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Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： Gui-Ming Deng Hai-Bin Song Zhong-Ze Du ying-wei Xue Hong-Jiang Song Yuan-Zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value of<41 Hounsfield units(HU)for patients with a body mass index(BMI)<25 kg/m^(2)and<33 HU for those with a BMI≥25 kg/m^(2).The log-rank test was used to compare progression-free survival(PFS)and overall survival(OS),and a Cox proportional hazard model was used to identify prognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor Prognostic factor Overall survival Progression-free survival

Machine learning algorithms able to predict the prognosis of gastric cancer patients treated with immune checkpoint inhibitors

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World Journal of Gastroenterology 2024年第40期30卷 4354-4366页

作者： Hong-wei Li Zi-Yu Zhu Yu-Fei Sun Chao-Yu Yuan Mo-Han Wang Nan Wang ying-wei Xue Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastroenterological Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Anesthesia Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Computer Science and Technology Heilongjiang UniversityHarbin 150000Heilongjiang ProvinceChina

BACKGROUND Although immune checkpoint inhibitors(ICIs)have demonstrated significant survival benefits in some patients diagnosed with gastric cancer(GC),existing prognostic markers are not universally applicable to all patients with advanced *** To investigate biomarkers that predict prognosis in GC patients treated with ICIs and develop accurate predictive *** Data from 273 patients diagnosed with GC and distant metastasis,who un-derwent≥1 cycle(s)of ICIs therapy were included in this *** were randomly divided into training and test sets at a ratio of 7:*** set data were used to develop the machine learning models,and the test set was used to validate their predictive *** additive explanations were used to provide insights into the best *** Among the 273 patients with GC treated with ICIs in this study,112 died within 1 year,and 129 progressed within the same *** features related to overall survival and 4 related to progression-free survival were identified and used to construct eXtreme Gradient Boosting(XGBoost),logistic regression,and decision *** comprehensive evaluation,XGBoost demonstrated good accuracy in predicting overall survival and progression-free *** The XGBoost model aided in identifying patients with GC who were more likely to benefit from ICIs *** nutritional status may,to some extent,reflect prognosis.

关键词： Gastric cancer Machine learning Immune checkpoint inhibitors Web-based calculator Progression-free survival Overall survival

MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-ying wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-Bo Cao Zhi-Yan Sun Sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

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阶级视角下的米莱斯作品风格之变

美术 2024年第6期 151-154页

作者：魏颖中国政法大学

在19世纪英国学院绘画的发展中,拉斐尔前派具有转折性意义。本文从特定历史时期下英国贵族与资产阶级的关系出发,探索拉斐尔前派代表人物米莱斯作品风格的转变,重点分析骑士题材作品的风格与内容选择,揭示其背后的资产阶级审美趣味。

关键词：约翰·埃弗里特·米莱斯拉斐尔前派资产阶级审美趣味骑士题材

“Steric Armor”Strategy of Blue Fluorescent Emitters against Photooxidation-Induced Degradation

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Chinese Journal of Chemistry 2024年第11期42卷 1223-1229页

作者： Sha-Sha Wang Jing-Rui Zhang Kuan-De Wang Hao-Ran Li Peng-Hui Meng Yang Zhou Xiang Yu ying wei Quan-You Feng Yu-He Kan Ling-Hai Xie Centre for Molecular Systems and Organic Devices(CMSOD) State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjingJiangsu210023 China Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials School of Chemistry and Chemical EngineeringHuaiyin Normal UniversityHuai'anJiangsu223300 China

Stability against oxygen is an important factor affecting the performance of organic semiconductor *** photooxidation stability can prolong the service life of the device and maintain the mechanical and photoelectric properties of the ***,various encapsulation methods from molecular structure to macroscopic device level are used to improve photooxidation ***,we adopted a crystallization strategy to allow 14H-spiro[dibenzo[c,h]acridine-7,9′-fluorene](SFDBA)to pack tightly to resist fluorescence decay caused by *** this case,the inert group of SFDBA acts as a“steric armor”,protecting the photosensitive group from being attacked by ***,compared with the fluorescence quenching of SFDBA powder under 2 h of sunlight,SFDBA crystal can maintain its fluorescence emission for more than 8 h under the same ***,the photoluminescence quantum yields(PLQYs)of the crystalline film is 327%higher than that of the amorphous *** shows that the crystallization strategy is an effective method to resist oxidation.

关键词： Organic semiconductor Photooxidation Spirocyclic aromatic hydrocarbons Crystal engineering Fluorescence

国家目标下的创新生态系统构建:以极紫外光刻机为例

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学术研究 2024年第1期 89-97页

作者：李君然魏莹清华大学人文学院写作与沟通教学中心北京100086 中国科学院科技战略咨询研究院北京100190

产业权力是一国在战略性产业国际体系中影响其他国家行为和利益以维护本国利益或相对优势的能力。新型举国体制面向国家重大战略需求突破关键核心技术的最终指向也在于谋求产业权力。产业权力的形成是国家与市场互相嵌入的过程,也是一... 详细信息

