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Comp.r.tive study of indocyanine gr.en-r.5,Child-p.gh scor.,and model for.end-stage liver.disease scor. for.p.ediction of hep.tic encep.alop.thy after.tr.nsjugular.intr.hep.tic p.r.osystemic shunt

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Wor.d Jour.al of Gastr.enter.logy 2021年第5期27卷 416-427页

作者： Zhong Wang yi-Fan wu Zhen-Dong Yue Hong-wei Zhao Lei Wang Zhen-Hua Fan Yu zhang Fu-Quan Liu department of Inter.entional Ther.p. Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGr.UND Hep.tic encep.alop.thy(HE)r.mains an enor.ous challenge in p.tients who under.o tr.nsjugular.intr.hep.tic p.r.osystemic shunt(TIp.)*** p.eop.r.tive indocyanine gr.en r.tention r.te at 15 min(ICG-r.5),as one of the liver.function assessment tools,has been develop.d as a p.ognostic indicator.in p.tients under.oing sur.er.,but ther. ar. limited data on its r.le in *** To deter.ine whether.the ICG-r.5 can be used for.p.ediction of p.st-TIp. HE in decomp.nsated cir.hosis p.tients with p.r.al hyp.r.ension(p.T)and comp.r. the clinical value of ICG-r.5,Child-p.gh scor.(Cp.),and model for.end-stage liver.disease(MELD)scor. in p.edicting p.st-TIp. HE with *** This r.tr.sp.ctive study included 195 p.tients with p.T who under.ent elective TIp. at beijing Shijitan Hosp.tal fr.m Januar. 2018 to June *** p.tients under.ent the ICG-r.5 test,Cp. evaluation,and MELD scor.ng 1 wk befor. *** to whether.they develop.d HE or.not,the p.tients wer. divided into two gr.up.:HE gr.up.and non-HE *** p.ediction of one-year.p.st-TIp. HE by ICG-r.5,Cp. and MELD scor. was evaluated by the ar.as under.the r.ceiver.op.r.ting char.cter.stic cur.es(AUCs).r.SULTS A total of 195 p.tients with p.r.al hyp.r.ension wer. included and 23%(45/195)of the p.tients develop.d p.st-TIp. *** ICG-r.5 was identified as an indep.ndent p.edictor.of p.st-TIp. *** AUCs for.the ICG-r.5,Cp.,and MELD scor. for.p.edicting p.st-TIp. HE wer. 0.664(95%confidence inter.al[CI]:0.557-0.743,p.0.0046),0.596(95%CI:0.508-0.679,p.0.087),and 0.641(95%CI:0.554-0.721,p.0.021),*** non-p.r.metr.c ap.r.ach(Delong-Delong&Clar.e-p.ar.on)showed that ther. was statistical significance in p.ir.ise comp.r.son between AUCs of ICG-r.5 and MELD scor.(p.0.0229).CONCLUSION The ICG-r.5 has ap.r.ciated clinical value for.p.edicting the occur.ence of p.st-TIp. HE and is a choice for.evaluating the p.ognosis of p.tients under.oing TIp..

关键词： Hep.tic encep.alop.thy Indocyanine gr.en-r.5 Child-p.gh scor. Model for.end-stage liver.disease scor. Tr.nsjugular.intr.hep.tic p.r.osystemic shunt p.r.al hyp.r.ention

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Identifying Car.on star. fr.m the LAMOST p.lot sur.ey with the efficient manifold r.nking algor.thm

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r.sear.h in Astr.nomy and Astr.p.ysics 2015年第10期15卷 1671-1694页

作者： Jian-Min Si yin-Bi Li A-Li Luo Liang-p.ng Tu Zhi-Xin Shi Jian-Nan zhang p.ng wei Gang Zhao yi-Hong wu Fu-Chao wu Yong-Heng Zhao Key Labor.tor. of Op.ical Astr.nomy National Astronomical ObservatoriesChinese Academy of Sciences National Key Labor.tor. of p.tter. r.cognition Institute of AutomationChinese Academy of Sciences university of Chinese Academy of Sciences School of Science Liaoning University of Science and Technology

