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Leap of Li Metal Anodes from Coin Cells to Pouch Cells:Challenges and Progress

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Electrochemical Energy Reviews 2023年第1期6卷 39-86页

作者： Qian Wang Tiantian Lu Yuanbin Xiao Jianyang Wu Lixiang Guan Lifeng Hou Huayun Du Huan wei Xiaoda Liu Chengkai Yang yinghui wei Henghui Zhou Yan Yu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Corrosion and Protection Engineering Technology Research Center of Shanxi Province Taiyuan 030024ShanxiChina Key Laboratory of Advanced Materials Technology College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108FujianChina College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Li metal anodes have attracted tremendous attention in the last decade because of their high theoretical capacities and low electrochemical ***,until now,there has only been limited success in improving the interfacial and structural stabilities and in realizing the highly controllable and large-scale fabrication of this emerging material;these limitations have posed great obstacles to further performing fundamental and applied studies in Li metal *** this review,we focus on summarizing the existing challenges of Li metal anodes based on the leap from coin cells to pouch cells and on outlining typical methods for designing Li metal anodes on demand;we controllably engineer their surface protection layers and structure sizes by encapsulating structured Li metal inside a variety of synthetic protection *** aim to provide a comprehensive understanding and serve as a strategic guide for designing and fabricating practicable Li metal anodes for use in pouch *** and opportunities regarding this burgeoning field are critically evaluated at the end of this review.

关键词： Li metal anode Dendrites Pouch cells Air stability Energy density

Cooperative coordination-mediated multi-component self-assembly of“all-in-one”nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3710-3725页

作者： Xiaojie Chen Xudong Fan Yue Zhang yinghui wei Hangsheng Zheng Dandan Bao Hengwu Xu Ji-Gang Piao Fanzhu Li Hongyue Zheng School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Libraries of Zhejiang Chinese Medical University Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Dermatology&Cosmetology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine)Hangzhou 310006China Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Pharmacy Jinhua People's HospitalJinhua 321000China

Carrier-free multi-component self-assembled nano-systems have attracted widespread attention owing to their easy preparation,high drug-loading efficiency,and excellent therapeutic ***,MnAs-ICG nanospike was generated by self-assembly of indocyanine green(ICG),manganese ions(Mn^(2+)),and arsenate(AsO_(4)^(3−))based on electrostatic and coordination interactions,effectively integrating the bimodal imaging ability of magnetic resonance imaging(MRI)and fluorescence(FL)imaging-guided synergistic therapy of photothermal/chemo/chemodynamic therapy within an“all-in-one”theranostic *** as-prepared MnAs-ICG nanospike had a uniform size,well-defined nanospike morphology,and impressive loading *** MnAs-ICG nanospike exhibited sensitive responsiveness to the acidic tumor microenvironment with morphological transformation and dimensional variability,enabling deep penetration into tumor tissue and on-demand release of functional therapeutic *** vitro and in vivo results revealed that MnAs-ICG nanospike showed synergistic tumor-killing effect,prolonged blood circulation and increased tumor accumulation compared to their individual components,effectively resulting in synergistic therapy of photothermal/chemo/chemodynamic therapy with excellent anti-tumor *** together,this new strategy might hold great promise for rationally engineering multifunctional theranostic nano-platforms for breast cancer treatment.

关键词： Carrier-free nanodrugs Self-assembly Nanospike Magnetic resonance imaging Tumor microenvironment-responsive Deep penetration Synergistic therapy Breast cancer

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《老友记》中话语标记语well的顺应性语用分析

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《老友记》中话语标记语well的顺应性语用分析

作者： wei yinghui 西安外国语大学

学位级别：硕士

本文旨在运用Verschueren(1999)的语言顺应论来探析话语标记语“well”的语用功能，并以美国情景喜剧《老友记》作为研究案例。话语标记语“well”作为一种成功实现交际目标的语言策略，在日常交际中，作为话语标记语的“well”使用频... 详细信息

