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Quantitative Mitochondrial Proteomics Study on Protective Mechanism of Grape Seed Proanthocyanidin Extracts Against Ischemia/Reperfusion Heart Injury in Rat

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Chemical Research in Chinese Universities 2012年第6期28卷 1035-1040页

作者： LU wei-da QIU Jie ZHAO Gai-xia QIE Liang-yi wei xin-bing GAO Hai-qing Key Laboratory of Cardiovascular Proteomics of Shandong Province Department of Geriatrics Qilu Hospital of Shandong University Institute of Pharmacology School of Medicine Shandong University Jinan 250012 P. R. China

Cardiac ischemia/reperfusion（I/R） injury is a critical condition,often associated with high morbidity and *** cardioprotective effect of grape seed proanthocyanidin extracts（GSPE） against oxidant injury during I/R has been described in previous ***,the underlying molecular mechanisms have not been fully *** study investigated the effect of GSPE on reperfusion arrhythmias especially ventricular tachycardia（VT） and ventricular fibrillation（VF）,the lactic acid accumulation and the ultrastructure of ischemic cardiomyocytes as well as the global changes of mitochondria proteins in in vivo rat heart model against I/R *** significantly reduced the incidence of VF and VT,lessened the lactic acid accumulation and attenuated the ultrastructure *** differential proteins related to cardiac protection were revealed by isobaric tag for relative and absolute quantitation（iTRAQ） *** proteins were mainly involved in energy ***,monoamine oxidase A（MAOA） was also *** differential expression of several proteins was validated by Western *** study offered important information on the mechanism of GSPE treatment in ischemic heart disease.

关键词： Grape seed proanthocyanidin extracts(GSPE) Ischemia-reperfusion heart injury In vivo rat model Mitochondria proteomics Energy metabolism

A novel bioreactor to simulate urinary bladder mechanical properties and compliance for bladder functional tissue engineering

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Chinese Medical Journal 2011年第4期124卷 568-573页

作者： wei xin LI Dao-bing XU Feng WANG Yan ZHU Yu-chun LI Hong WANG Kun-jie Department of Urology West China Hospital Sichuan UniversityChengdu Sichuan 610041 China

Background Bioreactors are pivotal tools for generating mechanical stimulation in functional tissue engineering *** study aimed to create a bioreactor that can simulate urinary bladder mechanical properties, and to investigate the effects of a mechanically stimulated culture on urothelial cells and bladder smooth muscle *** We designed a bioreactor to simulate the mechanical properties of bladder. A pressure-record system was used to evaluate the mechanical properties of the bioreactor by measuring the pressure in culture chambers. To test the biocompatibility of the bioreactor, viabilities of urothelial cells and smooth muscle cells cultured in the bioreactor under static and mechanically changed conditions were measured after 7-day culture. To evaluate the effect of mechanical stimulations on the vital cells, urethral cells and smooth muscle cells were cultured in the simulated mechanical conditions. After that, the viability and the distribution pattern of the cells were observed and compared with cells cultured in non-mechanical stimulated *** The bioreactor system successfully generated waveforms similar to the intended programmed model while maintaining a cell-seeded elastic membrane between the chambers. There were no differences between viabilities of urothelial cells （（91.90±1.22）% vs. （93.14±1.78）%, P 〉0.05） and bladder smooth muscle cells （（93.41±1.49）% vs.（92.61±1.34）%, P 〉0.05）. The viability of cells and tissue structure observation after cultured in simulated condition showed that mechanical stimulation was the only factor affected cells in the bioreactor and improved the arrangement of cells on silastic *** This bioreactor can effectively simulate the physiological and mechanical properties of the *** stimulation is the only factor that affected the viability of cells cultured in the bioreactor. The bioreactor can change the growth behavior of urothelial cells and bladder smooth muscle ce

关键词： bioreactor tissue engineering urinary bladder compliance

强化爬行训练对脑干卒中后平衡功能障碍的影响

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中医康复 2024年第6期1卷 1-5页

作者：谭霜韦冰心刘国成王金宇柳州市中医医院广西柳州545000

目的:探讨强化爬行训练对于脑干卒中后平衡功能障碍的治疗效果。方法:选择2019年5月~2020年5月柳州市中医医院康复医学科收治的50例脑干卒中后平衡功能障碍的患者。根据随机数字表将受试者为观察组和对照组各25例。对照组采用常规康复... 详细信息