Car.on star. ar. excellent kinematic tr.cer. of galaxies and can ser.e as a viable standar. candle, so it is wor.hwhile to automatically sear.h for.them in a lar.e amount of sp.ctr.. In this p.p.r. we ap.ly the efficient manifold r.nking algor.thm to sear.h for.car.on star. fr.m the Lar.e Sky Ar.a Multi-Object Fiber.Sp.ctr.scop.c Telescop. （LAMOST） p.lot sur.ey, whose p.r.or.ance and r.bustness ar. ver.fied comp.ehensively with four.test exp.r.ments. Using this algor.thm, we find a total of 183 car.on star., and 158 of them ar. new findings. Accor.ing to differ.nt sp.ctr.l featur.s, our.car.on star. ar. classified as 58 C-H star., 11 C-H star.candidates, 56 C-r.star., ten C-r.star.candidates, 30 C-N star., thr.e C-N star.candidates, and four.C-J star.. Ther. ar. also ten objects which have no sp.ctr.l typ. because of low sp.c- tr.l quality, and a comp.site sp.ctr.m consisting of a white dwar. and a car.on star. Ap.lying the sup.or. vector.machine algor.thm, we obtain the linear.op.imum clas- sification p.ane in the J - H ver.us/-/- Ks color.diagr.m which can be used to distinguish C-H fr.m C-N star. with their.J - H and H - Ks color.. In addition, we identify 18 dwar. car.on star. with their.r.latively high p.op.r.motions, and find thr.e car.on star. with FUV detections likely have op.ical invisible comp.nions by cr.ss matching with data fr.m the Galaxy Evolution Exp.or.r. In the end, we detect four.var.able car.on star. with the Nor.her. Sky Var.ability Sur.ey, the Catalina Sky Sur.ey and the LINEAr.var.ability databases. Accor.ing to their.p.r.ods and amp.i- tudes der.ved by fitting light cur.es with a sinusoidal function, thr.e of them ar. likely semir.gular.var.able star. and one is likely a Mir. var.able star.

关键词： methods: data analysis -- methods: statistical -- star.: car.on -- binar.es-- star.: var.ables

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Evidence for.p.r.icle acceler.tion ap.r.aching p.V ener.ies in the W51 comp.ex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collabor.tion Zhen Cao F.Ahar.nian Axikegu Y.X.Bai Y.W.Bao D.Bastier. X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor.B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Kar.0}kov D.Kuleshov K.Kur.nov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.r.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.r.Mao Z.Min W.Mitthumsir. H.J.Mu Y.C.Nan A.Ner.nov L.J.Ou p.p.ttar.kijwanich Z.Y.p.i J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.r.za D.r.ffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Step.nov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata p.H.T.Tam Q.W.Tang r.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang Kai Wang Kai Wang L.p.Wang L.Y.Wang p.H.Wang r.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.wei J.J.wei Y.J.wei T.Wen C.Y.wu H.r.wu Q.W.wu S.wu X.F.wu Y.S.wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.r.Xiong Z.Xiong D.L.Xu r.F.Xu r.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang r.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.yin N.yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.zhang F.zhang H.zhang 不详 Key Labor.tor. of p.r.icle Astr.p.ysics&Exp.r.mental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic r.y r.sear.h Center ChengduChina Dublin Institute for.Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-p.anck-Institut for.Nuclear.p.ysics P.O.Box 103980Heidelberg 69029Germany School of p.ysical Science and Technology&School of Infor.ation Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astr.nomy and Sp.ce Science Nanjing UniversityNanjing 210023China Center.for.Astr.p.ysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of p.ysics and Astr.nomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for.Nuclear.r.sear.h of r.ssian Academy of Sciences Moscow 117312Russia Hebei Nor.al university Shijiazhuang 050024China university of Science and Technology of china Hefei 230026China State Key Labor.tor. of p.r.icle Detection and Electr.nics China Key Labor.tor. of Dar. Matter.and Sp.ce Astr.nomy&Key Labor.tor. of r.dio Astr.nomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China r.sear.h Center.for.Astr.nomical Comp.ting Zhejiang LaboratoryHangzhou 311121China Key Labor.tor. for.r.sear.h in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of p.ysics and Astr.nomy Yunnan UniversityKunming 650091China Key Labor.tor. of Cosmic r.ys(Tibet university) Ministry of EducationLhasa 850000China National Astr.nomical Obser.ator.es Chinese Academy of SciencesBeijing 100101China School of p.ysics and Astr.nomy(Zhuhai)&School of p.ysics(Guangzhou)&Sino-Fr.nch Institute of Nuclear.Engineer.ng and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Fr.ntier.and Inter.iscip.inar. Science Shandong UniversityQingdao 266237China Ap. UniversitéParis Cité

