xenograft model in *** lesions were evaluated using tartrate-resistant acid phosphatase staining in vitro.A NOD/SCID-TIBIA mouse model was used to evaluate the effect of siAIMP1-loaded exosomes on bone lesion formation in ***:AIMP1 expression was increased in MM patients and strongly associated with unfavorable *** AIMP1 expression promoted MM cell proliferation in vitro and in vivo via activation of the mitogen-activated protein kinase(MAPK)signaling *** chip assays and subsequent experiments revealed that AIMP1 interacted with acidic leucine-rich nuclear phosphoprotein 32 family member A(ANP32A)to regulate histone h3 *** addition,AIMP1 increased histone h3 acetylation enrichment function of GRB2-associated and regulator of MAPK protein 2(GAREM2)to increase the phosphorylation of extracellular-regulated kinase 1/2(p-ERK1/2).Furthermore,AIMP1 promoted osteoclast differentiation by activating nuclear factor of activated T cells c1(NFATc1)in *** contrast,exo

关键词： multiple myeloma AIMP1 osteoclast differentiation MAPK signaling ANP32A histone h3 acetylation osteolytic lesions

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Generalized Energy-Based Fragmentation Approach for Accurate Binding Energies and Raman Spectra of Methane hydrate Clusters

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Chinese Journal of Chemical Physics 2022年第1期35卷 167-176,I0064页

作者： Lei Zhang Zheng Cheng wei Li Shuhua Li Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Methane hydrates(Mhs)play important roles in the fields of chemistry,energy,environmental sciences,*** this work,we employ the generalized energy-based fragmentation(GEBF)approach to compute the binding energies and Raman spectra of various Mh *** the GEBF binding energies of various Mh clusters,we first evaluated the various functionals of density functional theory(DFT),and compared them with the results of explicitly correlated combined coupled-cluster singles and doubles with noniterative triples corrections[CCSD(T)(F12^(*))]*** results show that the two best functionals are B3PW91-D3 and B97D,with mean absolute errors of only 0.27 and 0.47 kcal/mol,*** we employed GEBF-B3PW91-D3 to obtain the structures and Raman spectra of Mh clusters with mono-and *** results show that the B3PW91-D3 functional can well reproduce the experimental C-h stretching Raman spectra of methane in Mh crystals,with errors less than 3 cm^(-1).As the size of the water cages increased,the C-h stretching Raman spectra exhibited a redshift,which is also in agreement with the experimental“loose cage-tight cage”*** addition,the Raman spectra are only slightly affected by the neighboring environment(cages)of *** blueshifts of C-h stretching frequencies are no larger than 3 cm^(-1) for Ch_(4) from monocages to *** Raman spectra of the Mh clusters could be combined with the experimental Raman spectra to investigate the structures of methane hydrates in the ocean bottom or in the interior of interstellar icy *** on the B3PW91-D3 or B97D functional and machine learning models,molecular dynamics simulations could be applied to the nucleation and growth mechanisms,and the phase transitions of methane hydrates.

关键词： Generalized energy-based fragmentation approach Explicitly correlated coupled-cluster Density functional theory Methane hyrdrate Raman spectra

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h∞ Filtering for Networked Systems with Limited Communication

H∞ Filtering for Networked Systems with Limited Communicati...

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Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： wei-wei Che Jian-Liang Wang Guang-hong Yang School of Electrical and Electronic Engineering Nanyang Technological University the College of Information Science and Engineering Northeastern University

This paper is concerned with the quantized h∞filtering problem for discrete-time systems subject to limited communication capacity,which includes measurement quantization and random sensor packet *** introducing an improved quantized random packet-loss model,the effects of the packet-loss rate and the upper bound of consecutive packet losses and the quantization on the system performance are considered simultaneously.A quantized h∞ filter design strategy with the minimized static quantizer range is designed to guarantee the error system exponentially mean-square stable and also achieve the prescribed h∞ disturbance attenuation level.A numerical example is given to illustrate the effectiveness of the proposed filter design method.

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