产业权力是一国在战略性产业国际体系中影响其他国家行为和利益以维护本国利益或相对优势的能力。新型举国体制面向国家重大战略需求突破关键核心技术的最终指向也在于谋求产业权力。产业权力的形成是国家与市场互相嵌入的过程,也是一个系统性的过程。本文分析了创新生态系统中的权力结构及其形成过程,并以极紫外光刻机为例说明美国如何利用开放的市场机制完成其产业权力构建。研究发现,美国通过设计愿景、投放资源、定义规则等方式,成功在极紫外光刻机创新生态系统中嵌入了产业权力,实现其对极紫外光刻机产业的控制。创新生态系统能够调和国家战略控制与市场追求行业利润的目标差异,这为新型举国体制在国家战略目标下动员和整合各类要素资源、发挥政府机制与市场机制的作用提供了参考。

关键词：创新生态系统产业权力新型举国体制极紫外光刻机

传染病扩散的对策及医疗资源配置问题研究——以新冠疫情为例

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工业工程与管理 2024年第2期29卷 114-129页

作者：李锋魏莹华南理工大学工商管理学院广东广州510640 暨南大学企业管理系广东广州510632

疫情防控下的医疗资源配置需要同时考虑资源的服务水平和利用率两大评价指标。首先,将人员流动因素等引入流行病扩散的易感-潜伏-传染-恢复模型中,构建更加符合流行病扩散的多智能体模型。通过仿真,不仅能够得到传染病感染的总人数,还... 详细信息

疫情防控下的医疗资源配置需要同时考虑资源的服务水平和利用率两大评价指标。首先,将人员流动因素等引入流行病扩散的易感-潜伏-传染-恢复模型中,构建更加符合流行病扩散的多智能体模型。通过仿真,不仅能够得到传染病感染的总人数,还能得到病患人数的实时变化情况。结合病患人数的动态变化,计算医疗资源的需求满足率和利用率指标。在此基础上,分析了包括佩戴口罩、隔离病患、接种疫苗、筛查核酸和“封城”等多种疫情防控措施的实施效果,以及这些防控措施对医疗资源的影响。最后,以病床为例进行了医疗资源配置问题分析。结果表明:及时启动防疫对策,能够大幅降低对医疗资源的数量需求;反之,防疫对策不能够减少对医疗资源的数量需求,仅能够降低病患总人数。

关键词：传染病扩散资源配置对策研究 SEIR模型元胞自动机

寒门何以出贵子:农村低收入群体收入跃升的机会不平等

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财经问题研究 2024年第10期 93-104页

作者：平卫英黄斐江西财经大学统计与数据科学学院江西南昌330013

机会平等是实现低收入群体收入跃升的重要前提。本文基于2015—2021年中国社会状况综合调查数据,将“环境—努力”机会均等分析框架引入农村低收入群体收入跃升的影响因素研究中,采用相异指数衡量农村低收入群体陷入低收入状态的收入机... 详细信息

机会平等是实现低收入群体收入跃升的重要前提。本文基于2015—2021年中国社会状况综合调查数据,将“环境—努力”机会均等分析框架引入农村低收入群体收入跃升的影响因素研究中,采用相异指数衡量农村低收入群体陷入低收入状态的收入机会不平等程度,运用非参数条件推断树方法测算农村低收入群体陷入低收入状态的机会不平等系数,并进一步讨论了环境因素对农村低收入群体陷入低收入状态的机会不平等的直接影响和间接影响。研究发现:2015—2021年,农村低收入群体陷入低收入状态的机会不平等系数为0.2356—0.2925,说明农村居民收入跃升的机会不平等程度较高;农村低收入群体性别差异对机会不平等的影响最大,其次是地区和年龄。随着时间的变化,户口迁移和父母务农的农村低收入群体,机会差异对农村低收入群体陷入低收入状态的影响逐渐增加;环境因素通过教育渠道和就业渠道间接影响农村低收入群体陷入低收入状态的收入机会不平等的贡献度为43.34%—55.65%,其中,教育渠道的贡献度为34.34%—43.87%,就业渠道的贡献度仅有6.07%—14.26%。本文的研究结论为更好地保障农村低收入群体发展机会平等,助力农村低收入群体收入跃升提供了理论依据。

关键词：农村低收入群体收入跃升机会不平等非参数条件推断树方法

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基于CNN-LSTM的燃气轮机燃烧室故障预警

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热能动力工程 2024年第1期39卷 191-197,215页

作者：周锐康英伟上海电力大学自动化工程学院上海200090

为了解决燃气轮机燃烧室中的故障问题,结合深度学习的优势,在长短期记忆网络(Long Short-term Memory,LSTM)的基础上,提出了一种基于卷积神经网络-长短期记忆网络的燃烧室故障预警方法。首先,根据正常的历史运行数据构建燃烧室的预警模... 详细信息

为了解决燃气轮机燃烧室中的故障问题,结合深度学习的优势,在长短期记忆网络(Long Short-term Memory,LSTM)的基础上,提出了一种基于卷积神经网络-长短期记忆网络的燃烧室故障预警方法。首先,根据正常的历史运行数据构建燃烧室的预警模型,再将特征参数输入到预警模型中得到预测值,预测值与实际值之间的偏离度可以反映燃烧室内部工作是否正常。考虑到模型预测结果的非平稳性和非线性等特点,引入滑动窗口法确定故障预警阈值,最后根据确定的预警阈值判断是否出现故障。采用某燃气-蒸汽联合循环发电机组仿真平台对上述模型进行验证。仿真结果表明:该模型相较于LSTM预测模型具有更高的精确度,可以及时发现故障征兆,并对燃烧室故障做出有效预警。

关键词：燃烧室故障预警 LSTM神经网络卷积神经网络预测偏离度滑动窗口法