Theγ-r.y emission fr.m the W51 comp.ex is widely acknowledged to be attr.buted to the inter.ction between the cosmic r.ys(Cr.)acceler.ted by the shock of sup.r.ova r.mnant(SNr.W51C and the dense molecular.clouds in the adjacent star.for.ing r.gion,***,the maximum acceler.tion cap.bility of W51C for.Cr. r.mains *** on obser.ations conducted with the Lar.e High Altitude Air.Shower.Obser.ator.(LHAASO),we r.p.r. a significant detection ofγr.ys emanating fr.m the W51 comp.ex,with ener.ies fr.m 2 to 200 *** LHAASO measur.ments,for.the fir.t time,extend theγ-r.y emission fr.m the W51 comp.ex beyond 100 TeV and r.veal a significant sp.ctr.m bending at tens of *** combining the"π^(0)-decay bump.featur.d data fr.m Fer.i-LAT,the br.adbandγ-r.y sp.ctr.m of the W51 r.gion can be well-char.cter.zed by a simp.e p.-collision *** obser.ed sp.ctr.l bending featur. suggests an exp.nential cutoff at~400 TeV or.a p.wer.law br.ak at~200 TeV in the Cr.p.oton sp.ctr.m,most likely p.oviding the fir.t evidence of SNr. ser.ing as Cr.acceler.tor. ap.r.aching the p.V ***,two young star.cluster. within W51B could also be theor.tically viable to p.oduce the most ener.eticγr.ys obser.ed by *** findings str.ngly sup.or. the p.esence of extr.me Cr.acceler.tor. within the W51 comp.ex and p.ovide new insights into the or.gin of Galactic Cr..

关键词： UHE c-r.y Cosmic r.ys SNr.W51C Star.cluster.

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Gasder.in D-mediated hep.tocyte p.r.p.osis exp.nds inflammator. r.sp.nses that aggr.vate acute liver.failur. by up.egulating monocyte chemotactic p.otein 1/CC chemokine r.cep.or.2 to r.cr.it macr.p.ages

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Wor.d Jour.al of Gastr.enter.logy 2019年第44期25卷 6527-6540页

作者： Hong Li Xue-Ke Zhao yi-Ju Cheng Quan zhang Jun wu Shuang Lu wei zhang Yang Liu Ming-Yu Zhou Ya Wang Jing Yang Ming-Liang Cheng department of Infectious Diseases Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Comp.ehensive Liver.Cancer.Center.of the Fifth Medical Center.of p.A Gener.l Hosp.tal Beijing 100039China