目的:探讨强化爬行训练对于脑干卒中后平衡功能障碍的治疗效果。方法:选择2019年5月~2020年5月柳州市中医医院康复医学科收治的50例脑干卒中后平衡功能障碍的患者。根据随机数字表将受试者为观察组和对照组各25例。对照组采用常规康复治疗手段,观察组则在常规康复治疗的基础上加上爬行训练。采用10米步行试验(10WMT)、Holden步行能力分级(FAC)、Berg平衡量表(BBS)以及功能独立性评定(FIM)量表进行评价,比较两组治疗效果。结果:治疗8周后,观察组和对照组的Holden步行能力分级、BBS、FIM、10WMT评分均高于治疗前(P<0.05);观察组的各项测试评分皆明显优于对照组的评分(P<0.05)。结论:爬行训练有助于改善脑干卒中后平衡功能障碍,通过使用爬行设备可以使患者很好参与康复各个阶段,从而提高患者稳定性、活动性,改善患者当前的生活质量,具有积极的作用,值得推广。

关键词：爬行训练平衡功能脑干卒中核心训练本体感觉

2D all-organic perovskites refine flexible electronics

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Science China Materials 2024年第7期67卷 2365-2366页

作者： wei Zhou bing Chen College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Recent years have witnessed a paradigm shift with the advent of perovskites,a class of materials with a distinct CaTiO_(3)-type crystalline structure that show remarkable promise across a wide array of applications,including photovoltaics,photodetectors,lighting,lasers,and so *** them,the development of two-dimensional(2D)perovskites has garnered significant attention due to their tunable structures(mainly Dion-Jacobson and Ruddlesden-Popper structures)and enhanced stability in comparison with their 3D counterparts[1].Amidst the burgeoning research on perovskites,on the other side,all-organic perovskites stand out as a particularly intriguing subset[2].Unlike traditional perovskites that typically comprise all-inorganic(e.g.,CsPbBr_(3))or organic-inorganic hybrid components(e.g.,(PEA)_(2)PbI_(4)),all-organic perovskites are composed entirely of carbon-or nitrogen-based molecules.

关键词： perovskite inorganic entirely

A low-frequency and broadband wave-insulating vibration isolator based on plate-shaped metastructures

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1171-1188页

作者： wei wei Feng GUAN xin FANG College of Intelligent Science National University of Defense TechnologyChangsha410073China Naval Research Academy Beijing100161China

A metamaterial vibration isolator,termed as wave-insulating isolator,is proposed,which preserves enough load-bearing capability and offers ultra-low and broad bandgaps for greatly enhanced wave *** consists of plate-shaped metacells,whose symmetric and antisymmetric local resonant modes offer several low and broad mode bandgaps although the complete bandgap remains high and *** bandgap mechanisms,vibration isolation properties,effects of key parameters,and robustness to complex conditions are *** experimentally demonstrated,the wave-insulating isolator can improve the vibration insulation in the ranges of[50 Hz,180 Hz]and[260 Hz,400 Hz]by 15 dB and 25 dB,respectively,in contrast to the conventional isolator with the same first resonant frequency.

关键词： metamaterial and metastructure vibration isolation bandgap wave insulation plate

Multi-scale persistent spatiotemporal transformer for long-term urban traffic flow prediction

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Journal of Electronic Science and Technology 2024年第1期22卷 53-69页

作者： Jia-Jun Zhong Yong Ma xin-Zheng Niu Philippe Fournier-Viger bing Wang Zu-kuan wei School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China College of Computer Science&Software Engineering Shenzhen UniversityShenzhen518060China School of Computer Science Southwest Petroleum UniversityChengdu610500China

Long-term urban traffic flow prediction is an important task in the field of intelligent transportation,as it can help optimize traffic management and improve travel *** improve prediction accuracy,a crucial issue is how to model spatiotemporal dependency in urban traffic *** recent years,many studies have adopted spatiotemporal neural networks to extract key information from traffic ***,most models ignore the semantic spatial similarity between long-distance areas when mining spatial *** also ignore the impact of predicted time steps on the next unpredicted time step for making long-term ***,these models lack a comprehensive data embedding process to represent complex spatiotemporal *** paper proposes a multi-scale persistent spatiotemporal transformer(MSPSTT)model to perform accurate long-term traffic flow prediction in *** adopts an encoder-decoder structure and incorporates temporal,periodic,and spatial features to fully embed urban traffic data to address these *** model consists of a spatiotemporal encoder and a spatiotemporal decoder,which rely on temporal,geospatial,and semantic space multi-head attention modules to dynamically extract temporal,geospatial,and semantic *** spatiotemporal decoder combines the context information provided by the encoder,integrates the predicted time step information,and is iteratively updated to learn the correlation between different time steps in the broader time range to improve the model’s accuracy for long-term *** on four public transportation datasets demonstrate that MSPSTT outperforms the existing models by up to 9.5%on three common metrics.