本文旨在运用Verschueren(1999)的语言顺应论来探析话语标记语“well”的语用功能，并以美国情景喜剧《老友记》作为研究案例。话语标记语“well”作为一种成功实现交际目标的语言策略，在日常交际中，作为话语标记语的“well”使用频率很高。第一，“well”的使用能帮助说话者构建语篇，以及实现不同的交际目标和行使不同的功能。第二，话语标记语的使用能够帮助听话者阐释语篇并且推导说话者所说话语的意义。然而，大多数关于话语标记语的研究都是从语篇-连贯角度、语法-语用角度、认知-语用角度进行的，很少学者从顺应论的角度对其进行研究;顺应论全面考虑了语言因素、社会因素、文化因素以及认知因素，是一种比较全面的理论，它弥补了其它三种理论的不足。基于此，本文把它定为理论框架。情景喜剧《老友记》的语言近乎自然，而且适合英语口语的学习。“well”频繁出现于《老友记》中，并且对实现成功交际起着非常重要的作用。基于此，本文把它定为语料的来源。为了实现这一研究目标，作者以定性研究为主要研究方法。话语标记语“well”的语用功能通过“well”在情景喜剧《老友记》的使用体现出来。研究结果如下：首先，由于语言的变异性、商讨性以及顺应性使得语言使用者可以对语言做出选择，任何语言使用的过程都是一个不断做出选择的过程;同时，语言选择的过程是一个语言顺应的过程。本文论证了话语标记语“well”的使用过程也是如此。其次，语言顺应需要从语境、结构、动态性和意识程度这四个相互关联的角度进行分析，本文从这四个角度论证了话语标记语“well”也是语言顺应的结果。再次，除了对语言语境做出顺应，在话语生成和理解过程中，语言使用者还需对物质世界、社交世界以及心理世界做出顺应，通过例证，本文得出“well”的使用也是语言使用者对物理、社会、心理世界顺应的结果。最后，通过详细的分析，本文还得出“well”有以下语用功能：连贯标记语、缓延标记语、信息短缺标记语、面子威胁缓和语、信息修正语以及情感标记语。通过对《老友记》中频繁使用的话语标记语“well”这个看似简单、实则复杂的语言现象分析，有助于对其它话语标记语的功能做出进一步思考，同时对英语教学也是裨益非浅的。然而，本文主要采取定性研究，关于例子的阐释可能会有些主观;因此，为了使得结果更令人信服，以后需要做进一步的实证研究。

关键词：话语标记语话语标记语“well” 顺应论《老友记》

Lignin-assisted construction of sub-10 nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors

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Asian Journal of Pharmaceutical Sciences 2022年第5期17卷 713-727页

作者： Xudong Fan Tianxiang Yue Aidi Liu Xiaowei Xie weixiang Fang yinghui wei Hangsheng Zheng Hongyue Zheng Meiqi Zhou Jigang Piao Fanzhu Li School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Libraries of Zhejiang Chinese Medical University Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Breast Surgery Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationSecond Hospital of ZhejiangUniversity College of MedicineHangzhou 310009China Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

Photothermal therapy(PTT)has brought hope for cancer treatments,with hyperthermia-induced immunogenic cell death(ICD),which is a critical part of therapeutically induced antitumor immune *** immune stimulation response in PTT is the primary reason for incomplete tumor ablation,therefore demonstrating urgent requirements for ICD ***,a sub-10 nm supramolecular nanoassembly was formed by coassembly of clinically approved aluminum adjuvant and commonly used indocyanine green(ICG)under the assistance of lignosulfonate(LS,a green and sustainable multifunctional lignin derivative)for localized photothermal-immunotherapy of breast *** overall results revealed that LS-Al-ICG is capable of inducing amplified ICD,efficiently eliciting solid immune responses through dendritic cells(DCs)activation and cytotoxic T-cell responses initiation for tumor ***,anti-PD-1 therapy blocked the PD-1 pathway and led to remarkable anti-tumor efficacy against laser-irradiated primary tumors and distant tumors by potentiating systemic tumor specific T cell *** results of this study demonstrate a handy and extensible approach for engineering green natural lignin nanoparticles for cancer immunotherapy,which shows promise for delivering other therapeutics in biomedical applications.

关键词： Lignin Supramolecular self-assembly Photothermal-immunotherapy Anti-PD-1

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Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase

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National Science Review 2023年第8期10卷 78-87页

作者： Huawei Tong Nana Liu yinghui wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang HuidaGene Therapeutics Co. Ltd. Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of Neuroscience and Fujian Key Laboratory of Molecular Neurology Fujian Medical University Institute of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai Center for Brain Science and Brain-Inspired Intelligence

Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A), but no method for guanine(G) or thymine(T) editing is available at present. Here we developed a deaminase-free glycosylase-based guanine base editor(gGBE) with G editing ability, by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein(MPG). By several rounds of MPG mutagenesis via unbiased and rational screening using an intron-split EGFP reporter, we demonstrated that gGBE with engineered MPG could increase G editing efficiency by more than 1500 ***, this gGBE exhibited high base editing efficiency(up to 81.2%) and high G-to-T or G-to-C(i.e. G-to-Y) conversion ratio(up to 0.95) in both cultured human cells and mouse embryos. Thus, we have provided a proof-of-concept of a new base editing approach by endowing the engineered DNA glycosylase the capability to selectively excise a new type of substrate.

关键词： glycosylase base excision repair base editor depurination deaminase-free transversion