BACKGr.UND Massive hep.tocyte death is the cor. event in acute liver.failur.(ALF).Gasder.in D(GSDMD)-mediated p.r.p.osis is a typ. of highly inflammator. cell ***,the r.le of hep.tocyte p.r.p.osis and its mechanisms of exp.nding inflammator. r.sp.nses in ALF ar. *** To investigate the r.le and mechanisms of GSDMD-mediated hep.tocyte p.r.p.osis thr.ugh in vitr. and in vivo *** The exp.ession of p.r.p.osis p.thway-associated p.oteins in liver.tissues fr.m ALF p.tients and a hep.tocyte injur. model was examined by Wester. *** shor. hair.0}n r.A(shr.A)was used to investigate the effects of downr.gulation of GSDMD on monocyte chemotactic p.otein 1(MCp.)and its r.cep.or.CC chemokine r.cep.or.2(CCr.)in *** in vivo exp.r.ments,we used GSDMD knockout mice to investigate the r.le and mechanism of GSDMD in a D-galactose/lip.p.lysacchar.de(D-Galn/Lp.)-induced ALF mouse *** The levels of p.r.p.osis p.thway-associated p.oteins in liver.tissue fr.m ALF p.tients and a hep.tocyte injur. model incr.ased *** level of GSDMD-N p.otein incr.ased most obviously(p.0.001).In vitr.,downr.gulation of GSDMD by shr.A decr.ased the cell inhibition r.te and the levels of MCp./CCr. p.oteins(p.0.01).In vivo,GSDMD knockout dr.matically eliminated inflammator. damage in the liver.and imp.oved the sur.ival of DGaln/Lp.-induced ALF mice(p.0.001).Unlike the mechanism of immune cell p.r.p.osis that involves r.leasing inter.eukin(IL)-1βand IL-18,GSDMDmediated hep.tocyte p.r.p.osis r.cr.ited macr.p.ages via MCp./CCr. to aggr.vate hep.tocyte ***,this p.thological p.ocess was inhibited after.knocking down *** GSDMD-mediated hep.tocyte p.r.p.osis p.ays an imp.r.ant r.le in the p.thogenesis of ALF,r.cr.iting macr.p.ages to r.lease inflammator. mediator. by up.egulating MCp./CCr. and leading to exp.nsion of the inflammator. *** knockout can r.duce hep.tocyte death and inflammator. r.sp.nses,thus alleviating

关键词： Gasder.in D Hep.tocyte p.r.p.osis Acute liver failur. Monocyte chemotactic p.otein 1/CC chemokine r.cep.or.2

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B_(c)→J/ψhelicity for. factor. and the B_(c)^(+)→J/ψ+(p.V,ℓ^(+)ν_(ℓ))decays

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Chinese p.ysics C 2022年第5期46卷 29-37页

作者： wei Cheng yi zhang Long Zeng Hai-Bing Fu Xing-Gang wu School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China State Key Labor.tor. of Theor.tical p.ysics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China department of p.ysics Chongqing UniversityChongqing 401331China department of p.ysics Guizhou Minzu UniversityGuiyang 550025China Chongqing Key Labor.tor. for.Str.ngly Coup.ed p.ysics Chongqing 401331China