关键词： Graph neural network Multi-head attention mechanism Spatio-temporal dependency Traffic flow prediction

Histone deacetylase 6 mediated NALP3 inflammasome activation contributes to dopaminergic injury in experimental models of Parkinson disease

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中国药理学与毒理学杂志 2018年第9期32卷 686-687页

作者： YAN Shao-qi wei xin-bing JIAN Wen-cheng QIN Yue JIANG Fan LOU Hai-yan ZHANG Bin Department of Pharmacology School of Basic Medical SciencesShandong University Jinan 250012China Department of Radiology Qilu HospitalShandong University Jinan 250012China Department of Pathophysiology School of Basic Medical SciencesShandong University Jinan 250012China

OBJECTIVE To investigate the mechanisms of histone deacetylase 6(HDAC6)deacetylation activity on NALP3 inflammasome activation and explore the protective effect s of pharmacological inhibition of HDAC6 on dopaminergic *** In vitro and in vivo6-OHDA induced Parkinson disease(PD) model was *** distinguish the effect of deacetylase catalytic domains of HDAC6,we used a specific HDAC6 inhibitor tubastatin A(TBA),siRNAHDAC6,and pcDNA-HDAC6-FLAG ***,the role of pharmacological inhibition or siRNA or overexpression of HDAC6 on NALP3 inflammasome and cell death was explored by using Western blotting,TUNEL,and flow cytometric ***,the acetylation level of peroxiredoxin 2(Prx2) and the production of reactive oxygen species(ROS) in cells under different treatments was examined by using immunoprecipitation and DCFH-DA fluorescence *** effects of TBA on neuroinflammation and nigrostriatal dopaminergic system in vivo was further investigated by using Western blotting,immunohistochemistry and HPLC *** TBA remarkably inhibited 6-OHDA induced NALP3 inflammasome activation,reduced dopaminergic neurodegeneration and neuroinflammation as demonstrated by increased TH-positive neurons,striatal levels of DA and its metabolites,and decreased gliocyte *** recovered acetylation of Prx2,and reduced ROS production,which was associated with decreased NALP3 inflammasome *** HDAC6 may medicate deacetylation of Prx2 contributes to NALP3 inflammasome activation in PD pathology,suggesting that the development of specific pharmacological inhibitors of HDAC6 be required for this kind of disease.

关键词： histone deacetylase 6 NALP3 peroxiredoxin 2 reactive oxygen species

Hawking-Page transition and the dual relations of anti-de Sitter black holes surrounded by dark energy in general dimensions

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Communications in Theoretical Physics 2024年第7期76卷 94-104页

作者： Zhang xin Xu wei School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Recently,a dual relation T_(0)(n+1)=T_(HP)(n)between the minimum temperature(T_(0)(n+1))black hole phase and the Hawking-Page transition(T_(HP)(n))black hole phase in two successive dimensions was introduced by wei et al(2020 ***.D10210411);this was reminiscent of the anti-de Sitter/conformal field theory(AdS/CFT)correspondence,as the Hawking-Page transition temperature could be treated as the temperature of the dual physical quantity on the boundary and the latter corresponds to that in the *** this paper,we discuss the Hawking-Page transition and the dual relations in Ads black holes surrounded by dark energy in general *** findings reveal the occurrence of the Hawking-Page transition between the thermal AdS radiation and thermodynamically stable large AdS black holes,in both the spacetime surrounded by phantom dark energy and the spacetime surrounded by quintessence dark *** discuss the effects of the phantom dark energy and quintessence dark energy on the Hawking-Page transition *** the dual relation in particular,it works well for the case of an AdS black holes surrounded by phantom dark *** the case of an Ads black hole surrounded by quintessence dark energy,the dual relation should be modified under an open assumption that the state parameter and the density parameter of the quintessence dark energy depend on the dimensions of the spacetime.

关键词： Hawking-Page transition dark energy black hole thermodynamics

Dissipation-Driven Superradiant Phase Transition of a Two-Dimensional Bose-Einstein Condensate in a Double Cavity

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Chinese Physics Letters 2024年第6期41卷 44-48页

作者： Bo-Hao Wu xin-xin Yang Yu Chen wei Zhang Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Graduate School of China Academy of Engineering Physics Beijing 100193China Beijing Academy of Quantum Information Sciences Beijing 100193China

We study superradiant phase transitions in a hybrid system of a two-dimensional Bose–Einstein condensate of atoms and two cavities arranged with a tilt *** adjusting the loss rate of cavities,we map out the phase diagram of steady states within a mean field *** is found that when the loss rates of the two cavities are different,superradiant transitions may not occur at the same time in the two cavities.A first-order phase transition is observed between the states with only one cavity in superradiance and both in *** the case that both cavities are superradiant,a net photon current is observed flowing from the cavity with small decay rate to the one with large decay *** photon current shows a non-monotonic dependence on the loss rate difference,owing to the competition of photon number difference and cavity field phase *** findings can be realized and detected in experiments.

关键词： Einstein transitions decay