In this p.p.r.we calculate the B_(c)→J/ψhelicity for. factor.(HFFs)up.to twist-4 accur.cy by using the light-cone sum r.les(LCSr.*** extr.p.lating those HFFs to the p.ysically allowable q^(2)r.gion,we investigate the B_(c)^(+)-meson two-body decays and semi-lep.onic decays B_(c)^(+)→J/ψ+(p.V,ℓ^(+)ν_(ℓ)),wher. p.V stand for.light p.eudoscalar.and vector.mesons,*** br.nching fr.ctions can be der.ved using the CKM matr.x element and the B_(c)lifetime fr.m the p.r.icle Data Gr.up.and we obtain B(B^(+)_(c)→J/ψπ^(+))=(0.136+0.002−0.002)%,B(B^(+)_(c)→J/ψK^(+))=(0.010+0.000−0.000)%,B(B^(+)_(c)→J/ψρ+)=(0.768+0.029−0.033)%,B(B^(+)_(c)→J/ψK^(∗+))=(0.043+0.001−0.001)%,B(B^(+)_(c)→J/ψ_(μ)+ν_(μ))=(2.802+0.526−0.675)%and B(B^(+)_(c)→J/ψτ^(+)ν_(τ))=(0.559+0.131−0.170)%.We then obtain r.(π^(+)/μ+ν_(μ))=0.048+0.009−0.012 and r.(K^(+)/π^(+))=0.075+0.005−0.005,which agr.e with the LHCb measur.d value within 1σ-*** also obtain r.(J/ψ)=0.199+0.060−0.077,which like other.theor.tical p.edictions,is consistent with the LHCb measur.d value within 2σ-*** imp.y that the HFFs under.the LCSr.ap.r.ach ar. also ap.licable to the B+c meson two-body decays and semi-lep.onic decays B+c→J/ψ+(p.V,ℓ^(+)ν_(ℓ)),and the HFFs obtained using LCSr.in a new way imp.ies that ther. may be new p.ysics in the B_(c)→J/ψℓ^(+)ν_(ℓ)semi-lep.onic decays.

关键词： helicity for. factor. semilep.onic decays light-cone sum r.les nonlep.onic two-body decays

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p.nile p.osthesis imp.antation in Chinese p.tients wit sever. er.ctile dysfunction： 10-year.exp.r.ence

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Asian Jour.al of Andr.logy 2013年第5期15卷 658-661页

作者： wei-Dong Song yi-Ming Yuan Wan-Shou Cui Alex K wu yi-Chen Zhu Jing Liu Lin Wang Guang-yi Ba Jing p.ng Zhi-Chao zhang Bing Gao ying-Lu Guo Tom F Lue Zhong-Cheng Xin Andr.logy Center Peking University First Hospital Peking University Beijing 100034 China department of Ur.logy Beijing Youyi Hospital Beijing Capital University Beijing 100050 China department of Ur.logy University of California San Francisco CA 94143 USA

We r.tr.sp.ctively evaluated the clinical outcome of p.nile p.osthesis imp.antation （p.I） in Chinese p.tients with sever. er.ctile dysfunction （SED）. Fr.m July 2000 to December.2011, 224 p.tients （mean age： 35.9±11.8 year., r.nge： 20-75 year.） with SED under.ent p.I by exp.r.enced sur.eon accor.ing to standar. p.I p.ocedur. at our.centr.. A malleable p.osthesis （AMS 650） was imp.anted in 45 cases （20.1%）, and a thr.e-p.ece inflatable p.osthesis （AMS 700 CXM or.AMS 700 CXr. was imp.anted in 179 cases （79.9%）. Sur.ical outcomes, including p.stop.r.tive comp.ications, clinical efficacy and coup.e satisfaction, wer. evaluated over.than 6 months p.stop.r.tively using medical r.cor. abstr.ction, IIEF-5, quality of life （QoL） scor.s, and the p.tient/p.r.ner.sexual satisfaction scor. p.op.sed by Bhojwani etaL Of the 224 p.tients eligible for.the study, 201 subjects （89.7%） comp.eted follow-up. All of p.tients could p.r.or. sexual inter.our.e p.st p.I with the mean p.stop.r.tive IIEF-5 and QoL scor.s wer. 20.02±2.32 and 5.28±0.76, r.sp.ctively, which wer. significantly imp.oved comp.r.d with the p.eop.r.tive scor.s （6.29±1.5 and 2.13±0.84, p.0.01）. Of the 201 men, mechanical malfunction occur.ed in four.cases （2.0%） and thr.e cases wer. r.-imp.anted new device, and two cases （1.0%） develop.d a mild cur.atur. of the p.nis. Scr.tal er.sion with infection occur.ed in one case with diabetes mellitus （0.5%） and r.quir.d comp.ete r.moval of the imp.anted AMS 700 CXM. Satisfactor. sexual inter.our.e at least twice p.r.month was r.p.r.ed by 178 men （88.6%）, and over.ll satisfaction with the p.I sur.er. was r.p.r.ed by 89.0% of men and 82.5% of p.r.ner.. p.tient satisfaction in the thr.e-p.ece inflatable p.osthesis gr.up.was higher.than in the malleable p.osthesis gr.up.（p.0.05）. Satisfaction, however. between the typ.s of p.ostheses, did not differ.in the p.r.ner.sur.ey. p.I is a safe and effective tr.atment op.ion for.Chinese p.tients with SED and exp.r.enced sur.eon p.r.or. p.I ac

关键词： comp.ication er.ctile dysfunction (ED) imp.antation quality of life (QoL) p.nile p.osthesis satisfaction

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r.liable folding of hybr.d tetr.p.p.ides into shor.β-hair.0}ns

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Chinese Chemical Letter. 2022年第1期33卷 257-261页

作者： Xue-yi Sun Yulong Zhong Yao-Hua Li Daniel p.Miller.Sagar.Buttan Xiang-Xiang wu Yukun zhang Quan Tang Hong-wei Tan Jin Zhu r.i Liu Eva Zur.k Zhong-Lin Lu Bing Gong College of Chemistr. Beijing Normal UniversityBeijing 100875China department of Chemistr. University at BuffaloThe State University of New YorkBuffaloNY 14260United States department of Chemistr. Hofstra UniversityHempsteadNY 11549United States Academy of Chinese Medical Science Henan University of Chinese MedicineZhengzhou 450046China Chengdu Institute of Or.anic Chemistr. Chinese Academy of SciencesChengdu 610041China

Five hybr.d tetr.p.p.ides,each consisting a centr.l dip.p.ide segment ofα-amino acid r.sidues flanked by two ar.maticγ-amino acid r.sidues,ar. found to fold into well-definedβ-hair.0}n confor.ations as shown by NMr.comp.tational study,and X-r.y *** tur. loop.of thisβ-hair.0}n motif accommodates differ.nt two-r.sidueα-amino acid sequences fr.m the highly flexible Gly-Gly,to the mor. r.str.cted *** p.esence ofα-amino acid side chains enhances the stabilities of theβ-hair.0}ns with the excep.ion of D-p.o-Gly-which r.sults in *** on this hair.0}n/tur. motif,a var.ety of differ.nt dip.p.ide sequences ofα-amino acids which r.r.ly occur.inβ-tur.s can be intr.duced and p.esented as two-r.sidue loop..

关键词： β-Hair.0}n β-Tur. γ-Amino acid NMr X-r.y

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r.str.ctive Car.iomyop.thy r.sulting fr.m a Tr.p.nin Ⅰ Typ. 3 Mutation in a Chinese Family

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Chinese Medical Sciences Jour.al 2016年第1期31卷 1-7页

作者： Yan-p.ng r.an Chao-xia Lu Xiao-yi Zhao r.i-juan Liang Hui Lian Michael r.utledge wei wu Xue zhang Zhong-jie Fan department of Car.iology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China McKusick-zhang Center.for.Genetic Medicine Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100005 China Leeds Institute of Car.iovascular.& Metabolic Medicine University of Leeds Leeds LS2 9JZ UK

Objective To identify the p.thogenic var.ant r.sp.nsible for.r.str.ctive car.iomyop.thy （r.M） in aChinese *** Next gener.tion sequencing was used for.detecting the mutation and r.sults ver.fied bysequencing. We used r.str.ction enzyme digestion to test the mutation in the family member. and 200 unr.latednor.al subjects without any car.iac inher.ted diseases when the mutation was *** Five individuals died fr.m car.iac diseases, two of whom suffer.d fr.m sudden car.iacdeath. Two individuals have suffer.d fr.m chr.nic car.iac disor.er.. Mutation analysis r.vealed a novelmissense mutation in exon 7 of tr.p.nin I typ. 3 （TNNI3）, r.sulting in substitution of ser.ne （S） withp.oline （p. at amino acid p.sition 150, which cosegr.gated with the disease in the family, which is p.edictedto be p.obably damaging using p.lyp.en-2. The mutation was not detected in the 200 unr.lated subjectswe *** Using next gener.tion sequencing, which has ver. r.cently been shown to be successfulin identifying novel causative mutations of r.r. Mendelian disor.er., we found a novel mutation of TNNI3 in aChinese family with r.M.

关键词： r.str.ctive car.iomyop.thy autosomal dominant tr.p.nin I

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胆囊癌根治性目的切除术达到教科书式结局对远期预后影响的全国多中心队列研究

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中华消化外科杂志 2024年第7期23卷 926-933页

作者：刘智鹏李子沐罗宇乐赵小林白洁江艳李云峰喻超黄帆吴兆平周进学尹大龙丁睿郭伟朱沂陈伟林科灿岳平程遥戴海粟张东陈志宇陆军军医大学第一附属医院肝胆外科全军肝胆外科研究所重庆400038 湖南省人民医院肝胆胰外科长沙410002 贵州医科大学附属医院肝胆外科贵阳550004 安徽医科大学第一附属医院普通外科合肥230022 九江市第一人民医院肝胆胰外科九江332001 郑州大学附属肿瘤医院肝胆胰外科郑州450003 中国科学技术大学附属第一医院肝胆外科合肥230002 空军军医大学第一附属医院肝胆胰外科西安710032 首都医科大学附属北京友谊医院普通外科北京100050 浙江大学医学院附属第二医院肝胆胰外科杭州310003 中山大学第一附属医院肝胆胰外科中山510080 福建医科大学孟超肝胆医院肝病中心福州350025 兰州大学第一医院普通外科兰州730013 重庆医科大学附属第二医院肝胆外科重庆400010 西安交通大学第一附属医院肝胆外科西安710061

目的探讨胆囊癌根治性目的切除术后达到肝脏外科中教科书式结局(TOLS)对远期预后的影响。方法采用回顾性队列研究方法。收集2014年1月至2021年1月中华消化外科菁英荟胆道外科学组全国多中心数据库15家医学中心收治的824例胆囊癌患者的... 详细信息

目的探讨胆囊癌根治性目的切除术后达到肝脏外科中教科书式结局(TOLS)对远期预后的影响。方法采用回顾性队列研究方法。收集2014年1月至2021年1月中华消化外科菁英荟胆道外科学组全国多中心数据库15家医学中心收治的824例胆囊癌患者的临床病理资料;男285例,女539例;年龄为(62±11)岁。根据TOLS评价标准,将患者分为达到TOLS和未达到TOLS。正态分布的计量资料以x±s表示,组间比较采用独立样本t检验;偏态分布的计量资料以M(Q1,Q3)表示,组间比较采用Mann‑Whitney U检验。计数资料以绝对数表示,组间比较采用χ^(2)检验。等级资料比较采用Mann‑Whitney U检验。采用Kap.an‑Meier.计算生存率和绘制生存曲线,Log‑r.nk检验进行生存分析。单因素分析和多因素分析采用COX逐步回归模型向后Wald法。结果(1)TOLS情况。824例行胆囊癌根治性目的切除术患者中,510例达到TOLS,314例未达到TOLS。(2)随访情况。824例行胆囊癌根治性目的切除术患者,排除出院后90 d内死亡的112例,712例患者纳入生存分析。510例达到TOLS患者的中位随访时间为22.1(11.4,30.1)个月,中位总生存时间为47.6(30.6,64.6)个月,5年总生存率为47.5%。202例未达到TOLS患者的中位随访时间为14.0(6.8,25.5)个月,中位总生存时间为24.3(20.0,28.6)个月,5年总生存率为21.0%。两者总生存情况比较,差异有统计学意义(χ^(2)=58.491,p.0.05)。(3)影响患者生存情况的因素分析。多因素分析结果显示:TOLS、癌胚抗原、CA19‑9、肿瘤分化程度为低分化、第八版美国癌症联合委员会(AJCC)T2期、第八版AJCC T3期和T4期、第八版AJCC N1期、第八版AJCC N2期、辅助治疗是胆囊癌根治性目的切除术后患者总生存时间的独立影响因素(风险比=0.452,1.479,1.373,1.612,1.455,1.481,1.835,1.978,0.538,95%可信区间为0.352~0.581,1.141~1.964,1.052~1.791,1.259~2.063,1.102~1.920,1.022~2.147,1.380~2.441,1.342~2.915,0.382~0.758,p.0.05)。结论达到TOLS的胆囊癌根治性目的切除术患者能够获得更好的远期预后。

关键词：胆道肿瘤肝切除教科书式结局影响因素分析预后

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Indoor.Aller.en Levels and Household Distr.butions in Nine Cities Acr.ss china

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Biomedical and Envir.nmental Sciences 2015年第10期28卷 709-717页

作者： ZHENG yi wu LAI Xu Xin ZHAO De Yu zhang Chun Qing CHEN Jian Jun zhang Luo wei Qing Yu CHEN Shi LIU En Mei NOr.ACK Dan GJESING Bir.itte ZHONG Nan Shan Sp.NGFOr. D.Michael r.sear.h Asia p.cific ALK department of r.sp.r.tor. Medicine the Affiliated Children's Hospital of Nanjing Medical University State Key Labor.tor. of r.sp.r.tor. Disease the First Affiliated HospitalGuangzhou Medical University ENT department of wuhan Union Hosp.tal ENT department of beijing Tongr.n Hosp.tal Aller.ology department of Shenyang 202 Hosp.tal Asthmatic Childr.n's Immunother.p. Center.of p.op.e's Hosp.tal of Hainan p.ovince r.sp.r.tor. department Children's Hospital of Chongqing Medical University department of Medical Science and Occup.tional and Envir.nmental Medicine University HospitalUppsala University

Objective Chinese aller.ic subjects have high levels of sensitization to house dust mite （HDM） and other.indoor.aller.ens. This study quantifies common indoor.aller.en levels in Chinese households. Methods Dust samp.es wer. collected fr.m nine cities. Major.aller.ens Der.p.1 and Der.f I fr.m Der.atop.agoides p.er.nyssinus and D. far.nae, and sp.cific antigens of Blomia tr.p.calis, Tyr.p.agus p.tr.scentiae, Acar.s sir., and cockr.ach sp.cies Blattella ger.anica and p.r.p.aneta amer.cana wer. measur.d by *** HDM aller.ens wer. found in dust samp.es fr.m bedding in 95% of the Chinese households. The median levels var.ed fr.m 〈0.006 to 9.2 μg/g of dust, dep.nding on the city. The p.r.entages of households having HDM aller.en levels associated with the r.sk of develop.ng aller.y sensitization and asthma wer. 65% and 25%, r.sp.ctively. Sp.cific antigens of the stor.ge mite and cockr.ach wer. only found in samp.es fr.m the souther. and tr.p.cal r.gions of china. Levels of mite aller.ens wer. gener.lly higher.in samp.es fr.m bedding comp.r.d to samp.es fr.m the living r.om, even for.stor.ge mites, wher.as levels of cockr.ach antigens wer. higher.in the living r.om *** HDM aller.ens ar. p.esent in bedding dust samp.es fr.m most Chinese households. Cities in souther. and centr.l china have r.latively high levels of HDM major.aller.ens comp.r.d to cities in nor.her. and wester. china. Antigens of stor.ge mites and cockr.aches ar. not as common as HDM aller.ens.

关键词： Der.atop.agoides p.er.nyssinus D. far.nae House dust mite Indoor.aller.en Stor.ge mite

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